Category: 53636-17-2

Zhang, Ya-Wen; Shen, Zong-Xuan; Qin, Hong-Bing; Li, Yong-Hua; Yu, Kai-Bei published an article about the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2,SMILESS:C[C@H](O)CN(C)C ).Application of 53636-17-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:53636-17-2) through the article.

Some α-(dialkylamino) ketones and β-(dialkyl amino) ketones were reduced stereoselectively by 2 mol of borane-tetrahydrofuran in the presence of 10 mol% of an in situ-formed chiral oxazaborolidine, followed by diluted hydrochloric acid. The catalysts in this study included (3aR)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, (3aS)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole and (4R,5S)-2-methyl-4,5-diphenyl-1,3,2-oxazaborolidine. The resulting amino alc.-borane complexes were treated with hydrogen chloride-glycol-methanol to give the optically active amino alc. with the ee up to 99%. For example, the reduction of 3-(4-morpholinyl)-1-phenyl-1-propanone gave (+)-(αR)-α-phenyl-4-morpholinepropanol in 87.3% yield. The intermediate α-phenyl-4-morpholinepropanol-borane complex was characterized by x-ray crystallog.

Compound(53636-17-2)Application of 53636-17-2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-1-(Dimethylamino)propan-2-ol), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Banno, Taisuke; Kawada, Kazuo; Matsumura, Shuichi researched the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2 ).Safety of (S)-1-(Dimethylamino)propan-2-ol.They published the article 《Chemo-enzymatic synthesis and properties of novel optically active cationics containing carbonate linkages》 about this compound( cas:53636-17-2 ) in Journal of Oleo Science. Keywords: carbonate type cationic synthesis enzyme. We’ll tell you more about this compound (cas:53636-17-2).

Novel optically active carbonate-type cationics were designed and synthesized via a green method. A series of n-alkyl N,N-dimethylaminoalkyl carbonates was prepared via a two-step successive carbonate exchange reaction of di-Ph carbonate with 1-alkanol followed by the reaction of the optically active or racemic amino alc. in the presence of triethylamine. The quaternarization of the N,N-dimethylamino group was carried out using Me iodide. Furthermore, optically active cationics were prepared by the lipase-catalyzed enantioselective hydrolysis of the racemic cationics. Carbonate-type cationics having an isopropylene linkage showed high hydrolytic stability. They exhibited surfactant properties similar to those of the corresponding racemic cationics. Although no significant differences in the antimicrobial activities were observed owing to the stereochem. of the cationics, the biodegradability was strongly influenced by the stereochem. Some optically active cationics were rapidly biodegraded by activated sludge.

From this literature《Chemo-enzymatic synthesis and properties of novel optically active cationics containing carbonate linkages》,we know some information about this compound(53636-17-2)Safety of (S)-1-(Dimethylamino)propan-2-ol, but this is not all information, there are many literatures related to this compound(53636-17-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Quality Control of (S)-1-(Dimethylamino)propan-2-ol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Fluoride ion-catalyzed reduction of aldehydes and ketones with hydrosilanes. Synthetic and mechanistic aspects and an application to the threo-directed reduction of α-substituted alkanones. Author is Fujita, Makoto; Hiyama, Tamejiro.

Reduction of aldehydes and ketones with hydrosilanes proceeded in the presence of a catalytic amount of Bu4NF or tris(diethylamino)sulfonium difluorotrimethylsilicate in aprotic polar solvents under mild conditions. A significant isotope effect (kH/kD = 1.50) was observed in competitive reduction of acetophenone with HSiMe2Ph and DSiMe2Ph. The reaction was first order in the concentration of HMPA. Reduction of 2-methylcyclohexanone gave cis-2-methylcyclohexanol with selectivities up to 95%. The kinetic and stereochem. results suggest that a hexavalent fluorosilicate [HSiR3F(HMPA)]- is involved. α-Alkoxy (acyloxy or dimethylamino) ketones were transformed to threo alcs. in high diastereoselectivities. The reduction was also applied to α-methyl-β-oxo amides, RCOCHMeCONR12, to afford the corresponding threo alcs. in >98% selectivity. The threo selectivity is explained in terms of the Felkin-Anh model in which interaction of carbonyl oxygen with a countercation is ideally suppressed. The threo-directed reduction was applied to (R)-1-phenyl-4-(2-tetrahydropyranyloxy)-1-penten-3-one and N-(2-benzoylpropanoyl)piperidine. The resulting threo alcs. were resp. converted into (2R,3S)-2,3-(cyclohexylidenedioxy)butanal, a key intermediate of daunosamine synthesis, and into a pharmacol. useful compound, threo-N-(3-hydroxy-2-methyl-3-phenylpropyl)piperidine.

From this literature《Fluoride ion-catalyzed reduction of aldehydes and ketones with hydrosilanes. Synthetic and mechanistic aspects and an application to the threo-directed reduction of α-substituted alkanones》,we know some information about this compound(53636-17-2)Quality Control of (S)-1-(Dimethylamino)propan-2-ol, but this is not all information, there are many literatures related to this compound(53636-17-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Gas chromatographic separation of some enantiomers on optically active copper(II) complexes.Synthetic Route of C5H13NO.

Gas chromatog. separation of optically active amino alcs., amines, amino esters, and alcs. was achieved using optically active Cu(II) complexes. The binuclear Cu(II) complex of either (R)-2-(salicylidenamino)-1,1-bis(5-tert-butyl-2-octyloxyphenyl)propan-1-ol or (S)-2-(salicylidenamino)-1,1-diphenylpropan-1-ol was incorporated into the stationary phase on both capillary and packed columns. Separation results for 13 compounds, using the carrier gas, are tabulated. Trimethylsilylation decreased the separation of amino alc. enantiomers, and acylation destroyed it entirely.

From this literature《Gas chromatographic separation of some enantiomers on optically active copper(II) complexes》,we know some information about this compound(53636-17-2)Synthetic Route of C5H13NO, but this is not all information, there are many literatures related to this compound(53636-17-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Zhang, Ya-Wen; Shen, Zong-Xuan; Qin, Hong-Bing; Li, Yong-Hua; Yu, Kai-Bei published an article about the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2,SMILESS:C[C@H](O)CN(C)C ).Application of 53636-17-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:53636-17-2) through the article.

Some α-(dialkylamino) ketones and β-(dialkyl amino) ketones were reduced stereoselectively by 2 mol of borane-tetrahydrofuran in the presence of 10 mol% of an in situ-formed chiral oxazaborolidine, followed by diluted hydrochloric acid. The catalysts in this study included (3aR)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, (3aS)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole and (4R,5S)-2-methyl-4,5-diphenyl-1,3,2-oxazaborolidine. The resulting amino alc.-borane complexes were treated with hydrogen chloride-glycol-methanol to give the optically active amino alc. with the ee up to 99%. For example, the reduction of 3-(4-morpholinyl)-1-phenyl-1-propanone gave (+)-(αR)-α-phenyl-4-morpholinepropanol in 87.3% yield. The intermediate α-phenyl-4-morpholinepropanol-borane complex was characterized by x-ray crystallog.

Compound(53636-17-2)Application of 53636-17-2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-1-(Dimethylamino)propan-2-ol), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Banno, Taisuke; Kawada, Kazuo; Matsumura, Shuichi researched the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2 ).Safety of (S)-1-(Dimethylamino)propan-2-ol.They published the article 《Chemo-enzymatic synthesis and properties of novel optically active cationics containing carbonate linkages》 about this compound( cas:53636-17-2 ) in Journal of Oleo Science. Keywords: carbonate type cationic synthesis enzyme. We’ll tell you more about this compound (cas:53636-17-2).

Novel optically active carbonate-type cationics were designed and synthesized via a green method. A series of n-alkyl N,N-dimethylaminoalkyl carbonates was prepared via a two-step successive carbonate exchange reaction of di-Ph carbonate with 1-alkanol followed by the reaction of the optically active or racemic amino alc. in the presence of triethylamine. The quaternarization of the N,N-dimethylamino group was carried out using Me iodide. Furthermore, optically active cationics were prepared by the lipase-catalyzed enantioselective hydrolysis of the racemic cationics. Carbonate-type cationics having an isopropylene linkage showed high hydrolytic stability. They exhibited surfactant properties similar to those of the corresponding racemic cationics. Although no significant differences in the antimicrobial activities were observed owing to the stereochem. of the cationics, the biodegradability was strongly influenced by the stereochem. Some optically active cationics were rapidly biodegraded by activated sludge.

From this literature《Chemo-enzymatic synthesis and properties of novel optically active cationics containing carbonate linkages》,we know some information about this compound(53636-17-2)Safety of (S)-1-(Dimethylamino)propan-2-ol, but this is not all information, there are many literatures related to this compound(53636-17-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Gas chromatographic separation of some enantiomers on optically active copper(II) complexes.Synthetic Route of C5H13NO.

Gas chromatog. separation of optically active amino alcs., amines, amino esters, and alcs. was achieved using optically active Cu(II) complexes. The binuclear Cu(II) complex of either (R)-2-(salicylidenamino)-1,1-bis(5-tert-butyl-2-octyloxyphenyl)propan-1-ol or (S)-2-(salicylidenamino)-1,1-diphenylpropan-1-ol was incorporated into the stationary phase on both capillary and packed columns. Separation results for 13 compounds, using the carrier gas, are tabulated. Trimethylsilylation decreased the separation of amino alc. enantiomers, and acylation destroyed it entirely.

From this literature《Gas chromatographic separation of some enantiomers on optically active copper(II) complexes》,we know some information about this compound(53636-17-2)Synthetic Route of C5H13NO, but this is not all information, there are many literatures related to this compound(53636-17-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Quality Control of (S)-1-(Dimethylamino)propan-2-ol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Fluoride ion-catalyzed reduction of aldehydes and ketones with hydrosilanes. Synthetic and mechanistic aspects and an application to the threo-directed reduction of α-substituted alkanones. Author is Fujita, Makoto; Hiyama, Tamejiro.

Reduction of aldehydes and ketones with hydrosilanes proceeded in the presence of a catalytic amount of Bu4NF or tris(diethylamino)sulfonium difluorotrimethylsilicate in aprotic polar solvents under mild conditions. A significant isotope effect (kH/kD = 1.50) was observed in competitive reduction of acetophenone with HSiMe2Ph and DSiMe2Ph. The reaction was first order in the concentration of HMPA. Reduction of 2-methylcyclohexanone gave cis-2-methylcyclohexanol with selectivities up to 95%. The kinetic and stereochem. results suggest that a hexavalent fluorosilicate [HSiR3F(HMPA)]- is involved. α-Alkoxy (acyloxy or dimethylamino) ketones were transformed to threo alcs. in high diastereoselectivities. The reduction was also applied to α-methyl-β-oxo amides, RCOCHMeCONR12, to afford the corresponding threo alcs. in >98% selectivity. The threo selectivity is explained in terms of the Felkin-Anh model in which interaction of carbonyl oxygen with a countercation is ideally suppressed. The threo-directed reduction was applied to (R)-1-phenyl-4-(2-tetrahydropyranyloxy)-1-penten-3-one and N-(2-benzoylpropanoyl)piperidine. The resulting threo alcs. were resp. converted into (2R,3S)-2,3-(cyclohexylidenedioxy)butanal, a key intermediate of daunosamine synthesis, and into a pharmacol. useful compound, threo-N-(3-hydroxy-2-methyl-3-phenylpropyl)piperidine.

From this literature《Fluoride ion-catalyzed reduction of aldehydes and ketones with hydrosilanes. Synthetic and mechanistic aspects and an application to the threo-directed reduction of α-substituted alkanones》,we know some information about this compound(53636-17-2)Quality Control of (S)-1-(Dimethylamino)propan-2-ol, but this is not all information, there are many literatures related to this compound(53636-17-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C5H13NO. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Rapid determination of enantiomeric excess using infrared thermography. Author is Millot, Nicolas; Borman, Phil; Anson, Mike S.; Campbell, Ian B.; Macdonald, Simon J. F.; Mahmoudian, Mahmoud.

IR thermog. (IRT) is presented as a novel technique to screen a potentially large number of asym. catalysts or substrates in a high-throughput fashion. IRT was used as a simple, rapid, and practical approach for initial screening of the substrate specificity of Candida antarctica lipase. This was carried out using a 96-well microtiter plate format. Potential advantages and limitations of IRT for the enzymic stereoselective acylation of primary and secondary alcs. of interest are discussed.

There is still a lot of research devoted to this compound(SMILES：C[C@H](O)CN(C)C)Electric Literature of C5H13NO, and with the development of science, more effects of this compound(53636-17-2) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 53636-17-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Direct asymmetric aldol-Tishchenko reaction of aliphatic ketones catalyzed by syn-amino alcohol-Yb(III);complexes.

The asym. direct aldol condensation of aldehydes with ethyl- and Pr ketones is catalyzed by syn-α-amino alc.-Yb(OTf)3 complexes, yielding the anti-1,3-diol mono-esters with high diastereocontrol and good enantioselectivity. Three adjacent stereogenic centers are created in a simultaneous aldol condensation and Evans-Tishchenko reduction in an acyclic system.

There is still a lot of research devoted to this compound(SMILES：C[C@H](O)CN(C)C)HPLC of Formula: 53636-17-2, and with the development of science, more effects of this compound(53636-17-2) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics