Category: 54903-09-2

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Cytotoxic Mannich bases of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones.SDS of cas: 54903-09-2.

A series of 12 new Mannich bases with chalcone core structure were synthesized as potential antineoplastic agents, via N-aminomethylation of two parent 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones. The newly synthesized compounds as well as the chalcone prototypes were evaluated for cytotoxicity in the human pre-B-cell leukemia cell line BV-173 using the MTT-dye reduction assay. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations Ten of the Mannich bases characterized by significant activity in BV-173 were further evaluated against the chronic myeloid leukemia cell line K-562 and were found to suppress the growth of these cells at relatively higher concentrations as compared to the former tumor model. Selected Mannich bases induced programmed cell death in BV-173 at a concentration of 2.5 μM as evidenced by the encountered DNA-laddering. Taken together our data suggest that the presented heterocyclic chalcone derived Mannich bases necessitate detailed pharmacol. evaluation in order to define further the structure activity relationships, in a larger spectrum of tumor models and to elucidate the mechanisms implicated in the observed cytotoxic effects.

Here is just a brief introduction to this compound(54903-09-2)SDS of cas: 54903-09-2, more information about the compound(6-Acetylbenzo[d]oxazol-2(3H)-one) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 54903-09-2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about New halogenated chalcones with cytotoxic and carbonic anhydrase inhibitory properties: 6-(3-Halogenated phenyl-2-propen-1-oyl)-2(3H)-benzoxazolones. Author is Bilginer, Sinan; Gul, Halise I.; Erdal, Feyza S.; Sakagami, Hiroshi; Gulcin, Ilhami.

In this study, novel halogenated chalcones, 6-(3-halogenated phenyl-2-propen-1-one)-2(3H)-benzoxazolones (2a-n), were synthesized for the first time (except 2a), and their chem. structures were characterized by 1H NMR (NMR), 13C NMR, and high-resolution mass spectrometry spectra. Cytotoxic activities and carbonic anhydrase (CA) inhibitory effects of the compounds were studied to identify new possible drug candidate mols. Cytotoxicity results pointed out that compound 2m, 6-[3-(3-bromophenyl)-2-propenoyl]-2(3H)-benzoxazolone, had the highest cytotoxicity (CC50) and potency selectivity expression (PSE) values. Thus, compound 2m can be considered as a lead compound of the series in terms of cytotoxicity. When the CA inhibition results of the compounds were evaluated, it was found that the Ki values of the compounds ranged from 30.5 ± 11.3 to 65.5 ± 25.6 μM toward hCA I, and they ranged from 7.3 ± 1.8 to 58.8 ± 12.3 μM toward hCA II. However, the Ki values of the reference drug, acetazolamide (AZA), were 30.2 ± 7.8 and 4.4 ± 0.6 μM toward hCA I and hCA II, resp. According to the results obtained, compounds 2a-n had lower Ki values than AZA, whereas compounds 2a, 2b, 2e-g, 2l, and 2n had similar Ki values, compared with AZA. So, the compounds 2a, 2b, 2e-g, 2l, and 2n can be considered as lead mols. of this series for further considerations.

I hope my short article helps more people learn about this compound(6-Acetylbenzo[d]oxazol-2(3H)-one)Recommanded Product: 54903-09-2. Apart from the compound(54903-09-2), you can read my other articles to know other related compounds.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Celik, Hayati; Buyukaga, Mahmure; Celebier, Mustafa; Turkoz Acar, Ebru; Baymak, Melek Sirin; Gokhan-Kelekci, Nesrin; Palaska, Erhan; Erdogan, Hakki published the article 《Determination of pKa Values of Some Benzoxazoline Derivatives and the Structure-Activity Relationship》. Keywords: ionization constant deprotonation benzoxazolinone derivative analgetic antiinflammatory drug SAR.They researched the compound: 6-Acetylbenzo[d]oxazol-2(3H)-one( cas:54903-09-2 ).Recommanded Product: 54903-09-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:54903-09-2) here.

The acid ionization constant (pKa) values of 2-(3H)-benzoxazolinone and its 17 derivatives were determined in buffered solutions by UV-vis spectrophotometry, potentiometry, and capillary zone electrophoresis techniques. The pKa values of the studied compounds were found to be in the range of 9.01 to 7.15. The advantages and limitations of each technique are discussed. The results suggest that the removal of a proton from the mol. occurred on the nitrogen atom of the 2-(3H)-benzoxazolinone ring and the analgesic/anti-inflammatory activities of the benzoxazolinone derivatives decrease when the pKa values of the compounds increase.

I hope my short article helps more people learn about this compound(6-Acetylbenzo[d]oxazol-2(3H)-one)Recommanded Product: 54903-09-2. Apart from the compound(54903-09-2), you can read my other articles to know other related compounds.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Cytotoxic Mannich bases of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones.SDS of cas: 54903-09-2.

A series of 12 new Mannich bases with chalcone core structure were synthesized as potential antineoplastic agents, via N-aminomethylation of two parent 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones. The newly synthesized compounds as well as the chalcone prototypes were evaluated for cytotoxicity in the human pre-B-cell leukemia cell line BV-173 using the MTT-dye reduction assay. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations Ten of the Mannich bases characterized by significant activity in BV-173 were further evaluated against the chronic myeloid leukemia cell line K-562 and were found to suppress the growth of these cells at relatively higher concentrations as compared to the former tumor model. Selected Mannich bases induced programmed cell death in BV-173 at a concentration of 2.5 μM as evidenced by the encountered DNA-laddering. Taken together our data suggest that the presented heterocyclic chalcone derived Mannich bases necessitate detailed pharmacol. evaluation in order to define further the structure activity relationships, in a larger spectrum of tumor models and to elucidate the mechanisms implicated in the observed cytotoxic effects.

Here is just a brief introduction to this compound(54903-09-2)SDS of cas: 54903-09-2, more information about the compound(6-Acetylbenzo[d]oxazol-2(3H)-one) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of 6-Acetylbenzo[d]oxazol-2(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about 6-Acyl benzoxazolinones. II. Preparation of some transformation products. Author is Bonte, Jean P.; Lesieur, Daniel; Lespagnol, Charles; Cazin, Jean C.; Cazin, Micheline.

Alcs. I (R = H, R1 = MeCHOH, EtCHOH, PhCHOH, PhCH2CHOH) were prepared in 85-90% yield by reducing I (R = H, R1 = Ac, EtCO, Bz, Ph-CH2CO) and had analgesic activity comparable to that of I (R = R1 = H). Alk. hydrolysis of I (R = H, Me; R1 = HCO, Ac, EtCO, Bz, PhCH2CO, 2-thenoyl) gave 2,4-HO(R1)C6H3NHR with loss of analgesic activity. Reaction of I (R = H, R1 = Ac) with R2CHO (R2 = Ph, p-ClC6H4, p-MeOC6H4, m-MeOC6-H4, 2,3,4-HO2C(MeO)2C6H2, PhCH:CH, 2-thienyl, p-O2NC6H4, m-O2NC6H4) gave I (R = H, R1 = R2CH:CHCO), which were reduced to I (R = H, R1 = R2CH2CH2CO), both with loss of analgesic activity.

When you point to this article, it is believed that you are also very interested in this compound(54903-09-2)Application In Synthesis of 6-Acetylbenzo[d]oxazol-2(3H)-one and due to space limitations, I can only present the most important information.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Delot, Marc; Carato, Pascal; Furman, Christophe; Lemoine, Amelie; Lebegue, Nicolas; Berthelot, Pascal; Yous, Said published the article 《Synthesis of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones with potential topoisomerase I inhibitory activity》. Keywords: dihydrooxazolo indenoquinolinone Friedlander preparation antitumor.They researched the compound: 6-Acetylbenzo[d]oxazol-2(3H)-one( cas:54903-09-2 ).Category: piperazines. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:54903-09-2) here.

A series of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones I (R1 = H, Me; R2 = H, Me, Ph, 4-Cl-Ph; R3 = H, MeO) were prepared by means of Friedlander condensations. The starting materials for the preparations were com. substituted 2-aminoacetophenones and various 5,6-dihydro-2H-indeno[5,6-d][1,3]oxazole-2,7(3H)-diones that were synthesized from 2(3H)-benzoxazolones or their N-Me analogs. Antitumor activity of the title compounds has been tested on DU145 human androgen-independent prostate cancer cells.

When you point to this article, it is believed that you are also very interested in this compound(54903-09-2)Category: piperazines and due to space limitations, I can only present the most important information.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 54903-09-2, is researched, Molecular C9H7NO3, about Aluminum trichloride-DMF reagent in the Friedel-Crafts reaction. Application to 2(3H)benzoxazolones in the Haworth reaction, the main research direction is Friedel Crafts benzoxazolone; Haworth benzoxazolone; benzoxazolone Friedel Crafts Haworth.COA of Formula: C9H7NO3.

Benzoxazolones I (R = H, Me) underwent the Haworth reaction to give cyclic ketone derivatives II and III (n = 1, 2, X = NR, Y = O; n = 1, 2, X = O, Y = NR). Friedel-Crafts acylation of I followed by reduction, and intramol. Friedel-Crafts reaction gave II. To shorten the sequence, I was reacted with γ-butyro- and δ-valerolactone in the presence of polyphosphoric acid to give III.

When you point to this article, it is believed that you are also very interested in this compound(54903-09-2)COA of Formula: C9H7NO3 and due to space limitations, I can only present the most important information.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 54903-09-2, is researched, Molecular C9H7NO3, about Aluminum trichloride-DMF reagent in the Friedel-Crafts reaction. Application to 2(3H)benzoxazolones in the Haworth reaction, the main research direction is Friedel Crafts benzoxazolone; Haworth benzoxazolone; benzoxazolone Friedel Crafts Haworth.COA of Formula: C9H7NO3.

Benzoxazolones I (R = H, Me) underwent the Haworth reaction to give cyclic ketone derivatives II and III (n = 1, 2, X = NR, Y = O; n = 1, 2, X = O, Y = NR). Friedel-Crafts acylation of I followed by reduction, and intramol. Friedel-Crafts reaction gave II. To shorten the sequence, I was reacted with γ-butyro- and δ-valerolactone in the presence of polyphosphoric acid to give III.

When you point to this article, it is believed that you are also very interested in this compound(54903-09-2)COA of Formula: C9H7NO3 and due to space limitations, I can only present the most important information.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of 6-Acetylbenzo[d]oxazol-2(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about 6-Acyl benzoxazolinones. II. Preparation of some transformation products. Author is Bonte, Jean P.; Lesieur, Daniel; Lespagnol, Charles; Cazin, Jean C.; Cazin, Micheline.

Alcs. I (R = H, R1 = MeCHOH, EtCHOH, PhCHOH, PhCH2CHOH) were prepared in 85-90% yield by reducing I (R = H, R1 = Ac, EtCO, Bz, Ph-CH2CO) and had analgesic activity comparable to that of I (R = R1 = H). Alk. hydrolysis of I (R = H, Me; R1 = HCO, Ac, EtCO, Bz, PhCH2CO, 2-thenoyl) gave 2,4-HO(R1)C6H3NHR with loss of analgesic activity. Reaction of I (R = H, R1 = Ac) with R2CHO (R2 = Ph, p-ClC6H4, p-MeOC6H4, m-MeOC6-H4, 2,3,4-HO2C(MeO)2C6H2, PhCH:CH, 2-thienyl, p-O2NC6H4, m-O2NC6H4) gave I (R = H, R1 = R2CH:CHCO), which were reduced to I (R = H, R1 = R2CH2CH2CO), both with loss of analgesic activity.

When you point to this article, it is believed that you are also very interested in this compound(54903-09-2)Application In Synthesis of 6-Acetylbenzo[d]oxazol-2(3H)-one and due to space limitations, I can only present the most important information.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Delot, Marc; Carato, Pascal; Furman, Christophe; Lemoine, Amelie; Lebegue, Nicolas; Berthelot, Pascal; Yous, Said published the article 《Synthesis of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones with potential topoisomerase I inhibitory activity》. Keywords: dihydrooxazolo indenoquinolinone Friedlander preparation antitumor.They researched the compound: 6-Acetylbenzo[d]oxazol-2(3H)-one( cas:54903-09-2 ).Category: piperazines. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:54903-09-2) here.

A series of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones I (R1 = H, Me; R2 = H, Me, Ph, 4-Cl-Ph; R3 = H, MeO) were prepared by means of Friedlander condensations. The starting materials for the preparations were com. substituted 2-aminoacetophenones and various 5,6-dihydro-2H-indeno[5,6-d][1,3]oxazole-2,7(3H)-diones that were synthesized from 2(3H)-benzoxazolones or their N-Me analogs. Antitumor activity of the title compounds has been tested on DU145 human androgen-independent prostate cancer cells.

When you point to this article, it is believed that you are also very interested in this compound(54903-09-2)Category: piperazines and due to space limitations, I can only present the most important information.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics