Category: 13484-40-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 6 or 7 (0.68-0.74 mmol) in 3 mL of n-BuOH kept in a PV with stirring, cyclic amines (1.02-1.11 mmol) was added. The sealed PV was placed in an oil bath at 145-150 C and stirred for 50-60 min. The solvent was evaporated in vacuo with the aid of DCM and the residue was re-dissolved in 2:1 EtOAc/DCM and washed successively with saturated NaHCO3 and NaCl solution (1 x 15 mL), respectively. The aqueous layer was washed with EtOAc (3 x 5 mL) and the organic layer was dried over anhydrous MgSO4 then filtered. The solution was evaporated in vacuo and purified using silica gel column chromatography with appropriate eluents (EtOAc/hexanes 3:1 and 1:3 v/v, respectively or 9:1 DCM/EtOAc) to afford either solid or semisolid products., 13484-40-7

As the paragraph descriping shows that 13484-40-7 is playing an increasingly important role.

Reference：
Article; Mohamed, Tarek; Yeung, Jacky C.K.; Rao, Praveen P.N.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5881 – 5887;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 5-cyclopropyl-5-phenyl- (0.01 mol; 1) or 5-cyclopropyl-5-(4-chlorophenyl)-imidazolidine-2,4-dione (0.01 mol; 2), 40% solution of formaldehyde (0.01 mol) in 96% ethanol (20 mL), corresponding 4-substituted piperazines (0.01 mol), tetrahydroisoquinoline (THIQ) or morpholine dissolved in 96% ethanol (10 mL) were added. The mixture was left for ca. 12 h at room temperature and then refrigerated at ca. -10 C for 24 h. The precipitated crude products were washed with cold ethanol, separated by filtration and recrystallized from 96% ethanol.

13484-40-7, The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Byrtus, Hanna; Obniska, Jolanta; Czopek, Anna; Kami?ski, Krzysztof; Paw?owski, MacIej; Bioorganic and Medicinal Chemistry; vol. 19; 20; (2011); p. 6149 – 6156;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 7, 8 or 9 (0.74-0.91 mmol) in 3 mL of n-BuOH kept in a PV with stirring, cyclic amines (1.12 mmol) was added. The sealed PV was placed in an oil bath at 145-150 C and stirred for 30-40 min. n-BuOH was evaporated in vacuo and the residue was re-dissolved in 3:1 EtOAc/DCM and washed successively with saturated NaHCO3 and NaCl solution (1 ¡Á 15 mL), respectively. The aqueous layer was washed with EtOAc (3 ¡Á 5 mL) and the organic layer was dried over anhydrous MgSO4 then filtered. The solution was evaporated in vacuo to afford either solid or semisolid product. Some physical and spectroscopy data are provided below for 7a-r, 8a-f, 9a-e.

13484-40-7, As the paragraph descriping shows that 13484-40-7 is playing an increasingly important role.

Reference£º
Article; Mohamed, Tarek; Zhao, Xiaobei; Habib, Lila K.; Yang, Jerry; Rao, Praveen P.N.; Bioorganic and Medicinal Chemistry; vol. 19; 7; (2011); p. 2269 – 2281;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Acetic acid (5.76 g, 96 mmole) was added to a suspension of aldehyde (10 g, 24 mmole) and piperazine (6.91 g, 48 mmole) in NMP (150 mL). The reaction was stirred at room temp for 16h then treated with NaB (OAc) 3H (12.7 g, 60 mmole). The reaction was stirred at room temp for 20h during which time the reaction becomes very viscous. 1N NAOH (200 mL) was then added and the reaction was stirred for LH. The reaction was then poured onto H20 (750 mL) and filtered. The solid was washed with HO (2 x 350 mL), ETOH (100 mL), and ET20 (200 mL). The solid was then dried under vacuum to yield the desired amine as the free base (9.98 g, 76%).

13484-40-7, The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GPC BIOTECH, INC.; WO2004/92139; (2004); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 11; Preparation of (N-(2-aminophenyl)-4-{3-methyl-5-[(4-(2-methoxyethyl)-piperazin-1-yl)methyl]pyridin-2-yl}benzamide); tert-Butyl (2-{[4-(5-formylpyridin-2-yl)benzoyl]amino}phenyl)carbamate (0.20 g, 0.4634 mmol; prepared as described in method 3), 1-(2-methoxyethyl)-piperazine (104 mg, 0.7 mmol) and acetic acid (27 mul, 0.4634 mmol) were dissolved in tetrahydrofuran (5 ml). The mixture was stirred at ambient temperature for 1 hour then sodium triacetoxyborohydride (147 mg, 0.695 mmol) added and the mixture stirred for a further 16 hours. The mixture was concentrated and partitioned between dichloromethane (5 ml) and saturated sodium bicarbonate (5 ml). The organics were washed with further saturated sodium bicarbonate (2¡Á5 ml) and brine (5 ml) then dried over magnesium sulphate and filtered. This solution was then treated with trifluoroacetic acid (1.0 ml) and the solution then stirred at ambient temperature for 2 hours. The resulting solution was absorbed onto an SCX-2 column, which was washed with methanol (3 column volumes) and the product eluted with a 2M solution of ammonia in methanol (3 column volumes) which was concentrated to give the product as a gum. The residue was purified by acid modified reverse phase HPLC. Fractions containing the product were absorbed onto an SCX-2 column and washed with methanol (2 column volumes) then the products eluted with a 2M solution of ammonia in methanol (2 column volumes) and concentrated under reduced pressure, to give a residue which was triturated with ether to give title compound as a solid (12 mg, 6%). NMR Spectrum: (DMSO-d6); 2.37 (s, 3H), 2.43 (m, 10H), 3.24 (s, 3H), 3.43 (t, 2H), 3.53 (s, 2H), 4.92 (s, 2H), 6.62 (m, 1H), 6.80 (m, 1H), 6.99 (m, 1H), 7.21 (m, 1H), 7.66 (s, 1H), 7.69 (d, 2H), 8.07 (d, 2H), 8.42 (m, 1H), 9.72 (s, 1H). Mass Spectrum: M+H+460., 13484-40-7

13484-40-7 1-(2-Methoxyethyl)piperazine 2734638, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; US2008/119451; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A15. 1-(5-Bromo-pyridine-2-sulfonyl)-4-(2-methoxy-ethyl)-piperazine; 809 mg of 1-(2-methoxyethyl)-piperazine are dissolved in 9.0 ml of dichloromethane and 9.0 ml of an aqueous K2CO3 solution (strength 4.0 M). Subsequently, the reaction mixture is cooled in an ice bath and a solution of 1.20 g of 5-bromo-pyridine-2-sulfonyl chloride (compound B8) in 2.0 ml of dichloromethane is added dropwise. Thereafter, the reaction mixture is allowed to warm up to room temperature during which time the two-phase system is vigorously stirred for 1 hour. For workup, the organic layer is separated and the aqueous layer is extracted once with 10 ml of dichloromethane. The combined organic layers are dried, using Na2SO4, filtered with suction and evaporated to dryness to yield 1.70 g of the title compound as yellow oil, which crystallizes at room temperature. M. p. 940C. ESI- MS: 364.3/366.1 (MH+). TLC: Rf = 0.40 (dichloromethane/ethanol 20:1 parts by volume)., 13484-40-7

13484-40-7 1-(2-Methoxyethyl)piperazine 2734638, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ALTANA Pharma AG; WO2007/39578; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution containing 2 7g (18 9 mmol) of 1-[2-(methyloxy)ethyl]piotaperaziotane and 20 mL of THF at O0C was added 0 9 g (23 mmol) of a 60% suspension of sodium hydride in mineral oil The reaction mixture was allowed to stir for 15 mm and 3 O g (18 9 mmol) of 2-chloro-5-niotatropyriotadiotane was added The reaction mixture was heated at 60 0C overnight and then quenched by the addition of H2O and extracted with EtOAc The combined organic layers were dried over MgSO4 and the solvents were removed under reduced pressure The residue was subjected to silica gel chromatography to give 2 7g (54%) of 1-[2-(methyloxy)ethyl]-4-(5-niotatro-2- pyriotadiotanyl)piotaperaziotane as a yellow solid 1 H-NMR (400 MHz, DMSO-cfe) delta 8 95 (d, J = 2 8 Hz, 1 H), 8 21 (dd, J = 9 6 and 2 8 Hz, 1 H), 6 94 (d, J = 9 7 Hz, 2 H), 3 71 – 3 78 (m, 4 H), 3 46 (t, J = 5 7 Hz, 2 H), 3 24 (s, 3 H), and 2 50 – 2 53 (m, 6 H)

13484-40-7, The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE LLC; ADJABENG, George; BAUM, Erich; BIFULCO, Neil; DAVIS-WARD, Ronda, G.; DICKERSON, Scott, Howard; DONALDSON, Kelly, Horne; HORNBERGER, Keith; PETROV, Kimberly; RHEAULT, Tara, Renae; SAMMOND, Douglas, McCord; SCHAAF, Gregory, M.; STELLWAGEN, John; UEHLING, David, Edward; WATERSON, Alex, Gregory; WO2010/104899; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.

A stirred mixture of 5-chloro-7-{[methoxy(methyl)amino]carbonyl}quinolin-8-yl trifluoromethanesulfonate (0.120 g, 0.301 mmol), l-(2-methoxyethyl)piperazine (0.0522 g, 0.362 mmol, from Aldrich), palladium acetate (1 mg, 0.006 mmol), 2,2′-bis(diphenylphosphino)-l,l’- binaphthyl (6 mg, 0.009 mmol), and cesium carbonate (0.14 g, 0.42 mmol) in tetrahydrofuran (3 mL) was heated at 65 C overnight. The mixture was cooled, diluted with dichloromethane, and filtered. The filtrate was washed with brine, dried over sodium sulfate, and evaporated to dryness. The resultant residue was purified on silica gel, eluting with 0 to 10% MeOH in dichloromethane, to give the desired product (63 mg, 53%). LCMS calculated forCi9H26ClN403(M+H)+: m/z = 393.2; found: 393.1.

13484-40-7, The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INCYTE CORPORATION; LI, Yun-Long; COMBS, Andrew, P.; YUE, Eddy, W.; LI, Hui-Yin; WO2011/75630; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

13484-40-7, General Method FFl F2 F3Fl (1 equiv) was dissolved in CH2Cl2 (2 mL) and F2 (1.0-1.1 equiv) was added. The reaction mixture was stirred at room temperature for 3 hours whereafter it was washed with saturated NaHCO3 (2 mL). The organic phase was dried (Na2SO4), filtered and concentrated to afford F3.Example 44(a) l~[(4-Bromophenyl)sulfonyl]-4-(2-methoxyethyl)piperazineThe title compound was prepared in accordance with the general method F using 4- bromobenzenesulfonyl chloride (201.7 mg, 0.789 mmol) and l-(2- methoxyethyl)piperazine (113.8 mg, 0.789 mmol) to give the title compound (277 mg,97%).1H NMR (400 MHz, CDCl3) delta ppm 7.64 – 7.69 (m, 2 H) 7.57 – 7.62 (m, 2 H) 3.47 (t, J=5.2 Hz, 2 H) 3.30 (s, 3 H) 3.08 (s, 4 H) 2.62 (d, J=4.8 Hz, 6 H); MS (ESI) m/z 364 (M + 1).

The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2007/40440; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2 To a solution of (S)-3-cyano-3-({(1R,2S)-2-[(1-methyl-1H-indole-2-carbonyl)-amino]-cyclohexanecarbonyl}-amino)-propyl ester (223 mg, 0.484 mmol) in anhydrous DMF (2.0 ML) was added 1-(2-methoxyethyl)-piperizine (214 mg, 1.48 mmol), and the reaction mixture was placed in a 69 C. oil bath for 22 hours.The cooled reaction mixture was partitioned between water (75 ML) and ethyl acetate (75 ML).The organic layer was separated, washed with water (2*75 ML), dried with sodium sulfate, filtered, concentrated, and purified by column chromatography (5:95, MeOH/CH2Cl2) to give 173 mg (70%) of 1-methyl-1H-indole-2-carboxylic acid ((1S,2R)-2-{(S)-1-cyano-3-[4-(2-methoxy-ethyl)-piperazin-1-yl]-propylcarbamoyl}-cyclohexyl)-amide as an amorphous solid. MS: 509 (M+H+)., 13484-40-7

13484-40-7 1-(2-Methoxyethyl)piperazine 2734638, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Bamberg, Joe Timothy; Gabriel, Tobias; Krauss, Nancy Elisabeth; Mirzadegan, Taraneh; Palmer, Wylie Solang; Smith, David Bernard; US2004/77646; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics