Category: 53636-17-2

Related Products of 53636-17-2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Chirality sensing of choline derivatives by a triple anion helicate cage through induced circular dichroism. Author is Zuo, Wei; Huang, Zhe; Zhao, Yanxia; Xu, Wenhua; Liu, Zhihua; Yang, Xiao-Juan; Jia, Chuandong; Wu, Biao.

Chirality sensing of choline derivatives is achieved by a self-assembled, racemic triple anion helicate cage which exhibits induced CD (ICD) upon encapsulation of a chiral guest. The host-guest interactions were illustrated by NMR, crystal structure, CD and DFT calculations The absolute configurations and ee values were determined by ICD.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about A dissymmetric molecular capsule with polar interior and two mechanically locked hemispheres.Quality Control of (S)-1-(Dimethylamino)propan-2-ol.

The synthesis and chiral resolution of a dissym. tetraurea-calix[4]pyrrole/tetraurea-calix[4]arene mol. capsule with two hemispheres mech. locked is described. The assembly features a bis-[2]catenated topol. and shows reversible mol. co-encapsulation of two different neutral mols. or two oppositely charged ions.

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Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing. Author is Reader, John C.; Matthews, Thomas P.; Klair, Suki; Cheung, Kwai-Ming J.; Scanlon, Jane; Proisy, Nicolas; Addison, Glynn; Ellard, John; Piton, Nelly; Taylor, Suzanne; Cherry, Michael; Fisher, Martin; Boxall, Kathy; Burns, Samantha; Walton, Michael I.; Westwood, Isaac M.; Hayes, Angela; Eve, Paul; Valenti, Melanie; de Haven Brandon, Alexis; Box, Gary; van Montfort, Rob L. M.; Williams, David H.; Aherne, G. Wynne; Raynaud, Florence I.; Eccles, Suzanne A.; Garrett, Michelle D.; Collins, Ian.

Pyrazolopyridine lead inhibitors with micromolar affinities for the checkpoint kinase CHK1 and selective for CHK1 against CHK2 were refined by fragment-growing and scaffold morphing strategies to generate the isoquinolinylaminopyrazinecarbonitrile I as a potent and selective inhibitor of CHK1 [IC50 (CHK1) = 13 nM, IC50 (CHK2) = > 100 μM] as a potential antitumor agent. Scaffold morphing was used to improve the CHK1 potency and selectivity, synthetic accessibility, and novelty of the inhibitors; the inhibitor core was changed from pyrimido[2,3-b]azaindole to pyrazinylpyrimidinamine to imidazo[4,5-c]pyridine and isoquinoline. The toxicities, lipophilicities, and polar surface areas of selected compounds were determined, while ligand efficiencies were determined for the compounds prepared and tested; the microsomal stability and oral bioavailability of I in mice were determined I potentiated the efficacies of irinotecan and gemcitabine in SW620 human colon carcinoma xenografts in nude mice but had no effect on its own. The structures of six kinase inhibitors including I bound to the CHK1 kinase domain were determined by x-ray crystallog.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-1-(Dimethylamino)propan-2-ol(SMILESS: C[C@H](O)CN(C)C,cas:53636-17-2) is researched.Category: piperazines. The article 《Relative potencies of the stereoisomers of bethanechol on muscarinic receptors》 in relation to this compound, is published in Farmaco, Edizione Scientifica. Let’s take a look at the latest research on this compound (cas:53636-17-2).

The stereoisomers S(+)-bethanechol iodide  [86941-71-1] and R(-)-bethanechol iodide  [86941-72-2], as well as the racemate [86919-69-9], were prepared from the corresponding S(+)-, R(-)-, or RS-forms of 1-amino-2-propranol by refluxing the primary amine with a mixture of HCO2H and H2CO to produce the corresponding tertiary amines, which in turn were reacted with ClSO2NCO, the product being hydrolyzed with aqueous K2CO3 and the quaternary ammonium salts isolated by reacting the tertiary amines with excess MeI. The resulting bethanechol enantiomers and racemate were tested for their muscarinic receptor affinity (pD2) in an isolated rat ileum preparation As was previously reported for the enantiomers of acetyl-β-methylcholine, the highest activity was associated with the S configuration. The more active enantiomer had twice the affinity of the racemate, as would be the case if the R form had almost no affinity at all. It is concluded that acetyl-β-methylcholine and bethanechol satisfy the steric requirements of a common receptor site.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called New chiral ruthenium complexes for asymmetric catalytic hydrogenations, published in 1990-06-30, which mentions a compound: 53636-17-2, mainly applied to chiral ruthenium complex catalyst hydrogenation; asym hydrogenation ruthenium catalyst; crystal structure ruthenium binaphthyl complex, Product Details of 53636-17-2.

New mononuclear complexes Ru(OCOR)2(binap) [binap = bis(diphenylphosphino)-1,1′-binaphthyl, R = Me, Me3C] and cationic complexes [RuX(binap)(arene)]Y (X, Y = halo) have been prepared and characterized. These complexes and their derivatives are highly efficient catalysts for asym. hydrogenation of enamides, alkyl- and aryl-substituted acrylic acids, β,γ-unsaturated carboxylic acids, allylic and homoallylic alcs., and a variety of functionalized ketones such as β-keto esters and α-amino ketones.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Asymmetric synthesis by Ru-BINAP, published in 1995, which mentions a compound: 53636-17-2, mainly applied to ruthenium dinaphthylphosphine complex asym hydrogenation catalyst; phosphinobinaphthyl ruthenium complex asym hydrogenation catalyst, Synthetic Route of C5H13NO.

Chiral compounds were obtained in extremely high enantiomeric excesses by the Ru-BINAP catalysis. The catalysts are capable to hydrogenate numerous unsaturated substrates. The effect of substituents in ketones for enantio- and diastereo-differentiations is discussed. Practical applications in the production of pharmaceuticals and new materials are also described.

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Piperazine – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2 ) is researched.COA of Formula: C5H13NO.Gennari, Cesare; Molinari, Francesco; Cozzi, PierGiorgio; Oliva, Ambrogio published the article 《Auxiliary structure and asymmetric induction in the Mukaiyama-aldol reactions of chiral silyl ketene acetals》 about this compound( cas:53636-17-2 ) in Tetrahedron Letters. Keywords: auxiliary structure asym induction Mukaiyama aldol; silyl ketene acetal asym condensation aldehyde. Let’s learn more about this compound (cas:53636-17-2).

A variety of chiral auxiliaries [e.g., (1S,2R-Me2NCHMeCHPhOH, (S)-Me2NCH2CHMeOH] were prepared and tested for levels of asym. induction control in the Mukaiyama-aldol reaction of chiral silyl ketene acetals. Structural features required for high levels of control are discussed.

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COA of Formula: C5H13NO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Enantioselective addition of diorganozincs to aldehydes catalyzed by β-amino alcohols. Author is Noyori, R.; Suga, S.; Kawai, K.; Okada, S.; Kitamura, M.; Oguni, N.; Hayashi, M.; Kaneko, T.; Matsuda, Y..

Nucleophilic addition of dialkylzincs to aldehydes in hydrocarbon solvents is markedly accelerated by the presence of a catalytic amount of a β-dialkylamino alc. Use of certain sterically constrained chiral amino alcs. such as 3-exo-(dimethylamino)isoborneol or 1-tert-butyl-2-piperidinoethanol effects highly enantioselective catalysis, giving secondary alcs. in up to 99% ee. Dimethyl-, diethyl-, di-n-butyl-, and di-n-pentylzincs have been employed for the alkylation of substituted benzaldehydes and some olefinic or aliphatic aldehydes. Configurational correlation between the chiral auxiliary and alkylation products is discussed.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Dirhodium tetraacetate as an auxiliary chromophore in a circular dichroic study on vic-amino alcohols, published in 2005-07-18, which mentions a compound: 53636-17-2, Name is (S)-1-(Dimethylamino)propan-2-ol, Molecular C5H13NO, Category: piperazines.

The dirhodium method proposed herein, involves the in situ formation of chiral complexes of optically active vic-amino alcs. with the achiral dirhodium tetraacetate [Rh2(OAc)4] acting as an auxiliary chromophore. The resulting CD spectra are suitable for stereochem. studies, since the observed sign of Cotton effects arising within the d-d absorption bands of the metal core is determined by the chirality of the amino alc. ligand. In MeCN and CHCl3 solutions, chiral complexes are formed by axial ligation of the ligand to the metal atom(s) of the dirhodium core. This axial binding occurs through the N atom of the 1,2-amino alc. unit independently of the ligand-to-metal molar ratio, as shown from the 15N and low-temperature NMR experiments In agreement with NMR results, ESI MS experiments indicate that in solution, a mixture of chiral complexes with ligand-to-metal molar ratios 1:1 and 2:1 is present. An empirically based rule correlating the sign of Cotton effect occurring >600 nm with the stereochem. of ligand was formulated.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

COA of Formula: C5H13NO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Enantioselective addition of diorganozincs to aldehydes catalyzed by β-amino alcohols. Author is Noyori, R.; Suga, S.; Kawai, K.; Okada, S.; Kitamura, M.; Oguni, N.; Hayashi, M.; Kaneko, T.; Matsuda, Y..

Nucleophilic addition of dialkylzincs to aldehydes in hydrocarbon solvents is markedly accelerated by the presence of a catalytic amount of a β-dialkylamino alc. Use of certain sterically constrained chiral amino alcs. such as 3-exo-(dimethylamino)isoborneol or 1-tert-butyl-2-piperidinoethanol effects highly enantioselective catalysis, giving secondary alcs. in up to 99% ee. Dimethyl-, diethyl-, di-n-butyl-, and di-n-pentylzincs have been employed for the alkylation of substituted benzaldehydes and some olefinic or aliphatic aldehydes. Configurational correlation between the chiral auxiliary and alkylation products is discussed.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics