Category: 66-71-7

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,10-Phenanthroline(SMILESS: C1=CC3=C(C2=NC=CC=C12)N=CC=C3,cas:66-71-7) is researched.Related Products of 15418-29-8. The article 《Improved singlet oxygen generation in rhenium(I) complexes functionalized with a pyridinyl selenoether ligand》 in relation to this compound, is published in Polyhedron. Let’s take a look at the latest research on this compound (cas:66-71-7).

The synthesis, characterization, electrochem. and photophys. properties of three novel polypyridine rhenium(I) complexes coordinated to an organoselenide ligand, 4-(phenylseleno)-pyridine (PhSepy), and structurally related polypyridine ligands, fac-[Re(CO)3(NN)(PhSepy)]+ NN = 1,10-phenanthroline (phen), 4,7-diphenyl-1,10-phenanthroline (ph2phen) and pyrazino[2,3-f]-1,10-phenanthroline (dpq), are reported. In addition, their ability to act as a photosensitizer agent for the generation of singlet oxygen was investigated. Cyclic and differential pulse voltammetry experiments showed an overlap of the redox waves characteristic of the 4-(phenylseleno)-pyridine ligand and the Re(I) complex. This finding is consistent with a strong contribution of the pyridine-based ligand on the HOMO levels of the three investigated complexes, further supported by quantum mech. calculations Moreover, the lowest energy band observed in the absorption spectra of the complexes was also influenced by the organoselenide ligand, with a combination of the usual MLCTRe→NN transition with a ligand-to-ligand charge transfer (LLCT) one. The three complexes showed typical emission spectra for this class of compounds ascribed to 3MLCTRe→NN, with excellent quantum yields for the singlet oxygen generation (ΦΔ = 0.65-070). Remarkably, these are significantly larger (15-29%) than those for structurally related complexes with non-functionalized pyridyl ligands, revealing a significant ability as a photosensitizer agent. Therefore, authors envisage this work to be of interest to those engaged in the development of novel rhenium(I) complexes for optoelectronic applications.

From this literature《Improved singlet oxygen generation in rhenium(I) complexes functionalized with a pyridinyl selenoether ligand》,we know some information about this compound(66-71-7)COA of Formula: C12H8N2, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of 1,10-Phenanthroline. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Strong negative correlation between codon usage bias and protein structural disorder impedes protein expression after codon optimization.

As a common phenomenon existing in almost all genomes, codon usage bias has been studied for a long time. Codon optimization is a frequently used strategy to accelerate protein synthesis rate. Besides regulating protein translation speed, codon usage bias has also be reported to affect co-translation folding and transcription. P. pastoris is a well-developed expression system, whose efficiency is tightly correlated with com. value. However, few studies focus on the role of codon usage bias in affecting protein expression in P. pastoris. Besides, many genes in P. pastoris genome show significant neg. correlation between codon usage bias and protein structural disorder tendency. It’s not known whether this feature is important for their expression. In order to answer these questions, we picked 4P. pastoris gene candidates with strong neg. correlation between codon usage bias and protein structural disorder. We then performed full-length codon optimization which completely eliminated the correlation. Protein and RNA assays were then used to compare protein and mRNA levels before and after codon optimization. As a result, codon optimization failed to elevate their protein expression levels, and even resulted in a decrease. As represented by the trypsin sensitivity assays, codon optimization also altered the protein structure of 0616 and 0788. Besides protein, codon optimization also affected mRNA levels. Shown by in vitro and in vivo RNA degradation assays, the mRNA stability of 0616, 0788 and 0135 were also altered by codon optimization. For each gene, the detailed effect may be related with its specific sequence and protein structure. Our results suggest that codon usage bias is an important factor to regulate gene expression level, as well as mRNA and protein stabilities in P. pastoris. “”Extreme”” codon optimization in genes with strong neg. correlation between codon usage bias and protein structural disorder tendency may not be favored. Compromised strategies should be tried if expression is not successful. Besides, codon optimization may affect protein structural conformation more severely in structural disordered proteins.

Here is a brief introduction to this compound(66-71-7)Application In Synthesis of 1,10-Phenanthroline, if you want to know about other compounds related to this compound(66-71-7), you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Product Details of 66-71-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Manganese(II) complexes of substituted salicylaldehydes and α-diimines: Synthesis, characterization and biological activity. Author is Ntanatsidis, Savvas; Perontsis, Spyros; Konstantopoulou, Sofia; Kalogiannis, Stavros; Hatzidimitriou, Antonios G.; Papadopoulos, Athanasios N.; Psomas, George.

The interaction of Mn+2 with substituted salicylaldehydes (X-saloH) gave five manganese(II) complexes formulated as [Μn(X-salo)2(MeOH)2]. When the reactions took place in the presence of an α-diimine such as 2,2′-bipyridine, 1,10-phenanthroline or 2,2′-bipyridylamine, five manganese(II) complexes [Mn(X-salo)2(α-diimine)] were isolated. The characterization of the complexes was accomplished by various spectroscopic techniques and single-crystal x-ray crystallog. The antioxidant activity of the compounds was evaluated via the scavenging of 1,1-diphenyl-picrylhydrazyl, 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl free radicals. The antibacterial activity of the complexes was tested in vitro against Staphylococcus aureus and Xanthomonas campestris bacterial strains and was found moderate. Diverse techniques were employed to examine the interaction of the complexes with calf-thymus DNA which showed intercalation as the most possible interaction mode. The affinity of the complexes for bovine serum albumin was investigated by fluorescence emission spectroscopy and the binding constants were determined

There is still a lot of research devoted to this compound(SMILES：C1=CC3=C(C2=NC=CC=C12)N=CC=C3)Product Details of 66-71-7, and with the development of science, more effects of this compound(66-71-7) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ubale, Panchsheela; Mokale, Santosh; More, Shweta; Waghamare, Shailesh; More, Vikramsinh; Munirathinam, Nethaji; Dilipkumar, Suma; Das, Rajesh Kumar; Reja, Sahin; Helavi, Vasant B.; Kollur, Shiva Prasad researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Reference of 1,10-Phenanthroline.They published the article 《Evaluation of in vitro anticancer, antimicrobial and antioxidant activities of new Cu(II) complexes derived from 4(3H)-quinazolinone: Synthesis, crystal structure and molecular docking studies》 about this compound( cas:66-71-7 ) in Journal of Molecular Structure. Keywords: copper quinazolinone schiff base complex preparation crystal structure; mol docking copper quinazolinone schiff base complex; anticancer antimicrobial antioxidant activity copper quinazolinone schiff base complex. We’ll tell you more about this compound (cas:66-71-7).

Present study describes synthesis of a series of Cu(II) metal complexes (C1 – C3) of bidentate Schiff base ligands (L1 – L3) derived from the condensation reaction of 3-amino-2-methyl-4(3H)quinazolinone with 2-chlorobenzaldehyde, 4-bromobenzaldehyde and 2-nitrobenzaldehyde. The structural characterization of synthesized compounds was analyzed on the basis of FTIR, UV-Visible, 1H NMR and mass spectroscopy. The orthorhombic structure of the L3 is determined by x-ray crystallog. anal. In silico anal. of all compounds against various protein targets prove to have better interaction parameters in case of c-MET and VEGFR, thus in accordance with the docking score, the colon cell line (HT-29) was selected for further in vitro anal. and L3, C1, C2 and C3 exhibit important anticancer activity when compared with the standard drug Adriamycin. Further, synthesized compounds showed excellent activity against Gram-pos. (Staphylococcus aureus) and Gram-neg. pathogens (Escherichia coli) but exhibited poor activity against fungal strain. Antioxidant activity of the all compounds revealed that the complexes displayed a higher scavenging activity than the corresponding ligands. These studies reveal that the coordination of Cu(II) ion with mixed ligands play a vital role in the enhancement of the biol. potential of the complexes.

There is still a lot of research devoted to this compound(SMILES：C1=CC3=C(C2=NC=CC=C12)N=CC=C3)Reference of 1,10-Phenanthroline, and with the development of science, more effects of this compound(66-71-7) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 66-71-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Luminescence behavior of PMMA films doped with Tb(III) and Eu(III) complexes. Author is Knyazev, Andrey A.; Krupin, Aleksandr S.; Galyametdinov, Yuriy G..

Novel hybrid systems based on the poly(Me methacrylate) (PMMA) matrix and Eu(III) and Tb(III) tris(β-diketonates) complexes with 1,10-phenanthroline were synthesized and analyzed as light-conversion materials. Solutions of the Tb(III) and Eu(III) complexes doped into PMMA were spin-coated to fabricate films with various concentrations of luminophores. Long hydrocarbon substituents in the structure of complexes inhibit their crystallization In turn, it allows to vary the luminophore content in a polymer matrix in a broader range and achieve the maximum of emission with higher concentrations of dopants. The addition of the Tb(III) complex to the system results in a 26% increase in the relative luminescence quantum yield of the Eu(III) ions due to an addnl. energy transfer from the Tb(III) compound The results of this work illustrate that although the Eu(III) and Tb(III) complexes exhibit lower rate and efficiency of energy transfer than their well-known Tb(acac)3 and Eu(tta)3 analogs, the structural features of lanthanide complexes allow to efficiently dope a PMMA matrix with considerably larger amounts of luminophores. It offers broader application opportunities for the coordination Ln(III) compounds as polyfunctional materials for optics and optoelectronics.

There is still a lot of research devoted to this compound(SMILES：C1=CC3=C(C2=NC=CC=C12)N=CC=C3)Recommanded Product: 66-71-7, and with the development of science, more effects of this compound(66-71-7) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,10-Phenanthroline(SMILESS: C1=CC3=C(C2=NC=CC=C12)N=CC=C3,cas:66-71-7) is researched.Related Products of 15418-29-8. The article 《Improved singlet oxygen generation in rhenium(I) complexes functionalized with a pyridinyl selenoether ligand》 in relation to this compound, is published in Polyhedron. Let’s take a look at the latest research on this compound (cas:66-71-7).

The synthesis, characterization, electrochem. and photophys. properties of three novel polypyridine rhenium(I) complexes coordinated to an organoselenide ligand, 4-(phenylseleno)-pyridine (PhSepy), and structurally related polypyridine ligands, fac-[Re(CO)3(NN)(PhSepy)]+ NN = 1,10-phenanthroline (phen), 4,7-diphenyl-1,10-phenanthroline (ph2phen) and pyrazino[2,3-f]-1,10-phenanthroline (dpq), are reported. In addition, their ability to act as a photosensitizer agent for the generation of singlet oxygen was investigated. Cyclic and differential pulse voltammetry experiments showed an overlap of the redox waves characteristic of the 4-(phenylseleno)-pyridine ligand and the Re(I) complex. This finding is consistent with a strong contribution of the pyridine-based ligand on the HOMO levels of the three investigated complexes, further supported by quantum mech. calculations Moreover, the lowest energy band observed in the absorption spectra of the complexes was also influenced by the organoselenide ligand, with a combination of the usual MLCTRe→NN transition with a ligand-to-ligand charge transfer (LLCT) one. The three complexes showed typical emission spectra for this class of compounds ascribed to 3MLCTRe→NN, with excellent quantum yields for the singlet oxygen generation (ΦΔ = 0.65-070). Remarkably, these are significantly larger (15-29%) than those for structurally related complexes with non-functionalized pyridyl ligands, revealing a significant ability as a photosensitizer agent. Therefore, authors envisage this work to be of interest to those engaged in the development of novel rhenium(I) complexes for optoelectronic applications.

From this literature《Improved singlet oxygen generation in rhenium(I) complexes functionalized with a pyridinyl selenoether ligand》,we know some information about this compound(66-71-7)COA of Formula: C12H8N2, but this is not all information, there are many literatures related to this compound(66-71-7).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of 1,10-Phenanthroline. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Strong negative correlation between codon usage bias and protein structural disorder impedes protein expression after codon optimization.

As a common phenomenon existing in almost all genomes, codon usage bias has been studied for a long time. Codon optimization is a frequently used strategy to accelerate protein synthesis rate. Besides regulating protein translation speed, codon usage bias has also be reported to affect co-translation folding and transcription. P. pastoris is a well-developed expression system, whose efficiency is tightly correlated with com. value. However, few studies focus on the role of codon usage bias in affecting protein expression in P. pastoris. Besides, many genes in P. pastoris genome show significant neg. correlation between codon usage bias and protein structural disorder tendency. It’s not known whether this feature is important for their expression. In order to answer these questions, we picked 4P. pastoris gene candidates with strong neg. correlation between codon usage bias and protein structural disorder. We then performed full-length codon optimization which completely eliminated the correlation. Protein and RNA assays were then used to compare protein and mRNA levels before and after codon optimization. As a result, codon optimization failed to elevate their protein expression levels, and even resulted in a decrease. As represented by the trypsin sensitivity assays, codon optimization also altered the protein structure of 0616 and 0788. Besides protein, codon optimization also affected mRNA levels. Shown by in vitro and in vivo RNA degradation assays, the mRNA stability of 0616, 0788 and 0135 were also altered by codon optimization. For each gene, the detailed effect may be related with its specific sequence and protein structure. Our results suggest that codon usage bias is an important factor to regulate gene expression level, as well as mRNA and protein stabilities in P. pastoris. “”Extreme”” codon optimization in genes with strong neg. correlation between codon usage bias and protein structural disorder tendency may not be favored. Compromised strategies should be tried if expression is not successful. Besides, codon optimization may affect protein structural conformation more severely in structural disordered proteins.

Here is a brief introduction to this compound(66-71-7)Application In Synthesis of 1,10-Phenanthroline, if you want to know about other compounds related to this compound(66-71-7), you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Product Details of 66-71-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Manganese(II) complexes of substituted salicylaldehydes and α-diimines: Synthesis, characterization and biological activity. Author is Ntanatsidis, Savvas; Perontsis, Spyros; Konstantopoulou, Sofia; Kalogiannis, Stavros; Hatzidimitriou, Antonios G.; Papadopoulos, Athanasios N.; Psomas, George.

The interaction of Mn+2 with substituted salicylaldehydes (X-saloH) gave five manganese(II) complexes formulated as [Μn(X-salo)2(MeOH)2]. When the reactions took place in the presence of an α-diimine such as 2,2′-bipyridine, 1,10-phenanthroline or 2,2′-bipyridylamine, five manganese(II) complexes [Mn(X-salo)2(α-diimine)] were isolated. The characterization of the complexes was accomplished by various spectroscopic techniques and single-crystal x-ray crystallog. The antioxidant activity of the compounds was evaluated via the scavenging of 1,1-diphenyl-picrylhydrazyl, 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl free radicals. The antibacterial activity of the complexes was tested in vitro against Staphylococcus aureus and Xanthomonas campestris bacterial strains and was found moderate. Diverse techniques were employed to examine the interaction of the complexes with calf-thymus DNA which showed intercalation as the most possible interaction mode. The affinity of the complexes for bovine serum albumin was investigated by fluorescence emission spectroscopy and the binding constants were determined

There is still a lot of research devoted to this compound(SMILES：C1=CC3=C(C2=NC=CC=C12)N=CC=C3)Product Details of 66-71-7, and with the development of science, more effects of this compound(66-71-7) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ubale, Panchsheela; Mokale, Santosh; More, Shweta; Waghamare, Shailesh; More, Vikramsinh; Munirathinam, Nethaji; Dilipkumar, Suma; Das, Rajesh Kumar; Reja, Sahin; Helavi, Vasant B.; Kollur, Shiva Prasad researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Reference of 1,10-Phenanthroline.They published the article 《Evaluation of in vitro anticancer, antimicrobial and antioxidant activities of new Cu(II) complexes derived from 4(3H)-quinazolinone: Synthesis, crystal structure and molecular docking studies》 about this compound( cas:66-71-7 ) in Journal of Molecular Structure. Keywords: copper quinazolinone schiff base complex preparation crystal structure; mol docking copper quinazolinone schiff base complex; anticancer antimicrobial antioxidant activity copper quinazolinone schiff base complex. We’ll tell you more about this compound (cas:66-71-7).

Present study describes synthesis of a series of Cu(II) metal complexes (C1 – C3) of bidentate Schiff base ligands (L1 – L3) derived from the condensation reaction of 3-amino-2-methyl-4(3H)quinazolinone with 2-chlorobenzaldehyde, 4-bromobenzaldehyde and 2-nitrobenzaldehyde. The structural characterization of synthesized compounds was analyzed on the basis of FTIR, UV-Visible, 1H NMR and mass spectroscopy. The orthorhombic structure of the L3 is determined by x-ray crystallog. anal. In silico anal. of all compounds against various protein targets prove to have better interaction parameters in case of c-MET and VEGFR, thus in accordance with the docking score, the colon cell line (HT-29) was selected for further in vitro anal. and L3, C1, C2 and C3 exhibit important anticancer activity when compared with the standard drug Adriamycin. Further, synthesized compounds showed excellent activity against Gram-pos. (Staphylococcus aureus) and Gram-neg. pathogens (Escherichia coli) but exhibited poor activity against fungal strain. Antioxidant activity of the all compounds revealed that the complexes displayed a higher scavenging activity than the corresponding ligands. These studies reveal that the coordination of Cu(II) ion with mixed ligands play a vital role in the enhancement of the biol. potential of the complexes.

There is still a lot of research devoted to this compound(SMILES：C1=CC3=C(C2=NC=CC=C12)N=CC=C3)Reference of 1,10-Phenanthroline, and with the development of science, more effects of this compound(66-71-7) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 66-71-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Luminescence behavior of PMMA films doped with Tb(III) and Eu(III) complexes. Author is Knyazev, Andrey A.; Krupin, Aleksandr S.; Galyametdinov, Yuriy G..

Novel hybrid systems based on the poly(Me methacrylate) (PMMA) matrix and Eu(III) and Tb(III) tris(β-diketonates) complexes with 1,10-phenanthroline were synthesized and analyzed as light-conversion materials. Solutions of the Tb(III) and Eu(III) complexes doped into PMMA were spin-coated to fabricate films with various concentrations of luminophores. Long hydrocarbon substituents in the structure of complexes inhibit their crystallization In turn, it allows to vary the luminophore content in a polymer matrix in a broader range and achieve the maximum of emission with higher concentrations of dopants. The addition of the Tb(III) complex to the system results in a 26% increase in the relative luminescence quantum yield of the Eu(III) ions due to an addnl. energy transfer from the Tb(III) compound The results of this work illustrate that although the Eu(III) and Tb(III) complexes exhibit lower rate and efficiency of energy transfer than their well-known Tb(acac)3 and Eu(tta)3 analogs, the structural features of lanthanide complexes allow to efficiently dope a PMMA matrix with considerably larger amounts of luminophores. It offers broader application opportunities for the coordination Ln(III) compounds as polyfunctional materials for optics and optoelectronics.

There is still a lot of research devoted to this compound(SMILES：C1=CC3=C(C2=NC=CC=C12)N=CC=C3)Recommanded Product: 66-71-7, and with the development of science, more effects of this compound(66-71-7) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics