Category: 169447-86-3

169447-86-3, (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparative Example beta; Preparation of 2-[(S)-4-Boc-3-benzylpiperazinyl]-6-chloropyrazine 115; To a solution of 2,6-dichloropyrazine 114 (0.1 g, 0.67 mmol.) and (S)-1-Boc-2- benzylpiperazine 107 (0.37 g, 1.34 mmol) in dioxane (2 mL) and trifluoromethylbenzene (2 mL) was added diisopropylethylamine (0.26 g, 2.0 mmol). The reaction mixture was heated in a microwave reactor at 1800C for 20 minutes. Ethyl acetate (100 mL) was added. The organic layer was washed with saturated ammonium chloride solution, water and brine. The organic layer was dried over sodium sulfate. The organic solvent was evaporated under reduced pressure. The crude product was purified by flash column chromatography to yield the desired 2- [(S)-4-Boc-3-benzylpiperazinyl]-6-chloropyrazine 115 (0.234 g, 0.6 mmol).

169447-86-3, As the paragraph descriping shows that 169447-86-3 is playing an increasingly important role.

Reference：
Patent; SCHERING CORPORATION; WO2007/126964; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-86-3,(S)-tert-Butyl 2-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

The synthesis of compounds of this embodiment is shown in FIG. 1. As shown, pyridine, quinolines or isoquinolines were coupled with various piperazines through nucleophilic aromatic substitution or Hartwig Buchwald aryl amination., 169447-86-3

As the paragraph descriping shows that 169447-86-3 is playing an increasingly important role.

Reference：
Patent; UNIVERSITY OF SOUTH FLORIDA; YALE UNIVERSITY; WO2008/79945; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-86-3,(S)-tert-Butyl 2-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Step A: Amination of halopyrazine; Preparation of 2-amino-5-bromo-3-r(S)-4-Boc-3-benzylpiperazinyllpyrazine 108; To a solution of 2-arnino-3,5-dibromopyrazine 106 (0.2 g, 0.79 mmol.) and (S)- 1 -Boc-2-benzylpiperazine 107 (0.44 g, 1.59 mmol) in dioxane (2 ml_) and trifluoromethylbenzene (2 ml_) was added diisopropylethylamine (0.31 g, 2.4 mmol). The reaction mixture was heated in a microwave reactor at 210 0C for 20 minutes. Ethyl acetate (100 ml_) was added. The organic layer was washed with water and brine. The organic layer was dried over sodium sulfate. The organic solvent was evaporated under reduced pressure. The crude product was purified by RP-HPLC to yield the desired 2-amino-5-bromo-3-[(S)-4-Boc-3-benzylpiperazinyl]pyrazine 108 (0.24 g, 0.536 mmol).

169447-86-3, 169447-86-3 (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate 17750441, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; SCHERING CORPORATION; WO2007/126964; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

169447-86-3, (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 5 – Hybrid Analogs of Ureas and Carbamates; The synthesis of compounds of this embodiment is shown in FIGs. 14A through 14D. In this embodiment, the isoquinolinyl areas and carbamates were synthesized stepwise with a trichloroacetyl chloride., 169447-86-3

The synthetic route of 169447-86-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITY OF SOUTH FLORIDA; YALE UNIVERSITY; WO2008/79945; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-86-3,(S)-tert-Butyl 2-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of the free carboxylic acid (1 equiv.) in dry dichloromethane (0.05 M solution) (S)-lambdaM -Boc-2-benzylpiperazine (1.05 equiv.), EDCI (1.1 equiv.), HOBt (1.1 equiv.) and DIPEA (2 equiv.) were added at room temperature. The reaction was stirred overnight, the solvent evaporated under reduced pressure and the crude material purified by flash chromatography.; (S)-fert-butyl-2-benzyl-4-[5-/so-butyl-6-(3-/so-butyl-1W-pyrazol-5- yl)pyridazine-3-carbonyl]piperazine-1-carboxylate 12b: Rf = 0.21 (CH2CI2/Me0H = 98:2)., 169447-86-3

169447-86-3 (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate 17750441, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2009/25751; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

169447-86-3, (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compounds according to this embodiment are shown in Table 3, below. Synthesis of the relevant compounds is shown in FIGS. 1 1 A and 11 B., 169447-86-3

169447-86-3 (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate 17750441, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; UNIVERSITY OF SOUTH FLORIDA; YALE UNIVERSITY; WO2008/79945; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-86-3,(S)-tert-Butyl 2-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 122 and 123 (-0.216 mmol) in dioxane (3 ml_) was added (S)~N-Boc-2-benzylpiperazine (0.07 g, 0.254 mmol) and diisopropylethylamine (0.077 ml_, 0.443 mmol). The reaction mixture was heated at 600C for 1 hour. The organic solvent was evaporated under reduced pressure. The crude product mixture was purified by RP-HPLC to yield 3-(3-methylindazol-5-yl)-5-[(S)-4-Boc-3-benzylpiperazin-1-yl]- [1 ,2,4]triazine 124 (0.012 g, 0.025 mmol) and 6-chloro-3-(3-methylindazol-5- yl) )-5-[(S)-4-Boc-3-benzylpiperazin-1-yl]-[1 ,2,4]triazine 125 (0.02 g, 0.038 mmol).

169447-86-3, The synthetic route of 169447-86-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2006/81230; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics