Category: 5317-33-9

5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5317-33-9

Example 33; 4-(3-Chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide (I.33); Step 1; To a mixture of 0.158 g (1 mmole) of 3-(4-methyl-piperazin-1-yl)-propan-1-ol, and 5 mL of pyridine was added 0.001 g of 4-dimethylaminopyridine and 0.190 g (1 mmole) of p-toluenesulphonyl chloride. The mixture was stirred at ambient temperature overnight and then concentrated under reduced pressure. The residue was taken up in 20 mL of dichloromethane and washed once with 10 mL of saturated sodium bicarbonate, twice with 10 mL of water, and then brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 0.248 g of 3-(4-methyl-piperazin-1-yl)-propyl ester as a colorless oil.

The synthetic route of 5317-33-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Cai, Jianping; Chen, Shaoqing; Chen, Yi; Chu, Xin-Jie; Goodnow, JR., Robert Alan; Le, Kang; Luk, Kin-Chun; Mischke, Steven Gregory; Wovkulich, Peter Michael; US2010/160308; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5317-33-9,3-(4-Methylpiperazin-1-yl)propan-1-ol,as a common compound, the synthetic route is as follows.

5317-33-9, Preparation of 3-(4-methylpiperazin-1-yl)propan-1-yl chloroformate dihydrochloride 370 g of hydrogen chloride are passed into a solution of 712 g (4.50 mol) of 3-(4-methylpiperazin-1-yl)propan-1-ol in 8.0 l of acetonitrile with external cooling, and the suspension is stirred at room temperature for 18 hours. 1200 g (6.07 mol) of trichloromethyl chloroformate are subsequently added dropwise with cooling at an internal temperature of 2-10 C., and the resultant suspension is subsequently stirred for 3 days with gentle warming at an internal temperature of 35 C. The reaction mixture is filtered with suction, washed with 2 l of acetonitrile and 2 l of diethyl ether and dried in vacuo: 3-(4-methylpiperazin-1-yl)propan-1-yl chloroformate dihydrochloride as colourless crystals; m.p. 249 C. (decomposition).

As the paragraph descriping shows that 5317-33-9 is playing an increasingly important role.

Reference：
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRAeNKTER HAFTUNG; US2011/136819; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5317-33-9,3-(4-Methylpiperazin-1-yl)propan-1-ol,as a common compound, the synthetic route is as follows.,5317-33-9

A solution of MsCl ( 0.80 g, 7.00 mmol) in DCM (10 mL) was added dropwise to a stirred, ice- cold suspension of 3-(4-methylpiperazin-l-yl)propan-l-ol (1.00 g, 6.32 mmol) in DCM (5 mL). The reaction was stirred at room temperature for 2 h before the solvent was removed under vacuum. The crude product (white solid) was used directly without purification (1.4 g, 94% yield). ‘H NMR (500 MHz, CD3OD SPE) S: 4.38 (t, J= 5.9 Hz, 2H), 3.73 (dd, J= 22.6, 16.8 Hz, 8H), 3.44 – 3.38 (m, 2H), 3.13 (s, 3H), 3.02 (s, 3H), 2.31 – 2.23 (m, 2H).

As the paragraph descriping shows that 5317-33-9 is playing an increasingly important role.

Reference：
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; YE, Jinqi; (0 pag.)WO2020/2969; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5317-33-9,3-(4-Methylpiperazin-1-yl)propan-1-ol,as a common compound, the synthetic route is as follows.,5317-33-9

A solution of MsCl ( 0.80 g, 7.00 mmol) in DCM (10 mL) was added dropwise to a stirred, ice- cold suspension of 3-(4-methylpiperazin-l-yl)propan-l-ol (1.00 g, 6.32 mmol) in DCM (5 mL). The reaction was stirred at room temperature for 2 h before the solvent was removed under vacuum. The crude product (white solid) was used directly without purification (1.4 g, 94% yield). ‘H NMR (500 MHz, CD3OD SPE) S: 4.38 (t, J= 5.9 Hz, 2H), 3.73 (dd, J= 22.6, 16.8 Hz, 8H), 3.44 – 3.38 (m, 2H), 3.13 (s, 3H), 3.02 (s, 3H), 2.31 – 2.23 (m, 2H).

As the paragraph descriping shows that 5317-33-9 is playing an increasingly important role.

Reference：
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; YE, Jinqi; (0 pag.)WO2020/2969; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2.94 g (19 mmol) of 3-(N-methylpiperazine)propan-1-ol and 2.63 g (24.8 mmol) of sodium carbonate are added to a solution of 5.68 g (12.4 mmol) of 2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}acetamide in 25 ml of dimethylformamide, and the mixture is stirred at 100 C. for 20 hours. 50 ml of water are added to the reaction mixture, which is then extracted with dichloromethane. The organic phase is dried over sodium sulfate and evaporated. The residue is chromatographed on a silica-gel column with dichloromethane/methanol as eluent: 3-(4-methylpiperazin-1-yl)propyl{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}carbamate as colourless crystals.

5317-33-9, 5317-33-9 3-(4-Methylpiperazin-1-yl)propan-1-ol 79208, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRAeNKTER HAFTUNG; US2011/136819; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5317-33-9, 4-Toluenesulphonyl chloride (3.2 g) was added to a stirred mixture of 1-(3-hydroxypropyl)-4-methylpiperazine (2.4 g), triethylamine (4.6 ml) and methylene chloride (60 ml) and the resultant mixture was stirred at ambient temperature for 2 hours. The solution was washed in turn with a saturated aqueous sodium bicarbonate solution and with water and filtered through phase separating paper. The organic filtrate was evaporated to give 3-(4-methylpiperazin-1-yl)propyl 4-toluenesulphonate as an oil which crystallized on standing (3.7 g); Mass Spectrum: M+H+ 313.

5317-33-9 3-(4-Methylpiperazin-1-yl)propan-1-ol 79208, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AstraZeneca AB; US2004/48881; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5317-33-9,3-(4-Methylpiperazin-1-yl)propan-1-ol,as a common compound, the synthetic route is as follows.

170 mg (1.08 mmol) of 3-(4-methylpiperazin-1-yl)propan-1-ol are dissolved in 20 ml of DMF, 64.5 mg (1.61 mmol) of NaH in paraffin oil (60%) are added under nitrogen, and the mixture is stirred at room temperature. After 10 min, 200 mg (0.54 mmol) of 5-[6-oxo-3-(3,4,5-tri-fluorophenyl)-6H-pyridazin-1-ylmethyl]-1,3-dihydrobenzimidazol-2-one are added, and the mixture is stirred at room temperature under a nitrogen atmosphere. The reaction is monitored by means of HPLC. After 3 h, the reaction is terminated. The mixture is neutralised using 1N HCl.The mixture is evaporated to dryness, the residue is dissolved in 100 ml of ethyl acetate and 30 ml of water, the aqueous phase is separated off and neutralised using sodium hydrogencarbonate and subsequently extracted. A precipitate deposits in the process and is separated off. The residue is stirred with methanol, filtered off with suction and dried in vacuo.Yield: 41 mg of ?A56? as white solid; ESI 511; Rt.=1.97 min (method B)., 5317-33-9

5317-33-9 3-(4-Methylpiperazin-1-yl)propan-1-ol 79208, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRAeNKTER HAFTUNG; US2010/179149; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5317-33-9, Di-tert-butyl azodicarboxylate (0.478 g, 2.08 mmol) was added portionwise to a mixture of 4-chloro-7-hydroxy-6-methoxyquinazoline (0.350 g, 1.66 mmol), 3-(4-methyl-piperazin-1-yl)-propan-1-ol (Intermediate 9, 0.276 g, 1.74 mmol), and triphenylphosphine (0.544 g, 2.08 mmol) in dichloromethane (20 mL) at r.t.. If necessary, further alcohol was added. After stirring for 2 h, the solution was concentrated to 10 mL, mounted on silica and chromatographed (gradient, dichloromethane to dichloromethane : methanol = 3:2 within 1 h) to obtain 4-chloro-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazoline (brownish solid, 0.431 g, 1.23 mmol, 74 %). LC/ESI-MS: m/z = 351 [M(35Cl) +H]+; Rt = 1.88 min. Cf. also WO 04/043472, page 32.

As the paragraph descriping shows that 5317-33-9 is playing an increasingly important role.

Reference£º
Patent; 4SC AG; EP1674466; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5317-33-9,3-(4-Methylpiperazin-1-yl)propan-1-ol,as a common compound, the synthetic route is as follows.

General procedure: To a solution of triphenylphosphine (0.37 mmol) in THF (30 mL) was slowly added diisopropyl azodicarboxylate (0.37 mmol) in 15 min at 0 C and the mixture was stirred for another 15 min. At the same temperature, to the resulting mixture was slowly added a solution of 20 (0.185 mmol) and corresponding alcohol (0.37 mmol) dissolved in 20 mL THF. The ice bar was removed and the reaction mixture was stirred at room temperature for 12 h. The reaction mixture was evaporated in vacuo, and the residue was purified by column chromatography to afford the product., 5317-33-9

5317-33-9 3-(4-Methylpiperazin-1-yl)propan-1-ol 79208, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Xing, Weiqiang; Ai, Jing; Jin, Shiyu; Shi, Zhangxing; Peng, Xia; Wang, Lang; Ji, Yinchun; Lu, Dong; Liu, Yang; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 302 – 312;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5317-33-9, Sodium metal (10.1 mmol, 0.23 g) was added to a solution of 3-N-(4-methylpiperazinyl)propan-1-ol (6.71 mmol, 1.06 g) in THF (15 mL) under N2. The resulting suspension was stirred at 20 C. for 2 hours and then cannulated into a solution of 7-fluoro-4-[(3-methylphenyl)amino]-6-nitroquinazoline (0.50 g, 1.68 mmol) in THF (20 mL) under N2. The dark red solution was then heated at reflux for 24 hours before being diluted with water and extracted with EtOAc. The combined organic extracts were dried over anhydrous Na2SO4, concentrated under reduced pressure and chromatographed on alumina eluting with EtOAc/hexane (1:1) to EtOAc (2:3:5), to give 4-[(3-methylphenyl)amino]-7-[3-N-(4-methylpiperazinyl)propyloxy]-6-nitroquinazoline (0.67 g, 91%) as a yellow powder, mp (Et2O/hexane) 155-156 C. 1H NMR [(CD3)2SO]: delta 10.00 (s, 1H, NH), 9.26 (s, 1H, H5, H2H5), 8.61 (s, 1H, H2), 7.64 (br d, J=8.4 Hz, 1H, H-6′), 7.62 (br s, 1H, H-2′), 7.43 (s, 1H, H8), 7.29 (t, J=7.8 Hz, 1H, H-5′), 6.99 (br d, J=7.4 Hz, 1H, H-4′), 4.32 (t, J=6.0 Hz, 2H, CH2CH2CH2O), 2.44 (t, J=7.0 Hz, 2H, NCH2CH2CH2), 2.39-2.28 (br s, 8H, piperazinyl methylene), 2.34 (s, 3H, CH3Ar), 2.14 (s, 3H, CH3N), 1.92 (quintet, J=6.6 Hz, 2H, CH2CH2CH2). Analysis calculated for CH28N6O3 requires: C, 63.3; H, 6.5; N, 19.3%. Found: C, 63.4; H, 6.8; N, 19.6%.

As the paragraph descriping shows that 5317-33-9 is playing an increasingly important role.

Reference£º
Patent; Warner-Lambert Company; US6344459; (2002); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics