Category: 34334-28-6piperazines

34334-28-6, 4-(4-Methylpiperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2-((4-chlorophenyl)thio)acetohydrazide 50(1.00 mmol), the suitably substituted nitrile (3.00 mmol), andK2CO3 (0.5 mmol) in n-BuOH (2 mL) was stirred for 16 h in a reusablesealed tube at 150 C, in an oil bath. The progress of the reactionwasmonitored by the disappearance of the hydrazide by TLCanalysis. The solvent was removed in vacuo and the residue obtainedwas purified by flash chromatography (hexanes/EtOAc 1:1).4.7. 5-(4-Chlorophenyl)-3-(((4-chlorophenyl)thio)methyl)-1H-1,2,4-triazole, 5White solid. M. p. 121e122 C. Yield: 51%. 1H-NMR (d, ppm):10.63 (bs, 1H, exc.), 7.93 (d, 2H, J 8.4 Hz), 7.42 (d, 2H, J 8.0 Hz),7.31e7.25 (m, 4H), 4.27 (s, 2H). 13C-NMR (d, ppm): 159.52, 156.95,136.28, 133.43, 132.72, 131.22, 129.41, 129.13, 128.54, 127.74, 127.49,30.34. HRMS (ESI) [M H] calculated for C15H11Cl2N3S: 335.0051,found: 335.0233., 34334-28-6

34334-28-6 4-(4-Methylpiperazin-1-yl)benzonitrile 763205, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; La Pietra, Valeria; Sartini, Stefania; Botta, Lorenzo; Antonelli, Alessandro; Ferrari, Silvia Martina; Fallahi, Poupak; Moriconi, Alessio; Coviello, Vito; Quattrini, Luca; Ke, Yi-Yu; Hsing-Pang, Hsieh; Da Settimo, Federico; Novellino, Ettore; La Motta, Concettina; Marinelli, Luciana; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 491 – 505;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34334-28-6,4-(4-Methylpiperazin-1-yl)benzonitrile,as a common compound, the synthetic route is as follows.

4-(4-Methylpiperazin-1-yl)benzonitrile (0.035 mmol, 7 g) was dissolved inconcentrated HC1 (10 ml) at 0C and the resulting solution was immediately warmed up to100C and stirred for 5h. The solvent was removed and the residue was dried affording the title compound as a white solid (6.5 g, 73%).(ESI+) MS: m/z 221.2 (MHj.

34334-28-6, The synthetic route of 34334-28-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EUDENDRON S.R.L.; UNIVERSITA’ DEGLI STUDI DI MILANO; ANGIOLINI, Mauro; ZUCCOTTO, Fabio; BERNARDI, Anna; AIRAGHI, Francesco; (144 pag.)WO2016/96709; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics