Category: 53788-12-8

On March 28, 2013, Kolbe, Ludger; Scherner, Cathrin published a patent.Related Products of 53788-12-8 The title of the patent was Heterocyclocarbonyl aminothiazoles, cosmetic or dermatological preparations containing said heterocyclocarbonyl aminothiazoles, and use thereof to combat or prevent undesired pigmentation of the skin. And the patent contained the following:

The invention relates to cosmetic and dermatol. preparations having an effective content of one or more heterocyclocarbonyl aminothiazoles of formula I and to the use thereof for the cosmetic or dermatol. treatment and/or prophylaxis of undesired skin pigmentation. Compounds of formula I wherein R1 is morpholino, piperidin-1-yl, piperazin-1-yl, etc.; R2 is H, (un)branched C1-24 alkyl, (un)branched C1-24 alkenyl, etc.; X is H, Ph, 2,4-dihydroxyphenyl, etc.; Y is H, aryl, COO-aryl, etc.; as free bases and their cosmetic and dermatol. acceptable salts, are claimed. Example compound II was prepared by thioamidation of 4-morpholinecarbonyl chloride with thiourea followed by cyclocondensation of the resulting N-morpholinocarbonylthiourea with 2-bromo-2′,4′-bismethoxycarbonyloxyacetophenone. All the invention compounds were evaluated for their ability to inhibit pigmentation. From the assay, it was determined that example compound II exhibited 97% of inhibition. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Related Products of 53788-12-8

The Article related to heterocyclocarbonyl aminothiazole preparation cosmetic dermatol treatment pigmentation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 53788-12-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On August 31, 1977, Saikawa, Isamu; Takano, Shuntaro; Yoshida, Chosaku; Takashima, Okuta; Momonoi, Kaishu; Yasuda, Takashi; Kasuya, Kyoko published an article.Name: 4-Ethyl-piperazine-1-carbonyl chloride The title of the article was Studies on 尾-lactam antibiotics for medicinal purposes. I. Synthesis of D(-)-伪-[(monooxo)-1-piperazinecarboxamido]benzylpenicillins and structure-antibacterial activity. And the article contained the following:

D-(-)-I (R1 = Me, Et, PhCH2, Ac, MeSO2, Ph), D-(-)-II (R1 = C1-4 alkyl, PhCH2, Ac, EtCO, PrCO, BuCO, ClCH2CO, MeSO2), and D-(-)-III (R1 = H, C1-4 alkyl, PhCH2, allyl) were prepared by N-acylation of aminobenzylpenicillin (IV). In vitro bactericidal activity of I – III against S. aureus, E. coli, P. aeruginosa, P. vulgaris, and K. pneumoniae decreased in the order of II > I > III. The bactericidal activity of these compounds against P. aeruginosa and K. pneumoniae was stronger than that of IV or carbenicillin. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Name: 4-Ethyl-piperazine-1-carbonyl chloride

The Article related to bactericides piperazinecarboxamidobenzylpenicillin, piperazinecarboxamidobenzylpenicillin, penicillin piperazinecarboxamidobenzyl, benzylpenicillin piperazinecarboxamido, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Name: 4-Ethyl-piperazine-1-carbonyl chloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On March 28, 2013, Kolbe, Ludger; Scherner, Cathrin published a patent.Computed Properties of 53788-12-8 The title of the patent was Heterocyclocarbonyl aminothiazoles, cosmetic or dermatological preparations containing said heterocyclocarbonyl aminothiazoles, and use thereof to combat or prevent undesired pigmentation of the skin. And the patent contained the following:

The invention relates to cosmetic and dermatol. preparations having an effective content of one or more heterocyclocarbonyl aminothiazoles of formula I and to the use thereof for the cosmetic or dermatol. treatment and/or prophylaxis of undesired skin pigmentation. Compounds of formula I wherein R1 is morpholino, piperidin-1-yl, piperazin-1-yl, etc.; R2 is H, (un)branched C1-24 alkyl, (un)branched C1-24 alkenyl, etc.; X is H, Ph, 2,4-dihydroxyphenyl, etc.; Y is H, aryl, COO-aryl, etc.; as free bases and their cosmetic and dermatol. acceptable salts, are claimed. Example compound II was prepared by thioamidation of 4-morpholinecarbonyl chloride with thiourea followed by cyclocondensation of the resulting N-(morpholinocarbonyl)thiourea with 2-bromo-2′,4′-bismethoxycarbonyloxyacetophenone. All the invention compounds were evaluated for their ability to inhibit pigmentation. From the assay, it was determined that example compound II exhibited 97% of inhibition. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Computed Properties of 53788-12-8

The Article related to heterocyclocarbonyl aminothiazole preparation cosmetic dermatol treatment pigmentation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 53788-12-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On July 23, 1992, Boettcher, Matthias; Jaehrling, Renate; Walther, Klaus; Haber, Hanka; Rackwitz, Christina; Mohs, Barbara; Franke, Rainer; Kuehne, Ronald; Koch, Andreas published a patent.Application In Synthesis of 4-Ethyl-piperazine-1-carbonyl chloride The title of the patent was Preparation of penicillin amides as antibacterials. And the patent contained the following:

Title compounds [I; R1 = H, acyl; R2 = H, OH; R3 = H, alkyl; R4 = Yn(CONH)mZpX; m, n, p = 0, 1; Y, Z = alkyl; X = (substituted) aryl, heterocyclic; or R3R4N = (substituted) heterocycyl], were prepared Thus, piperacillin in CH2Cl2 containing Et3N at -10° was treated with ClCO2CHMe2 and then with PhCH2NH2 in CH2Cl2 to give 78% piperacillin benzylamide. I showed min. inhibitory concentrations of 4-8 mM/mL against Pseudomonas aeruginosa SG 137. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Application In Synthesis of 4-Ethyl-piperazine-1-carbonyl chloride

The Article related to penicillin amide preparation antibacterial, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Application In Synthesis of 4-Ethyl-piperazine-1-carbonyl chloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On March 28, 2013, Kolbe, Ludger; Scherner, Cathrin published a patent.Related Products of 53788-12-8 The title of the patent was Heterocyclocarbonyl aminothiazoles, cosmetic or dermatological preparations containing said heterocyclocarbonyl aminothiazoles, and use thereof to combat or prevent undesired pigmentation of the skin. And the patent contained the following:

The invention relates to cosmetic and dermatol. preparations having an effective content of one or more heterocyclocarbonyl aminothiazoles of formula I and to the use thereof for the cosmetic or dermatol. treatment and/or prophylaxis of undesired skin pigmentation. Compounds of formula I wherein R1 is morpholino, piperidin-1-yl, piperazin-1-yl, etc.; R2 is H, (un)branched C1-24 alkyl, (un)branched C1-24 alkenyl, etc.; X is H, Ph, 2,4-dihydroxyphenyl, etc.; Y is H, aryl, COO-aryl, etc.; as free bases and their cosmetic and dermatol. acceptable salts, are claimed. Example compound II was prepared by thioamidation of 4-morpholinecarbonyl chloride with thiourea followed by cyclocondensation of the resulting N-morpholinocarbonylthiourea with 2-bromo-2′,4′-bismethoxycarbonyloxyacetophenone. All the invention compounds were evaluated for their ability to inhibit pigmentation. From the assay, it was determined that example compound II exhibited 97% of inhibition. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Related Products of 53788-12-8

The Article related to heterocyclocarbonyl aminothiazole preparation cosmetic dermatol treatment pigmentation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 53788-12-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On March 28, 2013, Kolbe, Ludger; Scherner, Cathrin published a patent.Computed Properties of 53788-12-8 The title of the patent was Heterocyclocarbonyl aminothiazoles, cosmetic or dermatological preparations containing said heterocyclocarbonyl aminothiazoles, and use thereof to combat or prevent undesired pigmentation of the skin. And the patent contained the following:

The invention relates to cosmetic and dermatol. preparations having an effective content of one or more heterocyclocarbonyl aminothiazoles of formula I and to the use thereof for the cosmetic or dermatol. treatment and/or prophylaxis of undesired skin pigmentation. Compounds of formula I wherein R1 is morpholino, piperidin-1-yl, piperazin-1-yl, etc.; R2 is H, (un)branched C1-24 alkyl, (un)branched C1-24 alkenyl, etc.; X is H, Ph, 2,4-dihydroxyphenyl, etc.; Y is H, aryl, COO-aryl, etc.; as free bases and their cosmetic and dermatol. acceptable salts, are claimed. Example compound II was prepared by thioamidation of 4-morpholinecarbonyl chloride with thiourea followed by cyclocondensation of the resulting N-(morpholinocarbonyl)thiourea with 2-bromo-2′,4′-bismethoxycarbonyloxyacetophenone. All the invention compounds were evaluated for their ability to inhibit pigmentation. From the assay, it was determined that example compound II exhibited 97% of inhibition. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Computed Properties of 53788-12-8

The Article related to heterocyclocarbonyl aminothiazole preparation cosmetic dermatol treatment pigmentation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 53788-12-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On August 31, 1977, Saikawa, Isamu; Takano, Shuntaro; Yoshida, Chosaku; Takashima, Okuta; Momonoi, Kaishu; Yasuda, Takashi; Kasuya, Kyoko published an article.Name: 4-Ethyl-piperazine-1-carbonyl chloride The title of the article was Studies on 尾-lactam antibiotics for medicinal purposes. I. Synthesis of D(-)-伪-[(monooxo)-1-piperazinecarboxamido]benzylpenicillins and structure-antibacterial activity. And the article contained the following:

D-(-)-I (R1 = Me, Et, PhCH2, Ac, MeSO2, Ph), D-(-)-II (R1 = C1-4 alkyl, PhCH2, Ac, EtCO, PrCO, BuCO, ClCH2CO, MeSO2), and D-(-)-III (R1 = H, C1-4 alkyl, PhCH2, allyl) were prepared by N-acylation of aminobenzylpenicillin (IV). In vitro bactericidal activity of I – III against S. aureus, E. coli, P. aeruginosa, P. vulgaris, and K. pneumoniae decreased in the order of II > I > III. The bactericidal activity of these compounds against P. aeruginosa and K. pneumoniae was stronger than that of IV or carbenicillin. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Name: 4-Ethyl-piperazine-1-carbonyl chloride

The Article related to bactericides piperazinecarboxamidobenzylpenicillin, piperazinecarboxamidobenzylpenicillin, penicillin piperazinecarboxamidobenzyl, benzylpenicillin piperazinecarboxamido, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Name: 4-Ethyl-piperazine-1-carbonyl chloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On July 23, 1992, Boettcher, Matthias; Jaehrling, Renate; Walther, Klaus; Haber, Hanka; Rackwitz, Christina; Mohs, Barbara; Franke, Rainer; Kuehne, Ronald; Koch, Andreas published a patent.Application In Synthesis of 4-Ethyl-piperazine-1-carbonyl chloride The title of the patent was Preparation of penicillin amides as antibacterials. And the patent contained the following:

Title compounds [I; R1 = H, acyl; R2 = H, OH; R3 = H, alkyl; R4 = Yn(CONH)mZpX; m, n, p = 0, 1; Y, Z = alkyl; X = (substituted) aryl, heterocyclic; or R3R4N = (substituted) heterocycyl], were prepared Thus, piperacillin in CH2Cl2 containing Et3N at -10° was treated with ClCO2CHMe2 and then with PhCH2NH2 in CH2Cl2 to give 78% piperacillin benzylamide. I showed min. inhibitory concentrations of 4-8 mM/mL against Pseudomonas aeruginosa SG 137. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Application In Synthesis of 4-Ethyl-piperazine-1-carbonyl chloride

The Article related to penicillin amide preparation antibacterial, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Application In Synthesis of 4-Ethyl-piperazine-1-carbonyl chloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On March 28, 2013, Kolbe, Ludger; Scherner, Cathrin published a patent.Related Products of 53788-12-8 The title of the patent was Heterocyclocarbonyl aminothiazoles, cosmetic or dermatological preparations containing said heterocyclocarbonyl aminothiazoles, and use thereof to combat or prevent undesired pigmentation of the skin. And the patent contained the following:

The invention relates to cosmetic and dermatol. preparations having an effective content of one or more heterocyclocarbonyl aminothiazoles of formula I and to the use thereof for the cosmetic or dermatol. treatment and/or prophylaxis of undesired skin pigmentation. Compounds of formula I wherein R1 is morpholino, piperidin-1-yl, piperazin-1-yl, etc.; R2 is H, (un)branched C1-24 alkyl, (un)branched C1-24 alkenyl, etc.; X is H, Ph, 2,4-dihydroxyphenyl, etc.; Y is H, aryl, COO-aryl, etc.; as free bases and their cosmetic and dermatol. acceptable salts, are claimed. Example compound II was prepared by thioamidation of 4-morpholinecarbonyl chloride with thiourea followed by cyclocondensation of the resulting N-morpholinocarbonylthiourea with 2-bromo-2′,4′-bismethoxycarbonyloxyacetophenone. All the invention compounds were evaluated for their ability to inhibit pigmentation. From the assay, it was determined that example compound II exhibited 97% of inhibition. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Related Products of 53788-12-8

The Article related to heterocyclocarbonyl aminothiazole preparation cosmetic dermatol treatment pigmentation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 53788-12-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On March 28, 2013, Kolbe, Ludger; Scherner, Cathrin published a patent.Computed Properties of 53788-12-8 The title of the patent was Heterocyclocarbonyl aminothiazoles, cosmetic or dermatological preparations containing said heterocyclocarbonyl aminothiazoles, and use thereof to combat or prevent undesired pigmentation of the skin. And the patent contained the following:

The invention relates to cosmetic and dermatol. preparations having an effective content of one or more heterocyclocarbonyl aminothiazoles of formula I and to the use thereof for the cosmetic or dermatol. treatment and/or prophylaxis of undesired skin pigmentation. Compounds of formula I wherein R1 is morpholino, piperidin-1-yl, piperazin-1-yl, etc.; R2 is H, (un)branched C1-24 alkyl, (un)branched C1-24 alkenyl, etc.; X is H, Ph, 2,4-dihydroxyphenyl, etc.; Y is H, aryl, COO-aryl, etc.; as free bases and their cosmetic and dermatol. acceptable salts, are claimed. Example compound II was prepared by thioamidation of 4-morpholinecarbonyl chloride with thiourea followed by cyclocondensation of the resulting N-(morpholinocarbonyl)thiourea with 2-bromo-2′,4′-bismethoxycarbonyloxyacetophenone. All the invention compounds were evaluated for their ability to inhibit pigmentation. From the assay, it was determined that example compound II exhibited 97% of inhibition. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Computed Properties of 53788-12-8

The Article related to heterocyclocarbonyl aminothiazole preparation cosmetic dermatol treatment pigmentation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 53788-12-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics