Category: 27913-99-1

Highly Sensitive Built-In Strain Sensors for Polymer Composites: Fluorescence Turn-On Response through Mechanochemical Activation was written by Li, Zhong’an;Toivola, Ryan;Ding, Feizhi;Yang, Jeffrey;Lai, Po-Ni;Howie, Tucker;Georgeson, Gary;Jang, Sei-Hum;Li, Xiaosong;Flinn, Brian D.;Jen, Alex K.-Y.. And the article was included in Advanced Materials (Weinheim, Germany) in 2016.Synthetic Route of C12H16N2O This article mentions the following:

In this paper, the authors report the development of a new class of mechanochromic mols., that can be covalently linked to an epoxy thermoset network as built-in fluorescent strain sensors through simple and facile chem. Under mech. deformation, the sensing mols. in the epoxy matrix undergo a force-induced elimination reaction to regenerate the conjugated pathway between the donor and the acceptor forming a dipolar structure with strong intramol. charge-transfer. This sensor system can be activated even at a very low deformation strain about 0.14 accompanied with a fluorescence “turn-on” response, and is stable under prolonged exposure to light, demonstrating the significant value for practical applications of strain/damage sensing. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Synthetic Route of C12H16N2O).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Synthetic Route of C12H16N2O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Tuning the selectivity of N-alkylated styrylquinolinium dyes for sensing of G-quadruplex DNA was written by Wang, Ming-Qi;Xu, Jing;Zhang, Lan;Liao, Yue;Wei, Heng;Yin, Ying-Ying;Liu, Qiang;Zhang, Yuan. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Electric Literature of C12H16N2O This article mentions the following:

Selective and sensitive detection of G-quadruplex DNA structures is an important issue and attracts extensive interest. To this end, numerous small mol. fluorescent probes have been designed. Here, the authors present a series of N-alkylated styrylquinolinium dyes named Ls-1, Ls-2 and Ls-3 with varying side groups at the chain end. These dyes exhibited different binding behaviors to DNAs, and Ls-2 with a sulfonato group at the chain end displayed sensitivity and selectivity to G-quadruplex DNA structures in vitro. The characteristics of this dye and its interaction with G-quadruplex DNA were comprehensively studied by UV-visible spectrophotometry, fluorescence, CD and mol. docking. Furthermore, confocal fluorescence images and MTT assays indicated dye Ls-2 could pass through membrane and enter the living HepG2 cells with low cytotoxicity. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Electric Literature of C12H16N2O).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C12H16N2O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

New 3-aryl-2-(2-thienyl)acrylonitriles with high activity against hepatoma cells was written by Schaller, Eva;Ma, Andi;Gosch, Lisa Chiara;Klefenz, Adrian;Schaller, David;Goehringer, Nils;Kaps, Leonard;Schuppan, Detlef;Volkamer, Andrea;Schobert, Rainer;Biersack, Bernhard;Nitzsche, Bianca;Hoepfner, Michael. And the article was included in International Journal of Molecular Sciences in 2021.Quality Control of 4-(4-Methylpiperazin-1-yl)benzaldehyde This article mentions the following:

New 2-(thien-2-yl)-acrylonitriles with putative kinase inhibitory activity were prepared and tested for their antineoplastic efficacy in hepatoma models. Four out of the 14 derivatives were shown to inhibit hepatoma cell proliferation at (sub-)micromolar concentrations with IC₅₀ values below that of the clin. relevant multikinase inhibitor sorafenib, which served as a reference Colony formation assays as well as primary in vivo examinations of hepatoma tumors grown on the chorioallantoic membrane of fertilized chicken eggs (CAM assay) confirmed the excellent antineoplastic efficacy of the new derivatives Their mode of action included an induction of apoptotic capsase-3 activity, while no contribution of unspecific cytotoxic effects was observed in LDH-release measurements. Kinase profiling of cancer relevant protein kinases identified the two 3-aryl-2-(thien-2-yl)acrylonitrile derivatives 1b and 1c as (multi-)kinase inhibitors with a preferential activity against the VEGFR-2 tyrosine kinase. Addnl. bioinformatic anal. of the VEGFR-2 binding modes by docking and mol. dynamics calculations supported the exptl. findings and indicated that the hydroxy group of 1c might be crucial for its distinct inhibitory potency against VEGFR-2. Forthcoming studies will further unveil the underlying mode of action of the promising new derivatives as well as their suitability as an urgently needed novel approach in HCC treatment. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Quality Control of 4-(4-Methylpiperazin-1-yl)benzaldehyde).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Quality Control of 4-(4-Methylpiperazin-1-yl)benzaldehyde

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

A Precise Molecular Design to Achieve ACQ-to-AIE Transformation for Developing New Mechanochromic Material by Regio-Isomerization Strategy was written by Liu, Wei;Wang, Xinli;Li, Renfu;Sun, Shitao;Li, Zhenli;Hao, Jinle;Lin, Bin;Jiang, Hong;Xie, Lijun. And the article was included in ChemistrySelect in 2022.Application of 27913-99-1 This article mentions the following:

Herein, we have designed and synthesized a series of MeO-rofecoxib based fluorophore (MORF1-6) for exploiting new promising mechanochromic luminescent (MCL) materials. Among them, MORF1 and MORF3 exhibit aggregation-induced emission (AIE) effects when the substituent is located at the ortho-position on the benzene ring of b. Meanwhile, by changing the type and position of the substituent, the corresponding compounds MORF2, MORF4, MORF5, MORF6 show aggregation caused-quenching (ACQ) behavior. These results demonstrate that the position and type of the substituent have a great effect on their fluorescent properties. Furthermore, an X-ray crystal structure anal. of MORF3 revealed that the intermol. π-π stacking was suppressed and intramol. hydrogen bonding were formed, which could effectively restrict the mol. motions, thus causing typical AIE effect and mechanochromic property. Finally, a re-writable data recording device was fabricated using MORF3 as the active material. Our mol. design strategy may provide a new avenue for achieving efficient MCL materials. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Application of 27913-99-1).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application of 27913-99-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis of new hexahydropyrimido[1,2-a]azepine derivatives bearing functionalized aryl and heterocyclic moieties as anti-inflammatory agents was written by Hassanein, Hassanein H.;Abdel Rahman, Doaa E.;Fouad, Marwa A.;Ahmed, Rehab F.. And the article was included in Future Medicinal Chemistry in 2021.HPLC of Formula: 27913-99-1 This article mentions the following:

New hexahydropyrimido[1,2-a]azepine derivatives bearing functionalized aryl and heterocyclic moieties were synthesized as anti-inflammatory agents with better safety profiles. All synthesized compounds were assessed in vitro for their COX-1 and COX-2 inhibition activities. The most selective compounds, 2f, 5 and 6, were further evaluated for their in vivo anti-inflammatory activity and PGE2 inhibitory activity. To rationalize their selectivity, mol. docking within COX-1 and COX-2 binding sites was performed. Their physicochem. properties and drug-like nature profile were also calculated The good activity and selectivity of compounds 2f, 5 and 6 were rationalized using a mol. docking study and supported by in vivo studies. These promising findings are encouraging for performing future investigations of these derivatives In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1HPLC of Formula: 27913-99-1).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.HPLC of Formula: 27913-99-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Conjugated push-pull salts derived from linear benzobisthiazole: preparation and optical properties was written by Cibova, Alexandra;Magdolen, Peter;Fueloepova, Andrea;Zahradnik, Pavol. And the article was included in Chemical Papers in 2013.SDS of cas: 27913-99-1 This article mentions the following:

A series of novel monomethylated salts derived from linear benzobisthiazole was prepared The push-pull attributes of these new compounds are represented by a quaternized azolium cycle as the acceptor part at one end of the structure and the dialkylamino- or diarylamino-substituted benzene ring as the donor part at the opposite end. Both moieties are connected by a conjugated linker consisting of one or two double bonds. Such dipolar structures are promising candidates for non-linear optical materials. The quantum-chem. indexes describing linear and non-linear optical properties were obtained from semi-empirical calculations The relationships between the chem. structure and non-linear optical properties of the cations studied were obtained. Effective conjugation was confirmed by measuring the optical properties in the UV-VIS region. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1SDS of cas: 27913-99-1).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.SDS of cas: 27913-99-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics