N-Alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents was written by Liang, Gui-Bai;Qian, Xiaoxia;Feng, Dennis;Fisher, Michael;Crumley, Tami;Darkin-Rattray, Sandra J.;Dulski, Paula M.;Gurnett, Anne;Leavitt, Penny Sue;Liberator, Paul A.;Misura, Andrew S.;Samaras, Samantha;Tamas, Tamas;Schmatz, Dennis M.;Wyvratt, Matthew;Biftu, Tesfaye. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Application In Synthesis of 1,4-Dimethylpiperazine-2-carboxylic acid This article mentions the following:
Diaryl-(4-piperidinyl)pyrrole derivatives bearing cyclic amine substituents, e. g. I and II, have been synthesized and evaluated as anticoccidial agents. Improvements in potency of Et-PKG inhibition, such as azetidine derivative 3a, and broad spectrum anticoccidial activities in feed, such as morpholine derivative 8c, have been achieved. In the experiment, the researchers used many compounds, for example, 1,4-Dimethylpiperazine-2-carboxylic acid (cas: 58895-88-8Application In Synthesis of 1,4-Dimethylpiperazine-2-carboxylic acid).
1,4-Dimethylpiperazine-2-carboxylic acid (cas: 58895-88-8) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Application In Synthesis of 1,4-Dimethylpiperazine-2-carboxylic acid
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics