Category: 6531-38-0

6531-38-0, 2,2′-(Piperazine-1,4-diyl)diethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6531-38-0, General procedure: General synthetic procedure for m1-m5, 4-15, and 27-35 A mixture of 2-methylsulfanyl-1,3-thiazolin-4-one 3a-3l (1 mmol) and the appropriate diamine (0.5 mmol) or amine (1 mmol) in ethanol was refluxed for 8 h. After cooling, the precipitate was filtered, washed with ethanol and dried. (5Z,5’Z)-2,2′-[Piperazine-1,4-diylbis(ethane-2,1-diylimino)]bis(5-(4-hydroxybenzylidene)-1,3-thiazol-4(5H)-one) (14) Yellow solid (0.33 g, 58%), mp >250C; IR (cm-1) 3190, 3008, 2826, 1715, 1680, 1600, 1581, 1504, 1450, 1346, 1271, 1248, 1204, 1176, 1137, 1008; 1H RMN (250 MHz, DMSO-d6) d: 2.48-2.53 (m, 12H, 6xCH2), 3.65-3.68 (m, 4H, 2xCH2), 6.92 (d, J =8.5, 4H, Ar-H), 7.43 (d, 4H, Ar-H), 7.52 (s, 2H, 2xC=CH), 9.82 (s, 4H, OH/NH); 13C RMN (500 MHz, DMSO-d6) d: 41.7 (x2), 52.5 (x4), 56.1 (x2), 116.1 (x4), 124.6 (x2), 124.8 (x2), 129.4 (x2), 131.4 (x4), 158.9 (x2), 173.3 (x2), 179.9 (x2). ESI-MS (m/z) calcd for C28H30N6O4S2 : 578.1, found 577.2 [M-H]-.

6531-38-0 2,2′-(Piperazine-1,4-diyl)diethanamine 81020, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Sarkis, Manal; Tran, Diem Ngan; Kolb, Stephanie; Miteva, Maria A.; Villoutreix, Bruno O.; Garbay, Christiane; Braud, Emmanuelle; Bioorganic and Medicinal Chemistry Letters; vol. 22; 24; (2012); p. 7345 – 7350;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6531-38-0,2,2′-(Piperazine-1,4-diyl)diethanamine,as a common compound, the synthetic route is as follows.

To a 25ml RBF containing a magnetic stir bar was added the imidazolide of Bumetanide (0.207g , 0.99mmol) and dissolved in ImI DCM. To the above solution was added the amine (0.172g, 0.999mmol) and let stir overnight at it under argon. TLC in 10% MeOH in EtOAc indicated a very polar spot. Extracted the reaction mixture into EtOAc, washed with water (2x20ml) and then with brine (2x20ml). The organic layer was dried under MgSO4 and filtered. Concentrated the organic layerunder vacuum. Redissolved the crude product in the minimum amount of DCM and reprecipitated from hexanes. Filtered the above precipitate to obtain yellowish white solid. 1HNMR in DMSO-d6+2 drops of MeOD.1HNMR (300MHz, DMSO-d6+2 drops of MeOD) Q.80ppm (t, J=IOHz, 3H),1.1 lppm (m, 2H), 1.37rhopm (m,2H), 2.50ppm (m, 8H), 3.05ppm (t, J= 6.6Hz, 2H), 3.35ppm (t, J=.6Hz, 2H), 4.1ppm (s, br, 4H), 4.95ppm (t, br, IH), 6.85ppm (d, J=7.8Hz, 2H), 7.00ppm (t, 7.2Hz, IH), 7.26ppm (dd, J=7.8Hz, 2H), 7.6ppm (s, IH) 13CNMR (75MHz, DMSO-d6) 19.23, 24.93, 35.89, 47.50, 58.45, 62.50,107.50, 1 19.0, 121.16, 128.0, 134.66, 137.50, 144.0, 143.00, 147.80, 162.20, 171.0 FABMS 519 (M+H)+ calcd m/z for C25H39N6O4S+ 519.28 ; found 519.27, 6531-38-0

6531-38-0 2,2′-(Piperazine-1,4-diyl)diethanamine 81020, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; FLYNN, Gary, A.; YOOL, Andrea, J.; MIGLIATI, Elton, Rodrigues; RITTER, Leslie, S.; WO2008/52190; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6531-38-0,2,2′-(Piperazine-1,4-diyl)diethanamine,as a common compound, the synthetic route is as follows.

To Intermediate 50.2 (500 mg, 2 91 mmol, 1 00 equiv) m dichloromethane (10 mL) was added tnethylamme (1 46 g, 0 01 mmol, 2 00 equiv) and 4-(benzyloxy)benzene-l-sulfonyl chlo?de (2 0 g, 0 01 mmol, 240 equiv) and the resulting solution was stirred for 2 h at room temperature The reaction was diluted with dichloromethane, washed with 3×10 mL of water, dried over sodium sulfate then filtered and concentrated under vacuum to afford 0 9 g (47%) of Intermediate 50 3 as a yellow solid., 6531-38-0

The synthetic route of 6531-38-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARDELYX, INC.; CHARMOT, Dominique; JACOBS, Jeffrey, W.; LEADBETTER, Michael, Robert; NAVRE, Marc; CARRERAS, Chris; BELL, Noah; WO2010/78449; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

6531-38-0, 2,2′-(Piperazine-1,4-diyl)diethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6531-38-0, Example 35 (compound No.14*); l,4-bis{2-[4-fluorobenzyl)amino]ethyl}piperazine; To a solution of l,4-bis(2-aminoethyl)piperazine (0.43 g, 2.5 mmol) and 4- fluorobenzaldehyde (0.59 mL, 5.5 mmol) in absolute ethanol (20 mL), 3 A molecular sieves are added. After stirring the mixture at room temperature for 5h, NaBH4 (0.47 g,12.5 mmol) was added portionwise and the mixture was stirred for 12h at room temperature. The reaction was quentched by dropwise addition of water (20 mL) and ethanol was removed under reduced pressure. The aqueous residue was extracted with CH2Cl2 (3 x 30 mL). Combined organic layers were extracted with HCl IM. The combined aqueous layers were neutralized with NaOH IM and extracted with CH2Cl2. Combined organic layers were dried over MgSO4. Crude compound is purified by thick-layer chromatography (CH2Cl2/MeOH : 80/20).

The synthetic route of 6531-38-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DU DROIT ET DE LA SANTE – LILLE II; WO2006/51489; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics