Category: 54903-09-2

Electric Literature of C9H7NO3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5- or 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones. Author is Ivanova, Yordanka B.; Momekov, Georgi T.; Petrov, Ognyan I..

A number of chalcones bearing an oxazole cycle I (R1 = R2 = R3 = R4 = H, OCH3; X, Y = O, NH) were synthesized by Claisen-Schmidt condensation of 5-acetyl-2(3H)-benzoxazolone or 6-acetyl-2(3H)-benzoxazolone with appropriate aldehydes. The chalcones were evaluated for cytotoxic activity against several tumor cell lines – BV-173 (human B cell precursor leukemia), MCF-7 and MDA-MB-231 (human breast adenocarcinoma) using the MTT-dye reduction assay. The tested compounds exhibit concentration-dependent cytotoxic effects at micromolar concentrations Exposure of the BV-173 tumor cell line to compound I (R1 = H; R2 = R3 = R4 = OCH3; X = NH; Y = O) results in strong mono- and oligonucleosomal fragmentation of genomic DNA, as evidenced by a ‘cell death detection’ ELISA kit, which unambiguously indicates that the induction of apoptosis is implicated in the cytotoxic mode of action of the tested compound

The article 《New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5- or 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones》 also mentions many details about this compound(54903-09-2)Electric Literature of C9H7NO3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Photochemical reactions of N-2,3-dihydrobenzoxazol-2-ones, published in 1979-04-30, which mentions a compound: 54903-09-2, Name is 6-Acetylbenzo[d]oxazol-2(3H)-one, Molecular C9H7NO3, Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one.

Photo-Fries rearrangements of N-acyl-2,3-dihydrobenzoxazol-2-ones (I; R = Ac, COEt, COPr, COCHMe2, Bz, COC6H4Me-p) are described. Irradiation of I in MeCN afforded a mixture of 2-acyl-2,3-dihydrobenzoxazol-2-one and 6-acyl-2,3-dihydrobenzoxazol-2-one together with other minor products. However, I (R = H, Me) were very photostable. The reaction scheme involving Norrish type I dissociation is discussed.

The article 《Photochemical reactions of N-2,3-dihydrobenzoxazol-2-ones》 also mentions many details about this compound(54903-09-2)Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C9H7NO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of novel substituted 1,3-diarylpropenone derivatives and their in vitro cytotoxic activity. Author is Ivanova, Yordanka; Momekov, Georgi; Petrov, Ognyan.

The synthesis of 6-[3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone (I), its N-alkyl derivatives and their cytotoxic activity in vitro against the human cell line BV-173 (chronic myeloid leukemia in lymphoblast crisis) are described. 3-Methyl-6-[3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-2(3H)-benzoxazolone as a constitutional isomer of 3-methyl-6-[3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(3H)-benzoxazolone was also synthesized and its influence on cytotoxic activity was investigated.

The article 《Synthesis of novel substituted 1,3-diarylpropenone derivatives and their in vitro cytotoxic activity》 also mentions many details about this compound(54903-09-2)Synthetic Route of C9H7NO3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C9H7NO3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5- or 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones. Author is Ivanova, Yordanka B.; Momekov, Georgi T.; Petrov, Ognyan I..

A number of chalcones bearing an oxazole cycle I (R1 = R2 = R3 = R4 = H, OCH3; X, Y = O, NH) were synthesized by Claisen-Schmidt condensation of 5-acetyl-2(3H)-benzoxazolone or 6-acetyl-2(3H)-benzoxazolone with appropriate aldehydes. The chalcones were evaluated for cytotoxic activity against several tumor cell lines – BV-173 (human B cell precursor leukemia), MCF-7 and MDA-MB-231 (human breast adenocarcinoma) using the MTT-dye reduction assay. The tested compounds exhibit concentration-dependent cytotoxic effects at micromolar concentrations Exposure of the BV-173 tumor cell line to compound I (R1 = H; R2 = R3 = R4 = OCH3; X = NH; Y = O) results in strong mono- and oligonucleosomal fragmentation of genomic DNA, as evidenced by a ‘cell death detection’ ELISA kit, which unambiguously indicates that the induction of apoptosis is implicated in the cytotoxic mode of action of the tested compound

The article 《New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5- or 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones》 also mentions many details about this compound(54903-09-2)Electric Literature of C9H7NO3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Photochemical reactions of N-2,3-dihydrobenzoxazol-2-ones, published in 1979-04-30, which mentions a compound: 54903-09-2, Name is 6-Acetylbenzo[d]oxazol-2(3H)-one, Molecular C9H7NO3, Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one.

Photo-Fries rearrangements of N-acyl-2,3-dihydrobenzoxazol-2-ones (I; R = Ac, COEt, COPr, COCHMe2, Bz, COC6H4Me-p) are described. Irradiation of I in MeCN afforded a mixture of 2-acyl-2,3-dihydrobenzoxazol-2-one and 6-acyl-2,3-dihydrobenzoxazol-2-one together with other minor products. However, I (R = H, Me) were very photostable. The reaction scheme involving Norrish type I dissociation is discussed.

The article 《Photochemical reactions of N-2,3-dihydrobenzoxazol-2-ones》 also mentions many details about this compound(54903-09-2)Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C9H7NO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of novel substituted 1,3-diarylpropenone derivatives and their in vitro cytotoxic activity. Author is Ivanova, Yordanka; Momekov, Georgi; Petrov, Ognyan.

The synthesis of 6-[3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone (I), its N-alkyl derivatives and their cytotoxic activity in vitro against the human cell line BV-173 (chronic myeloid leukemia in lymphoblast crisis) are described. 3-Methyl-6-[3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-2(3H)-benzoxazolone as a constitutional isomer of 3-methyl-6-[3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(3H)-benzoxazolone was also synthesized and its influence on cytotoxic activity was investigated.

The article 《Synthesis of novel substituted 1,3-diarylpropenone derivatives and their in vitro cytotoxic activity》 also mentions many details about this compound(54903-09-2)Synthetic Route of C9H7NO3, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Quality Control of 6-Acetylbenzo[d]oxazol-2(3H)-one. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Pharmacomodulation of the benzoxazolinone model by aryl-piperazine structure. Author is Bermann, Marie Christine; Bonte, Jean Paul; Lesieur-Demarquilly, Isabelle; Debaert, Michel; Lesieur, Daniel; Leinot, Michel; Benoit, Joseph; Labrid, Claude.

N-(Piperazinoalkyl)benzoxazolinones I (R = H, CF3, OMe, F, Me; n = 1, 2, 3; R1 = H, PhCO, 2-ClC6H4CO, MeCO, EtCO) were prepared from benzoxazolinones II; I have analgesic activity and are useful as psychotropics (no data). Thus, II (R1 = H) was heated with HCHO and 1-phenylpiperazine to give I (R = R1 = H, n = 1). I (n = 2, 3) were prepared from II and 1-(chloroalkyl)-4-phenylpiperazines.

The article 《Pharmacomodulation of the benzoxazolinone model by aryl-piperazine structure》 also mentions many details about this compound(54903-09-2)Quality Control of 6-Acetylbenzo[d]oxazol-2(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C9H7NO3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Towards understanding the role of Lewis acid on the regioselectivity and mechanism for the acetylation reaction of 2-benzoxazolinone with acetyl chloride: a DFT study. Author is Yahia, Wassila; Nacereddine, Abdelmalek Khorief; Liacha, Messaoud.

A theor. study of the role of the Lewis acid on the regioselectivity in the acylation reaction of 2-benzoxazolinone with acetyl chloride has been carried out through DFT calculations at the B3LYP/6-31G** level of theory. FMO anal. and DFT-based reactivity indexes predicted favorable of the 6-regioisomer product. Anal. of the potential energy surfaces indicates that this acylation reaction proceeds with high 6-regioselectivity due to the favorable interactions in this pathway. The results obtained corroborate very well with the exptl. data.

After consulting a lot of data, we found that this compound(54903-09-2)Electric Literature of C9H7NO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and pharmacological evaluation of antioxidant chalcone derivatives of 2(3H)-benzoxazolones, published in 2009, which mentions a compound: 54903-09-2, mainly applied to chalcone derivative benzoxazolone preparation antioxidant activity, Synthetic Route of C9H7NO3.

Chalcones featuring an analgesic/anti-inflammatory pharmacophore, i.e., the 2(3H)-benzoxazolone heterocycle, on the one hand, and a radical scavenger moiety, i.e., 2,6-di-t-butylphenol, on the other hand were synthesized by condensation of a ketone 2(3H)-benzoxazolone precursor with 3,5-di-t-butyl-4-hydroxybenzaldehyde. Among the various methods explored (acid homogeneous or heterogeneous catalysis, base catalysis), heterogeneous catalysis conditions using KSF Montmorillonite were found to be the most convenient. The E-geometry of the so-obtained chalcones was ascertained both by 1H and 13C-NMR spectroscopy as well as B3LYP/6-31G** quantum mechanics calculations Eight chalcones, e.g. I, were pharmacol. evaluated in vitro for their ability to prevent human low-d. lipoprotein (LDL) copper-induced oxidation using Cu2+ as oxidizing agent. I emerged as the most promising agent as it was able to inhibit copper-mediated human LDL oxidation with an activity ten times greater than that of Probucol, a reference antioxidant drug.

After consulting a lot of data, we found that this compound(54903-09-2)Synthetic Route of C9H7NO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Formula: C9H7NO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of derivatives of oximes, hydrazones, and dichloroacetamides. Study of antiparasitic properties. Author is Berthelot, P.; Vaccher, C.; Flouquet, N.; Viana, M. N.; Savel, J.; Debaert, M..

Title compounds I and II [X = NOH, NNHCSNH2, morpholinoimino; R = Me, CH2Ph, 2-(2-thienyl)vinyl, 2-(5-bromo-2-thienyl)vinyl; R1 = CH2CO2H, H, Me; R2 = H, COCHCl2] and R3C(:NOH)CH2CH2CR4:NOH (R3 = 2-thienyl, R4 = Me, Ph; R3 = tetrahydronaphthyl, R4 = Me, 4-ClC6H4; R3 = 4-phenylcyclohexyl, R4 = 4-ClC6H4) were prepared The products were devoid of protozoacidal activity.

After consulting a lot of data, we found that this compound(54903-09-2)Formula: C9H7NO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics