With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182618-86-6,1-Boc-4-(4-Nitrophenyl)piperazine,as a common compound, the synthetic route is as follows.
Step 2. 4-(4-Amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester [0166] A mixture of 4- (4-NITRO-PHENYL)-PIPERAZINE-1-CARBOXYLIC acid TERT-BUTYL ester (11) (18. 9 MMOL), 10% palladium-on-carbon (600mg), ethanol (100 mL), and ethyl acetate (100 mL) is hydrogenated at room temperature and 40 psi for 2 hrs. The mixture is filtered through celite, washing with ethyl acetate (2 x 100 mL), and concentrated in vacuo to give 4- (4-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC acid tert-butyl ester (12) as a brown oil.
The synthetic route of 182618-86-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CELLULAR GENOMICS, INC.; WO2005/14599; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics