Category: 208167-83-3

208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Take 1.86g of 4-hydroxybenzaldehyde and 3.72g of intermediate A22 in a 50ml round bottom flask was added 15mlN, N- dimethylformamide, another additional 4.2g of potassium carbonate, the reaction solution in a 85 C oil bath Stirred for 3 hours, cooled to room temperature. The reaction mixture was diluted with ethyl acetate and washed with water four times. The ethyl acetate layer was separated and dried over anhydrous sodium sulfate and evaporated to dryness under reduced pressure. The residue was chromatographed on silica gel with petroleum ether-ethyl acetate = 4: 1, petroleum ether-ethyl acetate = 1: 1, then with petroleum ether-ethyl acetate = 1: 1 and 1% by volume of triethylamine Column chromatographyTo give 3.35 g of intermediate A23 in a yield of 66%, 208167-83-3

208167-83-3 tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate 22106269, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Tsinghua University; Rao Yu; Wu Wei; Lan Tianlong; Hu Jiantao; Fan Zhongyun; Huang Binlu; (31 pag.)CN107286098; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) Preparation of N-[1-butyl-4-[3-{2-(4-tert-butoxycarbonyl-1-piperazinyl)ethoxy}phenyl]-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N’-(2,6-diisopropylphenyl)urea STR99 The title compound was obtained in the same manner as in Example 41 from N-[4-(3-hydroxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N’-(2,6-diisopropylphenyl)urea and 1-tert-butoxycarbonyl-4-(2-chloroethyl)piperazine. 1 H-NMR delta (CD3 OD) 8.63 (1H, dd, J=4.6 Hz, 1.7 Hz), 7.75 (1H, dd, J=7.9 Hz, 1.7 Hz), 7.47 (1H, dd, J=8.2 Hz, 7.9 Hz), 7.04-7.30 (5H, m), 6.93-7.04 (2H, m), 4.60-4.73 (2H, m), 4.05-4.10 (2H, m), 3.38-3.53 (4H, m), 2.92-3.10 (2H, m), 2.55-2.68 (2H, m), 2.36-2.54 (4H, m), 1.95-2.10 (2H, m), 1.70-1.90 (2H, m), 1.45-1.62 (2H, m), 1.49 (9H, s), 1.15 (12H, d, J=6.6 Hz), 1.05 (3H, t, J=7.3 Hz)

208167-83-3, The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Pharmaceuticals Company, Ltd.; US5843957; (1998); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of tert-butyl 4-(2-((3-cyano-4-(6-(4-(5-fluoro-2- methylbenzamido)-4-methylpiperidin-l-yl)pyridin-3-yl)pyrazolo[l,5-a]pyridin-6- yl)oxy)ethyl)piperazine-l-carboxylate. To a mixture of N-(l-(5-(3-cyano-6- hydroxypyrazolo[l,5-a]pyridin-4-yl)pyridin-2-yl)-4-methylpiperidin-4-yl)-5-fluoro-2- methylbenzamide (Intermediate P68; 55 mg, 0.114 mmol), tert-Butyl 4-(2- chloroethyl)tetrahydro-l(2H)-pyrazine carboxylate (57 mg, 0.227 mmol) was added cesium carbonate (148 mg, 0.454 mmol) in DMA (1 mL) and was stirred overnight at 60C. After cooling to ambient temperature, reaction was diluted with EtOAc and washed with water and the organic extracts were dried over anhydrous Na2S04(S), filtered and concentrated in vacuo. The residue was purified using silica chromatography (50-100%) EtOAc in Hexanes) to afford the title compound (49 mg, 62% yield) MS (apci) m/z=697.4 (M+H).

208167-83-3, 208167-83-3 tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate 22106269, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 117(R)-ethyl 1-((1-(2-(4-(tert-butoxycarbonyl)piperazin-1-yl)ethyl)pyrrolidin-3-yl)methyl)-6-(6-(3-ethylureido)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-3-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylateTo a vial was charged (R)-ethyl 6-(6-(3-ethylureido)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-3-yl)-4-oxo-1-(pyrrolidin-3-ylmethyl)-1,4-dihydroquinoline-3-carboxylate (Intermediate 115) (50 mg, 0.081 mmol), tert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate (23 mg, 0.090 mmol) and potassium carbonate (15 mg, 0.11 mmol) in anhydrous acetonitrile (2 mL) and the resulting mixture was stirred at 60-65 C. for 1.5 hours. The mixture was then diluted with saturated sodium bicarbonate and the product extracted with ethyl acetate. The organics were dried over sodium sulfate, concentrated, and purified with another lot (1.3 mmol) by Analogix eluting with dichloromethane/methanol.MS (ESP): 827.1 (MH+) for C40H49F3N8O6S, 208167-83-3

As the paragraph descriping shows that 208167-83-3 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; US2010/317624; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Preparation of tert-butyl 4-(2-((3-cyano-4-(6-(4-methyl-4- (picolinamido)piperidin-l-yl)pyridin-3-yl)pyrazolo[l,5-a]pyridin-6-yl)oxy)ethyl)piperazine- 1-carboxylate. To a solution of N-(l-(5-(3-cyano-6-hydroxypyrazolo[l,5-a]pyridin-4- yl)pyridin-2-yl)-4-methylpiperidin-4-yl)picolinamide (Intermediate P90, 120 mg, 0.265 mmol) in DMA (2.646 mL) was added tert-Butyl 4-(2-chloroethyl)tetrahydro-l(2H)- pyrazinecarboxylate (65.8 mg, 0.265 mmol) and cesium carbonate (431 mg, 1.32 mmol). The reaction mixture was stirred at 60C for 48 h. After cooling to ambient temperature, the reaction mixture was diluted with 4: 1 DCM/IPA and washed successively with saturated NaHC03(aq) and saturated NaCl(aq). The organic extract was dried over anhydrous Na2S04(S), filtered, and concentrated in vacuo to afford the title compound (176 mg, 0.264 mmol, 99.9 % yield) in sufficient purity for step 2. MS (apci) m/z = 666.4 (M+H).

208167-83-3, The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics