Category: 139755-85-4

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCC)N1, belongs to piperazines compound. In a document, author is Jankowska, Agnieszka, introduce the new discover, Product Details of 139755-85-4.

Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity

A library of novel anilide and benzylamide derivatives of omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkanoic acids as combined 5-HT1A/5-HT7 receptor ligands and phosphodiesterase PDE4B/PDE7A inhibitors was designed using a structure-based drug design approach. The in vitro studies of 33 newly synthesized compounds (7-39) allowed us to identify 22 as the most promising multifunctional 5-HT1A/5-HT7 receptor antagonist (5-HT1AKi= 8 nM, K-b = 0.04 nM; 5-HT7 K-1 = 451 nM, K-b = 460 nM) with PDE4B/PDE7A inhibitory activity (PDE4B IC50 = 80.4 mu M; PDE7A IC50 = 151.3 mu M). Compound 22 exerted a very good ability to passively penetrate through biological membranes and a high metabolic stability in vitro. Moreover, the pharmacological evaluation of 22 showed its procognitive and antidepressant properties in rat behavioral tests. Compound 22 at a dose of 3 mg/kg (i.p.) significantly reversed MK-801-induced episodic memory deficits in the novel object recognition test, while at a dose of 10 mg/kg (i.p.) reduced the immobility time of animals (by about 34%) in the forced swimming test. The antidepressant-like effect produced by compound 22 was stronger than that of escitalopram used as a reference drug. This study opens a new perspective in the search for efficacious drugs for the treatment of cognitive and depressive disorders. (C) 2020 Elsevier Masson SAS. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 139755-85-4 is helpful to your research. Product Details of 139755-85-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCC)N1, in an article , author is Jacob, John, once mentioned of 139755-85-4, COA of Formula: C23H32N6O5S.

In vitro efficacy of anthelmintics on Angiostrongylus cantonensis L3 larvae

Angiostrongylus cantonensis is the leading cause of eosinophilic meningitis worldwide, with life-threatening complications if not managed correctly. Previous in vitro studies have utilized change in motility patterns of adult female worms to assess the efficacy of anthelmintics qualitatively. However, it is the third stage larvae (L3) that are infectious to humans. With differential staining using propidium iodide penetration as the indicator of death, we can distinguish between dead and live larvae. This assay has enabled us to quantify the in vitro efficacy of nine clinically established anthelmintics on A. cantonensis L3. All drugs were tested at a 1 mm concentration. Piperazine and niclosamide were ineffective in inducing larval death; however, albendazole sulfoxide, pyrantel pamoate, diethylcarbamazine, levamisole and praziquantel were effective as compared to unexposed controls (P < 0.05). Ivermectin and moxidectin did not induce significant levels of mortality, but they considerably reduced larval motility almost immediately. This study indicates the need for further in vivo studies to determine the optimal dose and time frame for post-infection treatment with anthelmintics that demonstrated efficacy. Interested yet? Read on for other articles about 139755-85-4, you can contact me at any time and look forward to more communication. COA of Formula: C23H32N6O5S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is an experimental science, Product Details of 139755-85-4, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is C23H32N6O5S, belongs to piperazines compound. In a document, author is Mishra, Chandra Bhushan.

Development of novel N-(6-methanesulfonyl-benzothiazol-2-yl)-3-(4-substituted-piperazin-1-yl)-propionamides with cholinesterase inhibition, anti-beta-amyloid aggregation, neuroprotection and cognition enhancing properties for the therapy of Alzheimer’s disease

A novel series of benzothiazole-piperazine hybrids were rationally designed, synthesized, and evaluated as multifunctional ligands against Alzheimer’s disease (AD). The synthesized hybrid molecules illustrated modest to strong inhibition of acetylcholinesterase (AChE) and A beta(1-42) aggregation. Compound 12 emerged as the most potent hybrid molecule exhibiting balanced functions with effective, uncompetitive and selective inhibition against AChE (IC50 = 2.31 mu M), good copper chelation, A beta(1-42) aggregation inhibition (53.30%) and disaggregation activities. Confocal laser scanning microscopy and TEM analysis also validate the A beta fibril inhibition ability of this compound. Furthermore, this compound has also shown low toxicity and is capable of impeding loss of cell viability elicited by H2O2 neurotoxicity in SHSY-5Y cells. Notably, compound 12 significantly improved cognition and spatial memory against scopolamine-induced memory deficit in a mouse model. Hence, our results corroborate the multifunctional nature of novel hybrid molecule 12 against AD and it may be a suitable lead for further development as an effective therapeutic agent for therapy in the future.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 139755-85-4, in my other articles. Product Details of 139755-85-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is C23H32N6O5S. In an article, author is Mouhoubi, Seloua,once mentioned of 139755-85-4, Name: 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Thermodynamic modeling of CO2 absorption in aqueous solutions of N,N-diethylethanolamine (DEEA) and N-methyl-1,3-propanediamine (MAPA) and their mixtures for carbon capture process simulation

Carbone capture by absorption-regeneration technology is a well-known process. However, the development and utilization of new solvents remains crucial to lower its energy consumption. Therefore, an accurate thermodynamic modeling is essential for the process simulation and optimization. This work focuses on the thermodynamic modeling of CO2 absorption in aqueous solutions of N,N-diethylethanolamine (DEEA), N-methyl-1,3-propanediamine (MAPA) and their mixtures using electrolyte NRTL model. A novel thermodynamic modeling of DEEA-H2O-CO2, MAPA-H2O-CO(2 )and DEEA-MAPA-H2O-CO2 systems was developed. The modeling was carried out by considering the pure vapor pressures, excess enthalpies, dielectric constants, physical solubilities of CO2, partial and total pressures experimental data. The predicted and correlated data such as vapor-liquid equilibrium (VLE) and heat of CO2 absorption were compared favorably to experimental data from the literature. Liquid-liquid phase separation of a specific mixture of these two amines was also highlighted. Subsequently, the developed model could be used for further simulations at large scale considering that successful validation was performed at pilot scale. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Interested yet? Keep reading other articles of 139755-85-4, you can contact me at any time and look forward to more communication. Name: 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is , belongs to piperazines compound. In a document, author is Al-Otaibi, Jamelah S., Product Details of 139755-85-4.

Cocrystals of hydrochlorothiazide with picolinamide, tetramethylpyrazine and piperazine: quantum mechanical studies, docking and modelling of the photovoltaic efficiency for DSSC

Cocrystals are of immense applications in crystal engineering and pharmaceutical chemistry. Hydrochlorothiazide is found to form cocrystals with picolinamide (H1), tetramethylpyrazine (H2) and piperazine (H3). It was characterized using IR spectra, and quantum mechanical calculations for geometry and other properties. Frontier orbital energies are used to predict the energy properties and model the possible charge transfer between the constituents of the cocrystal. The frontier molecular orbital analysis indicates chemical reactivity and bioactivity of the cocrystals. The MEP surface reveals the various reactive surfaces in the cocrystal system, which is very important in deciding various biological activities. The UV-Vis spectra show the possible electronic transitions of the molecules. Simulated electronic spectra using TDDFT method with CAM-B3LYP functional were used to investigate the suitability of the cocrystals to be used in DSSC. Moreover, the molecular docking analysis proves that the cocrystals can act as potential inhibitors and paves the way for developing effective drugs.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 139755-85-4, in my other articles. Product Details of 139755-85-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCC)N1, belongs to piperazines compound. In a document, author is Bouharkat, Bakhta, introduce the new discover, Product Details of 139755-85-4.

Bacterial ecology and antibiotic resistance mechanisms of isolated resistant strains from diabetic foot infections in the north west of Algeria

Background In front of the polymorphic bacterial ecology and antibiotic resistance in diabetic patients with foot infections and good patient care, collaboration between clinicians and microbiologists is needed to improve assessment and management of patients with this pathology. Objective This study was designed to characterize the bacterial ecology of diabetic foot infection (DFIs) and to determine the different mechanisms of resistance involved. Methods In this study bacterial strains and antibiotic resistance profiles were determined from diabetic foot infections patients (n = 117). The identification of resistance mechanisms, such as penicillinase and/or extended-spectrum beta-lactamase production (ESBL), methicillin-resistantStaphylococcus aureus(MRSA) and efflux pump over-expression were performed. Results A high prevalence of Gram-negative bacteria (61%) withEscherichia coli,and other Enterobacteriaceae andPseudomonas aeruginosabeing the predominant isolates. Gram positive bacteria mainly represented byStaphylococcus aureusaccounted for 39% of the isolates. 93.5% of theEnterobacteriaceaewere resistant to, at least, one molecule in the beta-lactam family, while the majority of theStaphylococciwere resistant to penicillin G and tetracycline (93.3% and 71.7%). The majority of non-fermenting Gram negative bacteria were also resistant to fluoroquinolones. beta-lactamase detection tests revealed the presence of extended-spectrum beta-lactamase in 43.5% of theEnterobacteriaceae,while methicillin-resistantStaphylococcus aureusrepresented 18.2% of the isolates. Additionally, 50.9% of non-fermenting Gram negative bacteria were overproducing efflux pumps. Conclusion AllAcinetobacter Baumanniiwere Multidrug-Resistant (MDR), as the majority ofStaphylococci,and Enterobacteriaceae. These results should be taken into account by the clinician in the prescription of probabilistic antibiotic therapy in this context.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 139755-85-4 is helpful to your research. Product Details of 139755-85-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCC)N1, belongs to piperazines compound. In a document, author is Lee, Yunje, introduce the new discover, Formula: C23H32N6O5S.

Operation of a Pilot-Scale CO2 Capture Process with a New Energy-Efficient Polyamine Solvent

A new blending recipe of a polyamine-based solvent for capturing post-combustion CO2 was proposed, and its performance and characteristics were investigated using a pilot-scale carbon capture process (PCCP). The proposed solvent is a blend of three types of amines and was designed to separate the solvent roles into those of a main amine, auxiliary amine, and reaction-rate-enhancing amine. Polyamine 3,3 ‘-iminobis (N, N-dimethylpropylamine) was selected as the main amine given its ability to capture large amounts of CO2. 2-Amino-2-methyl-1-propanol was used as the auxiliary amine, with piperazine added as the reaction-rate-enhancing amine. This solvent was tested in a PCCP that can handle 150 Nm(3)/h of flue gas. The proposed solvent was found to operate stably while consuming substantially lower reboiler duty than the monoethanolamine (MEA) 30 mass% solvent.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 139755-85-4 is helpful to your research. Formula: C23H32N6O5S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is , belongs to piperazines compound. In a document, author is Ji, Haodong, Formula: C23H32N6O5S.

Adsorptive removal of ciprofloxacin with different dissociated species onto titanate nanotubes

Exploring the specific characteristics of pharmaceuticals and personal care products (PPCPs) via adsorption and degradation are scientific and practical significance to control their release to water matrix. In this work, a good adsorbent and ion-exchange material, i.e., titanate nanotubes (TNTs), was employed for adsorption of ciprofloxacin (CIP, a model PPCPs). The adsorption behaviors and mecha-nisms of CIP with different dissociated species by TNTs were studied through both experimental and theoretical calculations. The multilayered TNTs with high BET surface area (272.3 m(2)/g) and large pore volume (1.26 cm(3)/g) exhibited good adsorption property for CIP. The CIP species (i.e., CIP+, CIP +/-, CIP-) at various pH exhibited significantly different adsorption favorability. Adsorption kinetics and isotherms data revealed that TNTs offered the high uptake for CIP+ (Q(max)= 464.47 mmol/g or 153.90 mg/g at pH 5) than CIP +/- and CIP-. Characterizations indicated the formation of Ti-O-N linkage between CIP molecules and TNTs after adsorption, suggesting the chemical interaction between CIP and TNTs. Density functional theory (DFT) calculations reveal variation on pH affects the protonation/deprotonation state of CIP, and then changes the distribution of molecular orbitals and the electrostatic potential (ESP) energy of CIP. ESP follows the trend as: CIP+ (180.57 kcal/mol) > CIP +/- (146.78 kcal/mol) > CIP- (12.30 kcal/mol), indicating the side of piperazine ring in CIP oriented to TNTs dominates the CIP adsorption. The integrated experimental and theoretical results, for the first time, suggest that ESP energy can serve as the indicator and predictor of adsorption ability for the PPCPs molecules with various speciation, and can help to deeply describe the adsorption mechanism of PPCPs. In addition, TNTs have great application for the removal of PPCPs through adsorption in practical wastewater treatment area. (C) 2020 Elsevier Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 139755-85-4, Formula: C23H32N6O5S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Mazari, Shaukat Ali, once mentioned the application of 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is C23H32N6O5S, molecular weight is 504.6024, MDL number is MFCD00908400, category is piperazines. Now introduce a scientific discovery about this category, Safety of 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Thermal degradation kinetics of morpholine for carbon dioxide capture

Deterioration of amines under process operating conditions for sour gas treatment is a severe problem. New amines are being investigated to replace conventional amines which face operational, economic and environmental challenges. Morpholine (MOR) is an understudied amine for carbon dioxide (CO2) capture which comes with good CO2 capture characteristics like CO2 absorption rate, CO2 solubility etc. This study investigates the stability of aqueous morpholine under stripper conditions. Effect of CO2 loading and temperature have been investigated on the degradation kinetics of MOR. CO2 loading is varied from 0 to 0.48 mol CO2/mol alkalinity and temperatures is varied 135-190 degrees C. Thermal degradation experiments were conducted using 316 stainless steel cylinders, closed with Swagelok (R) endcaps. The degraded samples were analyzed by using Gas Chromatography-Mass Spectrometry (GC-MS), Gas Chromatography-Flame Ionization Detector (GC-FID) and Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-QToE-MS) for morpholine concentration and identification of degradation products. Morpholine demonstrated higher stability up to 150 degrees C. However, higher degradation rate is found at temperatures 175 degrees C and above. Degradation rate increases with CO2 loading. Identified degradation products are tabulated in the text and reaction mechanisms for formation of some of the key degradation products are also provided. A kinetic model for the rate of degradation of morpholine is proposed, which shows a decent agreement with experimental data. Comparison shows that morpholine is thermally more stable compared to monoethanolamine (MEA), diethanolamine (DEA), methyldiethanolamine (MDEA) and piperazine (PZ).

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 139755-85-4, Safety of 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is , belongs to piperazines compound. In a document, author is Zhou, Guan, HPLC of Formula: C23H32N6O5S.

SLAP reagents for the photocatalytic synthesis of C3/C5-substituted, N-unprotected selenomorpholines and 1,4-selenazepanes

Herein, we disclose the first set of unique selenium-containing SLAP (SiLicon Amine Protocol) reagents for the direct synthesis of C3/C5-substituted selenomorpholines and 1,4-selenazepanes from diverse (hetero)aldehydes under mild photocatalytic conditions. Enantiomerically pure 1,2-amino alcohol/alpha-amino acid versions of these heterocycles were also synthesized. Further, we have shown the late-stage modification of certain biologically active agents using the developed seleno-SLAP reagents.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 139755-85-4, in my other articles. HPLC of Formula: C23H32N6O5S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics