Category: 21043-40-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: 5.1.4. Example A.6.1: general procedure 3 (GP3). The amine (1.0equiv) in ethanol (1mL per mmol amine) was added to the alkyl halide (1.1equiv) and sodium carbonate (3equiv) in ethanol (2mL per mmol amine). The reaction was heated to reflux then water (5mL per mmol amine) and aqueous sodium carbonate (1M, 5mL per mmol amine) were added. The product was extracted with ethyl acetate (3 times, 10mL per mmol amine) and the combined organic layers were dried over MgSO4, filtered and concentrated. The crude material was purified using the Combiflash (A buffer Et2O, B buffer 0.1M NH3 in 1:1 MeOH/Et2O) and the relevant fractions combined and concentrated to give the product., 21043-40-3

21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Kelly, Nicholas M.; Wellejus, Anja; Elbr°nd-Bek, Heidi; Weidner, Morten Sloth; J°rgensen, Signe Humle; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 3334 – 3347;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To mixture of (2S)(‘/WJ-5-(-1-(tert-butoxy)-2-methoxy-2-oxoethyl)-4-(8-fluoro-5-methylchroman- 6-yl)-1 ,6-dimethyl-1 H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (30 mg, 0.060 mmol) and 1- cyclopentylpiperazine (8.67 pL, 0.060 mmol) in ethyl acetate (1 mL) was added DIEA (0.026 mL, 0.150 mmol) followed by addition of 1-propanephosphonic acid cyclic anhydride (T3P) (0.072 mL, 0.120 mmol) as a 50% solution in ethyl acetate and stirred at room temperature for 30 min. Diluted with ethyl acetate, added water and saturated ammonium chloride and extracted with ethyl acetate. Organic phase was washed with brine, dried over IS^SC^, filtered and concentrated to give (2S (7WJ-methyl 2-(tert-butoxy)-2-(2-(4-cyclopentylpiperazine-1-carbonyl)-4- (8-fluoro-5-methylchroman-6-yl)-1 ,6-dimethyl-1 H-pyrrolo[2,3-b]pyridin-5-yl)acetate (37 mg, 97% yield) as a colorless oil. 1H NMR (400 MHz, CHLOROFORM-d) delta = 6.74 (br. s., 1 H), 5.99 (br. s., 1 H), 5.14 (s, 1 H), 4.32 (t, J=5.0 Hz, 2 H), 3.93 (br. s., 3 H), 3.78 – 3.88 (m, 1 H), 3.59 (s, 3 H), 2.78 – 2.86 (m, 3 H), 2.74 (br. s., 2 H), 2.53 (br. s., 2 H), 2.17 (br. s., 2 H), 1.89 (br. s., 2 H), 1.78 (s, 3 H), 1.57 (br. s., 12 H), 1.06 – 1.17 (m, 9 H); LC/MS (m/z) ES+ = 635 (M+1)

21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; VIIV HEALTHCARE UK LIMITED; DE LA ROSA, Martha Alicia; JOHNS, Brian, Alvin; KAZMIERSKI, Wieslaw, Mieczyslaw; SAMANO, Vicente; SUWANDI, Lita; TEMELKOFF, David; VELTHUISEN, Emile; WEATHERHEAD, Jason, Gordon; WO2014/9794; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-cyclopentyl Piperazine(507 mg, 0.003 mmol) was added to a stirred solution of 6 (1 g, 0.0029 mmol) in dry 1,4-Dioxaneand DIPEA (0.7 mL,0.005 mmol). The solution was stirred for 4 h at room temperature. After adding water a precipitate was formed which was filtered to give compound 7 (1.1g, 86% yield) as white solid (m.p-156-159 C).1H NMR (300 MHz, CDCl3) ^ 1.39 – 1.50 (m, 2H), 1.58 (dd, J=7.72, 4.71 Hz, 2H), 1.68 – 1.75 (m, 2H), 1.88 (br. s, 2H), 2.51 – 2.60 (m, 1H), 2.64 – 2.70 (m, 4H), 3.66 – 3.71 (m, 1H), 3.76 – 3.82 (m, 4H), 3.96 (s, 3H), 5.25 (s, 2H), 7.06 (s, 1H), 7.18 (s, 1H), 7.31 – 7.41 (m, 3H), 7.42 – 7.48 (m, 2H).ESI [M+H]+:453.40., 21043-40-3

21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; TALUKDAR, Arindam; GANGULY, Dipyaman; PAUL, Barnali; MUKHERJEE, Ayan; ROY, Shounak; ROY, Swarnali; GHOSH, Amrit Raj; BHATTACHARYA, Roopkatha; RAHAMAN, Oindrila; KUNDU, Biswajit; (89 pag.)WO2017/163264; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,21043-40-3

(General Procedure 16)4-Cyclopentyl-piperazine-1-carboxylic Acid 4-iodo-pyrazol-1-yl Ester The title compound was prepared from 1-hydroxy-4-iodopyrazole and N-cyclopentylpiperazine applying the general procedure 16. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane-3% Et3N) (61%, crystals). 1H NMR (300 MHz; CDCl3): delta 1.33-1.94 (m, 8H), 2.46-2.61 (m, 5H), 3.57 (bt, 2H), 3.67 (bt, 2H), 3.63 (bs, 2H), 3.77 (bs, 2H), 7.40 (d, 1H), 7.44 (d, 1H); HPLC-MS: m/z=391.1 (M+1); Rt=1.31 min.

21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,21043-40-3

(General Procedure 16)4-Cyclopentyl-piperazine-1-carboxylic Acid 4-iodo-pyrazol-1-yl Ester The title compound was prepared from 1-hydroxy-4-iodopyrazole and N-cyclopentylpiperazine applying the general procedure 16. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane-3% Et3N) (61%, crystals). 1H NMR (300 MHz; CDCl3): delta 1.33-1.94 (m, 8H), 2.46-2.61 (m, 5H), 3.57 (bt, 2H), 3.67 (bt, 2H), 3.63 (bs, 2H), 3.77 (bs, 2H), 7.40 (d, 1H), 7.44 (d, 1H); HPLC-MS: m/z=391.1 (M+1); Rt=1.31 min.

21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of compound 19 (100 mg, 0.33 mmol) in anhydrous DMF (3 mL) was added appropriate amine (0.43 mmol), EDC (82 mg, 0.43 mmol), 1-hydroxybenzotriazole monohydrate (66 mg, 0.43 mmol), and triethylamine (43 mg, 0.43 mmol). The reaction mixture was stirred at rt overnight, and partitioned between methylene chloride and brine. The organic phase was washed with brine, water, and concentrated. The residue was separated by HPLC to provide compounds 20. For compounds 20f, 20g, and 20h whose syntheses involved the use of BOC-protected amine, the coupling product was then treated with TFA (0.5 ml) in CH2Cl2 (2 mL) at rt for 1 h. Removal of the volatiles provided the crude 20 that can be further purified by HPLC to give the title products., 21043-40-3

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference£º
Article; Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Liu, Xuesong; Shi, Yan; Johnson, Eric F.; Donawho, Cherrie K.; Ellis, Paul A; Bouska, Jennifer J.; Osterling, Donald J.; Olson, Amanda M.; Park, Chang; Luo, Yan; Shoemaker, Alexander; Giranda, Vincent L.; Penning, Thomas D.; Bioorganic and Medicinal Chemistry; vol. 20; 15; (2012); p. 4635 – 4645;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of 2 g (14 mmol) 2-chloro-4-cyanopyridine and 2.34 g (15 mmol) 1- cyclopentylpiperazine in 5 ml DMF was heated to 80 0C for 16 h. The mixture was evaporated under reduced pressure and the residue was treated with 100 ml IM NaHCO3 aq. and extracted with two times 100ml ethyl acetate. The combined organic phases were dried with MgSO4 and evaporated under reduced pressure to yield 3.4 g (92 %) of the title compound as grey solid, (m/e): 257.3 (MH+; 100%).

21043-40-3, 21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; F.HOFFMANN-LA ROCHE AG; WO2006/63718; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 35; (4-Cyclopentyl-piperazin-1-yl)-[4-(2-fluoro-phenylamino)-cyclohexyl]-methanone; A mixture of 86 mg (0.5 mmol) 4-oxo-cyclohexanecarboxylic acid ethyl ester (commercially available), 100 mg (0.6 mmol) 2-fluoro-phenylamine and 300 mg (5 mmol) acetic acid in 5 mL THF was stirred for 1 h at 60 C. Afterwards 159 mg (0.75 mmol) sodium triacetoxyborohydride were added and the mixture was heated to 65 C. for 16 h. After evaporation of the volatiles 10 mL 1N NaHCO3 aq. was added and the mixture was extracted with DCM. The combined organic layers were evaporated and methanol and DMF were added and the mixture was subjected to preparative HPLC purification on reversed phase eluting with a gradient of acetonitrile/water (0.1% NEt3). The combined product fractions were evaporated to dryness to yield the intermediate 3-(2-fluoro-phenylamino)-cyclohexanecarboxylic acid ethyl ester. MS(m/e): 266.2 (MH+). A mixture of 21 mg (0.08 mmol) 4-(2-fluoro-phenylamino)-cyclohexanecarboxylic acid ethyl ester, 17 mg (0.4 mmol) LiOH.H2O in a mixture of 2 mL THF/methanol/water was heated to 45 C. for 2 h and subsequently evaporated. The intermediately built acid was dissolved in 2 mL DMF and treated with 30 mg (0.096 mmol) TBTU, 24 mg (0.24) NEt3 and 13.5 mg (0.88 mmol) 1-cyclopentyl-piperazine (commercially available) and stirred for 16 h at room temperature. The mixture was directly subjected to preparative HPLC purification on reversed phase eluting with a gradient of acetonitrile/water (0.1% NEt3). The combined product fractions were evaporated to dryness to yield 6.4 mg (21%) of the title compound. MS(m/e): 374.4 (MH+)., 21043-40-3

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference£º
Patent; Nettekoven, Matthias; Plancher, Jean-Marc; Roche, Olivier; Takahashi, Tadakatsu; Taylor, Sven; US2007/167436; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of sodium bicarbonate (6.5 mmol) in water (2 mL) and DCM (10 mL) at 00C is added bromoacetyl bromide (6.5 mmol), followed by immediate addition of 1-cyclopentylpiperazine (3.25 mmol). The mixture is stirred at 00C for an additional 40 min. To the mixture is added aqueous sodium bicarbonate (15 mL) and DCM (30 mL). The layers are separated and the organic layers dried (MgSO^ and solvent removed in vacuo to give the title compound, which is used in the next step reaction without further purification.

21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUROGEN CORPORATION; WO2007/16496; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 14 (200 mg, 0.63 mmol) in DMA (60 mL), HOBt(170 mg, 1.26 mmol), EDCI (242 mg, 1.26 mmol), and DIPEA(0.208 mL, 1.26 mmol) and then the corresponding piperazine wereadded, and the mixture was stirred overnight. Water (10 mL) wasadded to the mixture, which was stirred for an additional 1 h. Then,the mixture was extracted with ethyl acetate (50 mL x 3). Thecombined organic layers were washed with brine, dried overanhydrous sodium sulfate and concentrated to give the crudeproduct, which was purified by column chromatography to affordthe corresponding compounds in good yields., 21043-40-3

The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Wenhua; Guo, Ne; Qi, Minghui; Dai, Haiying; Hong, Minghuang; Guan, Longfei; Huan, Xiajuan; Song, Shanshan; He, Jinxue; Wang, Yingqing; Xi, Yong; Yang, Xinying; Shen, Yanyan; Su, Yi; Sun, Yiming; Gao, Yinglei; Chen, Yi; Ding, Jian; Tang, Yun; Ren, Guobin; Miao, Zehong; Li, Jian; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 514 – 531;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics