Category: 630125-91-6piperazines

630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

630125-91-6, 4-((4-ethylpiperazin-l-yl)methyl)-3-(trifluoromethyl)benzeneamine (30.6 mg) in 1,4-dioxane (1 mNo.), was added 4-nitrophenylchloroformate (21.6 mg) at room temperature. After 60 0C at 1 h, them mixture was cooled to rt and ethyl 6-(3-aminophenyl)-lH-indazole-3-carboxylate (30 mg) was added. The mixture was stirred at 90 0Cf or 12 h. Ethyl acetate and water were added and the aqueous layer was extracted with ethyl acetate three times. The combined organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was triturated in ethyl acetate/hexane to give6-(3-(3-(4-((4-ethylpiperazin-l-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenyl)-l H-indazole-3-carboxylate (16.2 mg).[643] [644] 1H NMR (400 MHz, DMSOd6) 613.98 (s, IH), 9.09 (s, IH), 8.93 (s, IH), 8.15 (8.4 Hz, IH), 7.99 (s, IH), 7.93 (s, IH), 7.81 (s, IH), 7.62 (m, 3H), 7.43 (br d, J = 4.4 Hz, 2H), 7.28 (m, IH), 4.41 (q, J = 7.2 Hz, 2H), 3.54 (s, 2H), 2.49 (m, 10H), 1.39 (t, J = 7.2 Hz, 3H).

As the paragraph descriping shows that 630125-91-6 is playing an increasingly important role.

Reference£º
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; SIM, Tae Bo; SON, Jung Beom; KIM, Hwan; PARK, Dong Sik; CHOI, Hwan Geun; HAM, Young Jin; HAH, Jung Mi; YOO, Kyung Ho; OH, Chang Hyun; LEE, So Ha; HA, Jae Du; CHO, Sung Yun; KWON, Byoung-Mog; HAN, Dong Cho; WO2010/64875; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

630125-91-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.630125-91-6,4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

To a solution of 4-bromo-2- (difluoromethyl) aniline (100 mg 0.450 mmol) in THF (10 mL) was added triphosgene (46.8 mg 0.158 mmol) . The resulting mixture was stirred at 70 . After 30 min LCMS analysis showed the starting material was disappeared. The solvent was removed in vacuo to give 4-bromo-2- (difluoromethyl) -1-isocyanatobenzene (110mg 0.417 mmol 93yield) . To a solution of 4- ( (4-ethylpiperazin-1-yl) methyl) -3- (trifluoromethyl) aniline (153 mg 0.532 mmol) Et3N (0.124 mL 0.887 mmol) and DMAP (10.84 mg 0.089 mmol) in THF (10 mL) was added a solution of 4-bromo-2- (difluoromethyl) -1-isocyanatobenzene (110 mg 0.444 mmol) in THF (10 mL) . The resulting mixture was stirred at 70 . After LCMS analysis showed the starting material was disappeared. The solvent was removed in vacuo. The residue was purified by preparative TLC (DCM/MeOH 10/1) to yield a solid of 1- (4-bromo-2- (difluoromethyl) phenyl) -3- (4- ( (4-ethylpiperazin-1-yl) methyl) -3- (trifluoromethyl) phenyl) urea (130 mg 0.172 mmol 38.9yield) 1HNMR(400 MHz CD3OD) delta 7.86 (s 1H) 7.75 (d J 8.8 Hz 1H) 7.67-7.63 (m 4H) 7.03-6.76 (m 1H) 3.67 (s 2H) 3.20-3.18 (m 2H) 2.96 (m 8H) 1.30 (m 3H) ES-LCMS m/z 535.1 537.1 (M+H)

The synthetic route of 630125-91-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

630125-91-6, A mixture of 4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (7, 17.5 mg, 0.06 mmol), triethylamine (0.014 mL, 0.1 mmol), and p-nitrophenyl chloroformate (12.4 mg, 0.06 mmol) in 1,4-dioxane (5 mL) was heated at 60 C for 2 h. A solution of 6a (20 mg, 0.06 mmol) in 1,4-dioxane (5 mL) was slowly added thereto. The reaction mixture was heated at 90 C overnight. The reaction mixture was concentrated under reduced pressure and then partitioned between water (5 mL) and ethyl acetate (5 mL). The organic layer was separated and the aqueous layer was then extracted with ethyl acetate (3 ¡Á 3 mL). The combined organic extracts were washed with brine and dried over anhydrous Na2SO4. After evaporation of the organic solvent, the residue was purified by column chromatography (silica gel, hexane-ethyl acetate 3:1 v/v then switching to hexane-ethyl acetate 1:1 v/v) to yield compound 8g (6.0 mg, 15%).

As the paragraph descriping shows that 630125-91-6 is playing an increasingly important role.

Reference£º
Article; El-Gamal, Mohammed I.; Jung, Myung-Ho; Lee, Woong San; Sim, Taebo; Yoo, Kyung Ho; Oh, Chang-Hyun; European Journal of Medicinal Chemistry; vol. 46; 8; (2011); p. 3218 – 3226;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics