Category: 53636-17-2

Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Cationic BINAP-Ru(II) Halide Complexes: Highly Efficient Catalysts for Stereoselective Asymmetric Hydrogenation of α- and β-Functionalized Ketones. Author is Mashima, Kazushi; Kusano, Koh-hei; Sato, Naomasa; Matsumura, Yoh-ichi; Nozaki, Kyoko; Kumobayashi, Hidenori; Sayo, Noboru; Hori, Yoji; Ishizaki, Takero.

Cationic ruthenium-BINAP complexes of the formula [RuX[(S)-BINAP](arene)]Y, where X = Cl, Br, I; Y = Cl, Br, I, BF4, B(C6H5)4; arene = benzene, p-cymene, Et benzoate, and their enantiomers have been prepared by the reaction of arene-ruthenium halide complexes with (S)-BINAP or (R)-BINAP [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl]. Structures of the complexes were established by spectroscopy, conductivity, and a single-crystal x-ray anal. BINAP derivatives with various substituents at the para and meta positions of four Ph rings on phosphorus atoms and their cationic Ru(II) complexes have also been synthesized. These BINAP-Ru(II) complexes have been used as catalysts for the asym. hydrogenation of various unsaturated organic compounds such as α- and β-keto esters, allylic alcs., and α,β-unsaturated carboxylic acids in excellent diastereo- and/or enantioselectivities. Catalytic activities and stereoselectivities depend highly on reaction conditions such as solvent, temperature, and additives. Variation of halogen ligands bound to ruthenium atom and substituents on four Ph rings of BINAP also have exerted remarkable effects on the efficiency of the catalysis. Asym. hydrogenation of methyl(±)-2-(benzamidomethyl)-3-oxobutanoate catalyzed by the species derived from [RuI2(p-cymene)]2 and 3,5-(Me3C)2-BINAP afforded the corresponding syn-(2S,3R)-I in 98% de and 99% ee.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of the American Chemical Society called Homogeneous asymmetric hydrogenation of functionalized ketones, Author is Kitamura, Masato; Ohkuma, Takeshi; Inoue, Shinichi; Sayo, Noboru; Kumobayashi, Hidenori; Akutagawa, Susumu; Ohta, Tetsuo; Takaya, Hidemasa; Noyori, Ryoji, which mentions a compound: 53636-17-2, SMILESS is C[C@H](O)CN(C)C, Molecular C5H13NO, Electric Literature of C5H13NO.

Under the influence of the (R)- or (S)-BINAP-based Ru(II) complexes [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl], a wide range of functionalized ketones are hydrogenated in a highly enantioselective and predictable manner. The hydrogenation proceeds smoothly in alc. media at room temperature with initial hydrogen pressure of 40-100 atm. The substrate to catalyst mole ratio ranges from 230 to 2200. Ru complexes of the type RuX2(binap) (X = Cl, Br), Ru2Cl4(binap)2NEt3, or Ru(OAc)2(binap) are employable as catalysts, depending on the substrates. Various functionalities including dialkylamino, hydroxyl, alkoxyl, siloxyl, keto, alkoxycarbonyl, alkylthiocarbonyl, dialkylaminocarbonyl, carboxyl, etc., can act as the efficient directive group. Neighboring halogen atoms also strongly affect the stereochem. outcome. Certain α- and β-diketones are hydrogenated to give isomeric diols by double stereodifferentiation; relative importance of efficacy of the catalyst/carbonyl chirality transfer and structural effect of the initially formed chiral hydroxy ketone intermediate is highly dependent on the ketonic substrates.

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Frelek, Jadwiga; Klimek, Agata; Ruskowska, Patrycja published an article about the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2,SMILESS:C[C@H](O)CN(C)C ).Quality Control of (S)-1-(Dimethylamino)propan-2-ol. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:53636-17-2) through the article.

A straightforward and versatile method for the determination of the absolute configuration of vic-amino alcs. is proposed. The proposed method involves the in situ formation of chiral complexes of optically active ephedrine- or adrenaline-type vic-amino alcs. with the achiral dimolybdenum tetraacetate [Mo2(OAc)4] acting as an auxiliary chromophore. The resulting CD spectra are suitable for the assignment of absolute configuration, since the observed sign of Cotton effects arising within the d-d absorption bands for the metal cluster depends solely upon the chirality of the amino alc. ligand. An empirically based rule correlating a pos./neg. helicity expressed by the O-C-C-N torsional angle with the sign of Cotton effects occurring in the 400-260 nm spectral range has been formulated.

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Mashima, Kazushi; Kusano, Kohhei; Ohta, Tetsuo; Noyori, Ryoji; Takaya, Hidemasa published the article 《Synthesis of new cationic BINAP-ruthenium(II) complexes and their use in asymmetric hydrogenation [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl]》. Keywords: BINAP ruthenium arene cationic complex; crystal mol structure bisdiphenylphosphinobinaphthylruthenium complex; asym hydrogenation catalyst ruthenium BINAP.They researched the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2 ).Safety of (S)-1-(Dimethylamino)propan-2-ol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:53636-17-2) here.

Reaction of [RuX2(arene)]2 with (S)-BINAP gives cationic BINAP-ruthenium complexes I (X = Cl, Br, iodo; Z = Cl, Br, iodo, BF4, BPh4; arene = C6H6, p-MeC6H4CHMe2) which are efficient catalyst precursors for enantioselective hydrogenation of various prochiral alkenic and ketonic substrates; a crystal structure of I (X = Cl, Z = BF4) was obtained.

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Piperazine – Wikipedia,
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Electric Literature of C5H13NO. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. Author is Tong, Lexian; Song, Pinrao; Jiang, Kailong; Xu, Lei; Jin, Tingting; Wang, Peipei; Hu, Xiaobei; Fang, Sui; Gao, Anhui; Zhou, Yubo; Liu, Tao; Li, Jia; Hu, Yongzhou.

Through virtual screening, we identified the lead compound MCL1020, which exhibited modest CHK1 inhibitory activity. Then a series of 5-(pyrimidin-2-ylamino)picolinonitrile derivatives as CHK1 inhibitors were discovered by further rational optimization. One promising mol., I, whose potency was one of the best, had an IC50 of 0.4 nM with remarkable selectivity (>4300-fold CHK1 vs. CHK2). Compound I effectively inhibited the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM) and displayed low affinity for hERG (IC50 > 40 μM). Moreover, I significantly suppressed the tumor growth in Z-138 cell inoculated xenograft model (20 mg/kg I.V., TGI = 90.29%) as a single agent with body weight unaffected. Taken together, our data demonstrated compound I could be a promising drug candidate for the treatment of hematol. malignancies.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Asymmetric Hydrogenation of Amino Ketones Using Chiral RuCl2(diphosphine)(1,2-diamine) Complexes.Product Details of 53636-17-2.

Chiral RuCl2(diphosphine)(1,2-diamine) complexes catalyzed the asym. hydrogenation of amino ketones. E.g., hydrogenation of MeCOCH2NMe2 in presence of trans-RuCl2[(R)-xylbinap][(R)-daipen] gave 79% (S)-MeCH(OH)CH2NMe2. Also prepared by this catalytic hydrogenation system were (R)-denopamine, (R)-fluoxetine, and BMS 181100.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about p-Hydroxymethadone: synthesis, crystal structure and CD properties.Name: (S)-1-(Dimethylamino)propan-2-ol.

Alkylation of 2-chloro-N,N-dimethylpropylamine with the Li salt derived from 2-(p-methoxyphenyl)-2-phenylacetonitrile gave a mixture of p-methoxymethadone nitrile (I) and p-methoxyisomethadone nitrile. The nitriles were separated chromatog. and the aminonitrile (I) was converted subsequently into the diastereomeric p-hydroxymethadone (II) hydrochlorides. Careful recrystallization afforded a separation of the (4RS,6RS)- and (4RS,6SR)-p-hydroxymethadone hydrochlorides. Repetition of the synthesis using (R)-2-chloro-N,N-dimethylpropylamine, derived in 3 steps from (S)-dilactide (III) yielded the (4S,6S)- and (4S,6S)-p-hydroxymethadone hydrochlorides which were also separated by fractional crystallization The absolute configuration of the products was verified by x-ray crystallog. The (4R,6S) salt exhibited a more intense Cotton effect than (S)-methadone hydrochloride while the (4S,6S) salt showed a less intense Cotton effect and less fine structure in the 260-275 nm range.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Enantiomeric separation of β-amino alcohols with a primary or tertiary amine moiety by reversed phase liquid chromatography with a chiral mobile phase containing copper(II) and (R)-mandelic acid, the main research direction is amino alc enantiomer separation liquid chromatog; copper mobile phase amino alc enantiomer; mandelic acid mobile phase aminoalc enantiomer.Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol.

Enantiomeric separation of β-amino alcs. with a primary or tertiary amine moiety was carried out on ODS column with aqueous mobile phase containing Cu(II) and (R)-mandelic acid. The analyte was detected by post-column chemiluminescence using a Ru(III) complex solution prepared from Ru(II) complex by photochem. oxidation The results were satisfactory.

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Related Products of 53636-17-2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Chirality sensing of choline derivatives by a triple anion helicate cage through induced circular dichroism. Author is Zuo, Wei; Huang, Zhe; Zhao, Yanxia; Xu, Wenhua; Liu, Zhihua; Yang, Xiao-Juan; Jia, Chuandong; Wu, Biao.

Chirality sensing of choline derivatives is achieved by a self-assembled, racemic triple anion helicate cage which exhibits induced CD (ICD) upon encapsulation of a chiral guest. The host-guest interactions were illustrated by NMR, crystal structure, CD and DFT calculations The absolute configurations and ee values were determined by ICD.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about A dissymmetric molecular capsule with polar interior and two mechanically locked hemispheres.Quality Control of (S)-1-(Dimethylamino)propan-2-ol.

The synthesis and chiral resolution of a dissym. tetraurea-calix[4]pyrrole/tetraurea-calix[4]arene mol. capsule with two hemispheres mech. locked is described. The assembly features a bis-[2]catenated topol. and shows reversible mol. co-encapsulation of two different neutral mols. or two oppositely charged ions.

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