Category: 21043-40-3piperazines

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-cyclopentylpiperazine (1.27 mL, 10 mmole) was added to 10 mL DMF containing 0.3 g of 6,9-dichloro-11H-indeno[1,2-c]quinolin-11-one (TC-XCl-1)(1 mmol). The mixture was heated while stirring at 150 C. for 4 hours and added pyridine (0.5 mL, 6.21 mmole) as the catalyst. Pour the mixture into ice water after the reaction is completed and filter to get the crude product. Recrystallized from hot EtOH to get compound SJ-14 (0.16 g). [0141] Mol. Wt.: 417.9306 (C25H24ClN3O); Rf: 0.46 (Dichloromethane:Hexane:Methanol=2:1:0.5); Yield: 37.3%; Mp.: 183-184 C. (EtOH); IR (KBr) cm-1: 1716 (C?O); HRMS (ESI) m/z calcd for C25H24ClN3O+[M]+: 417.1608. Found: [M+H]+=418.1689 (error1H-NMR (300 MHz, CDCl3) delta (ppm): 1.19 (t, 3H, J=7.2 Hz, -CH3), 2.57 (q, 2H, J=7.4 Hz, N-CH2-), 3.03 (br, 4H, -CH2-), 3.46 (br, 4H, -CH2-), 7.43-7.48 (m, 2H, Ar-H8,10), 7.57-7.63 (m, 3H, Ar-H2,3,4), 7.85 (d, J=8.7 Hz, 1H, Ar-H7), 8.69 (d, J=8.1 Hz, 1H, Ar-H1); 13C-NMR (300 MHz, CDCl3) delta (ppm): 24.32, 30.67, 50.12, 52.36, 67.87, 120.99, 124.28, 124.61, 125.05, 127.31, 128.50, 130.40, 131.56, 134.36, 135.19, 135.32, 136.58, 141.94, 149.85, 157.48, 194.40 (CO).

21043-40-3, 21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; National Defense Medical Center; Huang, Hsu-Shan; Chen, Tsung-Chih; Chen, Shiang-Jiun; Chen, Chun-Liang; Lee, Chia-Chung; US2015/197492; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-(chloromethyl)-l-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl} pyrrolidin-2-one a56 (0.26 g, 0.74 mmol, 1 eq), potassium carbonate (0.4 g, 2.96 mmol, 4 eq), 1-cyclopentylpiperazine a58 (0.34 g, 2.22 mmol, 3 eq) and a catalytic amount of sodium iodide in acetonitrile (20 ml) is stirred at reflux for 4 days. Potassium carbonate is filtered and the mixture is concentrated under vacuum, then the residue is dissolved in ethyl acetate, and washed twice with a saturated solution of aqueous sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate and concentrated under vacuum to give 0.17 g of crude material. This product is purified by chromatography over silicagel (dicloromethane/methanol/ammonia 94/6/0.6) to afford 0.052 g of 4-[(4-cyclopentylpiperazin-l-yl)methyl]-l-{4-[3-(2- methylpyrrolidin-l-yl)propoxy]phenyl} pyrrolidin-2-one 44 as an orange oil. Yield : 15 %. LC-MS (MH+): 469

21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCB PHARMA, S.A.; WO2007/48595; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics