Category: 184042-60-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184042-60-2,1-(2-Fluoroethyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.

To a mixture of 5′-chloro-7′-oxo-7′,8′-dihydro-6’H-spiro[cyclohexane-l,9′-furo[2,3- |quinazoline]-2′-carboxylic acid (Intermediate 15, 50 mg, 0.15 mmol) and l-(2-fluoroethyl) piperazine hydrochloride in DMF (5 mL) was added a solution of N-ethyl-N-isopropylpropan-2- amine (0.08 mL, 0.45 mmol) and 2-(3H-[l,2,3]triazolo[4,5- ?]pyridin-3-yl)- l, 1,3,3- tetramethylisouronium hexafluorophosphate (HATU, 68 mg, 0.18 mmol) in DMF (1 mL). The vial was sealed and the reaction mixture was stirred at room temperature for 3.5 h. The reaction mixture was diluted with water and EtOAc. A precipitate formed in the biphasic mixture, which was filtered, rinsed with H2O and dried under vacuum to give the title compound as a white solid (19 mg, 28%). NMR (400 MHz, DMSO-d6) delta 8.42 (s, 1H), 7.75 (s, 1H), 7.37 (s, 1H), 7.34 (s, 1H), 4.67 – 4.47 (m, 2H), 3.70 (br s, 4H), 2.77 – 2.63 (m, 2H), 2.59 – 2.54 (m, 4H), 2.36 – 2.25 (m, 2H), 1.95 – 1.81 (m, 4H), 1.72 (d, / = 12.7 Hz, 1H), 1.56 (d, / = 14.2 Hz, 2H), 1.35 – 1.22 (m, 1H). [M+H] = 449.0., 184042-60-2

As the paragraph descriping shows that 184042-60-2 is playing an increasingly important role.

Reference£º
Patent; DART NEUROSCIENCE, LLC; SANTORA, Vincent, John; CHEN, Mi; CHUNG, DeMichael; (377 pag.)WO2019/14305; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

184042-60-2, 1-(2-Fluoroethyl)piperazine hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 7-oxa-10,13,17,18,21 -pentaazatetracyclo[12.5.2.1A{2,6}.0A{17,20}]docosa- 1 (20),2,4,6(22),14(21 ),-15,18-heptaene hydrochloride (300 mg, 0.904 mmol) and diisopropylethylamine (616 muIota, 3.62 mmol) in tetrahydrofuran (2.5 ml) and N,N-dimethylformamide (2.5 ml) was added drop wise to a solution of di(imidazol- 1 -yl)methanone (220 mg, 1 .356 mmol) in tetrahydrofuran (1 .5 ml). The mixture was stirred at room temperature for 2 hours. 1 -(2-Fluoroethyl)piperazine hydrochloride (229 mg, 1 .36 mmol) was added and the reaction mixture was stirred at 80 C for 63 hours and at 1 10C for 24 hours. Di(imidazol-1 -yl)methanone (150 mg, 0.904 mmol) was added and the mixture was stirred at 1 10 0 C for 18 hours. The solvent was removed under reduced pressure and the residue was purified by reversed phase HPLC (HPLC method A). The product fractions were collected and the solvent was removed under reduced pressure. The product was taken up in dichloromethane/methanol (4:1 , 520 muIota) and 4N HCI in 1 ,4-dioxane (48 muIota, 0.191 mmol) was added. The reaction mixture was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure and the compound was triturated with diethyl ether, filtered and dried under vacuum.Yield: 84 mg of example 17 (19%)LCMS method 2: MH+ = 454, RT = 2.032 min

184042-60-2, 184042-60-2 1-(2-Fluoroethyl)piperazine hydrochloride 22281452, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; IPSEN PHARMA S.A.S.; ONCODESIGN S.A.; HOFLACK, Jan; BLOM, Petra; WO2013/46029; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics