Category: 2815-34-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2815-34-1,trans-2,5-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

Diisopropylethylamine (0.38 ml) was added to a solution of tra?is-2,5-dimethyl- piperazine (1.50 g), phenyl acetic acid (0.59 g) and HATU (1.55 g) in DMF (10 ml). The reaction mixture was stirred overnight at ambient temperature. The solution was diluted with water, then extracted with ethyl acetate. The organic extracts were dried (MgSO4) then concentrated in vacuo to give the sub-title compound (1.8 g). EPO MS: APCI (+ve): 233 (M+l)

2815-34-1, 2815-34-1 trans-2,5-Dimethylpiperazine 220672, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/56752; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

2815-34-1, trans-2,5-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 1-1 trans-4-(2,5-Dimethylpiperazin-1-yl)-2-trifluoromethylbenzonitrile A 1 g portion of 4-fluoro-2-trifluoromethylbenzonitrile and 2.4 g of trans-2,5-dimethylpiperazine were dissolved in 30 ml of DMF and heated at 80 C. for a whole day and night.. The reaction solution was mixed with water, extracted with ethyl acetate and dried over anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure.. The residue was purified by a silica gel column chromatography, and 1.3 g of the title compound was obtained from chloroform-methanol (10:1, v/v) elude., 2815-34-1

2815-34-1 trans-2,5-Dimethylpiperazine 220672, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Yamanouchi Pharmaceutical Co. Ltd.; US6673799; (2004); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2815-34-1,trans-2,5-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of 2, 2′-Bis [(DIPHENYLPHOSPHINO)-1,’-BINAPHTHYL] (0.068g, 0. 109mmol) and palladium acetate (0.016g, 0. [072MOL)] in toluene (5ml) were heated to [80C.] To this was added the product from example 316, step 1 [(1- [3- (4-IODO-PHENOXY)-PROPYL]-] piperidine) (0.5g, 1. 45mmol) pre-dissolved in toluene (5ml), (2S, 5R)-2, 5-dimethyl- piperazine (0.20g 1. [74MMOL)] predissolved in toluene (5ml), followed by sodium [TERT-] butoxide (0.20g, 2. [02MOL).] The mixture was heated at [100C] for 6 hours. After cooling to room temperature the reaction mixture was diluted with ethyl acetate, washed with water (x3), brine [(X1),] dried over magnesium sulphate and concentrated in vacuo. The residue was purified on silica gel eluting with a mixture of 0.88 ammonia solution : methanol : [DICHLOROMETHANE] (0.5 : 4.5 : 95) to furnish the title compound (0.98g, 20%); MS (ES+) m/e 332 [M+H] [+.]

2815-34-1, The synthetic route of 2815-34-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; GLAXO GROUP LIMITED; WO2004/35556; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2815-34-1,trans-2,5-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of 0.20 g (0.38 mmol) 2- (3, 5-BIS-TRIFLUOROMETHYL-PHENYL)-N- [6-CHLORO-4- (4- fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide, 87 mg (0.75 mmol) (2RS, 5SR) -dimethyl-piperazine, 0.01 g (0.03 mmol) cetyltrimethylammonium bromide, 0.01 g (0.02 mmol) bis (tri-t-butylphosphine) palladium (0), 0.075 ml NaOH 50 % and 3 ml toluene was degassed by two freeze-thaw cycles. The reaction mixture was heated under argon at 90 C for 48 h. After cooling to room temperature the mixture was diluted with water and brine and extracted with three portions of tert-butyl methyl ether. The combined organic layers were dried over sodium sulphate and concentrated in vacuo. Flash column chromatography gave 96 mg (42%) of the title compound as a light yellow solid. MS m/e (%): 611 (M+H+, 100)

2815-34-1, As the paragraph descriping shows that 2815-34-1 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/2577; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2815-34-1,trans-2,5-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

Diisopropylethylamine (0.38 ml) was added to a solution of tra?is-2,5-dimethyl- piperazine (1.50 g), phenyl acetic acid (0.59 g) and HATU (1.55 g) in DMF (10 ml). The reaction mixture was stirred overnight at ambient temperature. The solution was diluted with water, then extracted with ethyl acetate. The organic extracts were dried (MgSO4) then concentrated in vacuo to give the sub-title compound (1.8 g). EPO MS: APCI (+ve): 233 (M+l)

2815-34-1, 2815-34-1 trans-2,5-Dimethylpiperazine 220672, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/56752; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics