Category: 39539-66-7

39539-66-7, 4-Methylpiperazine-1-carbonyl chloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of this product (50 mg, 0.1 mmol), 4-methylpiperazine-1-carbonylchloride (89 mg, 0.6 mmol), diisopropylethylamine (142 mg, 1.1 mmol), in dioxane (0.5 mL) was submitted to microwave irradiation (300 W) for 60 minutes at 160 C. The reaction solution was cooled to room temperature and slowly poured into a stirring saline solution (10 mL). The resulting precipitate was collected by filtration, washed with water and purified by RP-HPLC (C18, 0 to 100% CH3CN in 0.1% aqueous HCO2H) to yield 1-280 as a pale yellow solid (6 mg, 10%) MS m/z=574 (M+H).

39539-66-7, The synthetic route of 39539-66-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Millennium Pharmaceuticals, Inc.; US2005/256102; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

39539-66-7, 4-Methylpiperazine-1-carbonyl chloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 5,6-dimethyl-2-(3-fluorophenyl)-3-hydroxyisoindolin-1-one (83 mg, 0.31 mmol) in anhydrous dimethylformamide (3 ml) was added to a suspension of 65% sodium hydride (13 mg, 0.34 mmol) in anhydrous dimethylformamide (3 ml), and stirred at 25C for 35 minutes. Then, a solution of 1-chlorocarbonyl-4-methylpiperazine (50 mg, 0.31 mmol) in anhydrous dimethylformamide was added thereto, and stirred with heating at 70C for 5 hrs. The reaction solution was concentrated under reduced pressure, and water was added to the residue, followed by extracting with chloroform. The extract was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (chloroform: methanol = 20: 1). The resulting crystals were washed with petroleum ether to give 21 mg of the title compound. melting point: 146-148C 1H-NMR (CDCl3) delta: 2.38 (3H, s, CH3), 2.40 (3H, s, CH3), 2.73 (3H, s, NCH3), 3.01-3.14 (6H, m, piperazine), 3.18-3.24 (1H, m, piperazine), 3.32-3.38 (1H, m, piperazine), 6.43 (1H, s, CH), 6.85-6.91 (1H, m, PhH), 7.33-7.39 (1H, m, PhH), 7.36 (1H, s, C4-H), 7.66 (1H, s, C7-H), 7.66-7.76 (2H, m, PhH), 39539-66-7

39539-66-7 4-Methylpiperazine-1-carbonyl chloride 3016935, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Maruishi Pharmaceutical Co., Ltd.; EP1566378; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39539-66-7,4-Methylpiperazine-1-carbonyl chloride,as a common compound, the synthetic route is as follows.

To a solution of the bromo methyl seco compound (0.074 mMoles) in 3 mL DMF was added the 5-actyl indole-2-carboxylate (30 mg, 0.15 mMoles) and EDC (28 mg, 0.15 mMoles) and the resulting mixture was stirred overnight. The reaction mixture was concentrated and purified by silica gel chromatography using 5% MeOH in DCM Tt give 29 mg (74 % yield) of product which was confirmed by mass spec M+1 = 523. To a solution of the compound synthesized in step C in 5 mL DCM and 300 muL allyl alcohol was added methyl piperazine carbonyl chloride (22 mg, 0.11 m Moles) and pyridine 44 muL. The reaction mixture was stirred at room temperature for 5 hours. Concentration followed by purification by silica gel chromatography using 5 % MeOH/DCM as eluant gave 48 mg of the desired product (73 % yield). The product was confirmed by Mass Spec. M+1 = 650. A solution of the above compound (8.2 mg , 0.012 mmoles) and Mal-PEG4-hydrazine in 5 % acetic acid in anhydrous DCM was stirred at room temperature for 20 minutes followed by evaporation of Solvents and Reverse phase Prep HPLC using acetonitrile and ammonium formate buffered aqueous phase gave 2.5 mg of the desired final product which was confirmed by mass Spec, M+1 = 1063

39539-66-7, 39539-66-7 4-Methylpiperazine-1-carbonyl chloride 3016935, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MEDAREX, INC.; WO2005/112919; (2005); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39539-66-7,4-Methylpiperazine-1-carbonyl chloride,as a common compound, the synthetic route is as follows.

Example 8 N- [3,3-Dimethyl -1- (4-methyl-piperazine-1-carbonyl) -2, 3- [ DIHYDRO-LH-INDOL-6-YL]-2- (4-FLUORO-BENZYLAMINO)-BENZAMIDE] Step A: Preparation of [N- [3, 3-DIMETHYL-L- (4-METHYL-] [PIPERAZINE-1-CARBONYL)-2, 3-DIHYDRO-LH-INDOL-6-YL]-2-NITRO-] benzamide [N- (3,] 3-dimethyl-2, [3-DIHYDRO-LH-INDOL-6-YL)-2-NITRO-] benzamide (Example 7, Step A) (300 mg, 0.96 mmol) was treated with [4-METHYL-PIPERAZINE-1-CARBONYL] chloride (200 mg, 1 mmol) in the presence of DIEA (40 mL) in THF overnight at 65 [C.] The mixture was partitioned between EtOAc and saturated aqueous [NAHC03.] The organic layer was washed with [H2O] and brine, then dried over [NA2SO4.] The organic solution was concentrated in vacuo to yield the desired compound., 39539-66-7

The synthetic route of 39539-66-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2004/5279; (2004); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39539-66-7,4-Methylpiperazine-1-carbonyl chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 2 1-Methyl-4-[N-(3,4,5-trimethoxyphenyl)-carbamoyl]piperazine (hydrochloride) A solution of 10 g (0.061 mole) 1-methyl-4-chloroformyl-piperazine in 100 ml dry methylene chloride is added to a solution of 11.2 g (0.061 mole) 3,4,5-trimethoxy-aniline in a 100 ml methylenechloride. After stirring at ambient temperature for 24 hours, the solvent is evaporated off in vacuo; the residue is dissolved in the minimum of ethanol and then the crude hydrochloride precipated by the addition of diethyl ether, and dried. Purification by recrystallisation from an acetone 3-ethanol 1 mixture gives the pure product (9.4 g; 44% yield) which melts at 184-86 C., 39539-66-7

As the paragraph descriping shows that 39539-66-7 is playing an increasingly important role.

Reference£º
Patent; Metabio-Joullie; US4252804; (1981); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39539-66-7,4-Methylpiperazine-1-carbonyl chloride,as a common compound, the synthetic route is as follows.

Example 18 : 2,3-Dichloro-N-((1S,2S)-1-{[(4-methylpiperazin-1-yl)carbonyl]amino}-2,3- dihydro-lH-inden-2-yl)-4H-thienof3, 2-blpyrrole-5-carboxamide; To a solution of N-[(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-yl]-2,3-dichloro-4H- thieno [3, 2-b] pyrrole-5-carboxamide (Method 9, 240 mg, 0. 5 mmol) and Et3N (101 mg, 1. 0 mmol) in DCM (4 mL) was added a solution of 4-methyl-1-piperazine carbonyl chloride (100 mg, 0. 5 mmol) in DCM (1 mL). The reaction was stirred at ambient temperature for 2 hours, washed with saturated Narc03 (1 mL), water (1 mL), brine (1 mL) and dried (MgS04). The volatiles were removed by evaporation under reduced pressure to give the title compound (110 mg, 45%) as a foam. MS m/z (M-H)-491.

39539-66-7, As the paragraph descriping shows that 39539-66-7 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/74531; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

39539-66-7, 4-Methylpiperazine-1-carbonyl chloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 8; 2-(2-difluoromethylbenzimidazoH-yI)-4-[4-(4-methylpiperaziii-l-ylcarbonyl)piperazin- 1 -y 1] -6-morpholinopy rimidine; Diisopropylethylamine (0.261 ml) was added to a stirred mixture of2-(2-difluoromethylbenzimidazol- 1 -yl)-6-morpholino-4-piperazin- 1 -ylpyrimidine (0.208 g), 4-methylpiperazin-l-ylcarbonyl chloride (0.122 g) and methylene chloride (20 ml) and the resultant mixture was stirred at ambient temperature for 1 hour. The reaction mixture was evaporated and the reaction product was purified using a Waters ‘Sunfre’ preparative reversed-phase column (5 microns silica, 19 mm diameter, 100 mm length) and decreasingly polar mixtures of a 0.1% solution of trifluoroacetic acid in water and a 0.1% solution of trifluoroacetic acid in acetonitrile as eluent. There was thus obtained the title compound (0.085 g); NMR Spectrum: (CDCl3) 2.85 (s, 3H), 3.35-3.43 (m, 2H), 3.45-3.5 (m, 4H), 3.5-3.62 (m, 4H), 3.63-3.73 (m, 8H), 3.75-3.88 (m, 6H), 5.53 (s, IH), 7.35-7.5 (m, 3H), 7.9-7.94 (d, IH), 8.18-8.22 (d, IH); Mass Spectrum: MH-H+ 542., 39539-66-7

As the paragraph descriping shows that 39539-66-7 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/32064; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics