Category: 21867-64-1

Guillon, Christophe D. et al. published their research in Bioorganic & Medicinal Chemistry in 2007 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Safety of 1-Propylpiperazine

Azetidinones as vasopressin V1a antagonists was written by Guillon, Christophe D.;Koppel, Gary A.;Brownstein, Michael J.;Chaney, Michael O.;Ferris, Craig F.;Lu, Shi-Fang;Fabio, Karine M.;Miller, Marvin J.;Heindel, Ned D.;Hunden, David C.;Cooper, Robin D. G.;Kaldor, Stephen W.;Skelton, Jeffrey J.;Dressman, Bruce A.;Clay, Michael P.;Steinberg, Mitchell I.;Bruns, Robert F.;Simon, Neal G.. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Safety of 1-Propylpiperazine This article mentions the following:

The azetidinone LY307174 (I) was identified as a screening lead for the vasopressin V1a receptor (IC50 45 nM at the human V1a receptor) based on mol. similarity to ketoconazole, a known antagonist of the LH releasing hormone receptor. Structure-activity relationships for the series, e.g., II, were explored to optimize receptor affinity and pharmacokinetic properties, resulting in compounds with K i values <1 nM and brain levels after oral dosing ∼100-fold higher than receptor affinities. Display Omitted. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Safety of 1-Propylpiperazine).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Safety of 1-Propylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Oliveira, Severino F. et al. published their research in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 1998 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Related Products of 21867-64-1

Kinetic study of the decomposition of hydrogen peroxide catalyzed by Co(II) acetylacetonate supported on a silica-propylpiperazine matrix was written by Oliveira, Severino F.;Espinola, Jose G. P.;Lemus, Wolfango Eloy S.;de Souza, Antonio G.;Airoldi, Claudio. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 1998.Related Products of 21867-64-1 This article mentions the following:

The catalytic decomposition of hydrogen peroxide by Co(II)acetylacetonate supported on a propylpiperazine-silica matrix (Co(II)(acac)-PPS) was studied in aqueous media. The results showed that the reaction was first order in H2O2. It was found that the reaction rate was pH dependent with a maximum at around pH=8. Activation parameters were determined in the temperature range 30-45°C. The low value obtained for the activation energy is in accordance with the proposed free-radical mechanism. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Related Products of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Related Products of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Kravchenko, D. V. et al. published their research in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2005 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Product Details of 21867-64-1

Synthesis of substituted 4-oxo-7-sulfamoyl-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepines was written by Kravchenko, D. V.;Ivanovskii, S. A.;Korsakov, M. K.;Dorogov, M. V.;Tkachenko, S. E.;AsHchenko, A. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2005.Product Details of 21867-64-1 This article mentions the following:

A combinatorial library of substituted 4-oxo-7-sulfamoyl-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepines was synthesized via chlorosulfonylation of tetrahydrobenzothiazepinones followed by reaction with a range of primary and secondary amines. Physicochem. parameters of some of the products, such as lipophilicity, number of rotating bonds and number of hydrogen bond donors and acceptors have been calculated In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Product Details of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Product Details of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Dorogov, M. V. et al. published their research in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2005 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).COA of Formula: C7H16N2

Producing of a novel condensed heterocycles and combinatorial libraries on the basis of 2-amino-5-bromopyridine-3-sulfochloride was written by Dorogov, M. V.;Solov’ev, M. Yu.;Kravchenko, D. V.;Blyumina, M. V.;Tkachenko, S. E.;Ivashchenko, A. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2005.COA of Formula: C7H16N2 This article mentions the following:

2-Amino-5-bromopyridine-3-sulfonyl chloride (I) was readily prepared by chlorosulfonylation of 2-amino-5-bromopyridine. Subsequent amination of I with primary or secondary amines or with amino acids, such as sarcosine or β-alanine, gave the libraries of the corresponding 2-amino-5-bromo-3-pyridinesulfonamides and 2-amino-5-bromo-3-pyridinesulfonylamino-substituted carboxylic acids, resp. The latter were further amidated with various primary and secondary amines to afford the libraries of pyridylsulfonylamino-functionalized carboxamides. On the other hand, N-(2-amino-5-bromopyridine-3-sulfonyl)-N-Me aminoacetic acid, available from I and sarcosine, undergoes intramol. cyclization on treatment with 1,1′-carbonyldiimidazole (CDI) at 40-100° to form novel pyrido[2,3-f][1,2,5]thiadiazepinone S,S-dioxide II. The reaction of N,N’-unsubstituted 2-amino-5-bromopyridine-3-sulfonamide with succinic anhydride afforded novel trioxocyclopenta[3,4]pyrido[2,3-e][1,2,4]thiadiazine III, which readily reacts with amines in the presence of CDI to provide the combinatorial library of pyrido[2,3-e][1,2,4]thiadiazines IV (R1R2NH is primary or secondary aliphatic cycloaliphatic, aromatic or heterocyclic amine). The mol. parameters, such as mol. weight, lipophilicity or a total number of hydrogen bond donors and acceptors, have been calculated for some of the products. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1COA of Formula: C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).COA of Formula: C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Walczynski, Krzysztof et al. published their research in European Journal of Medicinal Chemistry in 2005 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Safety of 1-Propylpiperazine

Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists was written by Walczynski, Krzysztof;Zuiderveld, Obbe P.;Timmerman, Henk. And the article was included in European Journal of Medicinal Chemistry in 2005.Safety of 1-Propylpiperazine This article mentions the following:

Propylpiperazinyl benzoxazoles, benzothiazoles, oxazolopyridines, and thiazolopyridines I [X = O, S; Y, Z, A, B = CH, N (either none or one of the variable groups is N)] and their hydrobromide salts are prepared as selective histamine H3 receptor antagonists; their histamine H3 antagonist activities and the relationship between their structures and activities are discussed. Propylpiperazinyl-substituted thiazolopyridines and a propylpiperazinyl-substituted benzothiazole are better histamine H3 antagonists than propylpiperazinyl-substituted oxazolopyridines and a propylpiperazinyl-substituted benzooxazole. I (X = S; Y = A = B = CH; Z = N) is the most potent histamine H3 antagonist of the series, with a pA2 value of 7.25, while the corresponding oxazolopyridine I (X = O; Y = A = B = CH; Z = N) has a pA2 value of 6.9. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Safety of 1-Propylpiperazine).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Safety of 1-Propylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Prelog, V. et al. published their research in Collection of Czechoslovak Chemical Communications in 1935 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C7H16N2

Bis(β-haloethyl)amines. VII. A new synthesis of N-monoalkylpiperazines was written by Prelog, V.;Stepan, V.. And the article was included in Collection of Czechoslovak Chemical Communications in 1935.Electric Literature of C7H16N2 This article mentions the following:

The N- and N,N’ -substituted piperazines are readily obtained by interaction of primary amines with (XCH2CH2)2NR (X = Cl or, better, Br). (HOCH2CH2)2NMe (I) (60 g.) in 100 g. 48% HBr, evaporated to a sirup and heated 6 hrs. at 160-80°, yields 66% (BrCH2CH2)2NMe (II), m. 151-2° (picrate, m. 121-2°). In 170 g. CHCl3, 20 g. I and 87 g. SOCl2, refluxed 1 hr. give 56% (ClCH2CH2)2NMe (III), m. 116-17°. Refluxed 15 hrs. in 100 cc. MeOH, 48 g. II and 28 g. PhNH2 give, after fractional distillation, 58% N-methyl-N’-phenylpiperazine (IV), b3 140-2°; similarly, III gives the HCl salt, m. 233.5°, in 26% yield. With MeI. IV gives an impure methiodide, m. 238-9°, which with AgCl yields a methochloride, decomposing at 215°. Treated with NaNO2 followed by SO2 (cf. Friedländer, III, 957), IV is decomposed to N-methyl-piperazine (V), b. 134-6° (dihydrochloride monohydrate, m. 242-3°; dichloroplatinate; dipicrate, decomposing at 272°; addition compound with CS2, subliming without decomposition about 180°). With BzCl, V gives C12H17ON2Cl, m. 240°. Prepared like II, in 58% yield, (BrCH2CH2)2NEt m. 170° (picrate, m. 120.5°) and yields 63.5% N-ethyl-N’-phenylpiperazine,m. 50-1°. This, with NaNO2, gives the unstable di-HCl salt of N-ethyl-N’-p-nitrosophenylpiperazine, decomposing near 210°, which with SO2 yields N-ethylpiperazine (di-HCl salt, m. 210-11°; dipicrate,decomposes at 257°). Similarly obtained are (BrCH2CH2)2N-Pr, m. 157° (picrate, m. 101-2°); N-propyl-N’-phenylpiperazine, b<0.1 102-3° (HBr salt, m. 231-2°) and N-propylpiperazine (di-HCl salt, decomposes at 256°; dipicrate, m. 241-2° (decomposition)). In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Electric Literature of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Kikumoto, Ryoji et al. published their research in Journal of Medicinal Chemistry in 1984 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Synthetic Route of C7H16N2

Substituted (ω-aminoalkoxy)stilbene derivatives as a new class of anticonvulsants was written by Kikumoto, Ryoji;Tobe, Akihiro;Fukami, Harukazu;Ninomiya, Kunihiro;Egawa, Mitsuo. And the article was included in Journal of Medicinal Chemistry in 1984.Synthetic Route of C7H16N2 This article mentions the following:

(ω-Aminoalkoxy)stilbenes I [R1 = H, Cl, F, 2-MeO, 2-Me, 3,4-Cl2; R2 = H, 3-MeO, 5-Cl; R3 = NMe2, NEt2, NHMe, NPr2, 1-pyrrolidinyl, 1-piperidinyl, morpholino, 4-alkyl-1-piperazinyl, 3-R4-substituted-1-piperidinyl (R4 = OH, alkoxy, OAc, CH2OH, CONH2, CO2Me, Me, CO2H); n = 2-5] and II (butoxy at 2, 3, 4) were prepared by successive Grignard reaction of benzyl chlorides III with salicylaldehydes IV, dehydration of (1-hydroxyphenethyl)phenols, ω-bromoalkylation of hydroxy-trans-stilbenes, and amination of the product bromoalkyl ethers with amines. The effect of structural modification of these mols. on the activities was examined Potent anticonvulsant activity was displayed by 2-[4-(4-methyl-1-piperazinyl)butoxy]stilbene and piperidinobutoxystilbene derivatives V (R4 = OH, OMe, OEt, and OAc) as determined by maximal electroshock seizure (MES) and pentylenetetrazol-induced convulsion tests in mice. V (R4 = OH) exhibited more potent anti-MES activity than diphenylhydantoin and carbamazepine in further pharmacol. tests in rats, and its therapeutic index was superior to those of two antiepileptic drugs. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Synthetic Route of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Synthetic Route of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics