With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.183742-34-9,4-Boc-1-Fmoc-2-piperazineacetic acid,as a common compound, the synthetic route is as follows.
l-(9H-fluoren-9-yl)methyl 4-f¡ãr^butyl 2-(2-(2-bromophenylamino)-2- oxoethyl)piperazine-l,4-dicarboxylate To a solution of 2-bromoaniline (3.69 g, 21.44 mmol), and 2-(l-(((9H-fluoren-9- yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazin-2-yl)acetic acid (10 g, 21.44 mmol) in a 1 :1 solution of Lambdaf,Lambda/-dimethylformamide:pyridine (100 mL) was added N-(3- dimethylaminopropyl)-Lambdaf’-ethylcarbodiimide hydrochloride (10.27 g, 53.6 mmol). The reaction mixture was stirred at ambient temperature for 16 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was separated and was subsequently washed with brine (3chi) and 1 MEtaC1 (3chi). The organic solution was then concentrated onto silica gel and purified via flash chromatography (10-70% ethyl acetate/hexanes) to afford the title compound. 1H NMR (400 MHz, DMSO-J6) delta ppm 9.43 (s, 1 H), 7.81 – 7.95 (m, J=7.67 Hz, 2 H), 7.53 – 7.75 (m, 4 H), 7.22 – 7.48 (m, 5 H), 7.10 (dd, J=7.21 Hz, 1 H), 4.56 (s, 1 H), 4.17 – 4.42 (m, 3 H), 3.61 – 3.98 (m, 3 H), 2.89 – 3.18 (m, 2 H), 2.62 – 2.88 (m, 2 H), 2.49 – 2.58 (m, 1 H), 1.32 – 1.50 (m, 9 H); MS (APCI+) m/z 522.2 (M-Boc+H)+., 183742-34-9
The synthetic route of 183742-34-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ABBOTT LABORATORIES; ABBOTT GMBH &; CO. KG; WANG, Ying; BREWER, Jason, T.; AKRITOPOULOU-ZANZE, Irini; DJURIC, Stevan, W.; POHLKI, Frauke; BRAJE, Wilfried; RELO, Ana-Lucia; WO2010/124042; (2010); A2;,
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