Category: 6531-38-0piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6531-38-0,2,2′-(Piperazine-1,4-diyl)diethanamine,as a common compound, the synthetic route is as follows.

Example 34 (compound No.13; *) l,4-bis{2-[4-chlorobenzyl)amino]ethyl}piperazine; To a solution of l,4-bis(2-aminoethyl)piperazine (0.43g, 2.5 mmol) and 4- chlorobenzaldehyde (737 mg, 5.24 mmol) in absolute ethanol (20 mL), 3 A molecular sieves are added. After stirring the mixture at room temperature for 12h, NaBH4 (1.9 g, 49.92 mmol) was added portionwise and the mixture was stirred for 12h at room temperature. The reaction was quentched by dropwise addition of water (20 mL) and ethanol was removed under reduced pressure. The aqueous residue was extracted with EPO CH2Cl2 (3 x 30 mL). Combined organic layers were extracted with HCl IM. The combined aqueous layers were neutralized with NaOH IM and extracted with CH2Cl2. Combined organic layers were dried over MgSO4. Crude compound is purified by thick-layer chromatography (CH2Cl2/Me0H : 80/20).

6531-38-0, As the paragraph descriping shows that 6531-38-0 is playing an increasingly important role.

Reference£º
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DU DROIT ET DE LA SANTE – LILLE II; WO2006/51489; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

6531-38-0, 2,2′-(Piperazine-1,4-diyl)diethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6531-38-0, To the MeOH solution of 2-[4-(2-amino-ethyl)-piperazine-1-yl]-ethylamine (0.344 g, 2 mmol), salicylaldehyde (0.484 g, 4 mmol) was added under ice-cold condition and stirred for 3 h to give a yellow solid which was separated by filtration through G4 sintered bed and washed thoroughly with ice cold MeOH. The isolated solid was next dried in vacuo over anhydrous CaCl2. The single crystals uitable for X-ray analysis were obtained from hot MeOH after 4 days and found to be same as reported earlier [21]. Yield 1.92 g (~87% yield), mp 152 C. Selected IR peaks (KBr, cm-1, vs = very strong, br = broad, s = strong, m = medium): 2939(b), 2823(b), 1641(vs), 1499(s), 1441(s), 1281(vs), 1159(s), 1017(s), 863(s), 764(s). 1H NMR (CDCl3, ppm): delta (phenolic OH) 13.43(s, 2H); 8.35 (s, 2H); 7.35-6.83(m, 8H); 3.73(t, 4H); 2.70(t, 4H); 2.57 (s, 8H). 13C NMR (CDCl3, ppm): delta (C7,16) 165.52; (C1,22) 161.16; (C6,17) 132.13; (C3,5, 18,20)131.14; (C4,19) 118.44; (C2,21) 116.98; (C9,14) 58.59; (C8,15) 56.98; (C10,11,12,13) 53.33.

As the paragraph descriping shows that 6531-38-0 is playing an increasingly important role.

Reference£º
Article; Basak, Dipmalya; Ray, Debashis; Inorganica Chimica Acta; vol. 503; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics