Category: 54903-09-2

Related Products of 54903-09-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of 3-(2-pyridylethyl)benzoxazolinone derivatives: potent analgesic and antiinflammatory compounds inhibiting prostaglandin E2. Author is Safak, Cihat; Erdogan, Hakki; Palaska, Erhan; Sunal, Rumeysa; Duru, Suna.

Fourteen new [(2- and 4-pyridyl)ethyl]benzoxazolinones I (R = H, acyl; R1 = H, Cl) were prepared by reacting 2- or 4-vinylpyridine with the appropriate benzoxazolinones. Analgesic activities of these compounds were investigated by a modified Koster’s Test. Except for compounds I (R = Ac, R1 = H) all the new derivatives showed higher analgesic activities than aspirin. Therefore the compounds were screened for their antiinflammatory activities using the carrageenan hind paw edema test. Compounds I (R = H, R1 = H, Cl; R = o-ClC6H4CO, R1 = H, Cl) that showed high antiinflammatory activity were then further screened for their ability to inhibit prostaglandin E2 (PGE2) induced paw edema. Although all the benzoxazolinone derivatives synthesized in this study showed higher antiinflammatory activity compared to indomethacin, those without a substituent at the 6-position of the ring were significantly more active than the rest of the group.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Formula: C9H7NO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of derivatives of oximes, hydrazones, and dichloroacetamides. Study of antiparasitic properties. Author is Berthelot, P.; Vaccher, C.; Flouquet, N.; Viana, M. N.; Savel, J.; Debaert, M..

Title compounds I and II [X = NOH, NNHCSNH2, morpholinoimino; R = Me, CH2Ph, 2-(2-thienyl)vinyl, 2-(5-bromo-2-thienyl)vinyl; R1 = CH2CO2H, H, Me; R2 = H, COCHCl2] and R3C(:NOH)CH2CH2CR4:NOH (R3 = 2-thienyl, R4 = Me, Ph; R3 = tetrahydronaphthyl, R4 = Me, 4-ClC6H4; R3 = 4-phenylcyclohexyl, R4 = 4-ClC6H4) were prepared The products were devoid of protozoacidal activity.

After consulting a lot of data, we found that this compound(54903-09-2)Formula: C9H7NO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 54903-09-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of 3-(2-pyridylethyl)benzoxazolinone derivatives: potent analgesic and antiinflammatory compounds inhibiting prostaglandin E2. Author is Safak, Cihat; Erdogan, Hakki; Palaska, Erhan; Sunal, Rumeysa; Duru, Suna.

Fourteen new [(2- and 4-pyridyl)ethyl]benzoxazolinones I (R = H, acyl; R1 = H, Cl) were prepared by reacting 2- or 4-vinylpyridine with the appropriate benzoxazolinones. Analgesic activities of these compounds were investigated by a modified Koster’s Test. Except for compounds I (R = Ac, R1 = H) all the new derivatives showed higher analgesic activities than aspirin. Therefore the compounds were screened for their antiinflammatory activities using the carrageenan hind paw edema test. Compounds I (R = H, R1 = H, Cl; R = o-ClC6H4CO, R1 = H, Cl) that showed high antiinflammatory activity were then further screened for their ability to inhibit prostaglandin E2 (PGE2) induced paw edema. Although all the benzoxazolinone derivatives synthesized in this study showed higher antiinflammatory activity compared to indomethacin, those without a substituent at the 6-position of the ring were significantly more active than the rest of the group.

Although many compounds look similar to this compound(54903-09-2)Related Products of 54903-09-2, numerous studies have shown that this compound(SMILES:O=C1OC2=CC(C(C)=O)=CC=C2N1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one( cas:54903-09-2 ) is researched.Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one.Meyers, Marvin J.; Arhancet, Graciela B.; Hockerman, Susan L.; Chen, Xiangyang; Long, Scott A.; Mahoney, Matthew W.; Rico, Joseph R.; Garland, Danny J.; Blinn, James. R.; Collins, Joe T.; Yang, Shengtian; Huang, Horng-Chih; McGee, Kevin F.; Wendling, Jay M.; Dietz, Jessica D.; Payne, Maria A.; Homer, Bruce L.; Heron, Marcia I.; Reitz, David B.; Hu, Xiao published the article 《Discovery of (3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy》 about this compound( cas:54903-09-2 ) in Journal of Medicinal Chemistry. Keywords: mineralocorticoid receptor antagonist benzoindazole derivative hypertension nephropathy. Let’s learn more about this compound (cas:54903-09-2).

We have discovered a novel class of nonsteroidal pyrazoline antagonists of the mineralocorticoid receptor (MR) that show excellent potency and selectivity against other nuclear receptors. Early analogs were poorly soluble and had a propensity to inhibit the hERG channel. Remarkably, both of these challenges were overcome by incorporation of a single carboxylate moiety. Structural modification of carboxylate-containing lead R-4g with a wide range of substituents at each position of the pyrazoline ring resulted in R-12o, which shows excellent activity against MR and reasonable pharmacokinetic profile. Introduction of conformational restriction led to a novel series characterized by exquisite potency and favorable steroid receptor selectivity and pharmacokinetic profile. Oral dosing of 3S,3aR-27d (PF-3882845) in the Dahl salt sensitive preclin. model of salt-induced hypertension and nephropathy showed blood pressure attenuation significantly greater than that with eplerenone, reduction in urinary albumin, and renal protection. As a result of these findings, 3S,3aR-27d was advanced to clin. studies.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 54903-09-2, is researched, Molecular C9H7NO3, about A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide, the main research direction is photoacoustic probe imaging nitric oxide.Product Details of 54903-09-2.

Photoacoustic (PA) imaging is an emerging, hybrid imaging modality that uses optical excitation and acoustic detection to enable high resolution at centimeter depths. The development of activatable PA probes can allow for detection of specific stimuli within a variety of live-animal models using this technol. Herein, the authors report the design, development, and evaluation of a series of Acoustogenic Probe(s) for Nitric Oxide (APNO) for the ratiometric, analyte-specific detection of nitric oxide (NO) in vivo. The best probe in this series, APNO-5 (I), responds rapidly to NO to form an N-nitrosylated product that exhibits an absorbance maximum that is 91 nm blue-shifted relative to the probe. This property enables ratiometric PA imaging upon selective irradiation of APNO-5 and the corresponding product. Moreover, APNO-5 displays the requisite photophys. characteristics for in vivo PA imaging (e.g., high absorptivity, low quantum yield) as well as high biocompatibility, stability, and selectivity for NO over a variety of biol. relevant analytes. APNO-5 was successfully applied to the detection of endogenous NO in a murine lipopolysaccharide-induced inflammation model at depths up to 2.5 cm. The authors’ studies show a 1.9-fold increase in PA signal at 680 nm and a 1.3-fold ratiometric turn-on relative to a saline control.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Base catalysis in the Willgerodt-Kindler reaction, the main research direction is Willgerodt Kindler reaction triethylamine solvent; methoxyacetophenone Willgerodt Kindler reaction triethylamine solvent; benzoxazolone acetyl Willgerodt Kindler reaction triethylamine solvent.Category: piperazines.

Yields in Willgerodt-Kindler reactions, e.g., of 4′-methoxyacetophenone with S8 and morpholine or of 6-acetyl-2(3H)-benzoxazolone with S8 and morpholine, piperidine, and piperazines, are improved when Et3N is used as the solvent.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C9H7NO3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Design and synthesis of 3-acyl-2(3H)-benzoxazolone and 3-acyl-2(3H)-benzothiazolone derivatives.

An efficient “”green”” method for facile and rapid N-acylation of 2(3H)-benzoxazolones and 2(3H)-benzothiazolones by acyl chlorides using solid sodium hydroxide in a solvent mixture of acetone/water is reported. was found to catalyze N-acylation N-acyl derivatives This method was applied to the synthesis of a series of 132 compounds I (R1 = H, O2N, Br, etc.; R2 = Me, Et, Ph, etc.; X = O, S) in excellent yields.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of chalcones condensed with an 1,3-azole ring using a SOCl2/EtOH catalytic system.Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one.

A series of substituted heterocyclic chalcones were synthesized by aldol condensation of corresponding heterocyclic ketones (preparation shown) aromatic aldehydes, in the presence of thionyl chloride-EtOH as a catalyst. The reaction was stereoselective and only trans-isomers were obtained in excellent yields and purity. Three out of 7 prepared chalcones (I, R = H, OH, OMe) were tested in vitro for their antitumor activity. They were found to have IC50 values ranging between 10-15 μM.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

SDS of cas: 54903-09-2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of some novel benzoxazolinonylcarboxamides as potential anti-inflammatory agents. Author is Messaoud, Liacha; Wassila, Yahia; Khemissi, Seddiki; Yasmina, Adjeroud; Hanane, Chabane.

The synthesis of 2(3H)-benzoxazolinonylcarboxamide derivatives I (R = H, CH3) starting from 2-amino-4,6-dimethylpyridine and substituted (benzoxazolinon-6-yl)carboxylic acids II, which were designed as anti-inflammatory agents is described. The II were obtained by Friedel-Crafts acylation of 2(3H)-benzoxazolone derivatives with oxalyl chloride and acetylchloride in the presence of the AlCl3-DMF complex.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Bilginer, Sinan; Bardaweel, Sanaa K.; Sabbah, Dima A.; Gul, Halise Inci published the article 《Docking Studies and Antiproliferative Activities of 6-(3-aryl-2-propenoyl)-2(3H)- benzoxazolone Derivatives as Novel Inhibitors of Phosphatidylinositol 3-Kinase (PI3Kα)》. Keywords: aryl propenoyl benzoxazolone preparation antiproliferative antitumor agent apoptosis; LDH; Molecular docking; PI3Kα; apoptosis; chalcone; colon cancer.They researched the compound: 6-Acetylbenzo[d]oxazol-2(3H)-one( cas:54903-09-2 ).Name: 6-Acetylbenzo[d]oxazol-2(3H)-one. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:54903-09-2) here.

Cancer is a life-threatening group of diseases and universally, the second main cause of death. The design and development of new scaffolds targeting selective cancer cells are considered a promising goal for cancer treatment. Aims and Objective: Chalcone derivatives; 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolone, were previously prepared and evaluated against the oral cavity squamous cell carcinoma cell line, HSC-2, and were reported to have remarkably high tumor selectivity. The aim of this study was to further investigate the anticancer activities of the chalcone derivatives against human colon cancer cells with a possible elucidation of their mechanism of action. Computational studies were conducted to explore the potential interaction of the synthesized mols. with the phosphatidylinositol-4,5-bisphosphate 3-kinaseα (PI3Kα). Biol. evaluation of the antiproliferative activities associated with compounds was carried out against the colon cancer cell line, HCT116. Lactate Dehydrogenase (LDH) activity was measured to study necrosis, while the caspase-3 activation and DNA measurements were used to evaluate apoptosis in the treated cells. Glide studies against PI3Kα kinase domain demonstrated that the 6-(3-aryl-2-propenoyl)-2(3H)- benzoxazolone scaffold forms H-bond with K802, Y836, E849, V851, N853, Q859, and D933, and it fits the fingerprint of PI3Kα active inhibitors. Biol. evaluation of the reported compounds in HCT116 cell line confirmed that the series inhibited PI3Kα activity and induced apoptosis via activation of caspase-3 and reduction of DNA content. The recently developed compounds might be employed as lead structures for the design of new antitumor drugs targeting PI3Kα.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics