Category: 55112-42-0

Analyzing the synthesis route of 55112-42-0

The synthetic route of 55112-42-0 has been constantly updated, and we look forward to future research findings.

55112-42-0, 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55112-42-0, Example 1: Preparation of Zopiclone in Ethyl acetate[0064] To a slurry of l-chlorocarbonyl-4-methyl piperazine hydrochloride(CMP) (52.96g) in Ethyl acetate (500 ml), mechanically stirred, was added tri-ethyl amine (Et3N) (46.12g) over 10 min. During Et3N addition, temperature rose by 2C. After Et3N addition ended, DMAP (4.62g) and 6-(5-chloro-2-pyridinyl]-6,7-dihydro- 7-hydroxy-5H-pyrrolo[3,4-b]pyrazine-5-one (7-OH-Py) (5Og) were added to the slurry. Then the slurry was heated to 6O0C. The slurry was stirred at 600C for 7.5 h. The heating was stopped and the slurry was cooled to room temperature. When the temperature reached the room temperature water was added (500 ml) and the slurry was stirred for 1 h. The obtained solid was filtered, washed with acetone (25 ml) and dried in vacuum oven at 400C overnight to give zopiclone product crude (7 Ig yield 90%; purity 99.22%). Zopiclone crude can be purified by crystallization to get zopiclone of a purity greater than 99.8%.

The synthetic route of 55112-42-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/2629; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Simple exploration of 55112-42-0

55112-42-0 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride 3016934, apiperazines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.

55112-42-0, Example 3: Preparation of Zopiclone in Acetone[0066] l-Chlorocarbonyl-4-methyl piperazine hydrochloride (4.92g) in acetone (50 ml) was stirred mechanically at room temperature for 5 min. Then Et3N (4.42g) was added to the slurry over 10 min. During the tri-ethyl amine (Et3N) addition, the temperature rose slightly. After Et3N addition ended, DMAP (0.46g) was added to the slurry, and after 1-2 min of stirring, 7-OH-Py (5g) was added. The reaction mixture was heated to reflux and stirred at reflux for 4 h. After 4h at reflux, heating was stopped and the slurry was cooled to room temperature and ice (~50g) was added. Temperature dropped to -6C and the slurry was stirred till the temperature reached about 200C. The solid was filtered, washed with water (10 ml), and dried in vacuum oven at 400C overnight to obtain zopiclone crude product (6.95g yield 89%; purity 99.62% by HPLC).

55112-42-0 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride 3016934, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/2629; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Simple exploration of 55112-42-0

55112-42-0 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride 3016934, apiperazines compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.

To a suspension OF 4-METHYLPIPERAZINE-1-CARBONYL chloride hydrochloride (19.9 g 0.1 mol) and piperidone monohydrate hydrochloride (15.3 g 0.1 mol), in 200 ML of dichloromethane, dry triethylamine (45 mL, 0.33 mol) was added dropwise. The mixture was stirred for 2 hours. The organic phase was washed with brine (2 x 20 mL) and dried over sodium sulfate. After filtration, the solvent was evaporated in vacuo and the crude product was dissolved in ETOH (50 mL) and diethylether (100 mL) and treated with HCl 4N in dioxane (25 mL). After 1 hour, the precipitate was filtered and dried in oven to give 13 g (yield 50%) of the title compound. 1 H NMR (400 MHz, DMSO-D6) 8 ppm 2.40 (t, J=6. 16 Hz, 4 H) 2.81 (s, 3 H) 3.00- 3.11 (m, 2 H) 3.12-3. 23 (m, 2 H) 3.28-3. 42 (m, 2 H) 3.51 (t, J=6. 16 Hz, 4 H) 3.73 (d, J=14. 27 Hz, 2 H) 10.12 (s, 1 H), 55112-42-0

55112-42-0 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride 3016934, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; PHARMACIA ITALIA S.P.A.; WO2004/104007; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics