Category: 130307-08-3

Chemistry is an experimental science, Name: 1-(4-Bromophenyl)-4-methylpiperazine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, belongs to piperazines compound. In a document, author is Xia, Fangbo.

Quantitative profiling of eicosanoids derived from n-6 and n-3 polyunsaturated fatty acids by twin derivatization strategy combined with LC-MS/MS in patients with type 2 diabetes mellitus

Eicosanoids derived from n-6 and n-3 polyunsaturated fatty acids (PUFAs), serving as important signaling molecules, are implicated in many physiological and pathological processes, including Type 2 diabetes mellitus (T2DM). However, the quantification of endogenous eicosanoids is challenged by high structural similarity, low abundance in biological sample and poor electrospray ionization efficiency. In the current study, a sensitive and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to quantify 65 eicosanoids derived from n-6 and n-3 PUFAs in plasma samples using twin derivatization strategy with a pair of reagents, 5-(dimethylamino) naphthalene-1-sulfonyl piperazine (Dns-PP) and (diethylamino) naphthalene-1-sulfonyl piperazine (Dens-PP). Dns-PP-derivatized plasma sample was mixed with the equal volume of Dens-PP-derivatized eicosanoid internal standards for LC-MS/MS analysis in multiple reaction monitoring (MRM) mode. After Dns-PP derivatization, the ionization efficiency and separation performance were substantially improved, resulting in the enhanced sensitivity by 446- to 1009-folds compared to intact eicosanoids. The quantitative accuracy determined by twin derivatization method was found to be comparable with stable isotope labeled internal standards (SIL-IS) method. The newly proposed method was successfully employed to quantify the target eicosanoids in plasma samples from healthy controls and the patients with T2DM. N-6 PUFA-derived eicosanoids, PGF2 alpha, PGD2, PGE2, PGA2, PGB2, 20-HETE and LTC4, significantly increased in plasma sample of T2DM patients. Oppositely, n-3 PUFA-derived eicosanoids, RvE1, 12(S)-HEPE and RvD1, remarkably decreased. Spearman’s correlation analysis indicated the strong correlations between these highlighted eicosanoids and clinical parameters of T2DM. Collectively, the sensitive and reliable eicosanoid quantification method may facilitate to elucidate the characteristics of eicosanoid metabolism and understand the role of eicosanoids in the pathogenesis of T2DM and other diseases. (C) 2020 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 130307-08-3, in my other articles. Name: 1-(4-Bromophenyl)-4-methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Synthetic Route of 130307-08-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, SMILES is CN1CCN(C2=CC=C(Br)C=C2)CC1, belongs to piperazines compound. In a article, author is Hadi, Raha, introduce new discover of the category.

Design and green synthesis of 1-(4-ferrocenylbutyl)piperazine chemically grafted reduced graphene oxide for supercapacitor application

In this paper, we report the green synthesis of 1-(4-ferrocenylbutyl)piperazine chemically grafted rGO (P.Fc/rGO) as a battery-type supercapacitor electrode material. For this purpose, initially, the ability of the aqueousDamsonfruit extract is investigated in the reduction reaction of graphene oxide (GO). 1-(4-ferrocenylbutyl)piperazine (P.Fc) is synthesizedvianucleophilic substitution reaction of piperazine with as-synthesized 4-chlorobutylferrocene. In continue, P. Fc is incorporated to GO by ring-opening reaction of epoxide groups on the GO surface. In the next step, the modified reduction method by aqueousDamsonfruit extract was used to prepare the P.Fc/rGO from P.Fc/GO. The prepared materials were characterized by various techniques including FT-IR, Uv-vis, XRD, SEM, EDX, and BET. N(2)adsorption-desorption data of P.Fc/rGO nanocomposite shows that the surface area is 37.746 m(2)g(-1). The capability of P.Fc/rGO nanocomposite for using as an energy storage electrode material in battery-type supercapacitor was examined by investigation of its electrochemical behavior by CV, EIS, and GCD measurements. The charge storage capacity of 1,102 mAh g(-1)is achieved at 2.5 A g(-1). This nanocomposite shows 89% retention of charge storage capacity after 2000 CV cycles.

Synthetic Route of 130307-08-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 130307-08-3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2. In an article, author is Falsini, Matteo,once mentioned of 130307-08-3, Category: piperazines.

New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A(2A) adenosine receptor antagonists

In this work, further structural investigations on the 8-amino-2-phenyl-6-aryl-1,2,4-triazolo[4,3-a]pyrazin-3-one series were carried out to achieve potent and selective human A(2A) adenosine receptor (AR) antagonists. Different ether and amide moieties were attached at the para-position of the 6-phenyl ring, thus leading to compounds 1-9 and 10-18, respectively. Most of these moieties contained terminal basic rings (pyrrolidine, morpholine, piperidine and substituted piperazines) which were thought to confer good physicochemical and drug-like properties. Compounds 11-16, bearing the amide linker, possessed high affinity and selectivity for the hA(2A) AR (K-i = 3.6-11.8 nM). Also derivatives 1-9, featuring an ether linker, preferentially targeted the hA(2A) AR but with lower affinity, compared to those of the relative amide compounds. Docking studies, carried out at the hA(2A) AR binding site, highlighted some crucial ligand-receptor interactions, particularly those provided by the appended substituent whose nature deeply affected hA(2A) AR affinity.

Interested yet? Keep reading other articles of 130307-08-3, you can contact me at any time and look forward to more communication. Category: piperazines.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Related Products of 130307-08-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, SMILES is CN1CCN(C2=CC=C(Br)C=C2)CC1, belongs to piperazines compound. In a article, author is Khan, Bilal Alam, introduce new discover of the category.

Energy Minimization in Piperazine Promoted MDEA-Based CO2 Capture Process

A piperazine (PZ)-promoted methyldiethanolamine (MDEA) solution for a carbon dioxide (CO2) removal process from the flue gas of a large-scale coal power plant has been simulated. An Aspen Plus was used to perform the simulation process. Initially, the effects of MDEA/PZ concentration ratio and stripper pressure on the regeneration energy of CO2 capture process were investigated. The MDEA/PZ concentration ratio of 35/15 wt.% (35 wt. MDEA and 15 wt.% PZ) was selected as an appropriate concentration. The reboiler duty of 3.235 MJ/kg CO2 was obtained at 35/15 wt.% concentration ratio of MDEA/PZ. It was considered a reference or base case, and process modifications including rich vapor compression (RVC) process, cold solvent split (CSS), and the combination of both processes were investigated to check its effect on the energy requirement. A total equivalent work of 0.7 MJ(e)/kg CO2 in the RVC and a reboiler duty of 2.78 MJ/kg CO2 was achieved in the CSS process. Similarly, the total equivalent work, reboiler duty, and condenser duty of 0.627 MJ(e)/kg CO2, 2.44 MJ/kg CO2, and 0.33 MJ/kg CO2, respectively, were obtained in the combined process. The reboiler duty and the total equivalent work were reduced by about 24.6 and 16.2%, respectively, as compared to the reference case. The total energy cost saving was 1.79 M$/yr. Considering the additional equipment cost in the combined process, the total cost saving was 0.67 M$ per year.

Related Products of 130307-08-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 130307-08-3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is an experimental science, COA of Formula: C11H15BrN2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, belongs to piperazines compound. In a document, author is Abdelrahman, Maha M..

Ecofriendly Validated Chromatographic Methods for Quantitation of Cyclizine and Its Toxic Impurities in Its Parenteral Formulation

Cyclizine (CYZ) abuse is commonly reported, either through oral or intravenous routes, for its euphoric or hallucinatory effects. The concomitant misuse of CYZ among addicted teenagers leads to life-threatening neuromuscular disorders. Consequently, two green and validated chromatographic methods were developed for the determination of CYZ, an antiemetic drug, in its parenteral formulation in the presence of 1-methyl piperazine and diphenylmethanol (benzhydrol) as the pharmacopeial stated impurities of CYZ. The first method was TLC-densitometry that relied on using a mixture consisting of ethyl acetate:isopropanol:ammonia (9.5:1:0.5, by volume) as a developing system, TLC 60 F-254 silica gel plates as a stationary phase and detection of the scanned bands was performed at 210.0 nm. On the other hand, the second method was UPLC which based on the separation of CYZ and its impurities using a mobile phase consisting of ethanol and acidic water at pH 5 adjusted by phosphoric acid in the ratio of (60:40, %v/v) at flow rate 0.2 mL min(-1) and UV detection were carried out at 210.0 nm. The greenness profile of the established methods was evaluated and calculated for the first time for CYZ and its toxic impurities through different assessment tools like analytical eco-scale, analytical method volume intensity and greenness profile methods. Validation of the developed methods was carried out in accordance with the guidelines of the International Conference on Harmonization. The suggested methods were accurate, reliable, time and cost-saving. Therefore, they could be used in quantification of CYZ abuse and its toxic impurities in parenteral formulation for routine quality control. The results achieved by applying the suggested methods were statistically analyzed and compared with those given by reported one and no significant differences were obtained regarding both precision and accuracy.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 130307-08-3, in my other articles. COA of Formula: C11H15BrN2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, belongs to piperazines compound, is a common compound. In a patnet, author is Feng, Aiqing, once mentioned the new application about 130307-08-3, Recommanded Product: 1-(4-Bromophenyl)-4-methylpiperazine.

Crystal structure of 1-(3-chlorophenyl)-4-(4-(((2,3-dihydro-1H-inden-5-yl)oxy)methyl)phenethyl) piperazine, C28H3ClN2O

C28H31ClN2O, monoclinic, P (1) over bar (no. 2), a -21.9309(11) angstrom, b = 9.9648(5) angstrom, c = 11.0049(7) angstrom, beta = 93.403(6)degrees, V = 2400.7(2) angstrom(3), Z = 4, R-gt(F) = 0.0566, wR(ref)(F-2) = 0.1355, T = 293 K.

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Piperazine – Wikipedia,
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Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, belongs to piperazines compound. In a document, author is Vinarov, Zahari, introduce the new discover, Quality Control of 1-(4-Bromophenyl)-4-methylpiperazine.

Solubilization of itraconazole by surfactants and phospholipid-surfactant mixtures: interplay of amphiphile structure, pH and electrostatic interactions

Although surfactants are frequently used in enabling formulations of poorly water-soluble drugs, the link between their structure and drug solubilization capacity is still unclear. We studied the solubilization of the brick-dust molecule itraconazole by 16 surfactants and 3 phospholipid:surfactant mixtures. NMR spectroscopy was used to study in more details the drug-surfactant interactions. Very high solubility of itraconazole (up to 3.6 g/L) was measured in anionic surfactant micelles at pH = 3, due to electrostatic attraction between the oppositely charged (at this pH) drug and surfactant molecules. H-1 NMR spectroscopy showed that itraconazole is ionized at two sites (2+ charge) at these conditions: in the phenoxy-linked piperazine nitrogen and in the dioxolane-linked triazole ring. The increase of amphiphile hydrophobic chain length had a markedly different effect, depending on the amphiphile type: the solubilization capacity of single-chain surfactants increased, whereas a decrease was observed for double-chained surfactants (phosphatidylglycerols). The excellent correlation between the chain melting temperatures of phosphatidylglycerols and itraconazole solubilization illustrated the importance of hydrophobic chain mobility. This study provides rules for selection of itraconazole solubilizers among classical single-chain surfactants and phospholipids. The basic physics underpinning the described effects suggests that these rules should be transferrable to other brick-dust molecules.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 130307-08-3. Quality Control of 1-(4-Bromophenyl)-4-methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Kuang, Lu, once mentioned the application of 130307-08-3, Quality Control of 1-(4-Bromophenyl)-4-methylpiperazine, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, molecular weight is 255.1542, MDL number is MFCD09029689, category is piperazines. Now introduce a scientific discovery about this category.

One-pot, two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazoles

A facile, one-pot two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazole derivatives has been developed. The protocol employs an N-allylation of N-propargylated amines with 2,3-dibromopropene in the presence of K2CO3 in DMSO and a CuI-catalyzed [3 + 2] cycloaddition reaction of the synthetic N-(2-bromoallyl)-N-propargyl amines with sodium azide sequentially. Such a method provides methylene-substituted 1,2,3-triazole fused piperazines with some advantages such as simple operation, high efficiency and good product yield (80-91%) through readily available starting materials.

If you are interested in 130307-08-3, you can contact me at any time and look forward to more communication. Quality Control of 1-(4-Bromophenyl)-4-methylpiperazine.

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Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Safety of 1-(4-Bromophenyl)-4-methylpiperazine, 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, belongs to piperazines compound. In a document, author is Patil, Mahadev, introduce the new discover.

Synthesis, molecular docking studies, and in vitro antimicrobial evaluation of piperazine and triazolo-pyrazine derivatives

For this work, two series of new piperazine derivatives (3a-o) and triazolo-pyrazine derivatives (3p-t) were synthesized in a single-step reaction. All twenty adducts were obtained in good to high yields and fully characterized by H-1 NMR, C-13 NMR, IR, and mass spectrometry techniques. To further confirm the chemical identity of the adducts, a crystal of N-{[(4-chlorophenyl)-3-(trifluoromethyl)]-5,6-dihydro-[1,2,4]triazolo[4,3-a]}pyrazine-7(8H)-carboxamide (3t) was prepared and analyzed using X-ray crystallography. In vitro screening of the antimicrobial activity of all compounds (3a-t) was evaluated against five bacterial and two fungal strains. This study disclosed that N-{[(3-chlorophenyl)]-4-(dibenzo[b,f][1,4]thiazepin-11-yl)}piperazine-1-carboxamide (3o) was the superior antimicrobial with good growth inhibition against A. baumannii. Furthermore, the results from the performed molecular docking studies were promising, since the observed data could be used to develop more potent antimicrobials.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 130307-08-3. Safety of 1-(4-Bromophenyl)-4-methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is an experimental science, Application In Synthesis of 1-(4-Bromophenyl)-4-methylpiperazine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, belongs to piperazines compound. In a document, author is Liu, Zhenxing.

AIE-based nanoaggregate tracker: high-fidelity visualization of lysosomal movement and drug-escaping processes

High-fidelity imaging and long-term visualization of lysosomes are crucial for their functional evaluation, related disease detection and active drug screening. However, commercial aggregation-caused quenching probes are not conducive to precise lysosomal imaging because of their inherent drawbacks, like easy diffusion, short emission and small Stokes shift, let alone their long-term tracing due to rapid photobleaching. Herein we report a novel aggregation-induced emission (AIE)-based TCM-PI nanoaggregate tracker for direct visualization of lysosomes based on the building block of tricyano-methylene-pyridine (TCM), wherein introduced piperazine (PI) groups behave as targeting units to lysosomes upon protonation, and the self-assembled nanostructure contributes to fast endocytosis for enhanced targeting ability as well as extended retention time for long-term imaging. The piperazine-stabilized TCM-PI nanoaggregate shifts the emission maximum to 677 nm in an aqueous environment, and falls within the desirable NIR region with a large Stokes shift of 162 nm, thereby greatly reducing biological fluorescent background interference. In contrast with the commercially available LysoTracker Red, the essential AIE characteristic of high photostability can guarantee three-dimensional high-fidelity tracing with low photobleaching, and little diffusion from lysosomes, and especially overcome the AIE bottleneck to target specificity. Consequently, the AIE-based nanoaggregate tracker successfully achieves the high-fidelity and long-term tracing of lysosomal movement and even monitors the drug-escaping process from lysosomes to cell nuclei, which provides a potential tool to benefit drug screening.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 130307-08-3. Application In Synthesis of 1-(4-Bromophenyl)-4-methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics