Category: 53636-17-2

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Dirhodium tetraacetate as an auxiliary chromophore in a circular dichroic study on vic-amino alcohols, published in 2005-07-18, which mentions a compound: 53636-17-2, Name is (S)-1-(Dimethylamino)propan-2-ol, Molecular C5H13NO, Category: piperazines.

The dirhodium method proposed herein, involves the in situ formation of chiral complexes of optically active vic-amino alcs. with the achiral dirhodium tetraacetate [Rh2(OAc)4] acting as an auxiliary chromophore. The resulting CD spectra are suitable for stereochem. studies, since the observed sign of Cotton effects arising within the d-d absorption bands of the metal core is determined by the chirality of the amino alc. ligand. In MeCN and CHCl3 solutions, chiral complexes are formed by axial ligation of the ligand to the metal atom(s) of the dirhodium core. This axial binding occurs through the N atom of the 1,2-amino alc. unit independently of the ligand-to-metal molar ratio, as shown from the 15N and low-temperature NMR experiments In agreement with NMR results, ESI MS experiments indicate that in solution, a mixture of chiral complexes with ligand-to-metal molar ratios 1:1 and 2:1 is present. An empirically based rule correlating the sign of Cotton effect occurring >600 nm with the stereochem. of ligand was formulated.

Here is just a brief introduction to this compound(53636-17-2)Category: piperazines, more information about the compound((S)-1-(Dimethylamino)propan-2-ol) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Electroreductive generation of (S)-(+)-N,N-dimethyl-2-(hydroxymethyl)-pyrrolidinium mercury compound for enantioselective synthesis of 2-amino-1-alkyl/aryl ethanols.COA of Formula: C5H13NO.

(S)-(+)-N,N-Dimethyl-2-(hydroxymethyl)-pyrrolidinium (DMHP+)-mercury compound mediated enantioselective reduction of aminomethyl alkyl/aryl ketones in dimethyl-formamide-2-propanol (9:1) was carried out using tetrabutylammonium tetrafluoroborate as a supporting electrolyte. The products viz. 2-amino-1-alkyl/aryl ethanols were obtained in good yield (68-92%) with 35-91% optical purity and were assigned (S)-configuration. The pinacol (racemic/meso) derivatives are also isolated as minor products (yield 5-20%) via dimerization of radical anion followed by protonation.

In some applications, this compound(53636-17-2)COA of Formula: C5H13NO is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Enantiomeric separation of β-aminoalcohol using (R)-mandelato-Cu(II) complex., published in 1994, which mentions a compound: 53636-17-2, Name is (S)-1-(Dimethylamino)propan-2-ol, Molecular C5H13NO, Application of 53636-17-2.

Enantiomeric separation of β-aminoalcs. with primary or tertiary amino groups was achieved by HPLC using ODS as the stationary phase and an aqueous solution containing (R)-mandelato-Cu(II) as the mobile phase. OPA fluorescence derivatizing reaction or Ru complex chemiluminescence reaction was applied as the postcolumn detection method.

In some applications, this compound(53636-17-2)Application of 53636-17-2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Category: piperazines. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Discovery of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors. Author is Lainchbury, Michael; Matthews, Thomas P.; McHardy, Tatiana; Boxall, Kathy J.; Walton, Michael I.; Eve, Paul D.; Hayes, Angela; Valenti, Melanie R.; de Haven Brandon, Alexis K.; Box, Gary; Aherne, G. Wynne; Reader, John C.; Raynaud, Florence I.; Eccles, Suzanne A.; Garrett, Michelle D.; Collins, Ian.

Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as potential antitumor agents, but the most advanced inhibitor series reported to date are not orally bioavailable. A novel series of potent and orally bioavailable 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrile CHK1 inhibitors was generated by hybridization of two lead scaffolds derived from fragment-based drug design and optimized for CHK1 potency and high selectivity using a cell-based assay cascade. Efficient in vivo pharmacokinetic assessment was used to identify compounds with prolonged exposure following oral dosing. The optimized compound I (CCT244747) was a potent and highly selective CHK1 inhibitor, which modulated the DNA damage response pathway in human tumor xenografts and showed antitumor activity in combination with genotoxic chemotherapies and as a single agent.

In some applications, this compound(53636-17-2)Category: piperazines is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Frelek, Jadwiga; Gorecki, Marcin; Jazwinski, Jaroslaw; Masnyk, Marek; Ruskowska, Patrycja; Szmigielski, Rafal published the article 《Configurational assignment of vic-amino alcohols from their circular dichroism spectra with dirhodium tetracetate as an auxiliary chromophore》. Keywords: configuration vic amino alc CD dirhodium tetracetate auxiliary chromophore.They researched the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2 ).Recommanded Product: (S)-1-(Dimethylamino)propan-2-ol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:53636-17-2) here.

The CD spectra of a variety of vic-amino alcs. in the presence of dirhodium tetraacetate as an auxiliary chromophore were measured in ethanol as the solvent. The method was tested with several model compounds, representing both acyclic and cyclic amino alcs., including biol. important adrenergic drugs as well as amino sugars. The study demonstrated that the sign of the Cotton effects is determined by the preferred helicity of the O-C-C-N unit in the chiral complex formed in situ. The combined anal. of the CD, UV-vis, 1H and 13C NMR indicated predisposition to form chiral complexes by initial coordination of the amino alc. at the axial coordination site followed by migration to the equatorial position. Finally, after migration of the ligand to an equatorial position(s) a bridging or a chelating complex is formed. Hence, vic-amino alcs. in ethanol act as bidentate ligands in the end.

When you point to this article, it is believed that you are also very interested in this compound(53636-17-2)Recommanded Product: (S)-1-(Dimethylamino)propan-2-ol and due to space limitations, I can only present the most important information.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Enantiomeric separation of β-aminoalcohol using (R)-mandelato-Cu(II) complex., published in 1994, which mentions a compound: 53636-17-2, Name is (S)-1-(Dimethylamino)propan-2-ol, Molecular C5H13NO, Application of 53636-17-2.

Enantiomeric separation of β-aminoalcs. with primary or tertiary amino groups was achieved by HPLC using ODS as the stationary phase and an aqueous solution containing (R)-mandelato-Cu(II) as the mobile phase. OPA fluorescence derivatizing reaction or Ru complex chemiluminescence reaction was applied as the postcolumn detection method.

In some applications, this compound(53636-17-2)Application of 53636-17-2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Electroreductive generation of (S)-(+)-N,N-dimethyl-2-(hydroxymethyl)-pyrrolidinium mercury compound for enantioselective synthesis of 2-amino-1-alkyl/aryl ethanols.COA of Formula: C5H13NO.

(S)-(+)-N,N-Dimethyl-2-(hydroxymethyl)-pyrrolidinium (DMHP+)-mercury compound mediated enantioselective reduction of aminomethyl alkyl/aryl ketones in dimethyl-formamide-2-propanol (9:1) was carried out using tetrabutylammonium tetrafluoroborate as a supporting electrolyte. The products viz. 2-amino-1-alkyl/aryl ethanols were obtained in good yield (68-92%) with 35-91% optical purity and were assigned (S)-configuration. The pinacol (racemic/meso) derivatives are also isolated as minor products (yield 5-20%) via dimerization of radical anion followed by protonation.

In some applications, this compound(53636-17-2)COA of Formula: C5H13NO is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Category: piperazines. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Discovery of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors. Author is Lainchbury, Michael; Matthews, Thomas P.; McHardy, Tatiana; Boxall, Kathy J.; Walton, Michael I.; Eve, Paul D.; Hayes, Angela; Valenti, Melanie R.; de Haven Brandon, Alexis K.; Box, Gary; Aherne, G. Wynne; Reader, John C.; Raynaud, Florence I.; Eccles, Suzanne A.; Garrett, Michelle D.; Collins, Ian.

Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as potential antitumor agents, but the most advanced inhibitor series reported to date are not orally bioavailable. A novel series of potent and orally bioavailable 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrile CHK1 inhibitors was generated by hybridization of two lead scaffolds derived from fragment-based drug design and optimized for CHK1 potency and high selectivity using a cell-based assay cascade. Efficient in vivo pharmacokinetic assessment was used to identify compounds with prolonged exposure following oral dosing. The optimized compound I (CCT244747) was a potent and highly selective CHK1 inhibitor, which modulated the DNA damage response pathway in human tumor xenografts and showed antitumor activity in combination with genotoxic chemotherapies and as a single agent.

In some applications, this compound(53636-17-2)Category: piperazines is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Frelek, Jadwiga; Gorecki, Marcin; Jazwinski, Jaroslaw; Masnyk, Marek; Ruskowska, Patrycja; Szmigielski, Rafal published the article 《Configurational assignment of vic-amino alcohols from their circular dichroism spectra with dirhodium tetracetate as an auxiliary chromophore》. Keywords: configuration vic amino alc CD dirhodium tetracetate auxiliary chromophore.They researched the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2 ).Recommanded Product: (S)-1-(Dimethylamino)propan-2-ol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:53636-17-2) here.

The CD spectra of a variety of vic-amino alcs. in the presence of dirhodium tetraacetate as an auxiliary chromophore were measured in ethanol as the solvent. The method was tested with several model compounds, representing both acyclic and cyclic amino alcs., including biol. important adrenergic drugs as well as amino sugars. The study demonstrated that the sign of the Cotton effects is determined by the preferred helicity of the O-C-C-N unit in the chiral complex formed in situ. The combined anal. of the CD, UV-vis, 1H and 13C NMR indicated predisposition to form chiral complexes by initial coordination of the amino alc. at the axial coordination site followed by migration to the equatorial position. Finally, after migration of the ligand to an equatorial position(s) a bridging or a chelating complex is formed. Hence, vic-amino alcs. in ethanol act as bidentate ligands in the end.

When you point to this article, it is believed that you are also very interested in this compound(53636-17-2)Recommanded Product: (S)-1-(Dimethylamino)propan-2-ol and due to space limitations, I can only present the most important information.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《An improved rhodium-DIOP catalyst system for the homogeneous asymmetric hydrogenation of acetophenone》. Authors are Chan, Albert S. C.; Landis, Clark R..The article about the compound:(S)-1-(Dimethylamino)propan-2-olcas:53636-17-2,SMILESS:C[C@H](O)CN(C)C).Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol. Through the article, more information about this compound (cas:53636-17-2) is conveyed.

Optical yields as high as 79% were obtained in the title reaction when a rhodium-DIOP-chloride catalyst system containing a tertiary hydroxyalkylamine promoter was used. The various factors governing the rates and selectivities are discussed.

As far as I know, this compound(53636-17-2)Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics