Category: 13754-38-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A solution of 2-chloroalkyl/aryl substitutedwith or without N-substitution as well as with or without 5 and/or 6-substituted benzimidazole derivative (1.75g,0.01051mol) and 1-[(4-phenyl)carbonyl]piperazine (3g,0.0105mol) in N, N dimethylformamide was taken in a RBF.K2CO3(2gm,) was added to the reaction mixture. The reaction mixture was stirred for 8h at 80C on a magnetic stirrer (heat + stirring). The progress of the reaction was monitored by thin layer chromatography (TLC).Upon completion of the reaction, water was added to the reaction mixture and the product extracted by shaking the reaction mixture with dichloromethane in a separating funnel.The dichloromethane layer was washed successively with water and brine, dried over anhydrous sodium sulfate. Evaporation of the solvent gave theproduct. 11a-l Recrystallized with various solvent like chloroform, ethanol, methanol., 13754-38-6

As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.

Reference£º
Article; Kankate, Rani S.; Gide, Parag S.; Belsare, Deepak P.; Oriental Journal of Chemistry; vol. 30; 4; (2014); p. 1855 – 1863;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: General Procedure 2c (1472) 1.0 equivalent of the respective intermediate, 1.0 equivalent of 1-hydroxy-1H-benzotriazole hydrate, 2.0 equivalents of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 3.0 equivalents of triethylamine and 1.2 equivalents of the amine were stirred in tetrahydrofuran at 25 C. for 18 h. Water was added to the reaction mixture. The solid was filtered off with suction, washed with water and diethyl ether and dried.

13754-38-6, 13754-38-6 1-Benzoylpiperazine 762654, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; BOTHE, Ulrich; SIEBENEICHER, Holger; SCHMIDT, Nicole; ROTGERI, Andrea; BOeMER, Ulf; RING, Sven; IRLBACHER, Horst; GUeNTHER, Judith; STEUBER, Holger; LANGE, Martin; SCHAeFER, Martina; (191 pag.)US2016/311833; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of amine 4 (1.82 g, 9.56 mmol) inDMF (20 mL) at 0 C was added K2CO3 (3.61 g, 26.13 mmol) followed by the addition of compound 3(1.96 g, 8.67 mmol) and the reaction mixture was stirred overnight at 60 C. After completion of thereaction (TLC analysis), the mixture was cooled to room temperature and diluted with ethyl acetate(75 mL). The solution was washed with H2O (30 mL ¡Á 3), brine (20 mL ¡Á 2) and the organic layer wasseparated, dried over Na2SO4 and evaporated under vacuum to afford the title compound 5 as as lightyellow amorphous solid (2.16 g, 74%), m.p. 196-197 C. IR (KBr): 3063, 2999, 2929, 2233, 1670,1622, 1596, 1578, 1457, 1430, 1389, 1341, 1294, 1249, 1155, 1094, 1072 cm-1. 1H-NMR (CDCl3): delta3.47 (br. s, 4H, -CH2NCH2-), 3.79 (br. s, 4H, -CH2NCH2-), 6.99 (dd, 1H, J = 2.6, 9.4 Hz, Ar-H), 7.14(d, 1H, J = 2.7 Hz, Ar-H), 7.40-7.48 (m, 5H, Ar-H), 8.19 (d, 1H, J = 9.5 Hz, Ar-H). 13C-NMR(CDCl3): delta 46.44, 46.84, 110.05, 115.66, 118.89, 126.93, 127.10, 127.79, 128.67, 130.33, 134.69,137.79, 153.10, 170.61. Anal. Calcd for C18H16N4O3: C, 64.28; H, 4.79; and N, 16.66. Found: C,64.22; H, 4.84; and N, 16.60.

13754-38-6, The synthetic route of 13754-38-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ba-Salem, Abdullah O.; Ullah, Nisar; Shaikh, M. Nasiruzzaman; Faiz, Mohamed; Ul-Haq, Zaheer; Molecules; vol. 20; 5; (2015); p. 7807 – 7819;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried pressure tube (15 mL) was charged with a magnetic stir bar, catalyst (5 mmol%), ligand (20 mmol%). The solvent (1.2 mL) was then added. Afterwards methyl sulfinates (0.30 mmol, 1 equiv) and amine (0.6 mmol, 2 equiv) were subsequently added into the reaction mixture. The reaction was stirred under an argon atmosphere at 100 for 15 h. After cooling to room temperature, the reaction mixture was directly removed under reduced pressure and subjected to flash column chromatography in petroleum ether/ethyl acetate to obtain the desired products., 13754-38-6

As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.

Reference£º
Article; Li, Gang-Jian; Pan, You-Lu; Liu, Yan-Ling; Xu, Hai-Feng; Chen, Jian-Zhong; Tetrahedron Letters; vol. 60; 46; (2019);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 4-6 (1 mmol) in 5 ml of dry DCM and piperazine derivative (1 mmol) was cooled in an ice bath. Then, 1.1 mmol of DCC in 5 ml of dry dichloromethane was added tothe mixture under nitrogen (N2) atmosphere. Reaction mixture was stirred for 0.5 hour in an ice bath, then 10-16 hours at room temperature. Reaction solvent was evaporated to the dryness. Residue was dissolved in hot acetonitrile then cooled in refrigerator to get the DCU precipitated. White crystalline DCU was removed by filtration. Liquid part was evaporated and crystallized from appropriate solvents to give compound 7-34, 13754-38-6

13754-38-6 1-Benzoylpiperazine 762654, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Akgun, Hulya; Yilmaz, Demet Us; Atalay, Rengul Cetin; Gozen, Damla; Letters in drug design and discovery; vol. 13; 1; (2016); p. 64 – 76;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

TRV 1094[00289] To a degassed solution of 5-bromo-2-chloro-N-phenylaniline (172 mg, 0.61 mmol), phenyl(piperazin- l -yl)methanonein, ( 139mg, 0.73 mmol), Cs2C03 ( 396mg, 1.22 mmol), BINAP ( 18.9 mg, 0.03 mmol) in toluene was charged Pd2(dba)3 ( 27.9 mg, 0.03 mmol). The reaction was sealed under an atmosphere of argon and heated to 100 C for 7h. The mixture was cooled, filtered through celite, washed with ethyl acetate and then concentrated in vacuum. The residue was subjected to silica gel column chromatography (60 % hexane/ ethyl acetate) to furnish the title compound (4-(4-chloro-3-(phenylamino)phenyl)piperazin- l -yl)(phenyl)methanone, TRV 1094 as a colorless solid ( 168mg, 0.43 mmol) 70%. NMR (500 MHz, CDC13) delta (ppm) 3.02-3.95 (m, 8H), 6.09 (bs, 1H), 6.45 (m, 1 H), 6.86 (d, J = 2 Hz, 1 H), 7.08 (t, J = 7.5Hz, 1 H), 7.19 (m, 2H), 7.24 (d, J = 8.5 Hz, 1 H), 7.36 (m, 2H), 7.40-7.50 (m, 5H

13754-38-6, As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.

Reference£º
Patent; TREVENTIS CORPORATION; REED, Mark, A.; YADAV, Arun; BANFIELD, Scott, C.; BARDEN, Christopher, J.; WO2012/119035; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 1-benzoylpiperazine (1.0 eq) and potassium carbonate (2.0 eq) in dimethylformamide was added dropwise a solution of the corresponding substituted 9-bromo-9H-fluorene (1.0 eq) in dimethylformamide (The synthesis of 9-bromo-9H-fluorene derivatives is reported in supporting information). After stirring for 24 h at room temperature, solvent was removed and the crude residue was dissolved in diethyl ether, washed with brine, dried over magnesium sulfate,filtered and concentrated under vacuum. The residue was purified by flash chromatography as indicated in each case to afford the title compound. Reagents: 1-Benzoylpiperazine (0.21 mmol, 40 mg), potassium carbonate (0.42 mmol, 58 mg) and 9-bromo-3-hexyloxy-9H-fluorene (0.21 mmol, 63 mg). The crude product was purified by flash chromatography (gradient, 100% petroleum ether to 100% ethyl acetate in 15 min) to afford a brown oil (54 mg, 57%). TLC Rf: 0.20 (petroleum ether/ethyl acetate 70/30). IR (cm-1): 615, 633, 670, 708, 734, 768, 788, 847, 1000, 1016, 1142, 1190, 1256, 1277, 1301, 1426, 1449, 1490, 1578, 1630, 2857, 2929. HPLC: method 2, rt = 5.36 min, purity 98%. 1H NMR (300 MHz, CDCl3) delta (ppm): 0.91-1.02 (m, 3H); 1.33-1.47 (m, 4H); 1.47-1.61 (m, 2H); 1.87 (quin, J = 6.9 Hz, 2H); 2.44 (s, 2H); 2.86 (s, 2H); 3.37 (s, 2H); 3.82 (s, 2H); 4.07 (t, J = 6.6 Hz, 2H); 4.85 (s, 1H); 6.87 (dd, J = 2.4 Hz, 8.4 Hz, 1H); 7.24 (d, J = 2.4 Hz, 1H); 7.32 (td, J = 1.5 Hz, 7.5 Hz, 1H); 7.36-7.45 (m, 6H); 7.52 (d, J = 8.4 Hz, 1H); 7.63 (d, J = 5.2 Hz, 1H); 7.67 (d, J = 6.9 Hz, 1H). 13C NMR (75 MHz, CDCl3) delta (ppm): 14.1 (CH3); 22.7 (CH2); 25.8 (CH2); 29.4 (CH2); 31.7 (CH2); 42.9 (CH2); 48.5 (CH2); 48.6 (CH2); 49.5 (CH2); 68.3 (CH2); 69.4 (CH); 105.8 (CH); 113.6 (CH); 119.7 (CH); 125.8 (CH); 126.6 (CH); 127.1 (2 * CH); 127.2 (CH); 128.2 (CH); 128.4 (2 * CH); 129.6 (CH); 135.2 (C); 135.9 (C); 141.0 (C); 142.5 (C); 144.4 (C); 159.9 (C); 170.3 (C). MS (DCI/CH4) m/z: 454.26 [M], 265.16 [M-189]. HRMS (DCI/CH4): for C30H34N2O2 [M]: calcd: 454.2620; found: 454.2607.

13754-38-6, 13754-38-6 1-Benzoylpiperazine 762654, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Chollet, Aurelien; Mori, Giorgia; Menendez, Christophe; Rodriguez, Frederic; Fabing, Isabelle; Pasca, Maria Rosalia; Madacki, Jan; Kordulakova, Jana; Constant, Patricia; Quemard, Annaik; Bernardes-Genisson, Vania; Lherbet, Christian; Baltas, Michel; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 218 – 235;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

Manufacturing Example 9 (4-(2-hydroxy-2-methylpropyl)piperazine-1-yl)phenylmethanone 500 mg (2.63 mmol) 1-benzoylpiperazine and 1.10 g (7.96 mmol, 3.0 eq.) potassium carbonate were suspended to 20 ml acetonitrile at room temperature. After adding 570 mg (7.90 mmol, 3.0 eq.) isobutylene oxide, it was heated at reflux and stirred overnight. After cooling to room temperature and adding 30 ml purified water, it was extracted twice with 30 ml ethylacetate. After collecting organic layer and drying with anhydrous magnesium sulfate, it was concentrated with decompression. The obtained residue was purified by chromatography using silicagel (mobile phase: dichloromethane/methanol=20:1) and 276 mg (40%) target compound as light-yellow solid was yielded. 1H NMR (400 MHz, DMSO-d6) 1.10 (6H, s), 2:23 (2H, s), 2.43-2.52 (2H, m), 2.53-2.62 (2H, m), 3.35-3.45 (2H, m), 3.55-3.65 (2H, m), 4.13 (1H, s), 7.35-7.38 (2H, m), 7.43-7.46 (3H, m)

13754-38-6, 13754-38-6 1-Benzoylpiperazine 762654, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; YANG JI CHEMICAL CO., LTD.; US2012/190689; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 12 (0.3 mmol) and PyBOP (0.45 mmol) in THF (20 mL) was stirred for 10 min. Afterwards, the corresponding amine (0.34 mmol) and DIPEA (0.76 mmol) were given to the mixture and stirred overnight at RT. The crude mixture was evaporated, the product was dissolved in EtOAc, washed with Na2CO3 solution, and dried over Na2SO4. After evaporation, the product was purified by column chromatography (eluent: CHCl3/MeOH)., 13754-38-6

The synthetic route of 13754-38-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sauer; Skinner-Adams; Bouchut; Chua; Pierrot; Erdmann; Robaa; Schmidt; Khalife; Andrews; Sippl; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 22 – 40;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of 2-chloroalkyl/aryl substitutedwith or without N-substitution as well as with or without 5 and/or 6-substituted benzimidazole derivative (1.75g,0.01051mol) and 1-[(4-phenyl)carbonyl]piperazine (3g,0.0105mol) in N, N dimethylformamide was taken in a RBF.K2CO3(2gm,) was added to the reaction mixture. The reaction mixture was stirred for 8h at 80C on a magnetic stirrer (heat + stirring). The progress of the reaction was monitored by thin layer chromatography (TLC).Upon completion of the reaction, water was added to the reaction mixture and the product extracted by shaking the reaction mixture with dichloromethane in a separating funnel.The dichloromethane layer was washed successively with water and brine, dried over anhydrous sodium sulfate. Evaporation of the solvent gave theproduct. 11a-l Recrystallized with various solvent like chloroform, ethanol, methanol., 13754-38-6

The synthetic route of 13754-38-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kankate, Rani S.; Gide, Parag S.; Belsare, Deepak P.; Oriental Journal of Chemistry; vol. 30; 4; (2014); p. 1855 – 1863;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics