34352-59-5 | Heterocyclic Building Blocks-piperazine

Dubey, M.’s team published research in Pharmazie in 1979 | CAS: 34352-59-5

1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..HPLC of Formula: 34352-59-5

Dubey, M.; Verma, V. K.; Shanker, K.; Sinha, J. N.; Bhargava, K. P.; Kishor, K. published an article on January 31 ,1979. The article was titled 《Synthesis of some newer piperazinoquinazolones as cardiovascular agents》, and you may find the article in Pharmazie.HPLC of Formula: 34352-59-5 The information in the text is summarized as follows:

Twenty-nine piperazinoquinazolones I (R1 = H, Cl, Br, I; R2 = H, Cl, Br; R3 = Me, Ph, 2- and 4-MeOC6H4, 3- and 4-ClC6H4) were prepared by Mannich reaction of II with HCHO and the appropriate piperazines. II were prepared in 40-60% yield by heating equimolar proportions of the appropriate acetanthranils with p-H2NC6H4COMe. Several I, e.g., I (R1 = R2 = H, R3 = Me, Ph, 2-MeOC6H4) elicited hypotensive activity. Several I elicited bradycardia and others produced tachycardia. Some others blocked the carotid occlusion response. In the experimental materials used by the author, we found 1-Methylpiperazine dihydrochloride(cas: 34352-59-5HPLC of Formula: 34352-59-5)

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mallevais, M. L.’s team published research in Biochimie in 1984 | CAS: 34352-59-5

Mallevais, M. L.; Delacourte, A.; Lesieur, I.; Lesieur, D.; Cazin, M.; Brunet, C.; Luyckx, M. published an article in Biochimie. The title of the article was 《2-(4-Methyl-1-piperazinylmethyl)acrylophenone dihydrochloride: a new antimicrotubular drug》.Safety of 1-Methylpiperazine dihydrochloride The author mentioned the following in the article:

2-(4-Methyl-1-piperazinylmethyl)acrylophenone (MPMAP)(I) [91401-12-6] possesses antimicrotubular activities. This compound inhibits 50% of the microtubule polymerization at a 3.10-5 M concentration It does not prevent tubulin paracrystal formation induced by vinblastine, and binding experiments reveal that this compound is a weak inhibitor of colchicine binding. The structure of this compound is different from the other antimicrotubular agents and has the advantage of being far less complex, highly soluble, and easy to synthesize. Thus, this and related compounds should be a new tool for the study of antimicrotubular activities and tubulin assembly. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Safety of 1-Methylpiperazine dihydrochloride)

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Lesieur, I.’s team published research in Acta Therapeutica in 1984 | CAS: 34352-59-5

The author of 《Antimicrotubular activity of 2-(4-methyl-1-piperazinylmethyl)acrylophenone dihydrochloride》 were Lesieur, I.; Delacourte, A.; Cazin, M.. And the article was published in Acta Therapeutica in 1984. Application In Synthesis of 1-Methylpiperazine dihydrochloride The author mentioned the following in the article:

The antimicrotubular activity of 3-(4-methyl-1-piperazinyl)propiophenone (I) [60868-01-1] was due to contamination of the synthetic product with 2-(4-methyl-1-piperazinylmethyl)acrylophenone (II) [91401-12-6]. Synthesis of I-2HCl [5470-92-8] and II-2HCl [91401-13-7] is described. Whereas I was devoid of any antimicrotubular activity, II, although less potent than colchicine, showed antimicrotubular activity. In addition to this study using 1-Methylpiperazine dihydrochloride, there are many other studies that have used 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Application In Synthesis of 1-Methylpiperazine dihydrochloride) was used in this study.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cabani, S.’s team published research in Journal of Physical Chemistry in 1977 | CAS: 34352-59-5

The author of 《Volume changes in the proton ionization of amines in water. 1. Morpholines and piperazines》 were Cabani, S.; Mollica, V.; Lepori, L.; Lobo, S. T.. And the article was published in Journal of Physical Chemistry in 1977. Electric Literature of C5H14Cl2N2 The author mentioned the following in the article:

Apparent molar volumes, Φv, at various concentrations in water at 25° of some cyclic bifunctional amines [morpholine, 4-methylmorpholine, piperazine, 1-methyl- and 1,4-dimethylpiperazine, 1,4-diazabicyclo[2.2.2]octane (triethylenediamine)] and their mono- and dihydrochlorides were determined The volume changes ΔV1° and ΔV2°, involved in the 1st and 2nd proton ionizations from the protonated amines, were calculated from the limiting partial molar volumes V̅2°. The volumes of ionization for the bifunctional cyclic amines were compared with those for the monofunctional amines ad the relationship between entropies and volumes of ionization was examined In the experiment, the researchers used 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Electric Literature of C5H14Cl2N2)

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Neamati, Nouri’s team published research in Journal of Medicinal Chemistry in 1999 | CAS: 34352-59-5

《Thiazolothiazepine Inhibitors of HIV-1 Integrase》 was written by Neamati, Nouri; Turpin, Jim A.; Winslow, Heather E.; Christensen, John L.; Williamson, Karen; Orr, Ann; Rice, William G.; Pommier, Yves; Garofalo, Antonio; Brizzi, Antonella; Campiani, Giuseppe; Fiorini, Isabella; Nacci, Vito. Recommanded Product: 1-Methylpiperazine dihydrochloride And the article was included in Journal of Medicinal Chemistry on August 26 ,1999. The article conveys some information:

A series of thiazolothiazepines were prepared and tested against purified human immunodeficiency virus type-1 integrase (HIV-1 IN) and viral replication. Structure-activity studies reveal that the compounds possessing the pentat. moiety SC(O)CNC(O) with two carbonyl groups are in general more potent against purified IN than those containing only one carbonyl group. Substitution with electron-donating or -withdrawing groups did not enhance nor abolish potency against purified IN. By contrast, compounds with a naphthalene ring system showed enhanced potency, suggesting that a hydrophobic pocket in the IN active site might accommodate an aromatic system rather than a halogen. The position of sulfur in the thiazole ring appears important for potency against IN, as its replacement with an oxygen or carbon abolished activity. Further extension of the thiazole ring diminished potency. I [R, R1 = H, X = S, Y = CH2; RR1 = CH:CHCH:CH; X = S, Y = CH2; X = CH2, Y = S] showed antiviral activity and inhibited IN within similar concentrations These compounds inhibited IN when Mn2+ or Mg2+ was used as cofactor. None of these compounds showed detectable activities against HIV-1 reverse transcriptase, protease, virus attachment, or nucleocapsid protein zinc fingers. Therefore, thiazolothiazepines are potentially important lead compounds for development as inhibitors of IN and HIV replication. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Recommanded Product: 1-Methylpiperazine dihydrochloride)

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Obniska, Jolanta’s team published research in Acta Poloniae Pharmaceutica in 1998 | CAS: 34352-59-5

Obniska, Jolanta; Kulig, Katarzyna; Zejc, Alfred published an article in Acta Poloniae Pharmaceutica. The title of the article was 《Synthesis and anticonvulsant properties of new N-piperazinylalkyl imides of succinic acid》.Name: 1-Methylpiperazine dihydrochloride The author mentioned the following in the article:

A number of N-[((4-aryl)- or (4-methyl)-1-piperazinyl)alkyl]imides of 3-aryl- or 3,3-pentamethylenesuccinic acid, I [R1 = 3-ClC6H4, 4-ClC6H4, R2 = H, R1R2 = (CH2)5, R3 = Ph, CH2Ph, Me.2HCl, 2-MeOC6H4, 3-ClC6H4, n = 1; R1 = Ph, R2 = Ph, Me, R1R2 = (CH2)5, R3 = H.2HCl, Me.2HBr, Me.2HCl, n = 2, 3; R1 = Ph, R2 = Me, R3 = Ph, n = 3], were synthesized and tested for anticonvulsant activity in the maximum electroshock seizure (MES) and pentylenetetrazole seizure threshold (scMet) tests. Structures of the novel compounds were confirmed by elemental and spectral analyses. In addition to this study using 1-Methylpiperazine dihydrochloride, there are many other studies that have used 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Name: 1-Methylpiperazine dihydrochloride) was used in this study.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cheng, Chuanjie’s team published research in Journal of Organic Chemistry in 2009 | CAS: 34352-59-5

Cheng, Chuanjie; Sun, Jianwei; Xing, Lixin; Xu, Jimin; Wang, Xinyan; Hu, Yuefei published their research in Journal of Organic Chemistry on August 7 ,2009. The article was titled 《Highly Chemoselective Pd-C Catalytic Hydrodechlorination Leading to the Highly Efficient N-Debenzylation of Benzylamines》.Application of 34352-59-5 The article contains the following contents:

In the presence of 1,1,2-trichloroethane, a novel procedure for the Pd-C catalytic N-debenzylation of benzylamines was established. The method proceeded in a synergistic catalytic system and directly gave the products as crystalline amine hydrochlorides in practically quant. yields. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Application of 34352-59-5)

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Kucwaj-Brysz, Katarzyna’s team published research in Bioorganic Chemistry in 2022 | CAS: 34352-59-5

《An exit beyond the pharmacophore model for 5-HT6R agents – a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential》 was written by Kucwaj-Brysz, Katarzyna; Ali, Wesam; Kurczab, Rafal; Sudol-Talaj, Sylwia; Wilczynska-Zawal, Natalia; Jastrzebska-Wiesek, Magdalena; Satala, Grzegorz; Mordyl, Barbara; Zeslawska, Ewa; Agnieszka-Olejarz-Maciej; Czarnota, Kinga; Latacz, Gniewomir; Partyka, Anna; Wesolowska, Anna; Nitek, Wojciech; Handzlik, Jadwiga. Quality Control of 1-Methylpiperazine dihydrochloride And the article was included in Bioorganic Chemistry on April 30 ,2022. The article conveys some information:

Herein, the first highly potent 5-HT6/5-HT2A receptor (5-HT6/5-HT2AR) dual antagonists in a group of 1,3,5-triazine compounds have been discovered as a result of an exit beyond the hydrophobic feature of the pharmacophore model for 5-HT6R antagonists. Design and synthesis of the series I (X = O, S; R1 = 4-PhOC6H4, 4-PhC6H4, 2-naphthyl, 1-naphthyl; R2 = H, Me, Et, n-Bu, R3 = H; R2 = R3 = Me) of ether and thioether derivatives of 1,3,5-triazines with the double-ring aromatic region have been performed. The new compounds I were examined within the comprehensive pharmacol. screening, including: radioligand binding assays, functional and ADMET studies in vitro as well as behavioral tests in rats. Crystallog. aspects and computer-aided structure-activity relationship were analyzed as well. This comprehensive approach led to selection of the compound I [X = S; R1 = 2-naphthyl; R2 = R3 = Me; (II)] with the most significant dual 5-HT6/5-HT2AR antagonistic action (5-HT6R Ki = 11 nM, 5-HT2AR Ki = 39 nM). Moreover, the compound II has satisfactory ADMETox properties in vitro, i.e.: the high permeability through biol. membranes, high metabolic stability, neither mutagenic nor hepatotoxic effects and moderate ability to inhibit CYP3A4. Above all, the compound II showed ability to reverse the pharmacol.-induced (MK-801) memory impairment at low doses (1-3 mg/kg) in Novel Object Recognition (NOR) test in rats. These results indicate a promising potency of dual 5-HT6/5-HT2AR antagonism in the search for novel strategy to fight Alzheimer’s disease, which remains an unmet clin. need. In the experiment, the researchers used 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Quality Control of 1-Methylpiperazine dihydrochloride)

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Raja Sekhara Reddy, B.’s team published research in Results in Chemistry in 2022 | CAS: 34352-59-5

Raja Sekhara Reddy, B.; Pratap Reddy Gajulapalli, V.; Madhu Rekha, Estharla; Siva Krishna, Vagolu; Sriram, Dharmarajan; Sudakar Babu, K.; Kim, Eunha published an article on January 31 ,2022. The article was titled 《Design, synthesis, and in vitro biological evaluation of dehydroaripiprazole derivatives as antituberculosis agents and molecular docking study》, and you may find the article in Results in Chemistry.Recommanded Product: 34352-59-5 The information in the text is summarized as follows:

In this study, we describe the synthesis of novel piperazine-substituted 7-(4-chlorobutoxy) quinolin-2(1H) derivatives 5a-z, which were designed through specific structural modifications of aripiprazole. Furthermore, the synthesized derivatives were described as potent in vitro inhibitors of Mycobacterium tuberculosis (MTB) H37Rv strain growth. Among these compounds, 5c, 5 h, and 5r were found to be the most active ones with a MIC of 0.78 μg/mL. This activity is better compared to that of ethambutol (MIC = 1.56 μg/mL). These compounds failed to inhibit normal RAW 264.7 macrophages. Moreover, in vitro findings were supported by mol. docking studies with the known anti-TB target (InhA). The mol. docking studies on 5c, 5 h, and 5r hit compounds clearly validated hydrogen bonds interactions with the Enoyl-acp reductase (INHA). Therefore, these results indicate that this class of compounds may provide candidates for future development, and hopefully provide drug alternatives for tuberculosis treatment. In the experimental materials used by the author, we found 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Recommanded Product: 34352-59-5)

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Ben Salah, Assila Maatar’s team published research in Monatshefte fuer Chemie in 2014 | CAS: 34352-59-5

Category: piperazinesOn October 31, 2014 ,《Crystal growth, thermal and magnetic characterizations of a new ferromagnetic Ni(II) dimer》 appeared in Monatshefte fuer Chemie. The author of the article were Ben Salah, Assila Maatar; Walha, Sondra; Yahyaoui, Samia; Abdalrahman, Mahmoud; Turnbull, Mark M.; Mhiri, Tahar; Naili, Houcine. The article conveys some information:

Abstract: Single crystals of 1-methylpiperazine-1,4-diium hexaaquatetrachlorodinickel(II) dichloride, (C5H14N2)[Ni2Cl4(H2O)6]Cl2, were grown by hydrothermal techniques in aqueous solution The compound was characterized by DTA (TG-TDXD), single crystal x-ray diffraction, and variable temperature magnetic susceptibility. The compound crystallizes in the triclinic system (space group P1̅, Z = 2) with the following unit cell dimensions: a 6.611(3), b 8.776(4), c 17.457(8) Å, α 101.34(2), β 96.31(2), and γ 105.38(2)°. The structure was solved using 4,243 independent reflections and refined to R = 0.024. The structure of (C5H14N2)[Ni2Cl4(H2O)6]Cl2 can be described as mixed organic-inorganic layers along the [-101] direction. The Ni dimers show ferromagnetic exchange (J ∼ 15 K), while the interactions between the dimers are antiferromagnetic (J approx. -3 K). The 3-dimensional network is further linked by three types of H bonds (N-H···Cl, OW-H···Cl, and N-H···O), to build cation-anion cohesion. Dehydration of the precursor proceeds through three stages, leading to crystalline intermediary hydrate phases and an anhydrous compound Crystallog. data are given. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Category: piperazines)

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics