Category: 3400-55-3

SDS of cas: 3400-55-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about Cyclization reactions yielding thiazolo[3,2-a]thieno[2,3-d]pyrimidines. Author is Sauter, F.; Deinhammer, W.; Stanetty, P..

Thiazolothienopyrimidines I [RR1 = (CH2)4, R = R1 = Me, R2R3 = CH:CH, CMe:CH, CH:CPh] were obtained together with some II by treating I (R2 = R3 = H) with ClCH2CHO, BrCHMeCHO, BrCH2Bz, ClCH2CO2Et, or ClCH2CO2H and cyclizing with acid. I (R2R3 = CH:CMe) were obtained directly from I (R2 = R3 = H) and ClCH2COMe. I [R2R3 = (CH2)2-3] and II [RR1 = (CH2)4, R2R3 = (CH2)2] were similarly formed directly from I (R2 = R3 = H) and 1,2-dibromoethane or 1,3-dibromopropane.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about Enol ether-iron complexes as vinyl cation equivalents. Vinylation of enolates, the main research direction is vinyl cation iron enol ether; vinylation stereochem enolate.Quality Control of 2-Bromopriopionaldehydediethylacetal.

The use of Fp(alkyl vinyl ether)+ BF4- complexes as vinyl cation equivalents is described [Fp = C5H5Fe(CO)2]. These salts react with cyclohexanone Li enolate, or its 2- or 6-Me derivatives to give I (R, R1, R2 = H, Me). I are transformed by protonation with HBF4 to the corresponding II, which with I- liberate III. The stereochem. of the alkylation reaction and several other transformations of intermediates are described.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about Enol ether-iron complexes as vinyl cation equivalents. Vinylation of enolates, the main research direction is vinyl cation iron enol ether; vinylation stereochem enolate.Quality Control of 2-Bromopriopionaldehydediethylacetal.

The use of Fp(alkyl vinyl ether)+ BF4- complexes as vinyl cation equivalents is described [Fp = C5H5Fe(CO)2]. These salts react with cyclohexanone Li enolate, or its 2- or 6-Me derivatives to give I (R, R1, R2 = H, Me). I are transformed by protonation with HBF4 to the corresponding II, which with I- liberate III. The stereochem. of the alkylation reaction and several other transformations of intermediates are described.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C7H15BrO2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about (Alkylthio)bis(alkylsulfonyl)- and tris(alkylthio)propanes. Author is Boehme, H.; Russmann, H..

(RSO2)2C-Me Na+ (R = Me, Et), formed in situ from (RSO2)2CHMe and Na in dioxane, reacted with R1SCH2Cl (R1 = Me, Et) to give (RSO2)2CMeCH2SR1, oxidation of which gave (RSO2)2CMeCH2SO2R1. Reaction of (MeSO2)2C-H Na+ with MeSCH2Cl gave [(MeSO2)2CH]2CH2 and (MeSO2)2C(CH2SMe)2, which was oxidized to give (MeSO2)2C(CH2SO2Me)2. Condensation of MeSH with MeCOCH2SMeHCl and BrCHMeCH(OEt)2-HBr yielded (MeS)2CMeCH2SMe (I) and (MeS)2CHCHMeSMe (II), resp. A 3:2 I-II mixture was obtained by condensation of MeSH with MeOCH2COMe and HCl.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Pyrazine derivatives. I. 2-Hydroxy-3,6-dimethylpyrazine, published in 1947, which mentions a compound: 3400-55-3, Name is 2-Bromopriopionaldehydediethylacetal, Molecular C7H15BrO2, Reference of 2-Bromopriopionaldehydediethylacetal.

An examination of the methods for the synthesis of 2-hydroxypyrazines was undertaken with the object of synthesizing deoxyaspergillic acid (Part II). MeCH(NH2)CHO.HCl is a resinlike salt which could not be condensed with MeCHBrCOBr. MeCHBrCHO yields 63-4% MeCHBrCH(OEt)2 (I), b14 63-4°. I (70 g.) and 134 g. NH3 in 500 g. absolute EtOH, heated 7.5 h. at 125-30°, give 39% MeCH(NH2)CH(OEt)2 (II), b21 66°. II (7.45 g.) and 5.1 g. 4-methylmorpholine in 50 cc. CHCl3 at 0°, treated dropwise (30 min.) with 10.8 g. MeCHBrCOBr in 50 cc. CHCl3, with stirring for an addnl. hr. (during which the reaction mixture warmed to room temperature), give 11 g. α-(α-bromopropionylamino) propionaldehyde di-Et acetal, m. 56.5-7°; this could not be hydrolyzed to the aldehyde and could not be converted directly to 2-hydroxy-3,6-dimethylpyrazine (III). II (18 g.) in 10 cc. H2O, treated successively at 0° with 80 cc. concentrated HCl and 30 cc. EtSH, the mixture kept 24 h. at room temperature, poured into 200 cc. 40% NaOH and 500 g. ice, and the oil extracted with CHCl3, gives 73% α-aminopropionaldehyde di-Et mercaptal (IV), b3 105° (picrate, m. 153-4°). IV (19.5 g.), 15 g. butylpiperidine, and 50 cc. CHCl3 at 0°, treated dropwise with 25 g. MeCHBrCOBr in 50 cc. CHCl3, give 31 g. (crude) α-(α-bromopropionylamino) propionaldehyde di-Et mercaptal (V), m. 47-8°, slowly decompose on standing in air. V (3.14 g.) and 10 g. CdCO3 in 50 cc. EtOH and 10 cc. H2O, stirred 24 h. with 5.6 g. HgCl2 in 50 cc. EtOH, the filtrate saturated with NH3 at 0°, allowed to stand 48 h., the filtrate evaporated to dryness, and extracted with C6H6, give 250 mg. III, m. 210-11° (picrate, m. 181-5°). 2-Amino-3,6-dimethylpyrazine (20% yield) with NaNO2 in N HCl gives 60% III. 2-Aminopyrazine yields 30% 2-hydroxypyrazine, m. 187-8° [the brilliant yellow color observed by Weijland, et al. (C.A. 39, 3001.2) must be due to an impurity].

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Piperazine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about Favored formation of an O-glycoside during ribosidation of 5-methyl-2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one.Formula: C7H15BrO2.

Condensing (±)-(EtO)2CHMeCHCH(CN)CO2Et and thiourea gave pyrimidine I. Alkylating I at 2-SH group with Me2SO4 followed by ring closure gave pyrrolo[2,3-d] pyrimidine II (R = Me, R1 = H) (III). Silylating III and then treating with 2,3,5-tri-O-acetyl-1-bromo-D-ribofuranose in the presence of Hg(II) salts gave nucleoside IV (R = Ac), not the N-7-glycoside from ribosidation of 2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one. Hydrolysis of IV (R = Ac) under mild conditions gave IV (R = H), which had a UV spectrum similar to II (R = R1 = Me) down to pH 2. At a lower pH hydrolysis of the glycosidic bond occurs.

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Synthetic Route of C7H15BrO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about Competitive processes in the hydration of dicarbonyl η5-(cyclopentadienyl) alleneiron cations. Author is Klemarczyk, Philip; Rosenblum, Myron.

Hydration of CpFe(CO)2(CH2:C:CH2) under acidic conditions gives a mixture of CpFe(CO)2CH2COMe and CpFe(CO)2CHMeCHO. The aldehyde complex is derived by acid-catalyzed rearrangement of an allyl alc. complex in a process involving a metal-stabilized cation.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors, the main research direction is imidazothiazole thiourea synthesis SAR indoleamine dioxygenase IDO1.Quality Control of 2-Bromopriopionaldehydediethylacetal.

Indoleamine 2,3-dioxygenase (IDO1) inhibitors are speculated to be useful in cancer immunotherapy, but a phase III clin. trial of the most advanced IDO1 inhibitor, epacadostat, did not meet its primary endpoint and was abandoned. In previous work we identified the novel IDO1 inhibitor N-(4-chlorophenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide 1 through high-throughput screening (HTS). Herein, we report a structure-activity relationship (SAR) study of this compound, which resulted in the potent IDO1 inhibitor 1-(4-cyanophenyl)-3-(3-(cyclopropylethynyl)imidazo[2,1-b]thiazol-5-yl)thiourea 47 (hIDO IC50 = 16.4 nM). X-ray co-crystal structural anal. revealed that the basis for this high potency is a unique sulfur-aromatic interaction network formed by the thiourea moiety of 47 with the F163 and F226. This finding is expected to inspire new approaches towards the discovery of potent IDO1 inhibitors in the future.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromopriopionaldehydediethylacetal(SMILESS: CC(Br)C(OCC)OCC,cas:3400-55-3) is researched.Electric Literature of C9H7NO3. The article 《Base-catalyzed dehydrobromination of several α-bromoacetals》 in relation to this compound, is published in Canadian Journal of Chemistry. Let’s take a look at the latest research on this compound (cas:3400-55-3).

Base-catalyzed dehydrohalogenation with tert-BuOK in tert-BuOH of the acetals obtained from homologs of α-bromoacetaldehyde and ethylene glycol[2-(α-bromoalkyl)-1,3-dioxolanes] or 1,3,-propanediol[2-(α-bromoalkyl)-1,3-dioxane] provides the corresponding ketene acetal, in some cases exclusively and in others as the major product along with a smaller proportion of the α,β-unsaturated acetal. In contrast, similar dehydrohalogenation conditions convert the acetals obtained from homologs of α-bromoacetaldehyde and monohydroxy alcs, to the α,β-unsaturated acetals, in some cases exclusively, and in others as the major product accompanied by a smaller proportion of the corresponding ketene acetal. The preference for the ketene acetal formation from the 2-(α-bromoalkyl)-1,3-dioxolanes (the ethylene acetals) is believed due to greater ease of approach by base to the methine proton as a result of the restricted shape of the 1,3-dioxolane ring. Approach by base to the methine proton of the α-bromoalkyl dialkylacetals is more hindered by the two alkoxy groups, which cause preferred attack by base at the β proton to provide the α,β-unsatd acetal. The proportion of α,β-unsaturated acetal obtained from base-catalyzed dehydrohalogenation of 2-(α-bromoalkyl)-1,3-dioxolanes can be greatly increased if the reaction is carried out in Me2SO. This marked change in proportion of products is thought to be due to a change in mechanism occasioned by the Me2SO.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromopriopionaldehydediethylacetal(SMILESS: CC(Br)C(OCC)OCC,cas:3400-55-3) is researched.Safety of 1-(Bromomethyl)-4-iodobenzene. The article 《Vinylindenes and some heteroanalogs in the Diels-Alder reaction. VI. Vinylbenzo[b]thiophenes and ethenetetracarbonitrile》 in relation to this compound, is published in Australian Journal of Chemistry. Let’s take a look at the latest research on this compound (cas:3400-55-3).

3-Vinylbenzo[b]thiophene and 3 simple homologs give normal Diels-Alder adducts, e.g. I, with ethenetetracarbonitrile, whereas the 3-methyl-2-vinyl- and 2-methyl-3-(1-propenyl) derivatives give cyclobutanes, e.g. II. 2-Methyl-3-vinylbenzo[b]thiophene and ethenetetracarbonitrile give an adduct resulting from reaction of a tautomeric form of the diene, but a naphthalene analog and a phenanthrene analog of this substituted benzothiophene give normal adducts.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics