Category: 27469-60-9

Palladium-Catalyzed Regio- and Stereoselective γ-Arylation of Tertiary Allylic Amines: Identification of Potent Adenylyl Cyclase Inhibitors was written by Ye, Zhishi;Brust, Tarsis F.;Watts, Val J.;Dai, Mingji. And the article was included in Organic Letters in 2015.COA of Formula: C17H18F2N2 This article mentions the following:

Substituted allylic amines and their derivatives are key structural motifs of many drug mols. and natural products. A general, mild, and practical palladium-catalyzed γ-arylation of tertiary allylic amines, one of the most challenging Heck arylation substrates, has been developed. The γ-arylation products, e.g. I, were obtained in excellent regio- and stereoselectivity. Moreover, novel and potent adenylyl cyclase inhibitors with the potential for treating neuropathic and inflammatory pain have been identified from the γ-arylation products. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9COA of Formula: C17H18F2N2).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.COA of Formula: C17H18F2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and anti-tumor activity evaluation of a novel series of dithiocarbamates bearing 1,2,3-triazole and [1-Bi(4-fluorophenyl)methyl]piperazine unit was written by Mo, Song;Ding, Yong;Zhang, Gang;Zhang, Zhen;Shao, Xuebei;Li, Qinghan;Yang, Xuejun;Chen, Feng. And the article was included in Youji Huaxue in 2017.Formula: C17H18F2N2 This article mentions the following:

Sixteen novel dithiocarbamates containing 1,2,3-triazole and [1-bi(4-fluorophenyl)methyl]piperazine group were prepared via two steps starting from [1-bis(4-fluorophenyl)methyl]piperazine, propargyl bromide, methanedithione and sodium azide, using a very simple catalytic system composed of 5 mol% copper(I) iodide and MDF-H₂O (V:V = 1:1) as solvent at 70°C for 4 h with moderate yield (34%-65%). The structures of the new compounds were characterized by IR, MS, ¹H NMR, ¹³C NMR and element anal. The bioactive assay for the newly prepared compounds manifested that fourteen dithiocarbamate derivatives exhibited good to excellent inhibitory activity against CDC25B in 20μg/mL (inhibitory rate up to 97.96%, IC₅₀ value up to 11.55μg/mL), and six dithiocarbamate derivatives exhibited excellent inhibitory activity against leukemia HL-60 and lung cancer A-549 cell in 40μmol·L^-1 (inhibitory rate up to 99.99% and 93.91%, resp.; IC₅₀ value up to 12.11 and 22.45μg/mL, resp.). In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Formula: C17H18F2N2).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Formula: C17H18F2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and biological screening of 1-N-[4-[bis((4-fluorophenyl)methyl]-1-piperazinyl]-4-arylidene-2-(4-methoxyphenyl)-5-oxoimidazolines was written by Savaliya, M. D.;Dobaria, J. G.;Bhuva, V. V.;Purohit, D. M.. And the article was included in Organic Chemistry: An Indian Journal in 2010.Quality Control of 4,4-Difluorobenzhydrylpiperazine This article mentions the following:

Several piperazine imidazolone derivatives were designed for a study of their antimicrobial activity, the synthesis of the target compounds was achieved by a reaction of 4-[bis(4-fluorophenyl)methyl]-1-piperazinamine with 2-(4-methoxyphenyl)-4-(arylmethylene)-5-oxazolone derivatives and the products thus obtained were confirmed by IR, ¹H-NMR, MS, and elemental anal. The title compounds thus obtained [i.e., 3-[4-bis(4-fluorophenyl)methyl]-3,5-dihydro-2-(4-methoxyphenyl)-5-(arylmethylene)-4H-imidazol-4-one derivatives] were evaluated against Bacillus subtilis, Bacillus cereus, Escherichia coli, Enterobacter aerogenes, and Aspergillus niger and it was discovered that these compounds displayed moderate antimicrobial activity in comparison with ampicillin, chloramphenicol, norfloxacin, and griseofulvin at a concentration of 50 μg/mL. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Quality Control of 4,4-Difluorobenzhydrylpiperazine).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Quality Control of 4,4-Difluorobenzhydrylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Reusable Co-nanoparticles for general and selective N-alkylation of amines and ammonia with alcohols was written by Ma, Zhuang;Zhou, Bei;Li, Xinmin;Kadam, Ravishankar G.;Gawande, Manoj B.;Petr, Martin;Zboril, Radek;Beller, Matthias;Jagadeesh, Rajenahally V.. And the article was included in Chemical Science in 2022.Name: 4,4-Difluorobenzhydrylpiperazine This article mentions the following:

A general cobalt-catalyzed N-alkylation of amines with alcs. by borrowing hydrogen methodol. to afford alkylated amines I [R = Pr-n, cyclohexyl, Ph, etc.; R¹ = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.] was reported. The optimal catalyst for this transformation was prepared by pyrolysis of a specific templated material, which was generated in situ by mixing cobalt salts, nitrogen ligands and colloidal silica and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary and tertiary amines including N-methylamines and selected drug mols. were conveniently prepared starting from inexpensive and easily accessible alcs. and amines or ammonia. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Name: 4,4-Difluorobenzhydrylpiperazine).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Name: 4,4-Difluorobenzhydrylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Design and synthesis of C-12 dithiocarbamate andrographolide analogues as an anticancer agent was written by Arsakhant, Patcharee;Sirion, Uthaiwan;Chairoungdua, Arthit;Suksen, Kanoknetr;Piyachaturawat, Pawinee;Suksamrarn, Apichart;Saeeng, Rungnapha. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Application of 27469-60-9 This article mentions the following:

A series of 21 new analogs of C-12 dithiocarbamate andrographolide, I (R = morpholino, 4-phenylpiperazino, dibenzylamino, etc.), was designed and synthesized from natural andrographolide isolated from a common Thai plant, Andrographis paniculata. The reaction used to manipulate the andrographolide scaffold was conducted in one pot under mild reaction conditions. This avoided toxic catalysts and gave nearly quant. yields of the new analogs, generally without byproducts and can be easily scaled up for industrial processing. All new analogs were evaluated against nine cancer cell lines; some analogs exhibited greater selective cytotoxic activity to MCF-7 cancer cell than that of the parent andrographolide and cancer drugs. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Application of 27469-60-9).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Application of 27469-60-9

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Highly Efficient Synthesis of 2-Substituted Benzo[ b ]furan Derivatives from the Cross-Coupling Reactions of 2-Halobenzo[ b ]furans with Organoalane Reagents was written by Wen, Chang;Wu, Chuan;Luo, Ruiqiang;Li, Qinghan;Chen, Feng. And the article was included in Synthesis in 2021.SDS of cas: 27469-60-9 This article mentions the following:

A highly efficient and simple route for the synthesis of benzo[ b]furans was developed by palladium-catalyzed cross-coupling reaction of 2-halobenzo[ b]furans with aryl, alkynyl, and alkylaluminum reagents. Various 2-aryl-, 2-alkynyl-, and 2-alkyl benzo[ b]furans was obtained in 23-97% isolated yields using 2-3 mol% PdCl 2/4-6 mol% XantPhos as the catalyst under mild reaction conditions. The aryls beared electron-donating or electron-withdrawing groups in 2-halobenzo[ b]furans gave products in 40-97% isolated yields. In addition, aluminum reagents containing thienyl, furanyl, trimethylsilanyl, and benzyl groups worked efficiently with 2-halobenzo[ b]furans as well, and three bioactive mols. with benzo[ b]furans skeleton were synthesized. Furthermore, the broad substrates scope and the typical maintenance of vigorous efficiency on gram scale made this protocol a potentially practical method to synthesize benzo[ b]furans. On the basis of the exptl. results, a possible catalytic cycle was proposed. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9SDS of cas: 27469-60-9).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).SDS of cas: 27469-60-9

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and in-vitro study of novel (Z)-1-benzhydryl-4-cinnamylpiperazine derivatives as potential anticancer agents was written by Shivaprakash, S.;Kiran, K. R.;Diwakar, Latha;Reddy, G. Chandrasekara. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2015.Related Products of 27469-60-9 This article mentions the following:

A series of novel (Z)-1-benzhydryl-4-cinnamylpiperazines I [R¹ = R² = Ph, 4-ClC₆H₄, 4-MeC₆H₄, 4-FC₆H₄; R¹ = Ph, R² = 4-ClC₆H₄, 4-BrC₆H₄; R³ = Ph, 4-MeOC₆H₄, 3,5-(MeO)₂C₆H₃, piperonyl, etc.] was synthesized in six steps starting from the corresponding benzophenones R¹COR². The final step was Wittig condensation of the appropriate benzyltriphenylphosphonium halides R³CH₂P⁺Ph₃ X^– (X = Cl, Br) with 1-benzhydryl-4-(formylmethyl)piperazines, which afforded pure (Z)-1-benzhydryl-4-cinnamylpiperazines I. The anticancer potential (MTT assay) of the synthesized compounds was tested against human cervical cancer (HeLa) and murine microglial (BV-2) cell lines. The compound I (R¹ = R² = 4-FC₆H₄; R³ = Ph) (cis-flunarizine) exhibited exceptionally superior activity against both HeLa and BV-2 cell lines with IC₅₀ value of 13.23±3.51 μM and 23.1±4.12 μM, resp. Hence, this compound may be considered as a potential lead mol. for further development. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Related Products of 27469-60-9).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Related Products of 27469-60-9

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Simultaneous determination of 10 new psychoactive piperazine derivatives in urine using ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction combined with gas chromatography-tandem mass spectrometry was written by Zhu, Binling;Meng, Liang;Cao, Jie;Yang, Wenrong;Conlan, Xavier A.. And the article was included in Journal of Forensic Sciences in 2021.Synthetic Route of C17H18F2N2 This article mentions the following:

With the rapid development of synthetic drugs, novel piperazine derivatives, as an increasingly important class of new psychoactive substances (NPS), have attracted global attention owing to their increasing demand in the illicit drug market. In this study, ten piperazine derivatives were analyzed in urine samples after pre-treatment with ultrasound-assisted low-d. solvent dispersive liquid-liquid microextraction (UA-LDS-DLLME) combined with gas chromatog.-tandem mass spectrometry (GC-MS/MS). This simple approach involved the use of urine samples (1 mL) adjusted to pH 12, which was added to 100 μL of n-hexane and subjected to ultrasonication for 3 min to completely disperse the sample in the n-hexane solution The resulting turbid suspension was centrifuged at 10,000 rpm for 3 min, and the supernatant was extracted and analyzed using GC-MS/MS. Under the optimized conditions presented in this study, the linear relationship between the analytes was good within 10-1500 ng/mL, and the correlation coefficient (r) was between .9914 and .9983. The limit of detection (LOD) was 0.3-2 ng/mL (S/N = 3), and the lower limit of quantification (LLOQ) was 10 ng/mL (S/N = 10) with the recovery of the analytes of interest from the spiked samples being 76.3%-93.3%. This method has been used to analyze real-world samples; our study shows that the UA-LDS-DLLME approach can be used for rapid anal. while consuming minimal solvent for the simultaneous determination of a range of analytes. This method has the potential for use in clin. analyses and forensic toxicol. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Synthetic Route of C17H18F2N2).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Synthetic Route of C17H18F2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Microwave-assisted synthesis of new 2-substituted phenyl-5-{N⁴-[bi-(4-fluoro phenyl)-methyl]-N¹-methylene} piperazine-1,3,4-oxadiazoles was written by Zhang, Zhen;Mo, Song;Zhang, Gang;Shao, Xue-bei;Li, Qing-han;Yang, Xue-jun;Chen, Feng. And the article was included in Xinan Minzu Daxue Xuebao, Ziran Kexueban in 2017.Application In Synthesis of 4,4-Difluorobenzhydrylpiperazine This article mentions the following:

Objective: Eight new 2-substituted phenyl-5-{N⁴-[bi-(4-fluorophenyl)-methyl]-N¹-methylene} piperazine-1,3,4-oxadiazoles 4a-4h were prepared starting from [bi-(4-fluorophenyl)-methyl]-piperazine under microwave irradiation with good yields. The technique of microwave irradiation proved to be an efficient, safe and environment-friendly technique with significant decreases in reaction time, comparably moderate yields, and easy manipulation. Furthermore, this method can be applied to the synthesis of many other oxadiazoles with more potential functional qualities. The structures of the eight compounds were determined by IR, MS and 1H NMR data. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Application In Synthesis of 4,4-Difluorobenzhydrylpiperazine).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application In Synthesis of 4,4-Difluorobenzhydrylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

A simple and efficient synthesis of calcium channel blocker flunarizine was written by Narsaiah, A. Venkat;Kumar, J. Kranthi. And the article was included in Organic Chemistry: An Indian Journal in 2011.Quality Control of 4,4-Difluorobenzhydrylpiperazine This article mentions the following:

T-type calcium channel blocker and anti-ischemic drug 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine synthesis was carried out in four steps with an average of 70% yield. This route is very convenient and can be applied for large scale preparation of Flunarizine with high yields. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Quality Control of 4,4-Difluorobenzhydrylpiperazine).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Quality Control of 4,4-Difluorobenzhydrylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics