Category: 208167-83-3

208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of N-(cyclohexylmethyl)-8-hydroxy-4-oxo-chromene-2-carboxamide (45 mg, 0.15 mmol) in DMF (2 ml_), potassium carbonate (48 mg, 0.34 mmol) was added and after 20 minutes fert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate (58 mg, 0.22 mmol) was also added and the reaction was stirred in a microwave reactor at 100 C for 1h. After that time LC-MS (ESI) analysis confirmed complete conversion of the starting material into desired intermediate product. The reaction mixture was then filtered and evaporated to give the crude intermediate material which was then purified further using flash column chromatography eluting with 0-10% MeOH in DCM to give iert-butyl 4-[2-[2-(cyclohexylmethylcarbamoyl)-4-oxo-chromen-8-yl]oxyethyl]piperazine-1 – carboxylate (23 mg, 0.04 mmol), in a 28% yield and as a white solid. LC-MS (ESI) analysis of the so-purified product was consistent with the desired product and the material was then taken directly into the next step, conversion to intermediate compound of general formula (V) without further analysis. LC-MS (ESI) m/z 514 [M + H]+., 208167-83-3

The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITY OF DUNDEE; FORTE, Barbara; NORCROSS, Neil; JANSEN, Chimed; BARAGANA, Beatriz; GILBERT, Ian; CLEGHORN, Laura; DAVIS, Susan; WALPOLE, Christopher; (194 pag.)WO2017/221002; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of compound 9 (200mg, 0.8mmol), sodium iodine (289mg, 1.93mmol) and substituted amines (1.61mmol) in methanol (30mL) was stirred at 40C for 5h. After the reaction was completed (monitored by TLC), the solution was concentrated under vacuum. Then the crude residue was purified by column chromatography (dichloromethane/methanol), affording pure product 10., 208167-83-3

The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liang, Yu-Kun; Yue, Zhi-Zhou; Li, Jia-Xin; Tan, Cun; Miao, Ze-Hong; Tan, Wen-Fu; Yang, Chun-Hao; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 505 – 515;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound 11 (248.0 mg, 1 . 0mmol) and sodium iodide (180.0 mg, 1 . 2mmol) is added to methanol (10.0 ml) and stirring, and then adding substituted amine (2.1mmol) and heating to 40 C reaction 3 – 6 hours, TLC monitoring display complete raw material reaction, concentrated, column chromatography to obtain compound 12, wherein R4 With the corresponding product in the definition of the same.

208167-83-3, 208167-83-3 tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate 22106269, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Yang Chunhao; Miao Zehong; Yue Zhizhou; Liang Yukun; Feng Jianming; Li Jiaxin; He Qian; (30 pag.)CN104250246; (2017); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 6-(tert-butylsulfonyl)-4-((5-fluoro-lH-indazol-3-yl)amino)quinolin-7-ol (100 mg, 0.24 mmol) and tert-butyl 4-(2-chloroethyl)piperazine-l-carboxylate (72 mg, 0.20 mmol) in N,N- Dimethylformamide (DMF) (0.8 mL) was added potassium carbonate (50.0 mg, 0.36 mmol) and sodium iodide (7.2 mg, 0.05 mmol). The reaction was warmed to 50 C and stirred under an atmosphere of nitrogen. It was cooled to room temperature and concentrated under vacuum. The residue was subjected directly to purification by flash chromatography (60g pre-packed C-18 SNAP cartridge: 40% to 90% acetonitrile (0.1% ammonia) in water (10 mM ammonium bicarbonate)). The desired fractions were combined and concentrated to afford the title compound (100 mg, 0.16 mmol, 66 % yield). LCMS Method B T= 1.18 min, ES+ve 627.

208167-83-3, As the paragraph descriping shows that 208167-83-3 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CASILLAS, Linda N.; HARLING, John David; MIAH, Afjal Hussain; SMITH, Ian Edward David; RACKHAM, Mark David; (204 pag.)WO2017/182418; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of tert-butyl 4-(2-((4-(6-(4-benzamido-4-methylpiperidin-l- yl)pyridin-3-yl)-3-cyanopyrazolo[l,5-a]pyridin-6-yl)oxy)ethyl)piperazine-l-carboxylate. To a solution of N-(l-(5-(3-cyano-6-hydroxypyrazolo[l,5-a]pyridin-4-yl)pyridin-2-yl)-4- methylpiperidin-4-yl)benzamide (Intermediate P87, 157.2 mg, 0.3474 mmol) in DMA (3.5 mL) was added tert-Butyl 4-(2-chloroethyl)tetrahydro-l(2H)-pyrazinecarboxylate (172.8 mg, 0.6948 mmol) and cesium carbonate (565.9 mg, 1.737 mmol). The reaction mixture was stirred at 60C for 16 h. After cooling to ambient temperature, the reaction mixture was diluted with EtOAc and washed successively with water and saturated NaCl(aq). The combined organic extracts were dried over anhydrous Na2S04(S), filtered, and concentrated in vacuo to afford the title compound (assumed theoretical yield, 231 mg, 0.3474 mmol) in sufficient purity for step 2. MS (apci) m/z = 665.4 (M+H).

208167-83-3, As the paragraph descriping shows that 208167-83-3 is playing an increasingly important role.

Reference£º
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of [l-(3,5-dichloro-benzyl)-lH-imidazol-2-ylmethyl]-(3-fluoro-benzyl)- amine (146 mg, 0.4 mmol) in TEtaF (1 mL) at -78 0C was added dropwise a solution of n- BuLi in hexane (0.19 mL, 0.44 mmol) and the mixture stirred at -78 0C for 30 min. A solution of 4-(2-Chloro-ethyl)-piperazine-l-carboxylic acid tert-butyl ester (116 mg, 0.46 EPO mmol) in THF (1 mL) was then added dropwise and the mixture allowed to warm to ambient temperature before stirring for an additional 24 h. The reaction was quenched with water (10 mL) and extracted with CH2Cl2 (2 x 40 mL). The combined CH2Cl2 extracts were dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography (silica gel, 20:1 CH2Cl2ZMeOH) to provide 4-{2-[[l-(3,5- dichloro-benzyl)-lH-imidazol-2-ylmethyl]-(3-fluoro-benzyl)-amino]-ethyl}-piperazine-l- carboxylic acid tert-butyl ester (102 mg, 44%) as a colorless viscous oil: ESI MS m/z 576 [C29H36Cl2FN5O2 + H]+.

208167-83-3, The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2006/107923; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Into a 25-mL sealed tube purged and maintained under an inert atmosphere of nitrogen, was placed a solution of 6-methoxy-2-[4-[3-(piperidin-4-yloxy)azetidin-l-yl]phenyl]-l,3-benzothiazole (110 mg, 0.28 mmol, 1 equiv), K2CO3(115 mg, 0.83 mmol, 3 equiv), ter/-butyl-4-(2- chloroethyl)piperazine-l-carboxylate (69 mg, 0.28 mmol, 1 equiv), and Nal (4.2 mg, 0.03 mmol, 0.1 equiv) in CH3CN (5 mL). The resulting mixture was stirred for 16 hours at 40 C. The solids were filtered off, and the filtrate was concentrated. The residue was applied onto a silica gel column eluting with dichloromethane/methanol (10:1). This resulted in 178 mg of tert-butyl-4-[2-[4-([l-[4-(6-methoxy-l,3- benzothiazol-2-yl)phenyl] azetidin-3 -yl] oxy)piperidin- 1 -yl] ethyl Ipiperazine- 1 -carboxylate as a yellow- green solid.

208167-83-3, As the paragraph descriping shows that 208167-83-3 is playing an increasingly important role.

Reference£º
Patent; ARVINAS OPERATIONS, INC.; CREW, Andrew P; DONG, Hanqing; BERLIN, Michael; SPARKS, Steven M.; (513 pag.)WO2020/41331; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 9 (200mg, 0.8mmol), sodium iodine (289mg, 1.93mmol) and substituted amines (1.61mmol) in methanol (30mL) was stirred at 40C for 5h. After the reaction was completed (monitored by TLC), the solution was concentrated under vacuum. Then the crude residue was purified by column chromatography (dichloromethane/methanol), affording pure product 10.

208167-83-3, As the paragraph descriping shows that 208167-83-3 is playing an increasingly important role.

Reference£º
Article; Liang, Yu-Kun; Yue, Zhi-Zhou; Li, Jia-Xin; Tan, Cun; Miao, Ze-Hong; Tan, Wen-Fu; Yang, Chun-Hao; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 505 – 515;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate (1.00 g, 4.02 mmol, 1.00 eq), 4-benzyloxyphenol (965 mg, 4.82 mmol, 1.20 eq) in N,N-dimethylformamide (20 mL) was added cesium carbonate (1.57 g, 4.82 mmol, 1.20 eq) and potassium iodide (66 mg, 0.4 mmol, 0.10 eq) under nitrogen. The reaction was stirred at 80 C. for 10 hours. TLC (Petroleum ether/Ethyl acetate=3/1) and LCMS showed most of the starting material was consumed. Water (100 mL) was added to the mixture, the resulting mixture was extracted with Ethyl acetate (50 mL*3). The combined organic phase was washed with brine (80 mL), dried over sodium sulfate, filtered and concentrated in vacuum. The residue was purified by silica gel chromatography (Petroleum ether/Ethyl acetate=50/1 to 3/1). tert-butyl 4-[2-(4-benzyloxyphenoxy)ethyl]piperazine-1-carboxylate (1.4 g, 3.39 mmol, 84% yield) was obtained as a colorless oil. Chemical Formula: C24H32N2O4, Molecular Weight: 412.5 Total H count from HNMR data: 32. ?H NMR: (400 MHz, CHEOROFORM-d)oe: 7.46-7.29 (m, 5H), 6.95-6.88 (m, 2H), 6.88-6.812H), 5.02 (s, 2H), 4.07 (t, J=5.8 Hz, 2H), 3.5 1-3.42 (m, 4H), 2.80 (t, J=5.8 Hz, 2H), 2.56-2.48 (m, 4H), 1.47 (s, 9H)

208167-83-3, The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Arvinas, Inc.; Crew, Andrew P.; Berlin, Michael; Dong, Hanqing; Homberger, Keith R.; Qian, Yimin; Snyder, Lawrence B.; Wang, Jing; Zimmermann, Kurt; (504 pag.)US2018/215731; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A suspension of IX-214 (30 mg; 0.065 mmol; Example 1), potassium carbonate (9 mg; 0.065 mmol) and potassium iodide (2 mg; 0.012 mmol) in ethanol (1 mL) was stirred 5 min at room temperature, was supplemented with /-butyl 4-(2-chloroethyl)piperazine-l-carboxylate (24.3 mg; 0.098 mmol; Acros Organics), and was stirred 6 h at 80C. The reaction mixture was evaporated, re-dissolved in 10 mL water, and extracted with dichloromethane (3 x 10 mL). The pooled extracts were dried over anhydrous sodium sulfate, filtered, and evaporated, and the product was purified by silica chromatography (methanol/di chloromethane gradient).Yield: 34.4 mg; 79%., 208167-83-3

The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; EBRIGHT, Richard H.; EBRIGHT, Yon W.; LIN, Chih-Tsung; (85 pag.)WO2019/226915; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics