Category: 21867-64-1

Synthesis, and antitumor activity of some N1-(7-coumarinyl)amidrazones and related congeners was written by Mustafa, Mohammad S.;El-Abadelah, Mustafa M.;Zihlif, Malek A.;Naffa, Randa G.;Mubarak, Mohammad S.. And the article was included in Molecules in 2011.Category: piperazines This article mentions the following:

Piperazine coumarin amidrazone derivatives and related congeners were designed, the synthesis of the target compounds was achieved using 2-oxo-N-(2-oxo-4-methyl-2H-1-benzopyran-7-yl)propanehydrazonoyl chloride and piperazine derivatives, piperidine, morpholine, thiomorpholine, 1-[2-ethyl-4-nitro-1-(phenylmethyl)-1H-imidazol-5-yl]piperazine, etc., as reactants and the products thus obtained [i.e., 1-(1-piperazinyl)-1,2-propanedione 1-[2-(3-methyl-2-oxo-2H-1-benzopyran-7-yl)hydrazone] derivatives, amidrazones] were confirmed by elemental analyses, ¹H-NMR, ¹³C-NMR, and ESI-HRMS spectral data. The title compounds were evaluated against the cell line MCF-7 (human mammary adenocarcinoma cell line), cell line K562 (human chronic myelogenous leukemia cell line), cell line HL60 (human promyelocytic leukemia cell line) and cell line ZR-75-1 (human mammary tumor, breast carcinoma cell line) it was discovered that they displayed activity as antitumor agents. Among all the compounds tested, 7-[2-[1-[4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)-1-piperazinyl]-2-(oxo)propylidene]hydrazinyl]-4-methyl-2-chromenone was the most potent against MCF-7 and K562 cells, with IC₅₀ values of 20.2 and 9.3 μM, resp. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Category: piperazines).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Nitroaldol reactions catalyzed by amine-MCM-41 hybrids was written by Wang, Qingqing;Shantz, Daniel F.. And the article was included in Journal of Catalysis in 2010.Product Details of 21867-64-1 This article mentions the following:

The catalytic properties of several amine-functionalized MCM-41 materials in a nitroaldol (Henry) reaction are reported. The work investigated the effects of organoamine type (primary, secondary, tertiary), amine d., and the presence of silanol groups on the catalytic activity and product selectivity. High selectivity to the nitro alc. product was achieved by introducing secondary and tertiary amine groups on the MCM-41 surface, while the nitroalkene is the dominant product for primary amines. Steric effects appear to be significant in determining the overall reactivity as the least sterically hindered amines are the most active. The capping of silanols with trimethylsilyl groups resulted in a reduction in catalytic activity for nearly all samples, indicating the importance of surface silanols and/or the surface polarity in the reaction. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Product Details of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Product Details of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

New Heterocyclic Hepatitis C Virus (HCV) Inhibitors Containing A 2-Aminomethyl-1H-Indole Fragment was written by Ivachtchenko, A. V.;Yamanushkin, P. M.;Mit’kin, O. D.;Ezhova, E. V.;Korzinov, O. M.;Bulanova, E. A.;Bichko, V. V.;Ivashchenko, A. A.. And the article was included in Pharmaceutical Chemistry Journal in 2015.SDS of cas: 21867-64-1 This article mentions the following:

A focused library of heterocyclic compounds including a 2-aminomethyl-1H-benzimidazole, 2-aminomethylindole, benzofuran-2-ylmethylamine, or 2-piperazin-1-ylmethylbenzoxazole fragment was screened for the ability to inhibit in vitro hepatitis C virus (HCV). The synthetic methods were described. The antiviral activity and cytotoxicity data were presented. Most of the compounds carrying a benzoxazol-2-ylmethylamine fragment inhibited Huh7.3 human hepatoma cells infected in vitro with HCV with nanomolar potency but were inactive against the HCV RNA-replicon. The only exception was 9-methyl-N(6)-(3-nitrophenyl)-2,3,4,9-tetrahydro-1H-carbazole-1,6-diamine, which demonstrated nanomolar potency against HCV in both models. The most active and selective compounds were (piperazin-1-yl)-[(1H-indol-2-ylmethyl)piperidin-4-yl]-ketones (EC₅₀ 0.31-2.2 μM, CC₅₀ 10.2-110 μM) and 2-(1,2,3a,4,5,6-hexahydropyrazino[3,2,1-jk]carbazol-3-yl)acetamide (EC₅₀ 1.69±0.5 μM, CC₅₀ 114±42 μM). The two most selective inhibitors I (TI₅₀ = 52) and II (TI₅₀ = 68) were selected for further preclin. trials. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1SDS of cas: 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.SDS of cas: 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and hypoglycemic activity of 7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives and related compounds was written by Ohno, Sachio;Mizukoshi, Kiyoshi;Komatsu, Osamu;Kuno, Yasuo;Nakamura, Yoshiki;Kato, Eiichi;Nagasaka, Mitsuaki. And the article was included in Chemical & Pharmaceutical Bulletin in 1986.Related Products of 21867-64-1 This article mentions the following:

Apparatus 80 amino piperazino derivatives of the title system were prepared and tested for hypoglycemic activity for potential use as antidiabetics. The most promising were I and II. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Related Products of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Related Products of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Tetrahydroquinoline sulfonamides as γ-secretase inhibitors was written by Asberom, Theodros;Bara, Thomas A.;Clader, John W.;Greenlee, William J.;Guzik, Henry S.;Josien, Hubert B.;Li, Wei;Parker, Eric M.;Pissarnitski, Dmitri A.;Song, Lixin;Zhang, Lili;Zhao, Zhiqiang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Synthetic Route of C7H16N2 This article mentions the following:

The development of a novel series of tetrahydroquinoline-derived γ-secretase inhibitors for the potential treatment of Alzheimer’s disease is described. Incorporation of a fluorine substituent at position 7 resulted in the most potent compound I. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Synthetic Route of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Synthetic Route of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Chemotherapeutically active anthraquinones. II. Aminomethylanthraquinones was written by Winkelmann, E.;Raether, W.. And the article was included in Arzneimittel-Forschung in 1986.SDS of cas: 21867-64-1 This article mentions the following:

Anthraquinones [I, R = OAc, S₂CNEt₂, Sc(:NH)NH₂, NH₂, dialkylamino, heterocyclic, S(CH₂)₂NEt₂, OC₆H₄NH₂, R¹ = H, XR, R² = H, XR, Me, R³ = R⁵ = H, OH, heterocyclic, R⁴ = H, OH] were prepared and tested in vitro and in vivo (in hamster) against Entamoeba histolytica and interferon-inducing property in mice. Activity against Trichomonas foetus (in mice) was also tested. Most of the compounds showed chemotherapeutic activities in these tests. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1SDS of cas: 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.SDS of cas: 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and evaluation of thiopyrano[3,4-c]quinoline-9-carboxamide derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) was written by Park, Chun-Ho;Chun, Kwangwoo;Joe, Bo-Young;Choi, Jong-Hee;Lee, Han-Chang;Ku, Il-Whea;Kim, Hyun Young;Koh, Seong-Ho;Cho, Goang Won;Kim, Seung Hyun;Kim, Myung-Hwa. And the article was included in Medicinal Chemistry Research in 2012.Product Details of 21867-64-1 This article mentions the following:

A series of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors, 5-oxo-2,4,5,6-tetrahydro-1H-thiopyrano[3,4-c]quinoline-9-carboxamides, were successfully synthesized, and their PARP-1 inhibitory activity was evaluated. These compounds were prepared from the corresponding carboxylate and appropriate amines, and a number of the synthesized compounds were found to have significant PARP-1 activity. Among them, one compound showed potent activity in a PARP-1 enzymic and cell-based assay (IC₅₀ = 0.045 μM, ED₅₀ = 0.54 μM). Mol. modeling confirmed the obtained biol. results. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Product Details of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Product Details of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis, characterization, and biological activity of novel metronidazole-piperazine amides was written by Al-Qtaitat, Malath A.;Saadeh, Haythem A.;Al-Bakri, Amal G.;Kaur, Hargobinder;Goyal, Kapil;Sehgal, Rakesh;Mubarak, Mohammad S.. And the article was included in Monatshefte fuer Chemie in 2015.Safety of 1-Propylpiperazine This article mentions the following:

A new series of metronidazole derivatives containing piperazine rings were prepared via the reaction of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetyl chloride with selected substituted piperazines in the presence of a base. Structures of the new compounds were confirmed by NMR and MS spectral data and by elemental analyses. The antibacterial and anti-parasitic activities of these compounds were evaluated in vitro. Some of the newly synthesized compounds exhibited superior activity against Clostridium sporogenes bacteria compared to the standard drug metronidazole (I). On the other hand, other derivatives exhibited remarkable antigiardial activity and were found to be more active than metronidazole with IC₅₀ ranging from 1.8 to 6.7 μg/dm³. 1-Ethyl-4-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]piperazine (II) also exhibited antigiardial activity with similar IC₅₀ value (7.6 μg/cm³) as compared to the reference drug metronidazole (IC₅₀ = 7.4 μg/cm³). Similarly, several of the new compounds exhibited significant antitrichomonal activity and found to be more active than metronidazole with IC₅₀ ranging from 6.7 to 8.65 μg/cm³ as compared to the reference drug metronidazole (8.9 μg/cm³). In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Safety of 1-Propylpiperazine).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Safety of 1-Propylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Syntheses of Mannich basic compounds of tetrahydronaphthol containing piperazine side chains was written by Gao, Shouhai;Li, Fulin. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 1993.Application of 21867-64-1 This article mentions the following:

Title compounds I (R = Me, Et, Pr, Me₂CH, Bu, iso-Bu, EtCHMe, pentyl, isopentyl) were prepared starting from 1-naphthol. I (R = Bu, EtCHMe, isopentyl) showed antimalarial activity comparable to that of chloroquine. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Application of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Application of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and Biological Evaluation of a Novel Series of “Ortho-Nitrated” Inhibitors of Catechol-O-methyltransferase was written by Learmonth, David A.;Bonifacio, Maria Joao;Soares-da-Silva, Patricio. And the article was included in Journal of Medicinal Chemistry in 2005.HPLC of Formula: 21867-64-1 This article mentions the following:

Novel regioisomeric ortho-nitrated catechols related to the catechol-O-methyltransferase (COMT) inhibitors BIA 3-202 and BIA 3-335 were synthesized and biol. evaluated. Changing the position of the nitro group from the classical meta- to the ortho-position relative to the side-chain substituent of the nitrocatechol pharmacophore exerted profound effects on selectivity and duration of COMT inhibition. 2,3,4-O₂N(HO)₂C₆H₂CO(CH₂)_nPh (I, n = 1-4) possessed shorter duration of action than their regioisomers, but I (n = 2) displayed reversed selectivity over BIA 3-202 at 3 and 6 h, exhibiting preferential central inhibition. In the amino-substituted series, 2,3,4-O₂N(HO)₂C₆H₂COCH₂CH₂R (II, R = 4-benzylpiperidino) was less peripherally selective than BIA 3-335 and short-acting, whereas II (R = decahydroquinolino, III) displayed an unprecedented combination of long-acting and selective peripheral inhibition. I (n = 2) could provide a useful tool to probe the pharmacol. utility of short-acting, centrally selective COMT inhibitors in the treatment of depression in Parkinsonian patients, and III represents a promising candidate for clin. evaluation as an adjunct to L-Dopa therapy. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1HPLC of Formula: 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).HPLC of Formula: 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics