Category: 381242-61-1

Downstream synthetic route of 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine

As the paragraph descriping shows that 381242-61-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.381242-61-1,1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 1-bromo-2-chloroethane (0.43 mL, 5.2 mmol),K2CO3 (0.71 g, 5.2 mmol) in ACN (10 mL) was stirred at 50 C for15 min and then 1-(2-methoxyphenyl)piperazine (4, 0.5 g,2.6 mmol) in ACN (5 mL), was added dropwise within 1 h duration.Reaction mixture was further stirred for 4 h. Then the mixture wasconcentrated under reduced pressure and residue was dissolved inEtOAc (15 mL) and the EtOAc layer was then washed with water(10mL x 3). The combined organic layer was dried (anhyd. Na2SO4)and concentrated under reduced pressure. The resultant waswashed with distilled hexane and again dried under high vaccum.The pure offwhite crystals were obtained by recrystallization usingEtOAc/Hexane (yield: 69%)., 381242-61-1

As the paragraph descriping shows that 381242-61-1 is playing an increasingly important role.

Reference：
Article; Gupta, Sonal; Pandey, Deepti; Mandalapu, Dhanaraju; Sharma, Vikas; Shukla, Mahendra; Singh, Seema; Singh, Nidhi; Yadav, Santosh Kumar; Tanpula, Dilip Kumar; Singh, Surabhi; Maikhuri, Jagdamba P.; Shukla, Shubha; Lal, Jawahar; Siddiqi, Mohammad I.; Gupta, Gopal; Sharma, Vishnu L.; European Journal of Medicinal Chemistry; vol. 132; (2017); p. 204 – 218;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Brief introduction of 381242-61-1

The synthetic route of 381242-61-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.381242-61-1,1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine,as a common compound, the synthetic route is as follows.

According to scheme 1, step 2: 1-(4-nitro-2-(trifluoromethyl)phenyl)piperazine (5.0 mmol) was taken in ethyl acetate (20 mL), to this, aqueous sodium hydroxide (6.2 mmol, 30%) was added keeping the temperature 0 C, carbon disulfide (6.2 mmol) dissolved in ethylacetate (5 mL) was added drop-wise with stirring at 0 C. The reaction mixture was further stirred at room temperature for one hour to furnish a yellow solid. Solvent was distilled off and the crude was recrystallised by methanolic ether to get sodium 4-(4-nitro-2- (trifluoromethyl)phenyl)piperazine-1 -carbodithioate as a yellow powder., 381242-61-1

The synthetic route of 381242-61-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; SHARMA, Vishanu Lal; LAL, Nand; SARSWAT, Amit; JANGIR, Santosh; BALA, Veenu; KUMAR, Lalit; RAWAT, Tara; JAIN, Ashish; KUMAR, Lokesh; MAIKHURI, Jagdamba Prasad; GUPTA, Gopal; WO2014/122670; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Some tips on 381242-61-1

381242-61-1, 381242-61-1 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine 2771413, apiperazines compound, is more and more widely used in various fields.

381242-61-1, 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 1-bromo-2-chloroethane (0.43 mL, 5.2 mmol),K2CO3 (0.71 g, 5.2 mmol) in ACN (10 mL) was stirred at 50 C for15 min and then 1-(2-methoxyphenyl)piperazine (4, 0.5 g,2.6 mmol) in ACN (5 mL), was added dropwise within 1 h duration.Reaction mixture was further stirred for 4 h. Then the mixture wasconcentrated under reduced pressure and residue was dissolved inEtOAc (15 mL) and the EtOAc layer was then washed with water(10mL x 3). The combined organic layer was dried (anhyd. Na2SO4)and concentrated under reduced pressure. The resultant waswashed with distilled hexane and again dried under high vaccum.The pure offwhite crystals were obtained by recrystallization usingEtOAc/Hexane (yield: 69%).

381242-61-1, 381242-61-1 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine 2771413, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Gupta, Sonal; Pandey, Deepti; Mandalapu, Dhanaraju; Sharma, Vikas; Shukla, Mahendra; Singh, Seema; Singh, Nidhi; Yadav, Santosh Kumar; Tanpula, Dilip Kumar; Singh, Surabhi; Maikhuri, Jagdamba P.; Shukla, Shubha; Lal, Jawahar; Siddiqi, Mohammad I.; Gupta, Gopal; Sharma, Vishnu L.; European Journal of Medicinal Chemistry; vol. 132; (2017); p. 204 – 218;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

New learning discoveries about 381242-61-1

As the paragraph descriping shows that 381242-61-1 is playing an increasingly important role.

381242-61-1, 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred mixture of 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate (1) (1.65 g, 0.005 mol), C2H5OH (30 mL) and N(C2H5)3 (3 mL), 1-[4-nitro-2-(trifluoromethyl)phenyl]piperazine (2) (1.65 g, 0.006 mol) was added and heated at 70-80 C for 5 h. The reaction was monitored by TLC. After filtration, the filtrate was evaporated under reduced pressure. Water (30 mL) was added to the residue, which was then extracted with ethyl acetate (80 mL ¡Á 3). The extract was washed with saturated NaCl solution (20 mL ¡Á 3), dried over anhydrous Na2SO4 and evaporated. The residue was crystallized from C2H5OH to afford a white solid 3 1.92 g, in 75% yield: m.p. 115-117 C. 1H NMR (DMSO-d6): 6.80-8.48 (6H, m, Ar-H), 7.81, 8.13 (2H, ss, triazole-H), 4.51-4.60 (2H, dd, J = 15 Hz, triazole-CH2-), 2.50-3.01 (8H, m, piperazine-H), 2.73-3.17 (2H, dd, J = 15 Hz, CH2-piperazine-), 5.10 (1H, s, OH). IR (KBr): 3200, 2940, 2893, 1605, 1514, 1338, 1257, 1136, 918 cm-1. LC-MS, m/z Calcd. for C22H21F5N6O3, 512.2, found [M + H]+ 513.3., 381242-61-1

As the paragraph descriping shows that 381242-61-1 is playing an increasingly important role.

Reference£º
Article; Chai, Xiaoyun; Zhang, Jun; Cao, Yongbing; Zou, Yan; Wu, Qiuye; Zhang, Dazhi; Jiang, Yuanying; Sun, Qingyan; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 3167 – 3176;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics