Category: 5521-39-1

5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5521-39-1

EXAMPLE 39 6-Methoxy-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid {4-[4-(2hydroxy-ethyl)-piperazin-1-yl]-phenyl}-amide. This compound was prepared from 6-methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 2) and 2-[4-(4-amino-phenyl)-piperazin-1-yl]-ethanol (Reference Example 19) as prepared in Example 12, yielding a yellow solid. (80mg=60%). mp=211.5-212.2 (dec.), MS-base peak at m/z=492 by positive ion and m/z=490 by negative ion CI

5521-39-1 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol 767100, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Pierson, Edward; Sohn, Daniel; Haeberlein, Markus; Davenport, Timothy; Chapdelaine, Marc; Horchler, Carey; McCauley, John P.; US2003/13708; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5521-39-1

EXAMPLE 39 6-Methoxy-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid {4-[4-(2hydroxy-ethyl)-piperazin-1-yl]-phenyl}-amide. This compound was prepared from 6-methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 2) and 2-[4-(4-amino-phenyl)-piperazin-1-yl]-ethanol (Reference Example 19) as prepared in Example 12, yielding a yellow solid. (80mg=60%). mp=211.5-212.2 (dec.), MS-base peak at m/z=492 by positive ion and m/z=490 by negative ion CI

5521-39-1 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol 767100, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Pierson, Edward; Sohn, Daniel; Haeberlein, Markus; Davenport, Timothy; Chapdelaine, Marc; Horchler, Carey; McCauley, John P.; US2003/13708; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

mCPBA (<77% pure) (102 mg, assumed 0.455 mmol) in DCM (0.5 mL) was added to a stirred solution of 6- (2,6- dichlorophenyl ) -2 - (methylthio) pyrido [4 , 3 -d] pyrimidin-5 ( 6H) - one (100 mg, 0.296 mmol) in toluene (3.0 mL) at RT undernitrogen. After 15 min, DIPEA (0.155 mL, 0.887 mmol) and 2- (4 - (4 -aminophenyl ) iperazin- 1 -yl ) ethanol (65.4 mg, 0.296 mmol) [commercially available] were added, successively, and the temperature was increased to 60 C. After 16 h, the reaction mixture was cooled and loaded directly onto a KP-NH column and purified by flash chromatography (0-100%, EtOAc in cyclohexane) to give material that required further purification by preparative HPLC . The pure fractions were concentrated to give the title compound (39.8 mg, 26%) as a yellow solid. LCMS (Method A): RT = 0.80 min, m/z = 511, 513 [M+H]+. 1U NMR (500 MHz, methanol -d4 ) : delta 9.19 (s, 1H) , 7.70-7.60 (m, 4H) , 7.52 (dd, 1H) , 7.47 (d, 1H) , 7.02 (d, 2H) , 6.60 (d, 1H) , 3.75 (t, 2H) , 3.23 (t, 4H) , 2.77 (m, 4H) , 2.66 (t , 2H) . 5521-39-1, 5521-39-1 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol 767100, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; ALMAC DISCOVERY LIMITED; O’DOWD, Colin Roderick; ROUNTREE, James Samuel Shane; BURKAMP, Frank; WILKINSON, Andrew John; WO2014/167347; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5521-39-1, To a stirred solution of 21 3-(2,6-dichlorophenyl)-7-(methylthio)-2,3-dihydro-4H-pyrimido[5,4-e][1,3]oxazin-4-one (0.2 g, 0.58 mmol, 1.0 eq) in 5 mL 24 toluene 25 m-CPBA (0.251 g, 1.46 mmol, 2.5 eq) was added under stirring and resulting mixture was allowed to stir at rt for 30 min. Further, 604 2-(4-(4-aminophenyl)piperazin-1-yl)ethan-1-ol (0.129 g, 0.58 mmol, 1.0 eq) and 27 DIPEA (0.302 g, 2.33 mmol, 4 eq) were added and the reaction was allowed to stir at rt for 12 h. The reaction was monitored by LCMS. After completion reaction was quenched with 7 water and extracted with ethyl acetate (5 mL×3). The combined organic layer was washed with brine solution (10 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product which was purified by flash chromatography (MeOH: CH2Cl2 1-10%) to afford 607 3-(2,6-dichlorophenyl)-7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2,3-dihydro-4H-pyrimido[5,4-e][1,3]oxazin-4-one (0.008 g, 10%) as white solid. (0628) LCMS: 515 [M+1]+ (0629) 1H NMR (400 MHz, DMSO-d6): delta 10.18 (s, 1H), 8.78 (s, 1H), 8.20 (s, 1H), 7.65 (d, J=8.33 Hz, 2H), 7.51 (d, J=7.45 Hz, 2H), 6.92 (d, J=8.33 Hz, 2H), 5.71 (br s, 2H), 4.43 (br s, 2H), 3.53 (d, J=6.14 Hz, 2H), 3.17 (d, J=5.26 Hz, 1H), 3.09 (br s, 1H), 1.23 (br s, 1H), 1.16 (d, J=10.09 Hz, 1H).

5521-39-1 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol 767100, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-39-1,2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.

5521-39-1, To a solution of Example 7 compound 1b (313 mg, 1 mmol) and TFE (2,2,2-trifluoroethanol, 4 mL) was added 2-[4- (4-aminophenyl)piperazin-1-yl]ethanol (265 mg, 1.2 mmol) and TFA (trifluoroacetic acid, 342 mg, 3 mmol). The resulting mixture was heated to reflux and stirred overnight, then cooled to room temperature. EtOAc (50 mL) was added and the mixture was washed with saturated NaHCO3 (50 mL). The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo to obtain the crude compound. Then purify with silica gel column, dichloromethane: methanol = 20: 1 rinse, after concentration to obtain the target compound 2o.

As the paragraph descriping shows that 5521-39-1 is playing an increasingly important role.

Reference£º
Patent; Guangdong University of Technology; Chen Huixiong; Yan Longjia; Li Yongliang; Chen Anchao; Deng Minggao; (30 pag.)CN110724137; (2020); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5521-39-1,5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00215] Step 3 : A flask was charged with intermiediate 2 (50 mg, 0.16 mmol), 2-(4-(4- aminophenyl)piperazin-l-yl)ethanol (30.4 mg, 0.16 mmol), DIPEA (60uL), DMSO (2 mL). The reaction was stirred at room temperature for over. The crude product was purified with flash chromatography (0-10% MeOH-in DCM) to afford the desired product as light yellow solids (42 mg, 54% yield). 1H MR (400 MHz, DMSO-d6) delta 11.83 (br, 1H), 9.86 (br, 1H), 8.23 (s, 1H), 7.30 (d, J=8.4Hz, 2H), 7.00 (dd, J=5.6Hz, J = 10.4 Hz, 1H), 6.90 (d, J=8.8Hz, 2H), 6.34 (s, 1H), 3.51 (m, 2H), 2.84 (m, 2H), 2.41 (s, 3H), 2.11 (m, 2H), 1.03 ( s, 3H), 1.01 (s, 3H); ESI-MS: calcd for (C26H25F2N70) 489, found 490 (MH+).

The synthetic route of 5521-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NANTBIOSCIENCE, INC.; TAO, Chunlin; POLAT,, Tulay; WEINGARTEN, Paul; NALLAN, Laxman; ARP, Forrest; WANG, Qinwei; HO, David; (129 pag.)WO2016/138527; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-39-1,2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.,5521-39-1

30 mg of the 7-chloro-3-(2,4-dichloropyridin-3-yl)-4-imino-l-methyl-3,4- dihydropyrimido[4,5-rf]pyrimidin-2(lH)-one obtained in Production Example 2, and 16 mg of TsOH monohydrate were added to a 5-ml n-butanol solution containing 18.6 mg of 2-[4-(4- aminophenyl)piperazin-l-yl]ethanol, and the mixture was heat stirred for 15 minutes at 100C. The reaction mixture was concentrated under reduced pressure, and purified by basic column chromatography. As a result, 21 mg of a white solid was obtained as a subject compound. iH-NMR (400 MHz, CD3OD) delta: 8.97 (IH, s), 7.60-7.46 (5H, m), 7.00 (2H, d, J = 8.8 Hz), 3.76(2H, br s), 3.61 (3H, s), 3.24 (4H, br), 2.76 (4H, br s), 2.64 (2H, br). ESI-MS Found: m/z[M+H] 542

5521-39-1 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol 767100, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; BANYU PHARMACEUTICAL CO.,LTD.; BAMBA, Makoto; FURUYAMA, Hidetomo; SAKAMOTO, Toshihiro; SUNAMI, Satoshi; TAKAHASHI, Keiji; YAMAMOTO, Fuyuki; YOSHIZUMI, Takashi; WO2010/67886; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5521-39-1, Example 39 6-Methoxy-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid {4-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-phenyl}-amide This compound was prepared from 6-methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 2) and 2-[4-(4-amino-phenyl)-piperazin-1-yl]-ethanol (Reference Example 19) as prepared in Example 12, yielding a yellow solid. (80 mg=60%). mp=211.5-212.2 (dec.), MS-base peak at m/z=492 by positive ion and m/z=490 by negative ion CI

The synthetic route of 5521-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chapdelaine, Marc; Davenport, Timothy; Haeberlein, Markus; Horchler, Carey; McCauley, John; Pierson, Edward; Sohn, Daniel; US2004/110745; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-39-1,2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.,5521-39-1

Synthesis of //ONo.is-4-(5-Bromo-2-{4-[4-(2- hydroxy-ethyl)-piperazin-l-yl]-phenylamino}-pyrimidin-4-ylamino)adamantan-l-ol:Conc.HCl (20mL) was added to a mixture of tra?s-4-(5-bromo-2-chloropyrirnidin-4- ylamino)adamantan-l-ol (50mg, 139 mmoles) and 2-[4-(4-aminophenyl)piperazin-l- yl]ethanol (37mg, 0.167mmoles) in n-butanol (3ml) was and the mixture was heated at 1 10- 120 overnight. The reaction mixture was cooled to 80, n-butanol (5 ml) was added and filtered. The residue was triturated with hot MeOH, purified by preparative HPLC to afford lOmg of trara-4-(5-Bromo-2-{4-[4-(2-hydroxy-ethyl)-piperazin-l-yl]-phenylamino}- pyrimidin-4-ylamino)adamantan-l-ol inl3% yield.’H NMR (DMSO-d6) delta 10.2-10.35 (br s, H), 9.2-9.3 (br s,lH), 8.1-8.2 (s,lH), 7.5 (d,2H), 7.0 (d,2H)?6.2(s,lH), 3.0-4.0 (m,12H), 2.2-2.3 (s,2H), 2.0-2.1 (s,lH), 1.6-1.8 (m,7H), 1.3-1.5 (m,4H) LC-MS: 543 (M + l)

The synthetic route of 5521-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara; WO2012/59932; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5521-39-1, Into a Microwave vial , 7-Bromo-2-methanesulfinyl-pyrrolo[2,l-f][l,2,4]triazine (0.480 g, 0.00184 mol), 2-[4-(4-Amino-phenyl)-piperazin-l-yl]-ethanol (0.8984 g, 0.004060 mol) and l-Methoxy-2-propanol (3.50 mL, 0.0358 mol) were added. The reaction was microwaved on 300 watts , 1800C for 60 minutes . The solvent was removed under vacuum. The desired product was isolated via ISCO column chromatograpy with DCM and methanol as eluant (0 to 7% methanol). The collected fractions afforded2-{4-[4- (7-Bromo-pyrrolo[2,l-fJ[l,2,4]triazin-2-ylamino)-phenyl]-piperazin- 1-yl} -ethanol as a yellow solid (280mg, 36%).

As the paragraph descriping shows that 5521-39-1 is playing an increasingly important role.

Reference£º
Patent; CEPHALON, INC.; BRESLIN, Henry J.; CHATTERJEE, Sankar; DIEBOLD, James L.; DORSEY, Bruce D.; DUNN, Derek; GINGRICH, Diane E.; HOSTETLER, Greg A.; HUDKINS, Robert L.; HUNTER, Rachael; JOSEF, Kurt; LISKO, Joseph; MESAROS, Eugen F.; MILKIEWICZ, Karen L.; OTT, Gregory R.; SUNDAR, Babu G.; THEROFF, Jay P.; THIEU, Tho; TRIPATHY, Rabindranath; UNDERINER, Theodore L.; WEINBERG, Linda; WELLS, Gregory J.; ZIFICSAK, Craig A.; WO2010/71885; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics