Category: 5753-26-4piperazines

5753-26-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5753-26-4,1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride,as a common compound, the synthetic route is as follows.

[4-CYCLOPENTYLAMINO-6-HYDROXY-QUINAZOLINE-2-CARBONITRILE] (0. [4MMOL),] 1- (2-Chloro- ethyl) -4-methyl-piperazine dihydrochloride [(0.] [55MMOL)] and cesium carbonate [(4MMOL)] are stirred in DMF [(5ML)] at RT for 20 hours. The suspension is filtered, washed with little DMF and water is added to the filtrate until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 110- [112C,] [RIF0.] 48 [(CH2CL2/MEOH=9] : 2) is obtained. [‘H-NMR] [(CDC13)] : 1.5-1. 9 [(M,] 6H), 2.2 [(M,] 2H), 2.35 (s, 3H), 2.4-2. 75 [(M,] 8H), 2.9 [(M,] [2H),] 4.25 [(M,] 2H), 4.6 [(M,] 1H), 6.85 (broad d, 1H), 7.05 (d, 1H), 7.45 (dd, 1H), 7.8 (d, [1H).]

5753-26-4 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride 11183940, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/20441; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5753-26-4,5753-26-4, 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) A mixture of 8.5 g of 9-acridanone, 180 ml of dimethylformamide and 3.3 g of sodium hydride is stirred for 0.5 hour, treated portionwise with 10.3 g of 2-[1-(4-methyl)-piperazinyl]ethyl chloride dihydrochloride, stirred at 80 for 3 days and evaporated. The residue is treated with water and extracted with methylene chloride. The extract is washed with water, dried over sodium sulfate and evaporated, whereupon the residue is recrystallized firstly from ether and then from ethyl acetate. There is obtained 10-[2-(4-methyl-1-piperazinyl)ethyl]-9-acridanone of melting point 156-157.

As the paragraph descriping shows that 5753-26-4 is playing an increasingly important role.

Reference£º
Patent; Hoffman-La Roche Inc.; US4711889; (1987); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics