Category: 13754-38-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of 4-(3-(4-cyanophenyl)imidazo[l,2-a]pyridin-6-yl)benzoic acid (100 mg, 0.294 mmol) in DMF (1.5 mL) were added HATU (168 mg, 0.441 mmol), N-methyl morpholine (129 iL, 1.18 mmol) and 1-benzoylpiperazine (67 mg, 0.441 mmol). The reaction mixture was stirred at room temperature under inert atmosphere for 18 h then, was diluted with water (15 mL) and extracted with EtOAc (3×30 mL). The combined organic layer was dried over Na2S04 and was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, eluent CHCl3/MeOH 92:8) to afford 4-(6-(4- (4-benzoylpiperazine- 1 -carbonyl)phenyl)imidazo[ 1 ,2-a]pyridin-3 -yl)benzonitrile (75 mg, 50%, AUC HPLC 99%) as a white solid. NMR (400 MHz, DMSO- 6) delta 8.75 (s, 1H), 7.95-7.89 (m, 4H), 7.88 (s, 1H), 7.82-7.55 (m, 4H), 7.59 (d, J= 8.0 Hz, 2H), 7.63-7.43 (m, 5H), 4.00-3.40 (m, 8H); 13C NMR (100 MHz, CD3OD): delta 172.90, 172.34, 147.49, 140.29, 136.50, 136.11, 134.87, 134.76, 134.43, 131.43, 129.87, 129.48, 129.22, 128.63, 128.59, 128.21, 127.85, 126.61, 122.92, 119.55, 118.51, 112.76; MS (ESI) m/z 512 [C32H25N50 + H]+..

13754-38-6, 13754-38-6 1-Benzoylpiperazine 762654, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao; WO2013/147711; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)benzoic acid (100 mg, 0.294 mmol) in DMF (1.5 mL) were added HATU (168 mg, 0.441 mmol), N-methyl morpholine (129 muL, 1.18 mmol) and 1-benzoylpiperazine (67 mg, 0.441 mmol). The reaction mixture was stirred at room temperature under inert atmosphere for 18 h then, was diluted with water (15 mL) and extracted with EtOAc (3*30 mL). The combined organic layer was dried over Na2SO4 and was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, eluent CHCl3/MeOH 92:8) to afford 4-(6-(4-(4-benzoylpiperazine-1-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile (75 mg, 50%, AUC HPLC 99%) as a white solid. 1H NMR (400 MHz, DMSO-d6) delta 8.75 (s, 1H), 7.95-7.89 (m, 4H), 7.88 (s, 1H), 7.82-7.55 (m, 4H), 7.59 (d, J=8.0 Hz, 2H), 7.63-7.43 (m, 5H), 4.00-3.40 (m, 8H); 13C NMR (100 MHz, CD3OD): delta 172.90, 172.34, 147.49, 140.29, 136.50, 136.11, 134.87, 134.76, 134.43, 131.43, 129.87, 129.48, 129.22, 128.63, 128.59, 128.21, 127.85, 126.61, 122.92, 119.55, 118.51, 112.76; MS (ESI) m/z 512 [C32H25N5O+H]+.

13754-38-6, As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.

Reference£º
Patent; Agency for Science, Technology and Research; Nacro, Kassoum; Duraiswamy, Athisayamani Jeyaraj; Rao, Lohitha; US2014/371199; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: The solution of 8 (1 equiv) and substituted phenyl piperazine (1 equiv) in dry DMF (5 ml) was cooled to 0 C. The N-ethyl-N?-(dimethyaminopropyl)carbodimide hydrochloride (EDC¡¤HCl) (1 equiv), 1-hyroxybenzotriazole hydrate (HOBt¡¤H2O) (1 equiv) and DIPEA (2 equiv) were added and the resulting mixture stirred for 24 h at room temperature. H2O (40 ml) was added to reaction mass and extracted with ethylacetate (40 ml ¡Á 3). The combined organic layer was washed with saturated aqueous NaHCO3 solution (30 ml), brine (30 ml), dried over MgSO4 and concentrated to give crude mass which were purified on silica gel CC to afforded desired products 9a-j., 13754-38-6

The synthetic route of 13754-38-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sharma, Rajni Kant; Younis, Yassir; Mugumbate, Grace; Njoroge, Mathew; Gut, Jiri; Rosenthal, Philip J.; Chibale, Kelly; European Journal of Medicinal Chemistry; vol. 90; (2015); p. 507 – 518;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 18: N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidin e-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide [Show Image] 400 mg (1.07 mmol) N-{[1-(2-hydroxypropyl)-pyrrolidin e-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide and 0.18 ml(1.29 mmol, 1.2 eq.)triethylamine described in manufacturing example 6 were dissolved to 20 ml dichloromethane and cooled to 3C under argon gas. 135 mg (1.18 mmol, 1.1 eq.) methansulfonyl chloride were slowly added to reaction solution and stirred at same temperature for 30 min. 20 ml purified water were added and then the organic layer was separated and concentrated with decompression. After 10 ml acetonitrile were added to obtained residues and dissolved them, 444 mg (3.21 mmol) potassium carbonate and 202 mg (1.06 mmol) 1-benzoylpiperazine were added. After stirring for 2 hours at room temperature, 15 ml saturated sodium chloride aqueous solution were added to the reaction solution and was extracted twice with 15 ml ethylacetate. After the organic layer was collected and dried with anhydrous magnesium sulfate, it was concentrated with decompression. 30 mg (51%) target compound as light-yellow solid were yielded by purifying obtained residues with chromatography using silicagel (mobile phase: dichloromethane/methanol=5:1 and 1:1). 1H NMR(400MHz,DMSO-d6) 1.05(3H,s), 1.55-1.65(1H,m), 2.00-2.10(1H,m), 2.15-2.25(1H,m), 2.28-2.55(9H,m), 2.70-2.85(2H,m), 3.17(1H,d) 3.54-3.65(2H,m), 3.87(2H,d), 4.10-4.20(1H,m) 7.35-7.40(2H,m), 7.40-7.47(3H,m), 7.74(1H,t), 7.92(1H,d), 8.14(1H,s) 8.18(1H,d) 8.23(1H,s), 9.01(1H,t) MS (M)+ 545.6, 13754-38-6

As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.

Reference£º
Patent; Yang Ji Chemical Co., Ltd.; EP2452939; (2012); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics