With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-70-5,tert-Butyl 4-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
57260-70-5, The procedure described for the preparation of 2a was used with compound 10c (400 mg, 1.22 mmol), 13a (322 mg,1.83 mmol), K2CO3 (337 mg, 2.44 mmol), NaI (catalyst) and CH3CN(15 mL) to obtain 2c (296 mg, 52%) as light brown liquid. Rf = 0.56(n-hexane: EtOAc: MeOH = 2.5:1.5:1). 1H NMR (500 MHz, CDCl3): d7.38-7.23 (m, 15H), 5.86 (s, 1H), 4.61 (t, J = 7 Hz, 2H), 3.54 (s, 2H),2.48-2.00 (m, 10H), 2.07-2.02 (m, 2H), 1.52-1.49 (m, 2H); 13CNMR (125 MHz, CDCl3): d 167.8, 140.9, 138.2, 129.2, 128.7, 128.6,128.2, 127.1, 127.0, 63.1, 57.6, 53.2, 53.1, 53.0, 48.7, 27.4, 23.6.
57260-70-5 tert-Butyl 4-benzylpiperazine-1-carboxylate 584330, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Paudel, Suresh; Acharya, Srijan; Yoon, Goo; Kim, Kyeong-Man; Cheon, Seung Hoon; Bioorganic and Medicinal Chemistry; vol. 25; 7; (2017); p. 2266 – 2276;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics