Category: 5308-25-8

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.36 g of N-[4-tert-butyl-5-(4-methoxybenzyl)thiazol-2-yl]-2-chloroacetamide and 5 mL of tetrahydrofuran, Stir at room temperature, 0.24 g of pyridine and 0.23 g of N-ethylpiperazine are added; Reaction overnight, Desolvent, Add dichloromethane, Saturated salt water wash, Drying with anhydrous sodium sulfate, Desolvent, Add petroleum ether to precipitate solids, Suction filtration Wash with petroleum ether, Dry to obtain light yellow solid N-[4-tert-butyl-5-(4-methoxybenzyl)thiazol-2-yl]-2-(4-ethylpiperazinyl)acetamide, yield 65.1%

5308-25-8, As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.

Reference£º
Patent; Hunan University; Hu Aixi; Wu Zhilin; Ding Na; Ye Jiao; (20 pag.)CN107365280; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5308-25-8, A mixture of 5-bromo-2-nitropyridine (1.02 g, 5.02 mmol) and 1 -ethylpiperazine (1 .71 g, 15.0 mmol) in N-methyl-2-pyrrolidinone (5 mL) was stirred at 120 C for 3 h. After this time, the reaction was cooled to room temperature, poured into water (100 mL) and extracted with methylene chloride (2 chi 100 mL). The combined organic layers were dried over sodium sulfate, filtered and the filtrate concentrated under reduced pressure. The resulting residue was purified by chromatography (silica, gradient, 1 :49 methanol/methylene chloride to 1 :9 methanol/methylene chloride) to afford l-ethyl-4-(6-nitropyridin-3- yl)piperazine as a yellow solid: 1H NMR (400 MHz, DMSO- )d 8.25 (d, J = 2.8 Hz, 1 H), 8.14 (d, J = 9.2 Hz, 1H), 7.48 (dd, J = 9.2, 2.8 Hz, 1H), 3.50-3.46 (m, 4H), 2.50-2.38 (m, 4H, merged with DMSO peak), 2.37 (q, J = 7.2 Hz, 2H), 1.02 (t, J= 7.2 Hz, 3H).

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GILEAD SCIENCES, INC.; BLOMGREN, Peter; CURRIE, Kevin, S; KROPF, Jeffrey, E.; LEE, Seung, H.; MITCHELL, Scott, A.; SCHMITT, Aaron, C.; XU, Jianjun; ZHAO, Zhongdong; WO2011/112995; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17 4-({3-Chloro-4-[(1-ethyl-4,5-dimethyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-[3-(4-ethyl-1-piperazinyl)propoxy]-6-methoxy-3-quinolinecarbonitrile To a stirred solution of 4-[3-chloro-4-(1-ethyl-4,5-dimethyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-7-(3-chloro-propoxy)-6-methoxy-quinoline-3-carbonitrile (0.300 g, 0.539 mmol) in DMF (2 mL) was added 1-ethyl-piperazine (0.137 mL, 1.08 mmol) and NaI (0.008 g, 0.0539 mmol). The solution was heated to 100 C., maintaining the temperature overnight. The solution was cooled to room temperature and then diluted with brine (2 mL) and H2O (2 mL). The precipitate was collected via vacuum filtration and washed with H2O and Et2O to afford the product (0.290 g, 85%) as a solid, mp. 229-230 C.; 1H NMR (DMSO-d6) delta 0.93 (t, J=7.2 Hz, 3H), 1.04 (t, J=7.1 Hz, 3H), 1.85-1.95 (m, 2H), 2.07 (s, 3H), 2.15 (s, 3H), 2.22-2.43 (m, 12H), 3.86 (s, 3H), 3.90 (dd, J=7.1, 14.4 Hz, 2H), 4.14 (t, J=6.4 Hz, 2H), 6.58 (d, J=8.6 Hz, 1H), 7.06 (dd, J=2.3, 8.7 Hz, 1H), 7.29 (s, 1H), 7.30 (d, J=2.3 Hz, 1H), 7.61 (s, 1H), 8.45 (s, 1H), 9.46 (s, 1H); mass spectrum [(+) ESI], m/z 634/636 (M+H)., 5308-25-8

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Wyeth; US2009/264427; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.,5308-25-8

General procedure: A solution of compound 2 (0.55 mmol), 1-substituted piperazine (0.83 mmol) and pyridine (0.8 mmol) in 10 mL THF (tetrahydrofuran) was stirred at room temperature overnight. When the reaction was completed, the solvent was evaporated under reduced pressure. The residues were dissolved in ethyl acetate and washed with water and saturated sodium chloride solution. After drying over anhydrous Na2SO4, the solvent was removed under reduced pressure to get crude product. The pure products were obtained by recrystallizing from ethanol.

The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Zhilin; Ding, Na; Tang, Yuting; Ye, Jiao; Peng, Junmei; Hu, Aixi; Research on Chemical Intermediates; vol. 43; 8; (2017); p. 4833 – 4850;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5308-25-8

5-Ch.oro-2-nitroaniline (3g, 17.4mmol), 1-ethylpiperazine (4.42ml, 34.9mmol) and potassium carbonate (2.4g, 17.4mmol) in DMF (8ml) were heated at 130C for 2h in a Smithcreator microwave. The mixture was diluted with water and ethyl acetate. A yellow solid formed, it was filtered off and dried to give 1.3g of the title compound. LC/MS Rt = 1.21 , [MH+] 251.2, 252.2

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/114272; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of 1-ethylpiperazine (3.23 g, 0.0283 mol) and l -fluoro-3 -nitrobenzene (2.0 g, 0.0142 mol) was heated at reflux for 2 days. The resulting mixture was cooled and concentrated in vacuo. The residue was poured into water (50 mL), extracted with EA (2*50 mL). The combined extracts were washed with brine, concentrated in vacuo. The residue was purified via ISCO (eluted with EA in PE 0 – 70%) to give a yellow solid (1.80 g, 54.0% yield). MS (m/z): 236.1 (M+H)+.(B) 3-(4-ethylpiperazin-l-yl)aniline A mixture of l-ethyl-4-(3-nitrophenyl)piperazine (1.8 g, 0.00765 mol) and Rany-Ni (1.0 g) in MeOH (20 mL) was stirred under 1 atm of H2 at room temperature for 6 h. The resulting mixture was filtered and the filtrate was concentrated in vacuo to give a grey slurry (1.5 g, 95.5% yield). MS (m/z): 206.2 (M+H)+., 5308-25-8

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; ZHANG, Weihan; LI, Jinshui; WO2014/139145; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A solution of 4-fluorobenzaldehyde (0.017 mol, 1.82 mL) and an appropriate secondary aminein DMF (10 mL) was refluxed (0.017 mol) in the presence of potassium carbonate (K2CO3, 0.017 mol,2.35 g). After completion of reaction, the mixture was cooled with ice-water (10 mL) and extractedwith ethyl acetate (3 20 mL). The ethyl acetate phases were combined, and the remaining productwas collected after evaporation of the solvent. The following compounds were prepared in this way:4-(4-methylpiperazin-1-yl)benzaldehyde (1a), CAS No:27913-99-1, Yield 82%, m.p. = 55-57 C (measured),m.p. = 58-60 C (reported) [60]; 4-(4-ethylpiperazin-1-yl)benzaldehyde (1b), CAS No:197638-76-9,Yield 79%, obtained as an oil; 4-(4-isopropylpiperazin-1-yl)benzaldehyde (1c), CAS No:197638-78-1,Yield 84%, obtained as an oil and 4-(4-cylopropylpiperazin-1-yl)benzaldehyde (1d), CAS No:1292778-23-4,Yield 78%, obtained as an oil., 5308-25-8

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Tokgoez, Gamze; Oezkay, Uemide Demir; Osmaniye, Derya; Yuecel, Nazl? Turan; Can, Oezguer Devrim; Kaplanc?kl?, Zafer As?m; Molecules; vol. 23; 11; (2018);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1.Synthesis of 4-Ethyl-1-(4-nitrophenyl)piperazine To 4-fluoro-1-nitrobenzene(1 eq) in N,N-dimethylformamide was added Ethyl piperazine (2 eq) and N,N-diisopropylethyl amine (2 eq) and heated at 80 C. for 16 h.Concentrated the resultant mixture and partitioned between ethyl acetate and water.The organic layer was then washed with brine and dried with sodium sulfate and concentrated.Passed through a plug of silica to yield 4-Ethyl-1-(4-nitrophenyl)piperazine. MS: MH+=235., 5308-25-8

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard; US2004/122237; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5308-25-8, 1-(Bromomethyl)-4-nitro-2-(trifluoromethyl)benzene (34 g, 120 mmol) obtained in Step (1) above was stirred in a solvent of dichloromethane (300 mL). The reaction solution was added with 1-ethylpiperazine (15.97 mL, 126 mmol) and DIPEA (27.2 mL, 156 mmol), followed by stirring for about 3 hours at room temperature. The reaction mixture was diluted with dichloromethane, washed with a saturated aqueous sodium bicarbonate solution and saline. The organic layer thus obtained was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain the title compound (21.7 g, 57%). 1H-NMR Spectrum (300 MHz, DMSO-d6): delta 8.52 (d, 1H), 8.40 (s, 1H), 8.09 (d, 1H), 3.71 (s, 2H), 2.35 (m, 10H), 1.00 (t, 3H). MS (ESI+, m/z): 318 [M+H]+

As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.

Reference£º
Patent; HANMI PHARM. CO., LTD.; Bae, In Hwan; Han, Sang Mi; Kwak, Eun Joo; Ahn, Young Gil; Suh, Kwee Hyun; US2015/191450; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5308-25-8, To a stirred solution of Ethyl piperazine (11.06 g, 96.8 mmol, 2.0 eq) and triethylamine (24.46 g, 242 mmol, 5.0 eq) in CH2Cl2 (150 ml) at 0C was added a solution of (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(chlorocarbonyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl acetate (25 g, 48.4 mmol, 1.0 eq) in CH2Cl2 (150 ml). The reaction mixture was allowed to stir at room temperature for overnight. TLC indicated starting material was consumed and the desired product was observed. The reaction mixture was quenched with water and extracted with CH2Cl2 (3×200 ml). The combined organic layers were dried over Na2S04, filtered and evaporated under reduced pressure. The crude residue was purified by silicagel column chromatography by using 2% methanol: dichloromethane as an eluent to obtain the desired product (26 g, 90% yield) as a white solid. 1H NMR (300 MHz, CDCl3): delta ppm 4.72 (s, 1H), 4.57 (s, 1H), 4.50-4.42 (m, 1H), 3.68-3.56 (m, 4H), 3.03-2.82 (m, 2H), 2.48-2.32 (m, 6H), 2.04 (s, 3H), 1.68 (s, 3H), 1.10 (t, J= 7.2 Hz, 3H), 0.95 (s, 3H), 0.94 (s, 3H), 0.84 (s, 3H), 0.836 (s, 3H), 0.83 (s, 3H), 2.15-0.75 (m, 23H); ES MS: [M+H]+ 595.4 (100%).

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PANDURANGA ADULLA, Reddy; PARTHASARADHI REDDY, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; PREM KUMAR, Mamnoor; BHASKAR REDDY, Kasireddy; NARSINGAM, Mogili; VENKATI, Mukkera; VL SUBRAHMANYAM, Lanka; MALLIKARJUN REDDY, Ravi; WO2013/160810; (2013); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics