Category: 13889-98-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: In a 25 mL two necked round bottom flask, azole (1 mmol), amine (2.0 mmol), Cu(acac)2 (52.6 mg, 20 mol %), and 5 mL xylene were added. The above mixture was kept under reflux condition and then molecular oxygen was bubbled into the reaction mixture till the completion of reaction. The progress of reaction was monitored using gas chromatography. After completion of the reaction, the reaction mixture was filtered through celite bed. The organic solvent was removed under reduced pressure. The reaction mixture was analyzed using gas chromatography (Perkin Elmer, Clarus 400) equipped with a flame ionization detector (FID) and capillary column. The crude product was purified by column chromatography (silica gel, 100-200 mesh; petroleum ether/ethyl acetate, 90:10) to afford pure products. All the prepared compounds were confirmed by comparing with their authentic samples and were characterized by GC-MS (Shimadzu QP 2010), 1H NMR (Varian 500 MHz).

13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Wagh, Yogesh S.; Bhanage, Bhalchandra M.; Tetrahedron Letters; vol. 53; 48; (2012); p. 6500 – 6503,4;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate (c) (1.82 g, 4.8 mmol), palladium acetate (52 mg, 0.24 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (240 mg, 0.48 mmol), cesium carbonate (2.32 g, 7.2 mmol) is dissolved in dioxane (15 ml), add 1-acetylpiperazine (0.92 g, 7.2 mmol), nitrogen protection, 100 C reflux stirring 6 hr, the reaction liquor is brown clear liquid. To the reaction solution to room temperature, add 15 ml water, ethyl acetate (10 ml ¡Á 3) extraction, the combined organic phase, dried with anhydrous sodium sulfate, filtered concentrated by reduced pressure distillation, column chromatography (PE: EtOAc=1:1), to obtain white solid 1.5 g, yield 75%.

13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Fudan University; Fu Wei; Sun Nannan; (18 pag.)CN108503584; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

The starting material was prepared as follows: A suspension of 1-acetylpiperazine (3.85 g, 0.03 mol) and 3-bromopropan-1-ol (4 ml) containing potassium carbonate (8.3 g, 60 mmol) in acetonitrile (30 ml) was stirred at 80 C. for 5 hours. The solid was filtered and the filtrate was evaporated. The residue was purified by column chromatography eluding with ethanol/methylene chloride (1/9 followed by 3/7) to give 3-(4-acetylpiperazin-1-yl)propan-1-ol (3.15 g, 56%). 1H NMR Spectrum: (CDCl3) 1.75 (m, 2H), 2.05 (s, 3H), 2.4-2.5 (m, 4H), 2.6 (t, 2H), 3.45 (t, 2H), 3.6 (m, 2H), 3.8 (t, 2H), 4.6 (br s, 1H) MS: 187.4 (M+H)+, 13889-98-0

As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; Hennequin, Laurent Francois Andre; US2003/212055; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound of formula 38 (10.0 g, 49.2 mmol) was added to the reaction flask at room temperature,100 mL of N, N-dimethylacetamide,1-acetylpiperazine 16 (8.2 g, 64.0 mmol)N, N-diisopropylethylamine (19.1 g, 147.8 mmol)90 reaction 7 ~ 8h,TLC monitoring reaction is complete,Down to room temperature,The reaction solution was poured into 300 mL of water,Extracted with ethyl acetate (80 mL x 3)Combined organic layer,Washed with saturated brine,Dried over anhydrous sodium sulfate,The compound of formula 41 (9.9 g) was obtained by steaming,As a beige solid (yield 80.6%).

13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Zhang Yinsheng; Gao Yong; Ren Jing; Wang Qinglin; Wang Zhao; (67 pag.)CN106905245; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

Intermediate 9 (3.0 g, 0.89 mmol) in NMP (15 mL) was treated with 1-acetyl- piperazine (2.8 g, 22 mmol) and DIPEA (5.7 g, 44 mmol) and heated in a sealed tube at 140C for 72 h. The reaction mixture was cooled to r.t. and diluted with ethyl acetate/ water. The organic phase was washed (water, brine), dried (phase separation cartridge) and evaporated in vacuo. The resulting residue was purified by silica flashchromatography, eluting with 50-60% EtOAc in isohexane, to give the title compound (3.4 g 89%) as a cream solid. deltaEta (CDC13) 7.95 (IH, s), 7.53 (IH, dd, J 8.9, 6.0 Hz), 7.16 (IH, t, J 8.9 Hz), 5.08-5.02 (IH, m), 3.95-3.90 (IH, m), 3.78-3.73 (2H, m), 3.64 (IH, m), 3.61-3.40 (2H, m), 3.19-3.15 (2H, m), 2.59 (3H, d, J2.4 Hz), 2.17 (3H, s), 1.58 (3H, d, J 6.5 Hz), 1.48-1.42 (9H, m).

13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MATTEUCCI, Mizio; OWENS, Andrew, Pate; RAPHY, Gilles; SHARPE, Andrew; WO2011/58108; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics