Category: 57184-25-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57184-25-5,1-(Cyclopropylmethyl)piperazine,as a common compound, the synthetic route is as follows.

57184-25-5, To a solution of 4-(dibenzylamino)cyclohexan-1-one (273, 5 g, 17.0 mmol) and 1- (cyclopropylmethyl)piperazine (276, 2.4 g, 17.1 mmol) in DCM (30 mL) was added HOAc (1 mL). NaHB(OAc)3 (20 g, 94.4 mmol) was then added in portions. After stirring at room temperature for 48 h, the reaction mixture was neutralized with saturated sodium bicarbonatesolution and extracted with DCM (50 mL x 3). The combined organic phases were dried over Mg504 and concentrated in vacuo. The resulting residue was purified by column chromatography to afford (1 r,4r)-N,N-dibenzyl-4-(4-(cyclopropylmethyl)piperazin- 1- yl)cyclohexan-1-amine (277, 670 mg, 1.6 mmol) and (ls,4s)-N,N-dibenzyl-4-(4- (cyclopropylmethyl)piperazin- 1 -yl)cyclohexan- 1-amine (278, 1.2 g, 2.9 mmol).(1R,4R)-N,N-Dibenzyl-4-(4-(cyclopropylmethyl)piperazin- 1-yl)cyclohexan- 1-amine(277): ?H NMR (300 MHz, CDC13): 37.29-7.26 (m, 4H), 7.24-7.18 (m, 4H), 7.15 -7.10 (m,2H), 3.53 (s, 4H), 2.81- 2.60 (m, 6H), 2.44 – 2.36 (m, 2H), 2.29 (d, J= 6.6 Hz, 2H), 1.96 – 1.88(m, 4H), 1.58 – 1.29 (m, 4H), 1.21 – 1.10 (m, 2H), 0.88 – 0.77 (m, 1H), 0.50 – 0.42 (m, 2H),0.10-0.02 (m, 2H).(1S,4S)-N,N-Dibenzyl-4-(4-(cyclopropylmethyl)piperazin- 1-yl)cyclohexan- 1-amine(278): ?H NMR (300 MHz, CDC13): oe 7.29-7.27 (m, 4H), 7.23 -7.18 (m, 4H), 7.14-7.09 (m,2H), 3.57 (s, 4H), 2.96 – 2.49 (m, 8H), 2.40 (d, J= 6.6 Hz, 2H), 2.20 (s, 1H), 1.89 – 1.85 (m,2H), 1.77 – 1.66 (m, 2H), 1.48 – 1.44 (m, 2H), 1.26 – 1.17 (m, 3H), 1.00 – 0.82 (m, 1H), 0.55 -0.49 (m, 2H), 0.16-0.11 (m, 2H).

57184-25-5 1-(Cyclopropylmethyl)piperazine 965875, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copeland; JUNG, David; (250 pag.)WO2018/5860; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57184-25-5,1-(Cyclopropylmethyl)piperazine,as a common compound, the synthetic route is as follows.

57184-25-5, To a solution of 4-(dibenzylamino)cyclohexan-1-one (273, 5 g, 17.0 mmol) and 1- (cyclopropylmethyl)piperazine (276, 2.4 g, 17.1 mmol) in DCM (30 mL) was added HOAc (1 mL). NaHB(OAc)3 (20 g, 94.4 mmol) was then added in portions. After stirring at room temperature for 48 h, the reaction mixture was neutralized with saturated sodium bicarbonatesolution and extracted with DCM (50 mL x 3). The combined organic phases were dried over Mg504 and concentrated in vacuo. The resulting residue was purified by column chromatography to afford (1 r,4r)-N,N-dibenzyl-4-(4-(cyclopropylmethyl)piperazin- 1- yl)cyclohexan-1-amine (277, 670 mg, 1.6 mmol) and (ls,4s)-N,N-dibenzyl-4-(4- (cyclopropylmethyl)piperazin- 1 -yl)cyclohexan- 1-amine (278, 1.2 g, 2.9 mmol).(1R,4R)-N,N-Dibenzyl-4-(4-(cyclopropylmethyl)piperazin- 1-yl)cyclohexan- 1-amine(277): ?H NMR (300 MHz, CDC13): 37.29-7.26 (m, 4H), 7.24-7.18 (m, 4H), 7.15 -7.10 (m,2H), 3.53 (s, 4H), 2.81- 2.60 (m, 6H), 2.44 – 2.36 (m, 2H), 2.29 (d, J= 6.6 Hz, 2H), 1.96 – 1.88(m, 4H), 1.58 – 1.29 (m, 4H), 1.21 – 1.10 (m, 2H), 0.88 – 0.77 (m, 1H), 0.50 – 0.42 (m, 2H),0.10-0.02 (m, 2H).(1S,4S)-N,N-Dibenzyl-4-(4-(cyclopropylmethyl)piperazin- 1-yl)cyclohexan- 1-amine(278): ?H NMR (300 MHz, CDC13): oe 7.29-7.27 (m, 4H), 7.23 -7.18 (m, 4H), 7.14-7.09 (m,2H), 3.57 (s, 4H), 2.96 – 2.49 (m, 8H), 2.40 (d, J= 6.6 Hz, 2H), 2.20 (s, 1H), 1.89 – 1.85 (m,2H), 1.77 – 1.66 (m, 2H), 1.48 – 1.44 (m, 2H), 1.26 – 1.17 (m, 3H), 1.00 – 0.82 (m, 1H), 0.55 -0.49 (m, 2H), 0.16-0.11 (m, 2H).

57184-25-5 1-(Cyclopropylmethyl)piperazine 965875, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copeland; JUNG, David; (250 pag.)WO2018/5860; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57184-25-5,1-(Cyclopropylmethyl)piperazine,as a common compound, the synthetic route is as follows.

57184-25-5, To a solution of 4-(dibenzylamino)cyclohexan-1-one (273, 5 g, 17.0 mmol) and 1- (cyclopropylmethyl)piperazine (276, 2.4 g, 17.1 mmol) in DCM (30 mL) was added HOAc (1 mL). NaHB(OAc)3 (20 g, 94.4 mmol) was then added in portions. After stirring at room temperature for 48 h, the reaction mixture was neutralized with saturated sodium bicarbonatesolution and extracted with DCM (50 mL x 3). The combined organic phases were dried over Mg504 and concentrated in vacuo. The resulting residue was purified by column chromatography to afford (1 r,4r)-N,N-dibenzyl-4-(4-(cyclopropylmethyl)piperazin- 1- yl)cyclohexan-1-amine (277, 670 mg, 1.6 mmol) and (ls,4s)-N,N-dibenzyl-4-(4- (cyclopropylmethyl)piperazin- 1 -yl)cyclohexan- 1-amine (278, 1.2 g, 2.9 mmol).(1R,4R)-N,N-Dibenzyl-4-(4-(cyclopropylmethyl)piperazin- 1-yl)cyclohexan- 1-amine(277): ?H NMR (300 MHz, CDC13): 37.29-7.26 (m, 4H), 7.24-7.18 (m, 4H), 7.15 -7.10 (m,2H), 3.53 (s, 4H), 2.81- 2.60 (m, 6H), 2.44 – 2.36 (m, 2H), 2.29 (d, J= 6.6 Hz, 2H), 1.96 – 1.88(m, 4H), 1.58 – 1.29 (m, 4H), 1.21 – 1.10 (m, 2H), 0.88 – 0.77 (m, 1H), 0.50 – 0.42 (m, 2H),0.10-0.02 (m, 2H).(1S,4S)-N,N-Dibenzyl-4-(4-(cyclopropylmethyl)piperazin- 1-yl)cyclohexan- 1-amine(278): ?H NMR (300 MHz, CDC13): oe 7.29-7.27 (m, 4H), 7.23 -7.18 (m, 4H), 7.14-7.09 (m,2H), 3.57 (s, 4H), 2.96 – 2.49 (m, 8H), 2.40 (d, J= 6.6 Hz, 2H), 2.20 (s, 1H), 1.89 – 1.85 (m,2H), 1.77 – 1.66 (m, 2H), 1.48 – 1.44 (m, 2H), 1.26 – 1.17 (m, 3H), 1.00 – 0.82 (m, 1H), 0.55 -0.49 (m, 2H), 0.16-0.11 (m, 2H).

57184-25-5 1-(Cyclopropylmethyl)piperazine 965875, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copeland; JUNG, David; (250 pag.)WO2018/5860; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57184-25-5,1-(Cyclopropylmethyl)piperazine,as a common compound, the synthetic route is as follows.

4-Cyclopropylmethyl-piperazine-1-carboxylic acid 4-(4-trifluoromethyl-phenoxy)-phenyl Ester The hydrochloride of the title compound was prepared from 4-(4-trifluoromethyl-phenoxy)-phenyl chloroformate and 1-cyclopropylmethyl-piperazine, yield 43%. White crystals, m.p. 238-2390C; IR (KBr): nu 1725 (C=O) cm-1.

57184-25-5, As the paragraph descriping shows that 57184-25-5 is playing an increasingly important role.

Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57184-25-5,1-(Cyclopropylmethyl)piperazine,as a common compound, the synthetic route is as follows.,57184-25-5

The cis-isomer may be prepared analogously. cis- and trans-4-(4-cyclopropylmethyl-piperazin-1-yl)-cyclohexylamine 9.8 g (33.4 mmol) of 4-dibenzylcyclohexanone is dissolved in 100 mL dichloromethane and stirred with 5.6 g (40 mmol) of N-cyclopropylmethylpiperazine and 8.5 g (40 mmol) of NaBH(OAc)3 for 12 h at RT. Then the mixture is combined with water and potassium carbonate, the org. phase is separated off and dried and the solvent is eliminated in vacuo. The residue is purified on a silica gel column (approx. 50 mL silica gel, approx. 3 L ethyl acetate 95/methanol 5+0.25% conc. ammonia). The desired fractions are evaporated down in vacuo. The faster eluding cis compound crystallises from ethyl acetate. The trans compound is crystallized from ethanol+conc. HCl. Yield: 8.5 g (61%) cis-isomer and 2.2 g (13%) trans-isomer.

The synthetic route of 57184-25-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Boehringer Ingelheim International GmbH; US2006/35903; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57184-25-5,1-(Cyclopropylmethyl)piperazine,as a common compound, the synthetic route is as follows.

4-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-[2-(4-chloro-phenyl)-ethylcarbamoyl]-phenyl Ester The title compound was prepared from 4-[2-(4-chloro-phenyl)-ethylcarbamoyl]-phenyl chloroformate and 1-cyclopropylmethyl-piperazine, yield 18%. White crystals, m.p. 225-226 C.; IR (KBr): nu 1710 (ester C=O), 1661 (amide C=O) cm-1.

57184-25-5, 57184-25-5 1-(Cyclopropylmethyl)piperazine 965875, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57184-25-5,1-(Cyclopropylmethyl)piperazine,as a common compound, the synthetic route is as follows.

4-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-[2-(4-chloro-phenyl)-ethylcarbamoyl]-phenyl Ester The title compound was prepared from 4-[2-(4-chloro-phenyl)-ethylcarbamoyl]-phenyl chloroformate and 1-cyclopropylmethyl-piperazine, yield 18%. White crystals, m.p. 225-226 C.; IR (KBr): nu 1710 (ester C=O), 1661 (amide C=O) cm-1.

57184-25-5, 57184-25-5 1-(Cyclopropylmethyl)piperazine 965875, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57184-25-5, 1-(Cyclopropylmethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57184-25-5, 4-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester The hydrochloride of the title compound was prepared from 4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-phenyl chloroformate and 1-cyclopropylmethyl-piperazine, yield 83%. White crystals, m.p. 254-255 C.; IR (KBr): nu 1728 (C=O) cm-1.

The synthetic route of 57184-25-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57184-25-5, 1-(Cyclopropylmethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57184-25-5, 4-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester The hydrochloride of the title compound was prepared from 4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-phenyl chloroformate and 1-cyclopropylmethyl-piperazine, yield 83%. White crystals, m.p. 254-255 C.; IR (KBr): nu 1728 (C=O) cm-1.

The synthetic route of 57184-25-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57184-25-5, 1-(Cyclopropylmethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57184-25-5, 4-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester The hydrochloride of the title compound was prepared from 4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-phenyl chloroformate and 1-cyclopropylmethyl-piperazine, yield 83%. White crystals, m.p. 254-255 C.; IR (KBr): nu 1728 (C=O) cm-1.

The synthetic route of 57184-25-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics