Category: 5294-61-1

5294-61-1, N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5294-61-1, To a solution of crude N- (4-METHOXYPHENYL)-2-OXIRAN-2-YLACETAMIDE (10) in ethanol (2. 5ML) was added triethylamine (0. 5ML), followed by N- (2, 6-dimethylphenyl) -2- piperazinylacetamide, a compound of fonnula (4) (150mg), and the mixture was heated to reflux for 18 hours. Solvent was removed from the reaction mixture under reduced pressure, and the residue purified by column chromatography on silica gel, eluting with 5% MeOH/dichloromethane, to give 4- (4-1 [N- (2, 6-dimethylphenyl) carbamoyl] methyl}- PIPERAZINYL)-3-HYDROXY-N- (4-METHOXYPHENYL) butanamide, a compound of Formula I as an off- white solid.

The synthetic route of 5294-61-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CV THERAPEUTICS, INC.; WO2004/63180; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5294-61-1,N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

5294-61-1, A mixture OF N- (2, 6-dimethylphenyl) -2-piperazinylacetamide (4) (100 mg, 0.4 mmol), 4- CHLORO-1-PHENYLBUTAN-1-ONE (12) (100 mg, 0.55 mmol), and triethylamine (0.4 mL) in ethanol (3 mL) was heated at reflux for 16 hours. Ethanol was removed under reduced pressure and the residue was purified by preparative TLC using 10% methanol in dichloromethane as mobile phase to afford N (2, 6-dimethylphenyl)-2- [4- (4-oxo-4-phenylbutyl) piperazin-1-yl] acetamide, a compound of formula (16).

As the paragraph descriping shows that 5294-61-1 is playing an increasingly important role.

Reference：
Patent; CV THERAPEUTICS, INC.; WO2004/63180; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide. In a document, author is Aubin, Simon, introducing its new discovery. Application In Synthesis of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

On-site comparison of the OSHA 47, Asset EZ4-NCO, Iso-Chek, DAN, and CIP10 methods for measuring methylene diphenyl diisocyanate (MDI) at an oriented-strand board (OSB) factory

Diisocyanates are occupational contaminants and known sensitizers causing irritation (skin and respiratory tract) as well as occupational asthma. Because of their physicochemical properties (semi-volatile and high reactivity) and low occupational limits, diisocyanate exposure evaluation is still a challenge nowadays for industrial hygienists and laboratories. The objective of this study was to compare the methylene diphenyl diisocyanate (MDI) concentrations measured by five methods using different collection or derivatization approaches in an oriented-strand board (OSB) factory. The methods used were: OSHA 47 (filter, 1-(2-pyridyl)piperazine) (OSHA), Asset EZ4-NCO (denuder and filter, dibutylamine) (Asset), Iso-Chek (double-filter, 9-(N-methylaminomethyl) anthracene and 1,2-methoxyphenylpiperazine), DAN (filter, 1,8-diaminonaphthalene), and CIP10 (centrifugation, 1,2-methoxyphenylpiperazine). Real-time monitoring of particle concentration and size distribution was performed to explain the potential bias between methods. The comparison study was performed over 3 consecutive days, generating at least 18 replicates for each of the 5 methods. The results of each methods were compared using linear mixed effect modeling. Compared to Asset, which yielded the highest concentrations overall, the OSHA method provided the smallest bias with -18% (95% CI [-61;24]) (not significant) for MDI monomer and the DAN method provided the smallest bias with -30 (95% CI [-70;9]) (not significant) for Total Reactive Isocyanate Group (TRIG). The CIP10 and Iso-Chek methods provided the largest biases for MDI monomer (-83% (95% CI [-115;-51]) and -78% (95% CI [-110;-46]), respectively) as well as for TRIG (-87% (95% CI [-120;-55]) and -75% (95% CI [-107;-44]), respectively). The underestimations of the CIP10 and Iso-Chek were explained by its inefficient sampling principle for fines particles and the use of a non-impregnated filter to collect aerosol MDI, respectively. This study confirms that impregnated filter, including denuding device such as the Asset EZ4-NCO sampler, collects the MDI-coated wood particles and MDI vapor with similar efficiency. It also demonstrates for the first time in this type of MDI emission a significant agreement for TRIG concentration between the DAN method in the impregnated filter configuration and an international standard one such as Asset.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 5294-61-1 help many people in the next few years. Application In Synthesis of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Synthetic Route of 5294-61-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, SMILES is O=C(NC1=C(C)C=CC=C1C)CN2CCNCC2, belongs to piperazines compound. In a article, author is Jaen-Gil, Adrian, introduce new discover of the category.

Effect-Based Identification of Hazardous Antibiotic Transformation Products after Water Chlorination

Antibiotic transformation products (TPs) generated during water treatment can be considered as an environmental concern, since they can retain part of the bioactivity of the parent compound. Effect-directed analysis (EDA) was applied for the identification of bioactive intermediates of azithromycin (AZI) and ciprofloxacin (CFC) after water chlorination. Fractionation of samples allowed the identification of bioactive intermediates by measuring the antibiotic activity and acute toxicity, combined with an automated suspect screening approach for chemical analysis. While the removal of AZI was in line with the decrease of bioactivity in chlorinated samples, an increase of bioactivity after complete removal of CFC was observed (at >0.5 mgCl(2)/L). Principal component analysis (PCA) revealed that some of the CFC intermediates could contribute to the overall toxicity of the chlorinated samples. Fractionation of bioactive samples identified that the chlorinated TP296 (generated from the destruction of the CFC piperazine ring) maintained 41%, 44%, and 30% of the antibiotic activity of the parent compound in chlorinated samples at 2.0, 3.0, and 4.0 mgCl(2)/L, respectively. These results indicate the spectrum of antibacterial activity can be altered by controlling the chemical substituents and configuration of the CFC structure with chlorine. On the other hand, the potential presence of volatile DBPs and fractionation losses do not allow for tentative confirmation of the main intermediates contributing to the acute toxic effects measured in chlorinated samples. Our results encourage further development of new and advanced methodologies to study the bioactivity of isolated unknown TPs to understand their hazardous effects in treated effluents.

Synthetic Route of 5294-61-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 5294-61-1.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, molecular formula is C14H21N3O, belongs to piperazines compound. In a document, author is Ding, Hao, introduce the new discover, Recommanded Product: N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Transformation of Commodity Poly(hydroxyether of bisphenol A) into Vitrimers via Post Crosslinking with Hindered Urea Bonds

In this contribution, we reported the preparation of vitrimers by using commodity thermoplasticsviapost crosslinking with hindered urea bonds (HUBs). First, three hindered urea diisocyanates (HUDIs) were synthesizedviathe reactions ofN,N’-di-tert-butylethylenediamine,N,N’-diethylethylenediamine, and piperazine with isophorone diisocyanate (IPDI). Thereafter, these HUDIs were used as the crosslinking agents to crosslink poly(hydroxyether of bisphenol A) (PH), a commodity thermoplastics. Fourier transform infrared (FTIR) spectroscopy and dynamic mechanical thermal analyses (DMTA) indicated that the PH thermosets were successfully obtained. It was found that the thermosets displayed the behavior of vitrimers. The PH thermosets can be reprocessed at elevated temperature without using catalyst and the mechanical strengths of vitrimers were recovered as high as 95%. The reprocessing properties are attributable to dynamic exchange reaction of hindered urea bonds, contingent on types of hindered urea bonds.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 5294-61-1. Recommanded Product: N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Synthetic Route of 5294-61-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, SMILES is O=C(NC1=C(C)C=CC=C1C)CN2CCNCC2, belongs to piperazines compound. In a article, author is Panday, Niraj Kumar, introduce new discover of the category.

Metabolite profiling of IMID-2, a novel anticancer molecule of piperazine derivative: In silico prediction, in vitro and in vivo metabolite characterization using UPLC-QTOF-MS/MS

IMID-2, a newly identified piperazine-based anticancer molecule, has been shown to be cytotoxic against various cancer cell lines. The primary aim of this research was to identify and characterize possible metabolites of the molecule formed during biotransformation. A metabolite identification study was first executed using an in silico tool to predict the possible metabolism sites of IMID-2. Thereafter, metabolites generated in vitro (rat liver microsomes, rat S9 fractions and human liver microsomes) and in vivo (rat plasma, urine and feces) were identified and characterized employing UPLC-QTOF-MS/MS. A total of eight metabolites, among which were six in phase I and two in phase II reactions, were recognized. The plausible structure of the metabolites and probable metabolic pathway have been established based on the mass fragmentation pattern, mass ppm error, ring double bond calculation and nitrogen rule. The majority of phase I metabolites were generated by N-oxidation, hydroxylation, oxidative deamination followed by reduction, oxidative dechlorination, N-dearylation, and N-dealkylation. Glucuronidation played a significant role in the formation of phase II metabolites of the molecule.

Synthetic Route of 5294-61-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 5294-61-1.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, molecular formula is C14H21N3O. In an article, author is Suresh, Gangadhari,once mentioned of 5294-61-1, SDS of cas: 5294-61-1.

DNA Binding, DFT and Spectroscopic Studies of a Charge Transfer Complex Consisting of a Bioactive Donor 1-(2-Methylbenzyl)piperazine

A bioactive donor, 1-(2-methylbenzyl)piperazine is used to synthesize a new charge transfer complex (CTC) with the p-acceptor p-chloranil (p-CHL), which is characterized spectrophotometrically. The quantitative estimation of electronic interaction of the acceptor with the donor has been examined in acetonitrile (AN). The 1:1 composition of the CTC is confirmed by Jobs’ method of continuous variation and spectrophotometric (at max 554 nm) methods at 298 K. The Benesi-Hildebrand method gives the formation constant (KCT) and molar extinction coefficient (e) values of CTC. The spectral analysis was used to characterize CTC and its stability in solution and in the crystalline form. A DNA binding study of the CT-complex was carried out using UV-visible spectroscopy. A density functional theory (DFT) study of the CTC (gas phase/PCM) at using the B3LYP functional and 6-31G(d,p) basis set supports the experimental work. The optimization of the frontier molecular orbital surfaces was carried out by using the DFT-gasphase/PCM correlation methods. Mulliken atomic charges and reactive parameters of acceptor and donor recommend the MBPZ acts as a good electron donor and p-CHL acts as a good electron acceptor to form a highly stable electron transfer complex.

Interested yet? Keep reading other articles of 5294-61-1, you can contact me at any time and look forward to more communication. SDS of cas: 5294-61-1.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, Application In Synthesis of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, begins with the direct observation of nature¡ª in this case, of matter.5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, SMILES is O=C(NC1=C(C)C=CC=C1C)CN2CCNCC2, belongs to piperazines compound. In a document, author is Akan, Aytac Perihan, introduce the new discover.

Post-combustion CO2 capture and recovery by pure activated methyldiethanolamine in crossflow membrane contactors having coated hollow fibers

Gas absorption and stripping using membrane contactors is one of a number of carbon capture and storage technologies being investigated for separating CO2 from flue gas. Energy consumption in CO2 absorption-stripping employing amine-containing aqueous absorbent solutions is strongly influenced by demanding stripping conditions involving higher temperatures. The utility of using pure methyldiethanolamine (MDEA) activated by piperazine as a reactive absorbent was studied using a compact hollow fiber device for the absorber as well as the stripper. Water needed for reactive absorption of CO2 in tertiary amine MDEA was obtained from simulated humidified flue gas stream which is saturated with moisture in actual practice. This study investigated also the absorption and stripping performances of aqueous absorbent solutions containing 80% and 90% activated MDEA (aMDEA). Considerable CO2 stripping from CO2-loaded pure aMDEA absorbent was achieved at 92 degrees C while absorption was carried out at 25-46 degrees C. Further, the CO2 stripping rate was far higher for pure MDEA compared to the other two aMDEA solutions with water. Results are reported for the performance of the absorption-stripping process as a function of humidified simulated flue gas flow rate and the absorbent flow rate. High values of the overall mass transfer coefficients (MTCs) have also been reported for absorption. The highest volumetric gas phase based overall MTC obtained was 0.504 sec(-1). This system has a much lower absorbent circulation load, eliminates the energy needed to heat and evaporate water present in aqueous absorbent solutions and benefits from the absence of excess water during stripping.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5294-61-1. Application In Synthesis of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Liu, Meihong, once mentioned the application of 5294-61-1, HPLC of Formula: C14H21N3O, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, molecular formula is C14H21N3O, molecular weight is 247.34, MDL number is MFCD06384973, category is piperazines. Now introduce a scientific discovery about this category.

Carbodiimide-assisted zwitterionic modification of poly(piperazine amide) thin-film composite membrane for enhanced separation and anti-depositing performances to cationic/anionic dye aqueous solutions

In this work, a novel method of carbodiimide-assisted zwitterionic modification was proposed and implemented to incorporate zwitterionic moieties onto poly(piperazine amide) membrane for improved water permeability and anti-depositing property, which are crucial for highly efficient nanofiltration of dye-contained effluents. Carboxyl groups of polyamide layer were firstly transferred into N-acylurea using excess l-ethyl-3-(3-(dimethylamino)propyl)-carbodiimide. Zwitterions were then incorporated through ring-opening reaction between tertiary amine groups of N-acylurea and 1, 4-butanesultone. Carbodiimide-assisted zwitterionic modification was verified by ATR-IR and XPS analyses and was found to not affect membrane pore size but significantly enhance membrane’s permeation and antidye-deposition performances. Compared with those of virgin membrane, water permeabilities of the desired zwitterionic membrane to pure water, Congo red aqueous solution and Victoria blue B aqueous solution were higher by 42.9, 62.3 and 95.2 %, respectively, hydraulic resistances from irreversible deposition of Congo red and Victoria blue B molecules were dramatically lowered by 68.4 and 91.8 %, respectively. Furthermore, the perm-selectivity performance of the desired zwitterionic membrane in terms of molecular weight cut-off and pure water permeability was better than most of the reported zwitterionic membranes, and the separation and anti-depositing performances to both anionic and cationic dye aqueous solutions were better than commercial membrane NF270.

If you are interested in 5294-61-1, you can contact me at any time and look forward to more communication. HPLC of Formula: C14H21N3O.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, SMILES is O=C(NC1=C(C)C=CC=C1C)CN2CCNCC2, belongs to piperazines compound. In a document, author is El Abbouchi, Abdelmoula, introduce the new discover, Computed Properties of C14H21N3O.

Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents

A series of ethacrynic acid (2-[2,3-dichloro-4-(2- methylidenebutanoyephenoxy]acetic acid) (EA, Edecrin) containing sulfonamides linked via three types of linkers namely 1,2-ethylenediamine, piperazine and 4-aminopiperidine was synthesized and subsequently evaluated in vitro against HL60 and HCT116 cancer cell lines. All the EA analogs, excluding 6a and 6c, showed anti-proliferative activity with IC50, in the micromolar range (less than 4 uM). Three derivatives 6b, 7 b and 7 e were selected for their interesting dual activity on HL60 cell line in order to be further evaluated against a panel of cancer cell lines (HCT116, A549, MCF7, PC3, U87-MG and SKOV3) as well as on MRCS as a normal cell line. These compounds displayed IC50 values in nanomolar range against A549, MCF7, PC3 and HCT116 cell lines, deducing the discovery that piperazine or 4-aminopiperidine is the linker’s best choice to develop EA analogs with highly potent anti-proliferative activities own up to 24 nM. Besides, in terms of selectivity, those linkers are more suitable offering safety ratios of up to 63.8.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5294-61-1 is helpful to your research. Computed Properties of C14H21N3O.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics