Category: 187669-28-9

Scattolin, Thomas published the artcileA Nucleophilic Deprotection of Carbamate Mediated by 2-Mercaptoethanol, HPLC of Formula: 187669-28-9, the main research area is carbamate mercaptoethanol nucleophilic deprotection; secondary amine preparation.

Carbamates, typically used for the protection of amines, including Cbz, Alloc, and Me carbamate, was readily deprotected by treatment with 2-mercaptoethanol in the presence of potassium phosphate tribasic in N,N-dimethylacetamide at 75°C. This nucleophilic deprotection protocol was superior to the standard hydrogenolysis or Lewis acid-mediated deprotection conditions for substrates bearing a functionality sensitive to these more traditional methods.

Organic Letters published new progress about Free energy. 187669-28-9 belongs to class piperazines, name is tert-Butyl 4-(piperazin-1-yl)benzoate, and the molecular formula is C15H22N2O2, HPLC of Formula: 187669-28-9.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Wang, Guangjun published the artcileAn efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins, Synthetic Route of 187669-28-9, the main research area is ABT263 Bcl2 protein inhibitor preparation.

ABT-263, a newly developed Bcl-2 inhibitor, was efficiently synthesized. The key intermediates 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl]methyl}piperazin-1-yl)benzoic acid and 4-fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide were efficiently prepared by a 3-component Mannich reaction and by nucleophilic fluorination of 1-nitro-2-[(trifluoromethyl)sulfonyl]benzene as the key steps, resp. Our work may lay a foundation for a new process development of this promising anticancer drug candidate.

Synthesis published new progress about Bcl-2 proteins Role: NUU (Other Use, Unclassified), USES (Uses) (inhibitors of). 187669-28-9 belongs to class piperazines, name is tert-Butyl 4-(piperazin-1-yl)benzoate, and the molecular formula is C15H22N2O2, Synthetic Route of 187669-28-9.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics