Category: 54903-09-2

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about 6-Alkylbenzoxazolinones. Chemical and pharmacodynamic studies.Related Products of 54903-09-2.

Eleven title compounds (I; R1 = Me or H; R2 = Me, Ph, benzyl, CH2Cl, CH2Br, or CHBrM4) were prepared by a general method consisting of reduction of the corresponding 6-acyl derivatives (OCR2) with Et3SiH in F3CCO2H medium. Yields were 50-90%, with no side products. Six I were screened in mice for acute toxicity and for analgesic and psychotropic activities. At 200 mg/kg, orally, these compounds had lower analgesic activity than the reference substance, 6-benzoylbenzoxazolinone; at 100 mg/kg, only 6-ethylbenzoxazolinone  [93771-18-7] was more active, but this analgesic activity was accompanied by a psychotropic component. Furthermore, this psychotropic activity was found with almost all the I at the dose of 200 mg/kg, a component which was not present in the previously studied carbonyl (6-acyl) analogs.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 54903-09-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Friedel-Crafts acylation of 2(3H)-benzoxazolone: investigation of the role of the catalyst and microwave activation. Author is Liacha, Messaoud; Yous, Said; Poupaert, Jacques H.; Depreux, Patrick; Aichaoui, Hocine.

To study the scope and limitations of the use of complexed species of AlCl3 in Friedel-Crafts reactions, we investigated the acetylation and benzoylation of 2(3H)-benzoxazolone and 3-methyl-2(3H)-benzoxazolone varying the amide complexing agent. We replaced DMF by N-methylformamide, dimethylacetamide, pyrrolidinone, N-methylpyrrolidinone, tetramethylurea, and DMSO. However, there was no particular advantage of substituting DMF by another amide ligand. This can probably be ascribed to the fact that the complex formed between AlCl3 and the complexing agent becomes too stable. Alternatively, a route using polyphosphoric acid and microwave activation was explored. The major advantage of running the reaction in a microwave oven was that a good yield was reached in a rather short period of time.

There is still a lot of research devoted to this compound(SMILES：O=C1OC2=CC(C(C)=O)=CC=C2N1)HPLC of Formula: 54903-09-2, and with the development of science, more effects of this compound(54903-09-2) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about 6-Alkylbenzoxazolinones. Chemical and pharmacodynamic studies.Related Products of 54903-09-2.

Eleven title compounds (I; R1 = Me or H; R2 = Me, Ph, benzyl, CH2Cl, CH2Br, or CHBrM4) were prepared by a general method consisting of reduction of the corresponding 6-acyl derivatives (OCR2) with Et3SiH in F3CCO2H medium. Yields were 50-90%, with no side products. Six I were screened in mice for acute toxicity and for analgesic and psychotropic activities. At 200 mg/kg, orally, these compounds had lower analgesic activity than the reference substance, 6-benzoylbenzoxazolinone; at 100 mg/kg, only 6-ethylbenzoxazolinone  [93771-18-7] was more active, but this analgesic activity was accompanied by a psychotropic component. Furthermore, this psychotropic activity was found with almost all the I at the dose of 200 mg/kg, a component which was not present in the previously studied carbonyl (6-acyl) analogs.

From this literature《6-Alkylbenzoxazolinones. Chemical and pharmacodynamic studies》,we know some information about this compound(54903-09-2)Related Products of 54903-09-2, but this is not all information, there are many literatures related to this compound(54903-09-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 54903-09-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Friedel-Crafts acylation of 2(3H)-benzoxazolone: investigation of the role of the catalyst and microwave activation. Author is Liacha, Messaoud; Yous, Said; Poupaert, Jacques H.; Depreux, Patrick; Aichaoui, Hocine.

To study the scope and limitations of the use of complexed species of AlCl3 in Friedel-Crafts reactions, we investigated the acetylation and benzoylation of 2(3H)-benzoxazolone and 3-methyl-2(3H)-benzoxazolone varying the amide complexing agent. We replaced DMF by N-methylformamide, dimethylacetamide, pyrrolidinone, N-methylpyrrolidinone, tetramethylurea, and DMSO. However, there was no particular advantage of substituting DMF by another amide ligand. This can probably be ascribed to the fact that the complex formed between AlCl3 and the complexing agent becomes too stable. Alternatively, a route using polyphosphoric acid and microwave activation was explored. The major advantage of running the reaction in a microwave oven was that a good yield was reached in a rather short period of time.

There is still a lot of research devoted to this compound(SMILES：O=C1OC2=CC(C(C)=O)=CC=C2N1)HPLC of Formula: 54903-09-2, and with the development of science, more effects of this compound(54903-09-2) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of some new substituted Di-tert-butylphenols as potential COX-2 inhibitors, published in 2004-09-30, which mentions a compound: 54903-09-2, mainly applied to aryl ketone benzaldehyde condensation; benzoxazolyl aryl propenone preparation; benzoxazinyl aryl propenone preparation, Name: 6-Acetylbenzo[d]oxazol-2(3H)-one.

Selective cyclooxygenase-2 (COX-2) inhibitors have been shown to be potent antiinflammatory agents with fewer side effects than currently marketed nonsteroidal antiinflammatory drugs (NSAIDs). In previous researches, di-tert-butylphenol derivatives were more potent and selective for COX-2 vs. COX-1 based on enzyme assays, the synthesis of benzoxazole-, benzoxazolinone- and benzoxazinone- derived di-tert-butylphenols in order to increase potential COX-2 inhibitory activity is described. Starting from the readily available 6-acetyl-2-benzoxazolinone, some substituted di-tert-butylphenols were prepared in good yield.

If you want to learn more about this compound(6-Acetylbenzo[d]oxazol-2(3H)-one)Name: 6-Acetylbenzo[d]oxazol-2(3H)-one, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(54903-09-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents, the main research direction is alkoxymethanesulfonamido acetophenone preparation ulcerogenic antiinflammatory.Synthetic Route of C9H7NO3.

A series of 3-alkoxy-4-methanesulfonamido acetophenone derivatives were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model. The synthesized compounds were also investigated for their gastric ulcerogenic potential. The compounds I (R = n-Bu, hexyl, and cyclohexyl) showed comparable anti-inflammatory activity to rofecoxib and indomethacin, the standard drugs taken in both studies and were also non ulcerogenic at the test doses. In silico (docking studies) were done to investigate the hypothetical binding mode of the target compounds to the cyclooxygenase isoenzyme (COX-2). A binding model has been proposed based on the docking studies. Selected physicochem. properties were calculated for theor. ADME profiling of the compounds and excellent compliance was shown with Lipinski’s rules.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Safety of 6-Acetylbenzo[d]oxazol-2(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Acylation of 2,3-dihydrobenzoxazol-2-one in a two-step method involving an acyl migration. Author is Cotelle, Nicole; Cotelle, Philippe; Lesieur, Daniel.

Acylation of dihydrobenzoxazolone I (R = R1 = H) with (R2CO)2O or with R2COCl in pyridine gave 90-99% I (R = R2 = Me, Pr, Me2CHCH2, Ph, o-, p-ClC6H4, etc.; R1 = H) (II). Treatment of II with polyphosphoric acid caused acyl migration to give 80-99% I (R = H, R1 = R2).

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Computed Properties of C9H7NO3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Antioxidant activity of heterocyclic chalcones.

A series of substituted heterocyclic chalcones are synthesized by aldol condensation in the presence of thionyl chloride-EtOH. The radical scavenging potentials of the chalcones are evaluated by DPPH and ABTS assays.

Here is a brief introduction to this compound(54903-09-2)Computed Properties of C9H7NO3, if you want to know about other compounds related to this compound(54903-09-2), you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics