Category: 27561-62-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27561-62-2,Cyclohexyl(piperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

General procedure: 10mM sulfochloride hydrochloride was suspendedin 50 ml ethylacetate and 11mM amine component wasadded with stirring. 2.8 ml triethylamine dissolved in 10 ml ethylacetatewas dropped in with stirring and kept stirring overnight atambient temperature. The reaction mixture was extracted threetimes with water, the organic phase was dried over sodium sulfatefiltered, and then evaporated to dryness. For cases in which an oilyproduct was obtained, the residue was treated with diisopropylether., 27561-62-2

As the paragraph descriping shows that 27561-62-2 is playing an increasingly important role.

Reference：
Article; Singh, Vinayak; Pacitto, Angela; Donini, Stefano; Ferraris, Davide M.; Boros, Sandor; Illyes, Eszter; Szokol, Balint; Rizzi, Menico; Blundell, Tom L.; Ascher, David B.; Pato, Janos; Mizrahi, Valerie; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 309 – 329;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27561-62-2,Cyclohexyl(piperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

General procedure: 5.1.5. General procedure 4 (GP4) A halide intermediate (1.0equiv), amine (0.9-10equiv) and optionally a base (2.7equiv) and halogenating agent (0.5equiv) were mixed together in industrial methylated spirits (15mL per g halide) and heated in a microwave at 150C for 1h, repeating if neccesary. Upon completion of the reaction, the mixture was passed through a phase seperation cartridge, concentrated and purified

27561-62-2, The synthetic route of 27561-62-2 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Kelly, Nicholas M.; Wellejus, Anja; Elbr°nd-Bek, Heidi; Weidner, Morten Sloth; J°rgensen, Signe Humle; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 3334 – 3347;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

27561-62-2, Cyclohexyl(piperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The mixture of compound 3 (1g, 4.6mmol) and 95% ethanol (30ml) was added to morpholine (0.4g, 4.6mmol).The mixture was stirred at room temperature for 30min, then warmed up to 60C. After the starting 3 was completely consumed (the reaction courses was monitored by TLC), evaporation of the ethanol, the crude yellow compound 4j was obtained and purified by preparative thin-layer chromatography over silica gel PF 254 (2mm, ethyl acetate: petroleum ether=1:1). Yield: 78%.

27561-62-2, 27561-62-2 Cyclohexyl(piperazin-1-yl)methanone 3437502, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Xu, Feng; Yang, Zhen-Zhen; Jiang, Jun-Rong; Pan, Wan-Gui; Yang, Xiao-Le; Wu, Jian-Yong; Zhu, Yan; Wang, John; Shou, Qi-Yang; Wu, Han-Gui; Bioorganic and Medicinal Chemistry Letters; vol. 26; 13; (2016); p. 3042 – 3047;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27561-62-2,Cyclohexyl(piperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

EXAMPLE 3 4-Amino-2-[4-(cyclohexylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline N-(Cyclohexylcarbonyl)piperazine (5.9 g., 0.03 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (7.2 g., 0.03 mole) are reacted according to the procedure of Example 1(a). The crude product crystallized from methanol affords analytically pure 4-amino-2-[4-(cyclohexylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline, m.p. 223-225 C., resolidifying and remelting at 248.0-250.0 C. (corr.) Analysis. Calcd. for C21 H29 N5 O3 (percent): C, 63.14; H, 7.32; N, 17.53. Found (percent): C, 63.07; H, 7.43; N, 17.63., 27561-62-2

27561-62-2 Cyclohexyl(piperazin-1-yl)methanone 3437502, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Mead Johnson & Company; US4060615; (1977); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

27561-62-2, Cyclohexyl(piperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 5.1.5. General procedure 4 (GP4) A halide intermediate (1.0equiv), amine (0.9-10equiv) and optionally a base (2.7equiv) and halogenating agent (0.5equiv) were mixed together in industrial methylated spirits (15mL per g halide) and heated in a microwave at 150C for 1h, repeating if neccesary. Upon completion of the reaction, the mixture was passed through a phase seperation cartridge, concentrated and purified, 27561-62-2

As the paragraph descriping shows that 27561-62-2 is playing an increasingly important role.

Reference£º
Article; Kelly, Nicholas M.; Wellejus, Anja; Elbr¡ãnd-Bek, Heidi; Weidner, Morten Sloth; J¡ãrgensen, Signe Humle; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 3334 – 3347;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

27561-62-2, Cyclohexyl(piperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-[4-(4-Cyclohexanecarbonyl-piperazine-1-carhonyl)-pyridin-2-ylmethyl-2H-phthalazin-1-one (5)To a stirred solution of 2-(4-oxo-3,4-dihydro-phthalazin-1-ylmethyl)-isonicotinic acid (iva)(0.25g, 0.89mol) in diemthylacetamide (2mL) was added cyclohexyl-piperazin-1-yl-methanone (0.20g, LOmmol) followed by HBTU (0.38g, LOmmol) and diisopropyl ethyl amine (0.35mL, 20.0 mmol) and stirred. The reaction mixture was then concentrated in vacuo and resulting oil subjected to flash chromatography eluent 9:1 EtOAc / MeOH. (rf of 0.3) The titledcompound was isolated as a white solid. Single peak in LC-MS analysis, (0.18g, 56%); m/z (LC-MS, ESP), RT=4.07mins, (M+H)=460; 1H NMR (300 MHz) 12.57 (1H, S -NH), 8.56 (1H, d, J 5.1 Hz), 8.26 (1H, dd, J 1.5, 8.1Hz), 7.95- 7.80 (3H, m), 7.38 (1H, S), 7.25 (1H, d, J 5.7Hz), 4.51 (2H, S), 3.56-3.17 (8H, m), 2.58 (1H, m), 1.71-1.61 (5H, m), 1.38-1.22 (5H, m).

27561-62-2, The synthetic route of 27561-62-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KUDOS PHARMACEUTICALS LIMITED; WO2006/21801; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics