Category: 21043-40-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 7 (0.1 mmol, 55 mg) in dry dichloromethane (3 ml) was added the appropriate amine (0.12 mmol, 1.2 equiv) and triethylamine (0.12 mmol) at room temperature. After stirring for overnight, the reaction mixture was purified directly by silica gel column chromatography., 21043-40-3

The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Jin, Yan; Liu, Jie; Huang, Wen-Ting; Chen, Shi-Wu; Hui, Ling; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4056 – 4061;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.,21043-40-3

1-Cyclopentyl piperazine (700?mg, 4.5?mmol) was added to a stirred solution of 1 (1?g, 3.0?mmol) in 15?mL dry 1,4-dioxane and DIPEA (0.8?mL, 4.5?mmol). The solution was stirred for 6?h?at room temperature. The reaction mixture was concentrated under reduced pressure and poured into ice water and extracted with ethyl acetate (3?*?50?mL). The combined organic part was washed with water followed by brine, dried over sodium sulphate and concentrated under reduced pressure. The crude residue was purified by flash column chromatography, eluting with 2-5% methanol in chloroform to provide pure compound 36 as white solid (940?mg, 86% yield, m.p- 156-160?C). 1H NMR (300?MHz, CDCl3) delta 7.47-7.44 (m, 2H), 7.41-7.32 (m, 3H), 7.18 (s, 1H), 7.06 (s, 1H), 5.25 (s, 2H), 3.96 (s, 3H), 3.79 (t, J?=?4.8?Hz, 4H), 2.67 (t, J?=?4.8?Hz, 4H), 2.58-2.53 (m, 1H), 1.94-1.85 (m, 2H), 1.76-1.66 (m, 2H), 1.60-1.53 (m, 2H), 1.47-1.40 (m, 2H). 13C NMR (75?MHz, CDCl3) delta 164.3, 154.8, 154.1, 150.5, 148.6, 135.4, 128.7, 128.3, 127.4, 109.1, 108.4, 103.6, 70.8, 67.6, 56.2, 51.8, 48.9, 30.0, 24.0. HRMS (EI) calcd for C25H29ClN4O2 (m/z) [M]+ 452.1979; found 452.1987.

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference：
Article; Paul, Barnali; Rahaman, Oindrila; Roy, Swarnali; Pal, Sourav; Satish, Sohal; Mukherjee, Ayan; Ghosh, Amrit R.; Raychaudhuri, Deblina; Bhattacharya, Roopkatha; Goon, Sunny; Ganguly, Dipyaman; Talukdar, Arindam; European Journal of Medicinal Chemistry; vol. 159; (2018); p. 187 – 205;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Substituted amine (1.2 equiv) was added to a mixture of 4-fluoronitrobenzene (1 equiv) and K2CO3 (2.0 equiv) in DMF (7mL/g). The reaction mixture was stirred at 40C and followed by TLC. After completion of the reaction, the mixture was poured into stirring ice-water. The resulting precipitate was filtered and dried to obtain compounds 11 as a yellow solid., 21043-40-3

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference：
Article; Hou, Yunlei; Zhu, Liangyu; Li, Zhiwei; Shen, Qi; Xu, Qiaoling; Li, Wei; Liu, Yajing; Gong, Ping; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 690 – 709;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

To the 25 ml round-bottom flask by adding 69A (159mul, 1mmol) and dichloromethane, after stirring to dissolve by adding 69B (270 mg, 1mmol), then adding STAB (254 mg, 1 . 2mmol) stirring overnight, TLC detection reaction is complete, water washing, the water layer is extracted with ethyl acetate, combined with the phase, saturated salt water washing, dry anhydrous sodium sulfate, concentrated after the silica gel to obtain the product 69 (217 mg, 56%).

21043-40-3, 21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Chengdu Biological Technology Co., Ltd. Kerry Bass; Li, Dequn; (92 pag.)CN105777632; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: One-pot synthesis of N-(aminosulfonyl)-4-podophyllotoxin carbamates from PPT in the presence of CSI and amine via the Burgess-type intermediates.1 CSI (170 mg, 1.2 mmol) was added dropwise to a solution of PPT (500 mg, 1.2 mmol) in DCM (5 mL) at -10. The reaction mixture was stirred at -10 for 30 min. Pyridine (1.0 equiv) was then added dropwise to above mixture and stirred for another 1 h at -10. Followed amine (2.0 equiv) was added to the reaction mixture at -10. The reaction mixture was stirred for 2 h at -10, then stirred at room temperature until the reaction was finished. The reaction mixture was washed in order by distilled water and saturated brine, and then the extract was dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography, using CH2Cl2/acetone as the eluent, to afford pure compounds 5-13.

21043-40-3, As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference：
Article; Xu, Xiao-Hui; Guan, Xiao-Wen; Feng, Shi-Liang; Ma, You-Zhen; Chen, Shi-Wu; Hui, Ling; Bioorganic and Medicinal Chemistry Letters; vol. 27; 13; (2017); p. 2890 – 2894;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 5.6 g (35 mmol) 2-chloro-4-nitropyridine, 5.75 g (37 mmol) 1-cyclo- pentyl piperazine and 4,59 g (35 mmol) N,N-diisopropylethylamine in 35 ml DMF and 12 ml water was heated to 95 0C for 3 h . After evaporation to dryness the residue was taken up in 150 ml NaHCO3 aq. and 150 ml ethyl acetate. The aqueous phase was extracted two times with 150 ml ethyl acetate each and the combined organic phases were washed twice with 10O1 ml NaHCO3 aq each and 100 ml NaCl aq. sat. and dried with MgSO4 and evaporated to dryness. The residue was purified with columnchromatography to^yield 2.85 g (29 %) l-cyclopentyl-4~(4-nitro-pyridin-2-yl)- piperazine (m/e): 277.3 (MH+; 100%) and 4.47 g (47 %) l-(2-chloro-pyridin-4-yl)-4- cyclopentyl-piperazine (m/e): 266.3 (MH+; 100%)., 21043-40-3

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference：
Patent; F.HOFFMANN-LA ROCHE AG; WO2006/63718; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 5.6 g (35 mmol) 2-chloro-4-nitropyridine, 5.75 g (37 mmol) 1-cyclo- pentyl piperazine and 4,59 g (35 mmol) N,N-diisopropylethylamine in 35 ml DMF and 12 ml water was heated to 95 0C for 3 h . After evaporation to dryness the residue was taken up in 150 ml NaHCO3 aq. and 150 ml ethyl acetate. The aqueous phase was extracted two times with 150 ml ethyl acetate each and the combined organic phases were washed twice with 10O1 ml NaHCO3 aq each and 100 ml NaCl aq. sat. and dried with MgSO4 and evaporated to dryness. The residue was purified with columnchromatography to^yield 2.85 g (29 %) l-cyclopentyl-4~(4-nitro-pyridin-2-yl)- piperazine (m/e): 277.3 (MH+; 100%) and 4.47 g (47 %) l-(2-chloro-pyridin-4-yl)-4- cyclopentyl-piperazine (m/e): 266.3 (MH+; 100%)., 21043-40-3

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference：
Patent; F.HOFFMANN-LA ROCHE AG; WO2006/63718; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

Combine 6- (4-formyl-phenoxy)-nicotinamide (compound of example 332, step 1) (0.303 g, 1.25 mmol) and 1-cyclopentyl piperazine (0.198 g, 1.28 mmol) in methanol (11 ML) and stir. After 15.5 h, add sodium borohydride (0.109 g, 2.88 mmol), and stir at ambient temperature. After 1 h, concentrate the reaction mixture and purify by silica gel chromatography (ethyl ACETATE- 4: 1 ethyl acetate: methanol) to provide 0.172 g (36%) of the title compound as an off white solid: high resolution mass spectrum (electrospray): M . TALC for C22H29N402 381. 2291, found 381.2306 ; 1H NMR (DMSO-D6) : 8.66 (d, 1H, J = 2. 4 HZ), 8. O0 (dd, 1H, J = 2. 9,8. 8 Hz), 7.48-7. 43 (M, 2H), 7.18-7. 13 (m, 2H), 7.04 (d, L H, J = 7.8 Hz), 3.61 (s, 2H), 3.00-2. 25 (m, 9H), 2.01-1. 88 (m, 2H), 1.82-1. 69 (m, 2H), 1.69-1. 56 (m, 2H), 1.53-1. 38 (m, 2H).

21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ELI LILLY AND COMPANY; WO2004/26305; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

4-Cyclopentyl-piperazine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester. The hydrochloride of the title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-cyclopentyl-piperazine. White solid, m.p. 294-295 C.; HPLC-MS m/z=436 (M+H), Rt: 2.92 min.; 1H NMR (DMSO-d6): delta 11.15 (br, 1H, NH), 8.60-8.55 (br, 1H, py-H6), 8.29-8.20 (m, 1H, py-H4), 7.32-7.21 (d+br s, 5H, py-H3+C6H4), 4.35-3.98 (br, 2H), 3.72-3.37 (br m, 5H), 3.29-2.97 (br, 2H), 2.12-1.45 (br m, 8H).

21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 511A 3-(4-cyclopentyl-1-piperazinyl)-1-propanamine A mixture of N-(3-bromopropyl)phthalimide (0.8 g, 3.0 mmol), 1-cyclopentylpiperazine (0.46 g, 3.0 mmol), and K2CO3 (1.66 g, 12.0 mmol) in CH3CN (30 mL) was heated to reflux for 3 hours, cooled to room temperature, and filtered through diatomaceous earth (Celite). The filtrate was concentrated, treated with 6N HCl (9.0 mL) and acetic acid (18.0 mL), heated to reflux overnight, and concentrated. The residue was treated with potassium carbonate (1.66 g) in CH3CN (30 mL) for 1 hour. After filtration of the solid, the solvent was evaporated to provide the desired product. MS (DCI/NH3) m/e 212 (M+H)+; 1H NMR (300 MHz, DMSO-d6) delta 8.04 (br s, 2H), 3.68 (m, 4H), 3.41 (m, 4H), 3.21 (m, 2H), 2.91 (m, 2H), 2.0 (m, 4H), 1.84-1.73 (m, 4H), 1.55 (m, 2H).

21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Comess, Kenneth M.; Erickson, Scott A.; Henkin, Jack; Kalvin, Douglas M.; Kawai, Megumi; Kim, Ki H.; BaMaung, Nwe Y.; Park, Chang Hoon; Sheppard, George S.; Vasudevan, Anil; Wang, Jieyi; Barnes, David M.; Fidanze, Steve D.; Kolaczkowski, Lawrence; Mantei, Robert A.; Park, David C.; Sanders, William J.; Tedrow, Jason S.; Wang, Gary T.; US2004/157836; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics