Category: 20327-23-5

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20327-23-5, Step 1 : 3-(4-Cyclopropyl-piperazin-1-yl)-6-(3-nitro-phenyl)-pyridazine: To a solution of 3-chloro-6-(3-nitro-phenyl)-pyridazine (10.0 g, 424 mmol) in n-BuOH (150 mL) was added 1 -cyclopropyl-piperazine (8.55 g, 678 mmol) and NH4CI (2.27 g, 424 mmol) and the mixture was stirred for 48 h at 800C. The solvent was removed under reduced pressure, and the residue was diluted with water. After alkalization with ammonia, the mixture was extracted with ethyl acetate. The extract was dried (Na2SO4) and concentrated to give 7.2 g of crude 3-(4-cyclopropyl-piperazin-1 -yl)-6-(3-nitro-phenyl)-pyridazine. 1H NMR (300 MHz, DMSO-c(6) delta 8.85 (s, 1 H), 8.45 (d, 1 H), 8.22 (d, 1 H), 8.1 1 (d, 1 H), 7.89- 7.66 (m, 1 H), 7.39 (d, 1 H), 3.69-3.65 (m, 4H), 2.80-2.76 (m, 4H), 1 .78-1.65 (m, 1 H), 0.54- 0.38 (m, 4H).

As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference£º
Patent; NOVO NORDISK A/S; WO2007/3604; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

To 80 mg (0.19 mmol) E-8 in 1 mL dioxane is added 0.12 g (0.93 mmol) 1-cyclopropyl- piperazine and 26 mu. (0.19 mmol) triethylamine and the reaction mixture is stirred for 3 h at 80C. A 1/1 acetonitrile/water mixture is added and the reaction mixture is purified by RP chromatography (C18). Yield: 49 mg (51%). HPLC-MS: M+H = 521; tR = 1.26 min.

20327-23-5, 20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; VEEN, Van Der, Lars; KRAEMER, Oliver; WO2012/101186; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

Step A: 2-(4-Cyclopropylpiperazin-1-yl)benzothiazole-6-carbonitrile; A suspension of 2-chlorobenzothiazole-6-carbonitrile (3.5 g, 18 mmol), 1-cyclopropyl- piperazine (3.63 g, 28.8 mmol) and ammonium chloride (0.96 g, 18 mmol) in butan-1-ol (1 12 ml.) was heated at reflux for 48 h. The solvent was removed under reduced pressure and the residue was diluted with water (30 ml_). The mixture was made alkaline with potassium carbonate and extracted with CH2CI2 (3 x 20 ml_). The combined organic extracts were concentrated to give a residue which was purified by column chromatography on silica gel (20 % ethyl acetate in petroleum ether) to give 2.2 g (43 5) of 2-(4-cyclopropylpiperazin-1-yl)benzo- thiazole-6-carbonitrile., 20327-23-5

The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVO NORDISK A/S; WO2007/110364; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of 1-bromo-3-(difluoromethyl)-5-fluoro-benzene (ig, 4.44 mmol) and 1- cyclopropylpiperazine (2.80 g, 22.22 mmol) was microwaved at 200 C for 1 h. Pumped down solvent and purified the crude mixture by ISCO purification (40g silica; 0 % to 5% to 30% of MeOH in DCM) to provide 1-[3-bromo-5-(difluoromethyl)phenyl]piperazine (920 mg, 89%). ?H NMR (300 MHz, CD3OD) oe 7.20 (s, 1H), 7.09 (s, 1H), 7.05 (d, J = 1.0 Hz, 1H), 6.66 (t, J = 56.1 Hz, 1H), 3.20 (dd, J = 6.2, 4.0 Hz, 4H), 2.98 (dd, J = 6.2, 4.1 Hz, 4H) ppm. ESI-MS m/z calc. 290.02, found 291.19 (M+1)+; Retention time: 0.63 minutes., 20327-23-5

The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; DAVIES, Robert, J.; CAO, Jingrong; COCKERILL, Meghan, Elise; COLLIER, Philip, Noel; DENINNO, Michael, Paul; DOYLE, Elisabeth; FRANTZ, James, Daniel; GAO, Huai; GOLDMAN, Brian, Anthony; GREY, Ronald, Lee; GRILLOT, Anne-laure; GU, Wenxin; HENDERSON, James, A.; IRARRAZAVAL, Raul Eduardo, Krauss; KOLPAK, Adrianne, Lynn; LIAO, Yusheng; MAGAVI, Sanjay Shivayogi; MALTAIS, Francois; MESSERSMITH, David; PIERCE, Albert, Charles; PEROLA, Emanuele; RYU, Elizabeth Jin-Sun; SYKEN, Joshua; WANG, Jian; (706 pag.)WO2016/197009; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 10 (0.17mmol, 1.0eq.), TEA (10.0eq.) and corresponding amine (5.0eq.) in ethanol (5mL) was stirred at reflux overnight. The reaction solution was evaporated. The residue was purified by silica gel column chromatography (dichloromethane/methanol/ammonium hydroxide=50/1/1) to give the desired product

20327-23-5, As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference£º
Article; Lin, Yu; Li, Zhanhui; Xu, Chen; Xia, Kaijiang; Wu, Shuwei; Hao, Yongjin; Yang, Qing; Ma, Haikuo; Zheng, Jiyue; Luo, Lusong; Zhu, Fang; He, Sudan; Zhang, Xiaohu; Bioorganic Chemistry; vol. 99; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

Compound 63 (100 mg, 0.228 mmol) was dissolved in ultra dry THF. After adding N-cyclopropylpiperazine (144 mg, 1.14 mmol), Stir overnight at room temperature. The reaction was quenched by the addition of a small amount of water and extracted three times with dichloromethane. Washed three times with saturated brine, dried over anhydrous magnesium sulfate, filtered and evaporated. Column chromatography to give the title compound (Yellow solid, 37 mg), yield 31%., 20327-23-5

20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jianhua; Xu Yechun; Huang Fubao; Liu Qiufeng; Wang Kai; (79 pag.)CN109651208; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

To 337 (28.6 mg, 0.0615 mmol) was added 1-cyclopropylpiperazine (61.2 mg, 0.3076 mmol) and Et3N (100 mu) in DMF (1 mL) and heated at 90 C for 1 h. Solvent was removed under reduced pressure and the residue was purified by preparatory TLC (CH2Cl2:MeOH, 20: 1) to afford 25.7 mg (75%) of 340. MS (ESI) m/z [M+H]+ 555.1., 20327-23-5

20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MEMORIAL SLOAN KETTERING CANCER CENTER; CHIOSIS, Gabriela; KANG, Yanlong; PATEL, Hardik J.; PATEL, Maulik; OCHIANA, Stefan; RODINA, Anna; TALDONE, Tony; SHRESTHA, Liza; (288 pag.)WO2015/175707; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20327-23-5, In 100 mL round bottom flask, 1.84 g (10 mmol) of compound II was added, 1.26 g (10 mmol) of compound III-2 and 20 mL of dry THF were added and the resulting mixture was stirred under ice-cooling in water. After adding 2.48 g (12 mmol) of DCC, stirring was continued at room temperature overnight. TLC shows the completion of the reaction.The reaction mixture was poured into ice water, stirred, extracted with 50 mL of X3 in dichloromethane, the combined organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and the solvent was evaporated on a rotary evaporator. The resulting residue was subjected to column chromatography purification, To give product 1-2 as a white solid.

The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhejiang Pharmaceutical College; GUO, ZHANG HUA; (6 pag.)CN104356060; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

500mg of4-(4-(( 1 -(3-isopropyl- 1 ,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3- enecarboxyilc acid was put into a 100 ml flask under a nitrogen atmosphere, 20 ml of dichloromethane was added thereto, and the resulting mixture was then dissolved while stirring. 0.32 ml of triethylamine, 160 mg of 1-cyclopropylpiperazine, and 510 mg of HATU were added dropwise thereto, and the mixture was stirred at 20C for an hour. After the reaction was terminated, 20 ml of dichloromethane was additionally added thereto, and the resulting organic layer was washed with 20 ml of distilled water, dried with anhydrous magnesium sulfate, concentrated, and then isolated by silica column chromatography to obtain the title compound (Amount obtained: 430 mg /Yield: 69%).1H NMR (400, CDC13): 7.31 (2H, d), 6.82 (2H, d), 6.03 (1H, m), 4.18 (2H, d), 3.82(2H, d), 3.64 (2H, m), 3.53 (2H, m), 3.12 (2H, m), 2.89 (1H, m), 2.77 (1H, m), 2.66(4H, m), 2.50 (3H, m), 2.30 (1H, m), 2.00 (5H, m), 1.67 (1H, m), 1.45 (2H, m), 1.28(6H, d), 0.49 (4H, m), 20327-23-5

20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; HYUNDAI PHARM CO., LTD.; YANG, Jin; KIM, Jin Woong; LEE, Han Kyu; KIM, Jae Hyun; SON, Chang Mo; LEE, Kyu Hwan; HWANG, Jeong Un; CHOI, Hyung Ho; KIM, Dae Hoon; RHEE, Jae Keol; (415 pag.)WO2017/78352; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

Step 4: A mixture of the chloropyrimidine (200 mg, 0.38 mmol), the piperazine (238 mg, 1.88 mmol) and N,N-diisopropylethylamine (0.26 mL, 1.51 mmol) in DMSO (1.5 mL) was heated in a sealed tube at 1 10 C for 2 h. The reaction was cooled to room temperature and diluted with water. The layer was then extracted with EtOAc (x2). The combined organic layers were washed with water and brine, dried over MgSC>4, filtered and concentrated to leave a residue which was used purified by column chromatography (Si02; elution with 2: 1 hexane:EtOAc) to yield the desired adduct. LCMS 621 [M+H]+.

20327-23-5, 20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; BASU, Kallol; DEMONG, Duane; SCOTT, Jack; LI, Wei; HARRIS, Joel; STAMFORD, Andrew; POIRIER, Marc; TEMPEST, Paul; WO2014/134772; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics